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O93299 (CP2K3_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2K3

EC=1.14.14.1
Alternative name(s):
CYPIIK3
Cytochrome P450 LMC2
Gene names
Name:cyp2k3
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2K3
PRO_0000051774

Sites

Metal binding4341Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O93299 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 2194A1054FFE928E

FASTA49155,288
        10         20         30         40         50         60 
MSLIEGLLQT SSTVTLLGTV LFLLVLYLRS SGSSSEGQGK EPPGPRPLPL LGNMLQLDLK 

        70         80         90        100        110        120 
KPYCTLCELS KKYGSIFTFH FGPKKVVVLA GYKTVKQALV NQAEDFGDRD ITPVFYDFNQ 

       130        140        150        160        170        180 
GHGILFANGD SWKEMRRFAL TNLRDFGMGK KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ 

       190        200        210        220        230        240 
SVLYAVSNII SAIVYGSRFE YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN 

       250        260        270        280        290        300 
LTRLKKNIAD MKMEVTELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL 

       310        320        330        340        350        360 
VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SGVIGSRQTL VEDRKNLPYT 

       370        380        390        400        410        420 
DAVIHETQRL ANIAPMSIPH TTSRDVTFQG YFIKKDDSEW ESPHTLTPSH FLDEKGGFVK 

       430        440        450        460        470        480 
RDAFMAFSAG RRVCLGEGLA RMELFLFFTS LLQHFRFSPP PGVTEDDLDL TPSVEFTHNP 

       490 
SPHQLCAVSR V 

« Hide

References

[1]"Cloning, sequencing and heterologous expression of CYP2K1 and CYP2K3 from sexually mature rainbow trout liver and their roles in aflatoxin B1 activation."
Yang Y.-H., Miranda C.L., Wang J.-L., Buhler D.R.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043551 mRNA. Translation: AAC26494.1.

3D structure databases

ProteinModelPortalO93299.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2K3_ONCMY
AccessionPrimary (citable) accession number: O93299
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: December 11, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families