Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O93299

- CP2K3_ONCMY

UniProt

O93299 - CP2K3_ONCMY

Protein

Cytochrome P450 2K3

Gene

cyp2k3

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2K3 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIK3
    Cytochrome P450 LMC2
    Gene namesi
    Name:cyp2k3
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2K3PRO_0000051774Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO93299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O93299-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLIEGLLQT SSTVTLLGTV LFLLVLYLRS SGSSSEGQGK EPPGPRPLPL    50
    LGNMLQLDLK KPYCTLCELS KKYGSIFTFH FGPKKVVVLA GYKTVKQALV 100
    NQAEDFGDRD ITPVFYDFNQ GHGILFANGD SWKEMRRFAL TNLRDFGMGK 150
    KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ SVLYAVSNII SAIVYGSRFE 200
    YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN LTRLKKNIAD 250
    MKMEVTELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL 300
    VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SGVIGSRQTL 350
    VEDRKNLPYT DAVIHETQRL ANIAPMSIPH TTSRDVTFQG YFIKKDDSEW 400
    ESPHTLTPSH FLDEKGGFVK RDAFMAFSAG RRVCLGEGLA RMELFLFFTS 450
    LLQHFRFSPP PGVTEDDLDL TPSVEFTHNP SPHQLCAVSR V 491
    Length:491
    Mass (Da):55,288
    Last modified:November 1, 1998 - v1
    Checksum:i2194A1054FFE928E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043551 mRNA. Translation: AAC26494.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043551 mRNA. Translation: AAC26494.1 .

    3D structure databases

    ProteinModelPortali O93299.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and heterologous expression of CYP2K1 and CYP2K3 from sexually mature rainbow trout liver and their roles in aflatoxin B1 activation."
      Yang Y.-H., Miranda C.L., Wang J.-L., Buhler D.R.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP2K3_ONCMY
    AccessioniPrimary (citable) accession number: O93299
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3