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Protein

Cytochrome P450 2K3

Gene

cyp2k3

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi434 – 4341Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2K3 (EC:1.14.14.1)
Alternative name(s):
CYPIIK3
Cytochrome P450 LMC2
Gene namesi
Name:cyp2k3
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2K3PRO_0000051774Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO93299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIEGLLQT SSTVTLLGTV LFLLVLYLRS SGSSSEGQGK EPPGPRPLPL
60 70 80 90 100
LGNMLQLDLK KPYCTLCELS KKYGSIFTFH FGPKKVVVLA GYKTVKQALV
110 120 130 140 150
NQAEDFGDRD ITPVFYDFNQ GHGILFANGD SWKEMRRFAL TNLRDFGMGK
160 170 180 190 200
KGSEEKILEE IPYLIEVFEK HEGKAFDTTQ SVLYAVSNII SAIVYGSRFE
210 220 230 240 250
YTDPLFTGMA DRAKESIHLT GSASIQMYNM FPWLGPWINN LTRLKKNIAD
260 270 280 290 300
MKMEVTELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGH MDSFYHDDNL
310 320 330 340 350
VFSVGNLFSA GTDTTGTTLR WGLLLMTKYP HIQDQVQEEI SGVIGSRQTL
360 370 380 390 400
VEDRKNLPYT DAVIHETQRL ANIAPMSIPH TTSRDVTFQG YFIKKDDSEW
410 420 430 440 450
ESPHTLTPSH FLDEKGGFVK RDAFMAFSAG RRVCLGEGLA RMELFLFFTS
460 470 480 490
LLQHFRFSPP PGVTEDDLDL TPSVEFTHNP SPHQLCAVSR V
Length:491
Mass (Da):55,288
Last modified:October 31, 1998 - v1
Checksum:i2194A1054FFE928E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043551 mRNA. Translation: AAC26494.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043551 mRNA. Translation: AAC26494.1.

3D structure databases

ProteinModelPortaliO93299.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing and heterologous expression of CYP2K1 and CYP2K3 from sexually mature rainbow trout liver and their roles in aflatoxin B1 activation."
    Yang Y.-H., Miranda C.L., Wang J.-L., Buhler D.R.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP2K3_ONCMY
AccessioniPrimary (citable) accession number: O93299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: October 31, 1998
Last modified: January 6, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.