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O93297 (CP2K4_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2K4

EC=1.14.14.1
Alternative name(s):
CYPIIK4
Gene names
Name:cyp2k4
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 2K4
PRO_0000051775

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
O93297 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: AC4292C18617C4B1

FASTA50456,734
        10         20         30         40         50         60 
MSLIEGLLQT SSTVTLLGTV LFLLVPYLRS SGSSSEEQGK EPPGPRPLPL LGNMLQLDLK 

        70         80         90        100        110        120 
KPYCTLCELS KKYGSIFTVH FGSKKVVVLA GYKTVKQALV NQAEDFGERD ITPAFYDFNQ 

       130        140        150        160        170        180 
GHGILFTNGD SWKEMRRFAL TNLRDFGMGK KGSEEKILEE IPYLIEVLEK HEGKAFDTTQ 

       190        200        210        220        230        240 
SVHHAVSNII SAIVYGSRFE YTDPLFTGMV DRVNENVHLI GSASIQMYNM FPWLGPWINN 

       250        260        270        280        290        300 
LTRLKKNVAD LKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGK MDSFYHDDNL 

       310        320        330        340        350        360 
LFSIGNLFGA GTDTTGTTLR WGLLLMAKYP HIQDQVQEEI SRVIGSRQTL VEDRKNLPYT 

       370        380        390        400        410        420 
DAVIHETQRL ANISPMAVPH TTSRDVTFQG YFIKKGTSVI PLLMSVLQDD NEWESPNTFN 

       430        440        450        460        470        480 
PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE GLARMELFLF FTSLLQRFRF SPPPGVTEDD 

       490        500 
LDLTPLLGFT LHPSPHQLCA VSRV 

« Hide

References

[1]"CYP2K4: a new cytochrome P450 isoform from male trunk kidney of post-spawning rainbow trout."
Yang Y.-H., Andersson T.B., Ryu B.-W., Wang J.-L., Buhler D.R.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043296 mRNA. Translation: AAC26492.1.
RefSeqNP_001118227.1. NM_001124755.1.
UniGeneOmy.30070.

3D structure databases

ProteinModelPortalO93297.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100142633.

Organism-specific databases

CTD100142633.

Phylogenomic databases

HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2K4_ONCMY
AccessionPrimary (citable) accession number: O93297
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families