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Protein

Cytochrome P450 2K4

Gene

cyp2k4

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2K4 (EC:1.14.14.1)
Alternative name(s):
CYPIIK4
Gene namesi
Name:cyp2k4
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2K4PRO_0000051775Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO93297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIEGLLQT SSTVTLLGTV LFLLVPYLRS SGSSSEEQGK EPPGPRPLPL
60 70 80 90 100
LGNMLQLDLK KPYCTLCELS KKYGSIFTVH FGSKKVVVLA GYKTVKQALV
110 120 130 140 150
NQAEDFGERD ITPAFYDFNQ GHGILFTNGD SWKEMRRFAL TNLRDFGMGK
160 170 180 190 200
KGSEEKILEE IPYLIEVLEK HEGKAFDTTQ SVHHAVSNII SAIVYGSRFE
210 220 230 240 250
YTDPLFTGMV DRVNENVHLI GSASIQMYNM FPWLGPWINN LTRLKKNVAD
260 270 280 290 300
LKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGK MDSFYHDDNL
310 320 330 340 350
LFSIGNLFGA GTDTTGTTLR WGLLLMAKYP HIQDQVQEEI SRVIGSRQTL
360 370 380 390 400
VEDRKNLPYT DAVIHETQRL ANISPMAVPH TTSRDVTFQG YFIKKGTSVI
410 420 430 440 450
PLLMSVLQDD NEWESPNTFN PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE
460 470 480 490 500
GLARMELFLF FTSLLQRFRF SPPPGVTEDD LDLTPLLGFT LHPSPHQLCA

VSRV
Length:504
Mass (Da):56,734
Last modified:November 1, 1998 - v1
Checksum:iAC4292C18617C4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043296 mRNA. Translation: AAC26492.1.
RefSeqiNP_001118227.1. NM_001124755.1.
UniGeneiOmy.30070.

Genome annotation databases

GeneIDi100142633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043296 mRNA. Translation: AAC26492.1.
RefSeqiNP_001118227.1. NM_001124755.1.
UniGeneiOmy.30070.

3D structure databases

ProteinModelPortaliO93297.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100142633.

Organism-specific databases

CTDi100142633.

Phylogenomic databases

HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CYP2K4: a new cytochrome P450 isoform from male trunk kidney of post-spawning rainbow trout."
    Yang Y.-H., Andersson T.B., Ryu B.-W., Wang J.-L., Buhler D.R.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCP2K4_ONCMY
AccessioniPrimary (citable) accession number: O93297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.