SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O93297

- CP2K4_ONCMY

UniProt

O93297 - CP2K4_ONCMY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome P450 2K4
Gene
cyp2k4
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi447 – 4471Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2K4 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIK4
    Gene namesi
    Name:cyp2k4
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2K4
    PRO_0000051775Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO93297.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG015789.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O93297-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLIEGLLQT SSTVTLLGTV LFLLVPYLRS SGSSSEEQGK EPPGPRPLPL    50
    LGNMLQLDLK KPYCTLCELS KKYGSIFTVH FGSKKVVVLA GYKTVKQALV 100
    NQAEDFGERD ITPAFYDFNQ GHGILFTNGD SWKEMRRFAL TNLRDFGMGK 150
    KGSEEKILEE IPYLIEVLEK HEGKAFDTTQ SVHHAVSNII SAIVYGSRFE 200
    YTDPLFTGMV DRVNENVHLI GSASIQMYNM FPWLGPWINN LTRLKKNVAD 250
    LKMEVIELVR GLKETLNPHM CRGFVDSFLV RKQTLEESGK MDSFYHDDNL 300
    LFSIGNLFGA GTDTTGTTLR WGLLLMAKYP HIQDQVQEEI SRVIGSRQTL 350
    VEDRKNLPYT DAVIHETQRL ANISPMAVPH TTSRDVTFQG YFIKKGTSVI 400
    PLLMSVLQDD NEWESPNTFN PSHFLDEQGG FVKRDAFMAF SAGRRVCLGE 450
    GLARMELFLF FTSLLQRFRF SPPPGVTEDD LDLTPLLGFT LHPSPHQLCA 500
    VSRV 504
    Length:504
    Mass (Da):56,734
    Last modified:November 1, 1998 - v1
    Checksum:iAC4292C18617C4B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043296 mRNA. Translation: AAC26492.1.
    RefSeqiNP_001118227.1. NM_001124755.1.
    UniGeneiOmy.30070.

    Genome annotation databases

    GeneIDi100142633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043296 mRNA. Translation: AAC26492.1 .
    RefSeqi NP_001118227.1. NM_001124755.1.
    UniGenei Omy.30070.

    3D structure databases

    ProteinModelPortali O93297.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100142633.

    Organism-specific databases

    CTDi 100142633.

    Phylogenomic databases

    HOVERGENi HBG015789.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CYP2K4: a new cytochrome P450 isoform from male trunk kidney of post-spawning rainbow trout."
      Yang Y.-H., Andersson T.B., Ryu B.-W., Wang J.-L., Buhler D.R.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiCP2K4_ONCMY
    AccessioniPrimary (citable) accession number: O93297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: June 11, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3
    Error
    SubmitCancel

    Skip Header

    You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

    500 Internal Server Error

    The server was not able to handle your request.

    If this error occurs repeatedly, please contact us and indicate the page you were trying to access.