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Protein

Amyloid beta A4 protein

Gene

app

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi148 – 1481CopperBy similarity
Metal bindingi152 – 1521CopperBy similarity
Metal bindingi169 – 1691CopperBy similarity
Sitei300 – 3012Reactive bond

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Beta-amyloid precursor proteinCurated
Cleaved into the following chain:
Alternative name(s):
A-beta
Beta-APP
Gene namesi
Name:app
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 668650ExtracellularSequence analysisAdd
BLAST
Transmembranei669 – 68921HelicalSequence analysisAdd
BLAST
Topological domaini690 – 73748CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 737719Amyloid beta A4 proteinPRO_0000000197Add
BLAST
Chaini639 – 68143Beta-amyloid proteinSequence analysisPRO_0000000198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 63PROSITE-ProRule annotation
Disulfide bondi74 ↔ 118PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi134 ↔ 188PROSITE-ProRule annotation
Disulfide bondi145 ↔ 175PROSITE-ProRule annotation
Disulfide bondi159 ↔ 187PROSITE-ProRule annotation
Disulfide bondi290 ↔ 340PROSITE-ProRule annotation
Disulfide bondi299 ↔ 323PROSITE-ProRule annotation
Disulfide bondi315 ↔ 336PROSITE-ProRule annotation
Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO93279.
SMRiO93279. Positions 29-124, 354-542, 643-680, 706-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini286 – 34459BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni726 – 7294Clathrin-bindingBy similarity

Sequence similaritiesi

Belongs to the APP family.Curated
Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO93279.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETTAFVLL LVATLTRSSE IPADDTVGLL TEPQVAMFCG KLNMHINVQN
60 70 80 90 100
GKWESDPSGT KSCLNTKEGI LQYCQEVYPE LQITNVVEAN QPVSIQNWCK
110 120 130 140 150
KGRKQCRSHT HIVVPYRCLV GEFVSDALLV PDKCKFLHQE RMNQCESHLH
160 170 180 190 200
WHTVAKESCG DRSMNLHDYG MLLPCGIDRF RGVKFVCCPA ETEQETDSSE
210 220 230 240 250
VEGEESDVWW GGADPEYSEN SPPTPSRATY VAGDAFERDE NGDGDEDEED
260 270 280 290 300
DEDVDPTDEQ ESDERTANVA MTTTTTTTTE SVEEVVRAVC WAQAESGPCR
310 320 330 340 350
AMLERWYFNP KKRRCVPFLF GGCGGNRNNF ESEEYCLAVC SSSLPTVAPS
360 370 380 390 400
PPDAVDQYFE APGDDNEHAD FRKAKESLEA KHRERMSQVM REWEEAERQA
410 420 430 440 450
KNLPRADKKA VIQHFQEKVE ALEQEAAGER QQLVETHMAR VEALLNSRRR
460 470 480 490 500
LTLENYLGAL QANPPRARQV LSLLKKYVRA EQKDRQHTLK HYEHVRTVDP
510 520 530 540 550
KKAAQIRPQV LTHLRVIDER MNQSLALLYK VPSVASEIQN QIYPAAGSDC
560 570 580 590 600
KDPVEHCVCP QVDGLVSYGN DALMPDQAYS SAPMDMGVDG LGSIDQSFNQ
610 620 630 640 650
ANTENHVEPV DARPIPDRGL PTRPVSSLKL EEMPEVRTET DKRQSAGYEV
660 670 680 690 700
YHQKLVFFAD DVGSNKGAII GLMVGGVVIA TVIVITLVML RKKQYTSIHH
710 720 730
GVIEVDAAVT PEERHLARMQ QNGYENPTYK FFEQMQN
Length:737
Mass (Da):82,857
Last modified:November 1, 1998 - v1
Checksum:i6FAD01E2E3B2B7E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090120 Genomic DNA. Translation: AAD13392.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090120 Genomic DNA. Translation: AAD13392.1.

3D structure databases

ProteinModelPortaliO93279.
SMRiO93279. Positions 29-124, 354-542, 643-680, 706-737.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiO93279.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.230.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR013803. Amyloid_glyco_Abeta.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF03494. Beta-APP. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
PR00204. BETAAMYLOID.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of pufferfish homologues of the AT-rich human APP gene."
    Villard L., Tassone F., Crnogorac-Jurcevic T., Clancy K., Gardiner K.
    Gene 210:17-24(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiA4_TAKRU
AccessioniPrimary (citable) accession number: O93279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.