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Protein

Amyloid-beta A4 protein

Gene

app

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi148CopperBy similarity1
Metal bindingi152CopperBy similarity1
Metal bindingi169CopperBy similarity1
Sitei300 – 301Reactive bond2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Amyloid-beta precursor proteinCurated
Cleaved into the following chain:
Alternative name(s):
A-beta
APP-beta
Gene namesi
Name:app
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 668ExtracellularSequence analysisAdd BLAST650
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Topological domaini690 – 737CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000019719 – 737Amyloid-beta A4 proteinAdd BLAST719
ChainiPRO_0000000198639 – 681Amyloid-beta proteinSequence analysisAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 63PROSITE-ProRule annotation
Disulfide bondi74 ↔ 118PROSITE-ProRule annotation
Disulfide bondi99 ↔ 106PROSITE-ProRule annotation
Disulfide bondi134 ↔ 188PROSITE-ProRule annotation
Disulfide bondi145 ↔ 175PROSITE-ProRule annotation
Disulfide bondi159 ↔ 187PROSITE-ProRule annotation
Disulfide bondi290 ↔ 340PROSITE-ProRule annotation
Disulfide bondi299 ↔ 323PROSITE-ProRule annotation
Disulfide bondi315 ↔ 336PROSITE-ProRule annotation
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO93279

Structurei

3D structure databases

ProteinModelPortaliO93279
SMRiO93279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 344BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni726 – 729Clathrin-bindingBy similarity4

Sequence similaritiesi

Belongs to the APP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiO93279

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di1.20.120.770, 1 hit
2.30.29.30, 1 hit
3.30.1490.140, 1 hit
3.90.570.10, 1 hit
4.10.230.10, 1 hit
4.10.410.10, 1 hit
InterProiView protein in InterPro
IPR036669 Amyloid_Cu-bd_sf
IPR008155 Amyloid_glyco
IPR013803 Amyloid_glyco_Abeta
IPR037071 Amyloid_glyco_Abeta_sf
IPR011178 Amyloid_glyco_Cu-bd
IPR024329 Amyloid_glyco_E2_domain
IPR008154 Amyloid_glyco_extra
IPR019744 Amyloid_glyco_extracell_CS
IPR015849 Amyloid_glyco_heparin-bd
IPR036454 Amyloid_glyco_heparin-bd_sf
IPR019745 Amyloid_glyco_intracell_CS
IPR028866 APP
IPR019543 APP_amyloid_C
IPR036176 E2_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR011993 PH-like_dom_sf
IPR020901 Prtase_inh_Kunz-CS
PANTHERiPTHR23103 PTHR23103, 1 hit
PTHR23103:SF7 PTHR23103:SF7, 1 hit
PfamiView protein in Pfam
PF10515 APP_amyloid, 1 hit
PF12924 APP_Cu_bd, 1 hit
PF12925 APP_E2, 1 hit
PF02177 APP_N, 1 hit
PF03494 Beta-APP, 1 hit
PF00014 Kunitz_BPTI, 1 hit
PRINTSiPR00203 AMYLOIDA4
PR00759 BASICPTASE
PR00204 BETAAMYLOID
SMARTiView protein in SMART
SM00006 A4_EXTRA, 1 hit
SM00131 KU, 1 hit
SUPFAMiSSF109843 SSF109843, 1 hit
SSF56491 SSF56491, 1 hit
SSF57362 SSF57362, 1 hit
SSF89811 SSF89811, 1 hit
PROSITEiView protein in PROSITE
PS00319 A4_EXTRA, 1 hit
PS00320 A4_INTRA, 1 hit
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETTAFVLL LVATLTRSSE IPADDTVGLL TEPQVAMFCG KLNMHINVQN
60 70 80 90 100
GKWESDPSGT KSCLNTKEGI LQYCQEVYPE LQITNVVEAN QPVSIQNWCK
110 120 130 140 150
KGRKQCRSHT HIVVPYRCLV GEFVSDALLV PDKCKFLHQE RMNQCESHLH
160 170 180 190 200
WHTVAKESCG DRSMNLHDYG MLLPCGIDRF RGVKFVCCPA ETEQETDSSE
210 220 230 240 250
VEGEESDVWW GGADPEYSEN SPPTPSRATY VAGDAFERDE NGDGDEDEED
260 270 280 290 300
DEDVDPTDEQ ESDERTANVA MTTTTTTTTE SVEEVVRAVC WAQAESGPCR
310 320 330 340 350
AMLERWYFNP KKRRCVPFLF GGCGGNRNNF ESEEYCLAVC SSSLPTVAPS
360 370 380 390 400
PPDAVDQYFE APGDDNEHAD FRKAKESLEA KHRERMSQVM REWEEAERQA
410 420 430 440 450
KNLPRADKKA VIQHFQEKVE ALEQEAAGER QQLVETHMAR VEALLNSRRR
460 470 480 490 500
LTLENYLGAL QANPPRARQV LSLLKKYVRA EQKDRQHTLK HYEHVRTVDP
510 520 530 540 550
KKAAQIRPQV LTHLRVIDER MNQSLALLYK VPSVASEIQN QIYPAAGSDC
560 570 580 590 600
KDPVEHCVCP QVDGLVSYGN DALMPDQAYS SAPMDMGVDG LGSIDQSFNQ
610 620 630 640 650
ANTENHVEPV DARPIPDRGL PTRPVSSLKL EEMPEVRTET DKRQSAGYEV
660 670 680 690 700
YHQKLVFFAD DVGSNKGAII GLMVGGVVIA TVIVITLVML RKKQYTSIHH
710 720 730
GVIEVDAAVT PEERHLARMQ QNGYENPTYK FFEQMQN
Length:737
Mass (Da):82,857
Last modified:November 1, 1998 - v1
Checksum:i6FAD01E2E3B2B7E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF090120 Genomic DNA Translation: AAD13392.1

Similar proteinsi

Entry informationi

Entry nameiA4_TAKRU
AccessioniPrimary (citable) accession number: O93279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health