Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
Gene namesi
Name:WDR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513431 – 609WD repeat-containing protein 1Add BLAST609

Proteomic databases

PaxDbiO93277
PRIDEiO93277

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024078

Structurei

3D structure databases

ProteinModelPortaliO93277
SMRiO93277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 47WD 1Add BLAST42
Repeati50 – 89WD 2Add BLAST40
Repeati95 – 137WD 3Add BLAST43
Repeati140 – 178WD 4Add BLAST39
Repeati182 – 220WD 5Add BLAST39
Repeati226 – 265WD 6Add BLAST40
Repeati272 – 308WD 7Add BLAST37
Repeati313 – 353WD 8Add BLAST41
Repeati360 – 410WD 9Add BLAST51
Repeati434 – 476WD 10Add BLAST43
Repeati482 – 520WD 11Add BLAST39
Repeati525 – 563WD 12Add BLAST39
Repeati568 – 606WD 13Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318 Eukaryota
ENOG410XQN1 LUCA
HOGENOMiHOG000162559
HOVERGENiHBG000780
InParanoidiO93277
PhylomeDBiO93277

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR020472 G-protein_beta_WD-40_rep
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50974 SSF50974, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O93277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMPYEIKKV FASLPQVERG VSKIIGGDPK GNNFLYTNGK CVVIRNIDNP
60 70 80 90 100
AIADIYTEHA HQVVVAKYAP SGFYIASGDV SGKLRIWDTT QKEHLLKYEY
110 120 130 140 150
QPFAGKIKDL AWTEDSKRIA VVGEGREKFG AVFLWDSGSS VGEITGHNKV
160 170 180 190 200
INSVDIKQTR PYRLATGSDD NCAAFFEGPP FKFKFTLSDH TRFVNCVRFS
210 220 230 240 250
PDGNRFATAS ADGQIFIYDG KTGEKVCALG GGKAHDGGIY AISWSPDSSQ
260 270 280 290 300
LLSASGDKTA KIWDVGANSV VSTFNMGSNV LDQQLGCLWQ KDHLLSLSLS
310 320 330 340 350
GYINYLDKNN PDKPLRVIKG HSKSIQCLTV HKNGGKSYIY SGSNDGHINY
360 370 380 390 400
WDSDTGENDG FSGKGHTNQV SRMAVDEMDQ LVTCSMDDTV RYTNLSKRDY
410 420 430 440 450
SGQDAVKMDV QPKCLAVGPG GYTVVLCIGQ IVLMKDKKKC FAIDDLGYEP
460 470 480 490 500
EAVAVHPGGG SVAVGGTDGN VRLYSIQGTS LKSDDKTLEA KGPVTDLAYS
510 520 530 540 550
HDGAFLAVCD ANKVVTVFSV PDGYVEHNVF YGHHAKVVCI AWSPDNEHFA
560 570 580 590 600
SGGMDMMVYV WTVSDPETRI KIPDAHRLHH VSGLAWLDEH TLVTTSHDAS

VKEWSISYN
Length:609
Mass (Da):66,567
Last modified:November 1, 1998 - v1
Checksum:i1DE89BE431DEE32A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020054 mRNA Translation: AAD05042.1
RefSeqiNP_001004402.1, NM_001004402.1
UniGeneiGga.2409

Genome annotation databases

GeneIDi422842
KEGGigga:422842

Similar proteinsi

Entry informationi

Entry nameiWDR1_CHICK
AccessioniPrimary (citable) accession number: O93277
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health