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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.By similarity

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
Gene namesi
Name:WDR1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609WD repeat-containing protein 1PRO_0000051343Add
BLAST

Proteomic databases

PaxDbiO93277.
PRIDEiO93277.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024078.

Structurei

3D structure databases

ProteinModelPortaliO93277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 9740WD 1Add
BLAST
Repeati102 – 14544WD 2Add
BLAST
Repeati146 – 18641WD 3Add
BLAST
Repeati189 – 22840WD 4Add
BLAST
Repeati234 – 27340WD 5Add
BLAST
Repeati320 – 36142WD 6Add
BLAST
Repeati365 – 40339WD 7Add
BLAST
Repeati445 – 48440WD 8Add
BLAST
Repeati489 – 52840WD 9Add
BLAST
Repeati532 – 57140WD 10Add
BLAST
Repeati576 – 60833WD 11Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiO93277.
PhylomeDBiO93277.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMPYEIKKV FASLPQVERG VSKIIGGDPK GNNFLYTNGK CVVIRNIDNP
60 70 80 90 100
AIADIYTEHA HQVVVAKYAP SGFYIASGDV SGKLRIWDTT QKEHLLKYEY
110 120 130 140 150
QPFAGKIKDL AWTEDSKRIA VVGEGREKFG AVFLWDSGSS VGEITGHNKV
160 170 180 190 200
INSVDIKQTR PYRLATGSDD NCAAFFEGPP FKFKFTLSDH TRFVNCVRFS
210 220 230 240 250
PDGNRFATAS ADGQIFIYDG KTGEKVCALG GGKAHDGGIY AISWSPDSSQ
260 270 280 290 300
LLSASGDKTA KIWDVGANSV VSTFNMGSNV LDQQLGCLWQ KDHLLSLSLS
310 320 330 340 350
GYINYLDKNN PDKPLRVIKG HSKSIQCLTV HKNGGKSYIY SGSNDGHINY
360 370 380 390 400
WDSDTGENDG FSGKGHTNQV SRMAVDEMDQ LVTCSMDDTV RYTNLSKRDY
410 420 430 440 450
SGQDAVKMDV QPKCLAVGPG GYTVVLCIGQ IVLMKDKKKC FAIDDLGYEP
460 470 480 490 500
EAVAVHPGGG SVAVGGTDGN VRLYSIQGTS LKSDDKTLEA KGPVTDLAYS
510 520 530 540 550
HDGAFLAVCD ANKVVTVFSV PDGYVEHNVF YGHHAKVVCI AWSPDNEHFA
560 570 580 590 600
SGGMDMMVYV WTVSDPETRI KIPDAHRLHH VSGLAWLDEH TLVTTSHDAS

VKEWSISYN
Length:609
Mass (Da):66,567
Last modified:November 1, 1998 - v1
Checksum:i1DE89BE431DEE32A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020054 mRNA. Translation: AAD05042.1.
RefSeqiNP_001004402.1. NM_001004402.1.
UniGeneiGga.2409.

Genome annotation databases

GeneIDi422842.
KEGGigga:422842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020054 mRNA. Translation: AAD05042.1.
RefSeqiNP_001004402.1. NM_001004402.1.
UniGeneiGga.2409.

3D structure databases

ProteinModelPortaliO93277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024078.

Proteomic databases

PaxDbiO93277.
PRIDEiO93277.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi422842.
KEGGigga:422842.

Organism-specific databases

CTDi9948.

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
HOGENOMiHOG000162559.
HOVERGENiHBG000780.
InParanoidiO93277.
PhylomeDBiO93277.

Miscellaneous databases

NextBioi20825413.
PROiO93277.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein."
    Adler H.J., Winnicki R.S., Gong T.-W.L., Lomax M.I.
    Genomics 56:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiWDR1_CHICK
AccessioniPrimary (citable) accession number: O93277
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.