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Protein

Keratin, type I cytoskeletal 19

Gene

KRT19

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei281 – 2811StutterSequence analysis
Sitei341 – 3411StutterSequence analysis

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
GK-19
Keratin-19
Short name:
K19
Gene namesi
Name:KRT19By similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Keratin, type I cytoskeletal 19CuratedPRO_0000227527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO93256.
PRIDEiO93256.

Expressioni

Developmental stagei

Expressed in the digestive tract throughout development in the epithelia of proventriculus and glandular structures. In 13 day embryo, strongly expressed in esophagus with moderate expression in proventriculus and lung. Weak expression in gizzard, small intestine, lung and dorsal skin. In embryos over 13 days old, observed in ectodermal, endodermal epithelium and also in neural and mesodermal tissues (i.e. notochord), floorplate in the neural tube, somatic mesoderm, splanchnic mesoderm and dermatome. In more developed embryos, expression was localized in the anterior lobe of the pituitary gland, notochord and hypothalamus of the diencephalon (derived from the floor plate of the neural tube). Also localized in the mesonephric mesoderm and lateral plate mesoderm.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi676134. 1 interaction.
STRINGi9031.ENSGALP00000006093.

Structurei

3D structure databases

ProteinModelPortaliO93256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9393HeadSequence analysisAdd
BLAST
Regioni94 – 401308RodSequence analysisAdd
BLAST
Regioni94 – 12936Coil 1ASequence analysisAdd
BLAST
Regioni130 – 14718Linker 1Sequence analysisAdd
BLAST
Regioni148 – 23992Coil 1BSequence analysisAdd
BLAST
Regioni240 – 26223Linker 12Sequence analysisAdd
BLAST
Regioni258 – 415158Necessary for interaction with PNNBy similarityAdd
BLAST
Regioni263 – 401139Coil 2Sequence analysisAdd
BLAST
Regioni402 – 41413Rod-like helical tailSequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 9278Gly-richSequence analysisAdd
BLAST

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.Curated

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO93256.
KOiK07604.
PhylomeDBiO93256.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYSFRQTT SSVAGGPCGR SLRLGGGSFR APSIHGGSGG RGVSVSSARF
60 70 80 90 100
VSSGLGSGLG GGYGGAFSSS FSAGFGGGYG GGLGSGDGLL SGNEKTTMQN
110 120 130 140 150
LNDRLASYLD KVRALEEANS DLETKIREWY LKQGPGPARD YSPYYKAIED
160 170 180 190 200
LRDQILAATI DNSKVVLQID NARLAADDFK TKFETEQALR MSVEADINGL
210 220 230 240 250
RRVLDELTLA RTDLELQIEN LKEELAYLKK NHEEEMSALG GQVASQVSVE
260 270 280 290 300
VDSAPGIDLS KILADMRDQY EHMAEKNRKD AEAWFHSKTE ELNRELAVNT
310 320 330 340 350
EQLQSSKSEV TDLRRTLQGL EIELQSQLSM KGALESTLAD TEGRYGAQLA
360 370 380 390 400
QIQDMIGSIE AQLAELRADM ERQNSEYKML MDIKTRLEQE IATYRQLLEG
410 420
QESQLFGSLS GSPDKRDKPA DGK
Length:423
Mass (Da):46,082
Last modified:November 1, 1998 - v1
Checksum:iE03390A9558AD2D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016281 mRNA. Translation: BAA31952.1.
RefSeqiNP_990340.2. NM_205009.2.
UniGeneiGga.2612.

Genome annotation databases

GeneIDi395861.
KEGGigga:395861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016281 mRNA. Translation: BAA31952.1.
RefSeqiNP_990340.2. NM_205009.2.
UniGeneiGga.2612.

3D structure databases

ProteinModelPortaliO93256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676134. 1 interaction.
STRINGi9031.ENSGALP00000006093.

Proteomic databases

PaxDbiO93256.
PRIDEiO93256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395861.
KEGGigga:395861.

Organism-specific databases

CTDi3880.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiO93256.
KOiK07604.
PhylomeDBiO93256.

Miscellaneous databases

NextBioi20815928.
PROiO93256.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chicken keratin-19: cloning of cDNA and analysis of expression in the chicken embryonic gut."
    Sato K., Yasugi S.
    Dev. Growth Differ. 39:751-761(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo1 Publication.

Entry informationi

Entry nameiK1C19_CHICK
AccessioniPrimary (citable) accession number: O93256
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.