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Protein

Keratin, type I cytoskeletal 19

Gene

KRT19

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei281StutterSequence analysis1
Sitei341StutterSequence analysis1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
GK-19
Keratin-19
Short name:
K19
Gene namesi
Name:KRT19By similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275271 – 423Keratin, type I cytoskeletal 19CuratedAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO93256
PRIDEiO93256

Expressioni

Developmental stagei

Expressed in the digestive tract throughout development in the epithelia of proventriculus and glandular structures. In 13 day embryo, strongly expressed in esophagus with moderate expression in proventriculus and lung. Weak expression in gizzard, small intestine, lung and dorsal skin. In embryos over 13 days old, observed in ectodermal, endodermal epithelium and also in neural and mesodermal tissues (i.e. notochord), floorplate in the neural tube, somatic mesoderm, splanchnic mesoderm and dermatome. In more developed embryos, expression was localized in the anterior lobe of the pituitary gland, notochord and hypothalamus of the diencephalon (derived from the floor plate of the neural tube). Also localized in the mesonephric mesoderm and lateral plate mesoderm.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity).By similarityCurated

Protein-protein interaction databases

BioGridi676134, 1 interactor
STRINGi9031.ENSGALP00000006093

Structurei

3D structure databases

ProteinModelPortaliO93256
SMRiO93256
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 405IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 93HeadSequence analysisAdd BLAST93
Regioni94 – 129Coil 1ASequence analysisAdd BLAST36
Regioni130 – 147Linker 1Sequence analysisAdd BLAST18
Regioni148 – 239Coil 1BSequence analysisAdd BLAST92
Regioni240 – 262Linker 12Sequence analysisAdd BLAST23
Regioni258 – 415Necessary for interaction with PNNBy similarityAdd BLAST158
Regioni263 – 401Coil 2Sequence analysisAdd BLAST139
Regioni402 – 414Rod-like helical tailSequence analysisAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 92Gly-richSequence analysisAdd BLAST78

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.Curated

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiO93256
KOiK07604
PhylomeDBiO93256

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O93256-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYSFRQTT SSVAGGPCGR SLRLGGGSFR APSIHGGSGG RGVSVSSARF
60 70 80 90 100
VSSGLGSGLG GGYGGAFSSS FSAGFGGGYG GGLGSGDGLL SGNEKTTMQN
110 120 130 140 150
LNDRLASYLD KVRALEEANS DLETKIREWY LKQGPGPARD YSPYYKAIED
160 170 180 190 200
LRDQILAATI DNSKVVLQID NARLAADDFK TKFETEQALR MSVEADINGL
210 220 230 240 250
RRVLDELTLA RTDLELQIEN LKEELAYLKK NHEEEMSALG GQVASQVSVE
260 270 280 290 300
VDSAPGIDLS KILADMRDQY EHMAEKNRKD AEAWFHSKTE ELNRELAVNT
310 320 330 340 350
EQLQSSKSEV TDLRRTLQGL EIELQSQLSM KGALESTLAD TEGRYGAQLA
360 370 380 390 400
QIQDMIGSIE AQLAELRADM ERQNSEYKML MDIKTRLEQE IATYRQLLEG
410 420
QESQLFGSLS GSPDKRDKPA DGK
Length:423
Mass (Da):46,082
Last modified:November 1, 1998 - v1
Checksum:iE03390A9558AD2D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016281 mRNA Translation: BAA31952.1
RefSeqiNP_990340.2, NM_205009.2
UniGeneiGga.2612

Genome annotation databases

GeneIDi395861
KEGGigga:395861

Similar proteinsi

Entry informationi

Entry nameiK1C19_CHICK
AccessioniPrimary (citable) accession number: O93256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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