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Protein

Dynamin-like 120 kDa protein, mitochondrial

Gene

opa1

Organism
Oncorhynchus masou (Cherry salmon) (Masu salmon)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis.By similarity
Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by oma1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.By similarity

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi307 – 3148GTPSequence analysis
Nucleotide bindingi410 – 4145GTPSequence analysis
Nucleotide bindingi478 – 4814GTPSequence analysis

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-like 120 kDa protein, mitochondrial (EC:3.6.5.5)
Alternative name(s):
120 kDa G protein expressed in motor neurons
Optic atrophy protein 1 homolog
mG120
Cleaved into the following chain:
Gene namesi
Name:opa1
OrganismiOncorhynchus masou (Cherry salmon) (Masu salmon)
Taxonomic identifieri8020 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini90 – 989Mitochondrial matrixSequence analysis
Transmembranei99 – 11517HelicalSequence analysisAdd
BLAST
Topological domaini116 – 971856Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8989MitochondrionBy similarityAdd
BLAST
Chaini90 – 971882Dynamin-like 120 kDa protein, mitochondrialPRO_0000007399Add
BLAST
Chaini201 – 971771Dynamin-like 120 kDa protein, form S1By similarityPRO_0000417515Add
BLAST

Post-translational modificationi

Proteolytic processing produces an antiapoptotic soluble form Cleaved by oma1 at position S1 following stress conditions.By similarity

Proteomic databases

PRIDEiO93248.

Expressioni

Tissue specificityi

Strongly expressed in the brain, ovary and skeletal muscle. In the brain, expression of the mRNA was observed specifically in motor neurons, in nucleus oculomotorius, in nucleus valvulae lateralis, in the medulla oblongata and in the spinal cord.

Interactioni

Subunit structurei

Oligomeric complex consisting of membrane-bound and soluble forms of OPA1. Binds PARL (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO93248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 572276Dynamin-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili219 – 26547Sequence analysisAdd
BLAST
Coiled coili906 – 97166Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG019108.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVGRAVAC VACNNLASKN MGVRFRMPLQ KLHPLSRAIH HRYNASANAQ
60 70 80 90 100
RPPHCSAARH FTSMSRLPMR PPKPSPGGHG GWRYQQHRSF WMLRLASRLL
110 120 130 140 150
KLRYIVLGSA VGGGYTAKKT YEEWKDMLPD MSAYNWVIPD FVWELSDQID
160 170 180 190 200
LDKLTKILPE LEEIAKLLPE LPDFDKIGEN FTFLKSILFT AEAPGDTPVK
210 220 230 240 250
AATEAPVTAT PEASDKQFKK SSDKEKVDQL QEELLRTQMK YQRMLERLEK
260 270 280 290 300
ENKDLRKVVL QKDEKGIHQR KIKKSLIDMY SEVLDILSDF DSNYNTQDHL
310 320 330 340 350
PRVVVVGDQS AGKTSVLEMI AQARIFPRGS GEMMTRSPVK VTLSEGPHHV
360 370 380 390 400
AMFKDSSREF DLGKEEDLAA LRHEIELRMR KSVKEGQTVS PETISLSVKG
410 420 430 440 450
PGIQRMVLVD LPGVISTVTA GMAADTKETI FSISKNYMQN PNAIILCIQD
460 470 480 490 500
GSVDAEADRH RPGQSNGPAG ERTIFVLTKV DLAEKNLASP NRIQQIVEGK
510 520 530 540 550
LFPMKALGYF AVVTGKGSAG ESIDSIKDYE EDFFQNSRLL RDGMLKAHQV
560 570 580 590 600
TTKNLSLAVS DCFWKMVRES VEQQADAFKA SRFNLETEWK NNYPRLRELD
610 620 630 640 650
RNELFEKAKN EILDEVISLS QVTPKHWEAI LQKKLWERVS THVIENIYLP
660 670 680 690 700
AAQTMNSGTF NTTVDIKLKQ WTDKQLPHKA LEVAWETLQE EFARFMAEYK
710 720 730 740 750
GKDQDDIFDK LKEAVKDESI KRHKWNERAM DSLRVIQHNA LEDRSITDKP
760 770 780 790 800
QWDAAIQFME ETLQARLKDT DSVINDMVGP DWKQRWMSWK NRSPEQHTRN
810 820 830 840 850
ETRNELERLL KLHEDHTAYL ANDEVTTVRK NLEGRGVEVD PALIKDTWHQ
860 870 880 890 900
LYRRHFLQKA LQHCNLCRRG FYYYQRHFVD SELECNDVVL FWRIQRMLLI
910 920 930 940 950
TANTLRQQLT NTEVRRLEKN VKEVLEDFGE DNERKVHLIT GRRVQLAEDL
960 970
KKVREIQEKL EAFIEALHKE K
Length:971
Mass (Da):112,070
Last modified:November 1, 1998 - v1
Checksum:i462958C03C1A4F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012720 mRNA. Translation: BAA32279.1.
PIRiT00394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012720 mRNA. Translation: BAA32279.1.
PIRiT00394.

3D structure databases

ProteinModelPortaliO93248.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO93248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG019108.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001401. Dynamin_GTPase.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR033047. Opa1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PTHR11566:SF67. PTHR11566:SF67. 1 hit.
PfamiPF00350. Dynamin_N. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51718. G_DYNAMIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPA1_ONCMA
AccessioniPrimary (citable) accession number: O93248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.