Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Dharma

Gene

dharma

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • axial mesoderm formation Source: ZFIN
  • axial mesoderm morphogenesis Source: ZFIN
  • determination of left/right asymmetry in lateral mesoderm Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • embryonic heart tube morphogenesis Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • eye morphogenesis Source: ZFIN
  • floor plate development Source: ZFIN
  • heart looping Source: ZFIN
  • notochord development Source: ZFIN
  • notochord formation Source: ZFIN
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
  • regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  • somite development Source: ZFIN
  • Spemann organizer formation Source: ZFIN
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DharmaImported
Submitted name:
NieuwkoidImported
Gene namesi
Name:dharmaImported
Synonyms:nwkImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990415-22. dharma.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060017.

Structurei

3D structure databases

ProteinModelPortaliO93236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 17361Homeobox DNA-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0484. Eukaryota.
ENOG4111YNP. LUCA.
HOVERGENiHBG105660.
PhylomeDBiO93236.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93236-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQKFSNFS IDYILGDTSR QTAESPGVDH PASSQDFQGH LRKLDLLYQE
60 70 80 90 100
GCRGHCDRAA LMVNFPCPSW PGMYCCCVPV SYYQSTYYAG QPWPYAVAGC
110 120 130 140 150
ETAENHYHTI AQRPRGRIRT VFTDNQTEQL ERLFAVTDYP TVETRAELAQ
160 170 180 190
NTGLSEETVR VWFKNRRARR KRQTTCADKH ANRALEDHQE SD
Length:192
Mass (Da):22,007
Last modified:November 1, 1999 - v2
Checksum:iA75CF8E37F928C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098202 mRNA. Translation: AAC78640.1.
BC122095 mRNA. Translation: AAI22096.1.
AB010103 mRNA. Translation: BAA32030.2.
RefSeqiNP_571054.1. NM_130979.3.
UniGeneiDr.75841.

Genome annotation databases

GeneIDi30170.
KEGGidre:30170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098202 mRNA. Translation: AAC78640.1.
BC122095 mRNA. Translation: AAI22096.1.
AB010103 mRNA. Translation: BAA32030.2.
RefSeqiNP_571054.1. NM_130979.3.
UniGeneiDr.75841.

3D structure databases

ProteinModelPortaliO93236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30170.
KEGGidre:30170.

Organism-specific databases

CTDi30170.
ZFINiZDB-GENE-990415-22. dharma.

Phylogenomic databases

eggNOGiKOG0484. Eukaryota.
ENOG4111YNP. LUCA.
HOVERGENiHBG105660.
PhylomeDBiO93236.

Miscellaneous databases

NextBioi20806638.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafish."
    Koos D.S., Ho R.K.
    Curr. Biol. 8:1199-1206(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner."
    Yamanaka Y., Mizuno T., Sasai Y., Kishi M., Takeda H., Kim C.-H., Hibi M., Hirano T.
    Genes Dev. 12:2345-2353(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.

Entry informationi

Entry nameiO93236_DANRE
AccessioniPrimary (citable) accession number: O93236
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.