ID   O93234_XENLA            Unreviewed;       375 AA.
AC   O93234;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Alpha-2,8-polysialyltransferase {ECO:0000313|EMBL:BAA32617.1};
DE   SubName: Full=Alpha-2,8-sialyltransferase 8B {ECO:0000313|RefSeq:XP_041442801.1};
GN   Name=st8sia2.L {ECO:0000313|RefSeq:XP_041442801.1,
GN   ECO:0000313|Xenbase:XB-GENE-960447};
GN   Synonyms=LOC397702 {ECO:0000313|EMBL:AAI69801.1}, st8sia2
GN   {ECO:0000313|Xenbase:XB-GENE-960447};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:BAA32617.1};
RN   [1] {ECO:0000313|EMBL:BAA32617.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9639538; DOI=10.1093/glycob/8.8.771;
RA   Kudo M., Takayama E., Tashiro K., Fukamachi H., Nakata T., Tadakuma T.,
RA   Kitajima K., Inoue Y., Shiokawa K.;
RT   "Cloning and expression of an alpha-2,8-polysialyltransferase (STX) from
RT   Xenopus laevis.";
RL   Glycobiology 8:771-777(1998).
RN   [2] {ECO:0000313|EMBL:AAI69801.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocytes {ECO:0000313|EMBL:AAI69801.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:XP_041442801.1}
RP   IDENTIFICATION.
RC   STRAIN=J_2021 {ECO:0000313|RefSeq:XP_041442801.1};
RC   TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_041442801.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
CC       {ECO:0000256|ARBA:ARBA00006003}.
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DR   EMBL; BC169801; AAI69801.1; -; mRNA.
DR   EMBL; BC169803; AAI69803.1; -; mRNA.
DR   EMBL; AB007468; BAA32617.1; -; mRNA.
DR   RefSeq; NP_001081189.1; NM_001087720.1.
DR   RefSeq; XP_041442801.1; XM_041586867.1.
DR   STRING; 8355.O93234; -.
DR   CAZy; GT29; Glycosyltransferase Family 29.
DR   PaxDb; 8355-O93234; -.
DR   KEGG; xla:397702; -.
DR   AGR; Xenbase:XB-GENE-960447; -.
DR   Xenbase; XB-GENE-960447; st8sia2.L.
DR   OMA; ATRFCNT; -.
DR   OrthoDB; 5348004at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 397702; Expressed in brain and 9 other cell types or tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008373; F:sialyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   Gene3D; 3.90.1480.20; Glycosyl transferase family 29; 1.
DR   InterPro; IPR001675; Glyco_trans_29.
DR   InterPro; IPR038578; GT29-like_sf.
DR   InterPro; IPR012163; Sialyl_trans.
DR   PANTHER; PTHR11987; ALPHA-2,8-SIALYLTRANSFERASE; 1.
DR   PANTHER; PTHR11987:SF30; ALPHA-2,8-SIALYLTRANSFERASE 8B; 1.
DR   Pfam; PF00777; Glyco_transf_29; 1.
DR   PIRSF; PIRSF005557; Sialyl_trans; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:BAA32617.1};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAA32617.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..375
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010503452"
FT   DISULFID        157..307
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005557-2"
SQ   SEQUENCE   375 AA;  42538 MW;  7DEF5D9DB028EAFC CRC64;
     MNPDFRSWVL ATVTLLVVFL ILADISELEE EIGSTGGSGT IRSAAGNVHS KSNRAELILN
     NSSTSSTAGR SNESIKYRTK PVPYIWRHNQ TLALKIRKQI LHFLDAERDI SVLKGTLKPG
     DIIHYVFDRD STMNISKNLY ELLPRTSPLK NKHFKTCAIV GNSGILLNSG CGKEIDSHDF
     VIRCNLAPVE EYAKDVGTKT NLVTMNPSVV QRAFEDLVND TWKDKFLQRL KSLNESILWI
     PAFMAKGGEE RVEWVNDLII KHHINVHTAY PSLRLLHAVR GYWLTNKVHI KRPTTGILMY
     TLATRFCNRI YLYGFWPFPR DLHQNPVKYH YYDSLKYGYT SQAGPHAMPL EFKALKNLHL
     QGALKLNVGE CEAAT
//