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Protein

Phospholipase A2 inhibitor

Gene
N/A
Organism
Gloydius brevicaudus siniticus (Chinese mamushi) (Agkistrodon blomhoffii siniticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the enzymatic activity of the basic phospholipase A2 (PLA2).1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A2 inhibitor
Short name:
beta-PLI
OrganismiGloydius brevicaudus siniticus (Chinese mamushi) (Agkistrodon blomhoffii siniticus)
Taxonomic identifieri31147 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeGloydius

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000002206824 – 331Phospholipase A2 inhibitorAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi271N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer.

Structurei

3D structure databases

ProteinModelPortaliO93233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 101LRR 1Add BLAST22
Repeati104 – 125LRR 2Add BLAST22
Repeati128 – 149LRR 3Add BLAST22
Repeati152 – 173LRR 4Add BLAST22
Repeati176 – 197LRR 5Add BLAST22
Repeati200 – 221LRR 6Add BLAST22
Repeati224 – 245LRR 7Add BLAST22
Repeati247 – 268LRR 8Add BLAST22
Domaini279 – 331LRRCTAdd BLAST53

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

HOVERGENiHBG008209.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93233-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSSVPSLLI ACLVMSLNSY TQQVLYCPPT PAPENVTEFV CNSPSLHEFP
60 70 80 90 100
TGFPARAKMI SVEFTQVSSL GVEALQGLPN LQELHLSNNR LKTLPSGLFR
110 120 130 140 150
NLPQLHTLDL STNHLEDLPP EIFTNASSLI LLPLSENQLA ELHPSWFQTL
160 170 180 190 200
GELRILGLDH NQVKEIPISC FDKLKKLTSL DLSFNLLRRL APEMFSGLDN
210 220 230 240 250
LEKLILESNP IQCIVGRTFH WHPKLTVLSL KNSSLTNIMG FFQPLEQLEL
260 270 280 290 300
LDLSDNELTT MEPPVYKTSA NLSLDLSGNP WACDCRLDNL LTWVNEHNIH
310 320 330
LYSKEEIVCA SPKHFKGECA TSLHKSQICP C
Length:331
Mass (Da):37,092
Last modified:November 1, 1998 - v1
Checksum:iC82FB5DE0E494C46
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45S → L AA sequence (PubMed:9230137).Curated1

Mass spectrometryi

Molecular mass is 43857.2±81.9 Da from positions 24 - 331. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007198 mRNA. Translation: BAA31994.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007198 mRNA. Translation: BAA31994.1.

3D structure databases

ProteinModelPortaliO93233.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008209.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLIB_GLOBS
AccessioniPrimary (citable) accession number: O93233
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.