##gff-version 3 O92972 UniProtKB Initiator methionine 1 1 . . . Note=Removed%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26664 O92972 UniProtKB Chain 2 3010 . . . ID=PRO_0000450912;Note=Genome polyprotein O92972 UniProtKB Chain 2 191 . . . ID=PRO_0000278742;Note=Core protein precursor O92972 UniProtKB Chain 2 177 . . . ID=PRO_0000278743;Note=Mature core protein O92972 UniProtKB Propeptide 178 191 . . . ID=PRO_0000278744;Note=ER anchor for the core protein%2C removed in mature form by host signal peptidase O92972 UniProtKB Chain 192 383 . . . ID=PRO_0000278745;Note=Envelope glycoprotein E1 O92972 UniProtKB Chain 384 746 . . . ID=PRO_0000278746;Note=Envelope glycoprotein E2 O92972 UniProtKB Chain 747 809 . . . ID=PRO_0000278747;Note=Viroporin p7 O92972 UniProtKB Chain 810 1026 . . . ID=PRO_0000278748;Note=Protease NS2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01030 O92972 UniProtKB Chain 1027 1657 . . . ID=PRO_0000278749;Note=Serine protease/helicase NS3 O92972 UniProtKB Chain 1658 1711 . . . ID=PRO_0000278750;Note=Non-structural protein 4A O92972 UniProtKB Chain 1712 1972 . . . ID=PRO_0000278751;Note=Non-structural protein 4B O92972 UniProtKB Chain 1973 2419 . . . ID=PRO_0000278752;Note=Non-structural protein 5A O92972 UniProtKB Chain 2420 3010 . . . ID=PRO_0000278753;Note=RNA-directed RNA polymerase O92972 UniProtKB Topological domain 2 168 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Transmembrane 169 189 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Topological domain 190 358 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 359 379 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Topological domain 380 725 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 726 746 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Topological domain 747 757 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 758 778 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Topological domain 779 781 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 782 803 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Topological domain 804 813 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 814 834 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Topological domain 835 838 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Transmembrane 839 859 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Topological domain 860 881 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Transmembrane 882 902 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Topological domain 903 1657 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Transmembrane 1658 1678 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Topological domain 1679 1805 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Transmembrane 1806 1824 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Topological domain 1825 1828 . . . Note=Lumenal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 1829 1849 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Topological domain 1850 1850 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Transmembrane 1851 1871 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Topological domain 1872 1881 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Transmembrane 1882 1902 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Topological domain 1903 1972 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Intramembrane 1973 2002 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Topological domain 2003 2989 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Transmembrane 2990 3010 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Domain 903 1026 . . . Note=Peptidase C18;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01030 O92972 UniProtKB Domain 1027 1208 . . . Note=Peptidase S29;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01166 O92972 UniProtKB Domain 1217 1369 . . . Note=Helicase ATP-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 O92972 UniProtKB Domain 2633 2751 . . . Note=RdRp catalytic;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00539 O92972 UniProtKB Region 2 75 . . . Note=Disordered;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 2 59 . . . Note=Interaction with DDX3X;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q5EG65 O92972 UniProtKB Region 2 58 . . . Note=Interaction with EIF2AK2/PKR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Region 2 23 . . . Note=Interaction with STAT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Region 112 152 . . . Note=Important for endoplasmic reticulum and mitochondrial localization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Region 122 173 . . . Note=Interaction with APOA2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P29846 O92972 UniProtKB Region 164 167 . . . Note=Important for lipid droplets localization;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 265 296 . . . Note=Important for fusion;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 385 411 . . . Note=HVR1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 474 479 . . . Note=HVR2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 480 493 . . . Note=CD81-binding 1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Region 544 551 . . . Note=CD81-binding 2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Region 660 671 . . . Note=PKR/eIF2-alpha phosphorylation homology domain (PePHD);Ontology_term=ECO:0000250;evidence=ECO:0000250 O92972 UniProtKB Region 904 1206 . . . Note=Protease NS2-3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Region 929 949 . . . Note=Interaction with host SCPS1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Region 1486 1497 . . . Note=RNA-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Region 1679 1690 . . . Note=NS3-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 2120 2332 . . . Note=Transcriptional activation;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Region 2120 2208 . . . Note=FKBP8-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Region 2135 2139 . . . Note=Interaction with non-structural protein 4A;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Region 2187 2219 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O92972 UniProtKB Region 2189 2441 . . . Note=Interaction with host SKP2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Region 2210 2275 . . . Note=Interaction with EIF2AK2/PKR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Region 2210 2249 . . . Note=ISDR;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Region 2249 2306 . . . Note=NS4B-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Region 2351 2407 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O92972 UniProtKB Region 2354 2377 . . . Note=V3;Ontology_term=ECO:0000250;evidence=ECO:0000250 O92972 UniProtKB Motif 5 13 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Motif 38 43 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Motif 58 64 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Motif 66 71 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Motif 1316 1319 . . . Note=DECH box;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Motif 2322 2325 . . . Note=SH3-binding;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Motif 2326 2334 . . . Note=Nuclear localization signal;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Compositional bias 47 69 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O92972 UniProtKB Compositional bias 2195 2217 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O92972 UniProtKB Active site 952 952 . . . Note=For protease NS2 activity%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01030 O92972 UniProtKB Active site 972 972 . . . Note=For protease NS2 activity%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01030 O92972 UniProtKB Active site 993 993 . . . Note=For protease NS2 activity%3B shared with dimeric partner;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01030 O92972 UniProtKB Active site 1083 1083 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01166 O92972 UniProtKB Active site 1107 1107 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01166 O92972 UniProtKB Active site 1165 1165 . . . Note=Charge relay system%3B for serine protease NS3 activity;Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01166,ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Binding site 1123 1123 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01166,ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Binding site 1125 1125 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01166,ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Binding site 1171 1171 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01166,ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Binding site 1175 1175 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU01166,ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Binding site 1230 1237 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00541 O92972 UniProtKB Binding site 1237 1237 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Binding site 1317 1317 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Binding site 2011 2011 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Binding site 2029 2029 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Binding site 2031 2031 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Binding site 2052 2052 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Binding site 2639 2639 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Binding site 2737 2737 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Binding site 2738 2738 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26663 O92972 UniProtKB Site 177 178 . . . Note=Cleavage%3B by host signal peptide peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Site 191 192 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Site 383 384 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Site 746 747 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250 O92972 UniProtKB Site 809 810 . . . Note=Cleavage%3B by host signal peptidase;Ontology_term=ECO:0000250;evidence=ECO:0000250 O92972 UniProtKB Site 1026 1027 . . . Note=Cleavage%3B by protease NS2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01030 O92972 UniProtKB Site 1657 1658 . . . Note=Cleavage%3B by serine protease/helicase NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Site 1711 1712 . . . Note=Cleavage%3B by serine protease/helicase NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Site 1972 1973 . . . Note=Cleavage%3B by serine protease/helicase NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Site 2419 2420 . . . Note=Cleavage%3B by serine protease/helicase NS3;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q913V3 O92972 UniProtKB Modified residue 53 53 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01403 O92972 UniProtKB Modified residue 99 99 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01403 O92972 UniProtKB Modified residue 116 116 . . . Note=Phosphoserine%3B by host PKA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01403 O92972 UniProtKB Modified residue 2194 2194 . . . Note=Phosphoserine%3B by host%3B in p56;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Modified residue 2197 2197 . . . Note=Phosphoserine%3B by host%3B in p58;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Modified residue 2201 2201 . . . Note=Phosphoserine%3B by host%3B in p58;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Modified residue 2204 2204 . . . Note=Phosphoserine%3B by host%3B in p58;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9WMX2 O92972 UniProtKB Modified residue 2207 2207 . . . Note=Phosphoserine%3B by host%3B in p58;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Modified residue 2210 2210 . . . Note=Phosphoserine%3B by host%3B in p58;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99IB8 O92972 UniProtKB Modified residue 2448 2448 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Modified residue 2461 2461 . . . Note=Phosphoserine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26662 O92972 UniProtKB Lipidation 922 922 . . . Note=S-palmitoyl cysteine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Lipidation 1968 1968 . . . Note=S-palmitoyl cysteine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Lipidation 1972 1972 . . . Note=S-palmitoyl cysteine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 196 196 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 209 209 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 234 234 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 250 250 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 305 305 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Glycosylation 417 417 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 423 423 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 430 430 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 448 448 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 478 478 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Glycosylation 532 532 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 540 540 . . . Note=N-linked (GlcNAc...) asparagine%3B by host;Ontology_term=ECO:0000255;evidence=ECO:0000255 O92972 UniProtKB Glycosylation 556 556 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 576 576 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 623 623 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Glycosylation 645 645 . . . Note=N-linked (GlcNAc...) (high mannose) asparagine%3B by host;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 429 552 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 452 459 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 486 494 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 503 508 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 564 569 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 581 585 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 597 620 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 607 644 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Disulfide bond 652 677 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Cross-link 2350 2350 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P27958 O92972 UniProtKB Natural variant 52 52 . . . Note=In strain: Isolate pCV-J4L4S and Isolate HC-J4/91. A->T O92972 UniProtKB Natural variant 70 70 . . . Note=In strain: Isolate HC-J4/91. R->Q O92972 UniProtKB Natural variant 231 231 . . . Note=In strain: Isolate pCV-J4L2S and Isolate pCV-J4L6S. R->Q O92972 UniProtKB Natural variant 250 250 . . . Note=In strain: Isolate HC-J4/91 and Isolate pCV-J4L4S. N->D O92972 UniProtKB Natural variant 304 304 . . . Note=In strain: Isolate pCV-J4L2S. C->Y O92972 UniProtKB Natural variant 384 390 . . . Note=In strain: Isolate HC-J4/91. ETHTTGR->ATYTSGG O92972 UniProtKB Natural variant 394 394 . . . Note=In strain: Isolate HC-J4/91 and Isolate pCV-J4L4S. H->R O92972 UniProtKB Natural variant 434 434 . . . Note=In strain: Isolate HC-J4/91. Q->H O92972 UniProtKB Natural variant 438 438 . . . Note=In strain: Isolate pCV-J4L4S. F->L O92972 UniProtKB Natural variant 444 444 . . . Note=In strain: Isolate pCV-J4L4S and Isolate HC-J4/91. A->T O92972 UniProtKB Natural variant 450 450 . . . Note=In strain: Isolate pCV-J4L4S. S->P O92972 UniProtKB Natural variant 464 464 . . . Note=In strain: Isolate HC-J4/91. W->G O92972 UniProtKB Natural variant 476 476 . . . Note=In strain: Isolate pCV-J4L4S and Isolate HC-J4/91. K->E O92972 UniProtKB Natural variant 480 480 . . . Note=In strain: Isolate HC-J4/91. S->P O92972 UniProtKB Natural variant 496 496 . . . Note=In strain: Isolate pCV-J4L4S and Isolate HC-J4/91. V->I O92972 UniProtKB Natural variant 536 536 . . . Note=In strain: Isolate pCV-J4L2S. V->M O92972 UniProtKB Natural variant 934 934 . . . Note=In strain: Isolate pCV-J4L2S. V->I O92972 UniProtKB Natural variant 937 937 . . . Note=In strain: Isolate pCV-J4L6S. A->V O92972 UniProtKB Natural variant 1043 1043 . . . Note=In strain: Isolate pCV-J4L2S and Isolate pCV-J4L4S. I->V O92972 UniProtKB Natural variant 1215 1215 . . . Note=In strain: Isolate pCV-J4L6S. S->T O92972 UniProtKB Natural variant 1223 1223 . . . Note=In strain: Isolate pCV-J4L2S. F->S O92972 UniProtKB Natural variant 1528 1528 . . . Note=In strain: Isolate pCV-J4L4S. Y->H O92972 UniProtKB Natural variant 1662 1662 . . . Note=In strain: Isolate pCV-J4L2S. L->P O92972 UniProtKB Natural variant 1753 1753 . . . Note=In strain: Isolate pCV-J4L2S. K->R O92972 UniProtKB Natural variant 1805 1805 . . . Note=In strain: Isolate pCV-J4L2S. N->H O92972 UniProtKB Natural variant 1949 1949 . . . Note=In strain: Isolate pCV-J4L4S. S->P O92972 UniProtKB Natural variant 2138 2138 . . . Note=In strain: Isolate pCV-J4L4S. K->R O92972 UniProtKB Natural variant 2385 2385 . . . Note=In strain: Isolate pCV-J4L4S. Y->H O92972 UniProtKB Natural variant 2785 2785 . . . Note=In strain: Isolate pCV-J4L2S. C->R O92972 UniProtKB Natural variant 2824 2824 . . . Note=In strain: Isolate pCV-J4L2S. I->V O92972 UniProtKB Natural variant 2999 2999 . . . Note=In strain: Isolate HC-J4/91. S->F O92972 UniProtKB Mutagenesis 922 922 . . . Note=Almost complete loss of NS2/3 auto-cleavage activity%3B slight loss of NS3 protease activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Mutagenesis 1123 1123 . . . Note=Almost complete loss of NS3 protease activity and NS2/3 auto-cleavage activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Mutagenesis 1125 1125 . . . Note=Almost complete loss of NS3 protease activity and NS2/3 auto-cleavage activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Mutagenesis 1165 1165 . . . Note=Almost complete loss of NS3 protease activity%3B no effect on NS2/3 auto-cleavage activity. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Mutagenesis 1171 1171 . . . Note=Almost complete loss of NS3 protease activity and NS2/3 auto-cleavage activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Mutagenesis 1175 1175 . . . Note=Slight loss of NS2/3 auto-cleavage activity and 70%25 loss of NS3 protease activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Mutagenesis 1185 1185 . . . Note=No effect on NS2/3 auto-cleavage activity%3B slight loss of NS3 protease activity. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17239391;Dbxref=PMID:17239391 O92972 UniProtKB Helix 535 538 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5NPH O92972 UniProtKB Helix 750 760 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MTS O92972 UniProtKB Helix 762 767 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MTS O92972 UniProtKB Helix 769 777 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MTS O92972 UniProtKB Helix 786 789 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MTS O92972 UniProtKB Helix 790 792 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MTS O92972 UniProtKB Helix 797 802 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2MTS O92972 UniProtKB Beta strand 1224 1227 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1232 1235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Turn 1236 1238 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1239 1245 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Turn 1246 1248 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1251 1256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1258 1270 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1277 1279 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1292 1295 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1296 1301 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Turn 1302 1306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1311 1315 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1323 1335 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1337 1339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1342 1346 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1362 1366 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1382 1385 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1386 1393 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1397 1408 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Turn 1409 1411 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1414 1417 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1423 1425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1428 1436 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1448 1453 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1456 1462 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1467 1469 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1471 1478 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1483 1486 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1488 1490 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1491 1495 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1497 1503 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1514 1525 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1532 1543 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1555 1563 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1570 1577 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Turn 1578 1580 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1584 1596 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1615 1617 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 1627 1629 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Helix 1640 1648 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2F55 O92972 UniProtKB Beta strand 2421 2425 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2444 2449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2453 2455 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2456 2458 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2461 2463 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2464 2471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2481 2494 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2504 2509 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2513 2515 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4JU1 O92972 UniProtKB Beta strand 2519 2521 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4JJU O92972 UniProtKB Helix 2524 2528 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2532 2547 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2549 2551 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2555 2559 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2563 2565 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Turn 2568 2570 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3HKY O92972 UniProtKB Beta strand 2578 2581 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2584 2606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2607 2609 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2611 2613 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2616 2629 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2630 2638 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2643 2646 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2649 2659 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2666 2678 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Turn 2679 2681 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2683 2686 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2692 2696 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2701 2703 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4J08 O92972 UniProtKB Helix 2706 2724 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2728 2735 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2738 2744 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2748 2764 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2769 2771 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2776 2778 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2779 2781 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2787 2793 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2799 2805 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2808 2819 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2826 2834 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2838 2842 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2844 2854 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2858 2860 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1NB4 O92972 UniProtKB Beta strand 2862 2866 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2869 2873 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2875 2877 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2878 2886 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2888 2891 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2898 2911 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2916 2933 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2935 2944 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Helix 2946 2948 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Beta strand 2949 2951 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5CZB O92972 UniProtKB Helix 2959 2963 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Turn 2967 2970 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3TYQ O92972 UniProtKB Turn 2975 2977 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4RY7