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Protein

Genome polyprotein

Gene
N/A
Organism
Hepatitis C virus subtype 3a
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation
NTP + H2O = NDP + phosphate.SAAS annotation
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

Activation of host autophagy by virusSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiHepatitis C virus subtype 3aImported
Taxonomic identifieri356426 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Subcellular locationi

  • Virion SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei264 – 287HelicalSequence analysisAdd BLAST24
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei344 – 362HelicalSequence analysisAdd BLAST19
Transmembranei724 – 745HelicalSequence analysisAdd BLAST22
Transmembranei757 – 784HelicalSequence analysisAdd BLAST28
Transmembranei791 – 810HelicalSequence analysisAdd BLAST20
Transmembranei822 – 841HelicalSequence analysisAdd BLAST20
Transmembranei897 – 919HelicalSequence analysisAdd BLAST23
Transmembranei3001 – 3020HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

Structurei

3D structure databases

ProteinModelPortaliO92933.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini909 – 1032Peptidase C18InterPro annotationAdd BLAST124
Domaini1223 – 1356Helicase ATP-bindingInterPro annotationAdd BLAST134
Domaini1382 – 1544Helicase C-terminalInterPro annotationAdd BLAST163
Domaini2644 – 2762RdRp catalyticInterPro annotationAdd BLAST119

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR002521. HCV_core_C.
IPR002522. HCV_core_N.
IPR002519. HCV_env.
IPR002531. HCV_NS1.
IPR002518. HCV_NS2.
IPR000745. HCV_NS4a.
IPR001490. HCV_NS4b.
IPR002868. HCV_NS5a.
IPR013193. HCV_NS5a_1B_dom.
IPR024350. HCV_NS5a_C.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR013192. NS5A_1a.
IPR027417. P-loop_NTPase.
IPR009003. Peptidase_S1_PA.
IPR004109. Peptidase_S29.
IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF07652. Flavi_DEAD. 1 hit.
PF01543. HCV_capsid. 1 hit.
PF01542. HCV_core. 1 hit.
PF01539. HCV_env. 1 hit.
PF01560. HCV_NS1. 1 hit.
PF01538. HCV_NS2. 1 hit.
PF01006. HCV_NS4a. 1 hit.
PF01001. HCV_NS4b. 1 hit.
PF01506. HCV_NS5a. 1 hit.
PF08300. HCV_NS5a_1a. 1 hit.
PF08301. HCV_NS5a_1b. 1 hit.
PF12941. HCV_NS5a_C. 1 hit.
PF02907. Peptidase_S29. 1 hit.
PF00998. RdRP_3. 1 hit.
[Graphical view]
ProDomiPD001388. HCV_env. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51693. HCV_NS2_PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O92933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLPKPQRK TKRNTIRRPQ DVKFPGGGQI VGGVYVLPRR GPRLGVCATR
60 70 80 90 100
KTSERSQPRR RRQPIPKARQ SGGRSWAQPG YPWPLYGNEG CGWAGWLLSP
110 120 130 140 150
RGSRPSWGPN DPRRRSRNLG KVIDTLTCGF ADLMGYIPLV GAPVGGVARA
160 170 180 190 200
LAHGVRALED GINFATGNLP GCSFSIFLLA LFSCLIHPAA SLEWRNTSGL
210 220 230 240 250
YVLTNDCSNS SIVYEADDVI LHTPGCVPCV QNDNISTCWT PVTPTVAVRY
260 270 280 290 300
VGATTASIRS HVDLLVGAAT MCSALYVGDM CGAVFLVGQA FTFRPRRHQT
310 320 330 340 350
VQTCNCSLYP GHLSGHRMAW DMMMNWFPAL GMAVAHVLRV PQTLFDIIAG
360 370 380 390 400
AHWGILAGLA YYSMQGNWAK VAIIMVMFSG VDAVTYTTGG SAAHATRGLT
410 420 430 440 450
SLFSVGAQQK LQLVNTNGSW HINSTALNCN ESINTGFIAG LFYYHRFNST
460 470 480 490 500
GCPQRLSSCK PITFFKQGWG PLTDANISGP SDDKPYCWHY APRPCKVVPA
510 520 530 540 550
SGVCGPVYCF TPSPVVVGTT DAKGVPTYTW GANDTDVFLL ESLRPPGGRW
560 570 580 590 600
FGCTWMNSTG FVKTCGASPC DIYGGGGNSG NESDLFCPTD CFRKHPEATY
610 620 630 640 650
SRCGAGPWLT PRCMVDYPYR LWHYPCTVNF TLFKVRMFVG GFEHRFTAAC
660 670 680 690 700
NWTRGERCDI EDRDRSEQHP LLHSTTELAI LPCSFTPMPA LSTGLIHLHQ
710 720 730 740 750
NIVDVQYLYG VGSGMVGWAL KWEFVILIFL LLADRRVCVA LWLMLMITQA
760 770 780 790 800
EAALENLVTL NAVAAAGTHG IGWYLVAFCA AWYVRGKLVP VVTYSLTGLW
810 820 830 840 850
PLALLVLMLP QRAYAWSGED SATLGAGVLA LFGFFTLSPW YKHWIGRLIW
860 870 880 890 900
WNQYTICRCE SALQVWVPPL LARGSRDGVI LLTSLLYPSL IFDITKLLIA
910 920 930 940 950
VLGPLYLIQA AVTTTPYFVR AQVLVRLCML VRSVMGGKYF QMIILSIGRW
960 970 980 990 1000
FNTYLYDHLA PMQHWAAAGL KDLAVATEPV IFSPMEIKVI TWGADTAACG
1010 1020 1030 1040 1050
DILCGLPVSA RLGREVLLGP ADDYREMGWR LLAPITAYAQ QTRGLLGTIV
1060 1070 1080 1090 1100
TSLTGRDKNV VTGEVQVLST ATQTFLGTTV GGVTWTVYHG AGSRTLAGAK
1110 1120 1130 1140 1150
HPALQMYTNV DQDLVGWPAP PGAKSLEPCA CGSADLYLVT RDADVIPARR
1160 1170 1180 1190 1200
RGDSTASLLS PRPLACLKGS SGGPVMCPSG HVAGIFRAAV CTRGVAKALQ
1210 1220 1230 1240 1250
FIPVETLSTQ TRSPSFSDNS TPPAVPQSYQ VGYLHAPTGS GKSTKVPAAY
1260 1270 1280 1290 1300
VAQGYTVLVL NPSVAATLGF GSFMSRAYGI DPNIRTGNRT VTTGAKLTYS
1310 1320 1330 1340 1350
TYGKFLADGG CSGGAYDVII CDECHAQDAT SILGIGTVLD QAETAGVRLT
1360 1370 1380 1390 1400
VLATRTPPGS ITVPHSNIEE VALGSEGEIP FYGKAIPIAL LKGGRHLIFC
1410 1420 1430 1440 1450
HSKKKCDEIA SKLRGMGLNA VAYYRGLDVS VIPTTGDVVV CATDALMTGY
1460 1470 1480 1490 1500
TGDFDSVIDC NVAVEQYVDF SLDPTFSIET RTAPQDAVSR SQRRGRTGRG
1510 1520 1530 1540 1550
RLGTYRYVAP GERPSGMFDS VVLCECYDAG CSWYDLQPAE TTVRLRAYLS
1560 1570 1580 1590 1600
TPGLPVCQDH LDFWESVFTG LTHIDAHFLS QTKQQGLNFS YLTAYQATVC
1610 1620 1630 1640 1650
ARAQAPPPSW DETWKCLVRL KPTLHGPTPL LYRLGPVQNE ICLSHPITKY
1660 1670 1680 1690 1700
VMACMSADLE VTTSTWVLLG GVLAALAAYC LSVGCVVIVG HIELGGKPAL
1710 1720 1730 1740 1750
VPDKEVLYQQ YDEMEECSQA APYIEQAQAI AHQFKEKVLG LLQRATQQQA
1760 1770 1780 1790 1800
VIEPIVATNW QKLEAFWHKH MWNFVSGIQY LAGLSTLPGN PAVASLMAFT
1810 1820 1830 1840 1850
ASVTSPLTTN QTMFFNILGG WVATHLAGPQ SSSAFVVSGL AGAAIGGIGL
1860 1870 1880 1890 1900
GRVLLDILAG YGAGVSGALV AFKIMGGELP TAEDMVNLLP AILSPGALVV
1910 1920 1930 1940 1950
GVICAAILRR HVGPGEGAVQ WMNRLIAFAS RGNHVSPTHY VPESDAAARV
1960 1970 1980 1990 2000
TALLSSLTVT SLLRRLHQWI NEDYPSPCSD DWLRIIWDWV CSVLSDFKSW
2010 2020 2030 2040 2050
LSAKIMPALP GLPFISCQKG YKGVWRGDGV MSTRCPCGAT ITGHVKNGSM
2060 2070 2080 2090 2100
RLAGPRTCAN MWHGTFPINE YTTGPSTPCP SPNYTRALWR VAANSYVEVR
2110 2120 2130 2140 2150
RVGDFHYITG ATEDELKCPC QVPAAEFFTE VDGVRLHRYA PPCKPLLREE
2160 2170 2180 2190 2200
ITFSVGLNSY TIGSQLPCEP EPDVSVLTSM LRDPSHITAE TAARRLARGS
2210 2220 2230 2240 2250
PPSEASSSAS QLSAPSLKAT CQTHRPHPDA ELVNANLLWR QEMGSNITRV
2260 2270 2280 2290 2300
ESETKVVILD SFEPLRAETD DAELSVAAEC FKKPPKYPPA LPIWARPDYN
2310 2320 2330 2340 2350
PPLLDRWKAP DYVPPTVHGC ALPPRGAPPV PPPRRKRTIQ LDGSNVSAAL
2360 2370 2380 2390 2400
RALAEKSFPS LKPQEENNSS SGVDTQSSTT SKVPPSPGGE SDSESCSSMP
2410 2420 2430 2440 2450
PLEGEPGDPD LSCDSWSTVS DSEEQSVVCC SMSYSWTGAL ITPCSAEEEK
2460 2470 2480 2490 2500
LPISPLSNSL LRHHNLVYST SSRSASQRQR KVTFDRLQVL DDHYKTVLKE
2510 2520 2530 2540 2550
VKERASRVKA RMLTIEEACA LVPPHSARSK FGYSAKDVRS LSSRAINQIR
2560 2570 2580 2590 2600
SVWEDLLEDT TTPIPTTIMA KNEVFCVDPA KGGRKPARLI VYPDLGVRVC
2610 2620 2630 2640 2650
EKRALYDVIQ KLAIETIGSA YGFQYSPQQR VERLLKMWTS KKTPLGFSYD
2660 2670 2680 2690 2700
TRCFDSTVTE QDIRVEEEIY QCCNLEPEAR KVISSLTERL YCGGPMFNSK
2710 2720 2730 2740 2750
GAQCGDRRCR ASGVLPTSFG NTITCYIKAT AAANGAGLRD PDFLVCGDDL
2760 2770 2780 2790 2800
VVVAESDGVD EDGAALRAFT EAMTRYSAPP GDAPQPTYDL ELITSCSSNV
2810 2820 2830 2840 2850
SVARDDKGRR YYYLTRDATT PLARAAWETA RHTPVNSWLG NIIMYAPTIW
2860 2870 2880 2890 2900
VRMVMMTHFF SILQSQEILD RPLDFEMYGA TYSVTPLDLP AIIERLHGLS
2910 2920 2930 2940 2950
AFTLHSYSPV ELNRVAGTLR KLGCPPLRAW RHRARAGRAK LIAQGGKAKI
2960 2970 2980 2990 3000
CGLYLFNWAV RTKTKLTPLP RAGQLDLSIW FTVGVGGNDI YHSVSRARTR
3010 3020
YLLLCLLLLT VGVGIFLLPA R
Length:3,021
Mass (Da):328,908
Last modified:November 1, 1998 - v1
Checksum:iD7B6133B330303CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046866 Genomic RNA. Translation: AAC03058.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046866 Genomic RNA. Translation: AAC03058.1.

3D structure databases

ProteinModelPortaliO92933.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

euHCVdbiAF046866.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR002521. HCV_core_C.
IPR002522. HCV_core_N.
IPR002519. HCV_env.
IPR002531. HCV_NS1.
IPR002518. HCV_NS2.
IPR000745. HCV_NS4a.
IPR001490. HCV_NS4b.
IPR002868. HCV_NS5a.
IPR013193. HCV_NS5a_1B_dom.
IPR024350. HCV_NS5a_C.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR013192. NS5A_1a.
IPR027417. P-loop_NTPase.
IPR009003. Peptidase_S1_PA.
IPR004109. Peptidase_S29.
IPR007094. RNA-dir_pol_PSvirus.
IPR002166. RNA_pol_HCV.
[Graphical view]
PfamiPF07652. Flavi_DEAD. 1 hit.
PF01543. HCV_capsid. 1 hit.
PF01542. HCV_core. 1 hit.
PF01539. HCV_env. 1 hit.
PF01560. HCV_NS1. 1 hit.
PF01538. HCV_NS2. 1 hit.
PF01006. HCV_NS4a. 1 hit.
PF01001. HCV_NS4b. 1 hit.
PF01506. HCV_NS5a. 1 hit.
PF08300. HCV_NS5a_1a. 1 hit.
PF08301. HCV_NS5a_1b. 1 hit.
PF12941. HCV_NS5a_C. 1 hit.
PF02907. Peptidase_S29. 1 hit.
PF00998. RdRP_3. 1 hit.
[Graphical view]
ProDomiPD001388. HCV_env. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51693. HCV_NS2_PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO92933_9HEPC
AccessioniPrimary (citable) accession number: O92933
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.