Gag polyprotein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• aspartic-type endopeptidase activity Source: UniProtKB-KW
• DNA binding Source: UniProtKB-KW
• DNA-directed DNA polymerase activity Source: UniProtKB-KW
• RNA binding Source: UniProtKB-KW
• RNA-directed DNA polymerase activity Source: UniProtKB-KW
• RNA-DNA hybrid ribonuclease activity Source: InterPro
• structural molecule activity Source: InterPro
• zinc ion binding Source: InterPro

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• DNA integration Source: UniProtKB-KW
• DNA recombination Source: UniProtKB-KW
• establishment of integrated proviral latency Source: UniProtKB-KW
• suppression by virus of host gene expression Source: UniProtKB-KW
• viral entry into host cell Source: UniProtKB-KW
• viral genome integration into host DNA Source: UniProtKB-KW
• viral penetration into host nucleus Source: UniProtKB-KW
• viral release from host cell Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• host cell cytoplasm Source: UniProtKB-SubCell
• host cell nucleus Source: UniProtKB-SubCell
• host cell plasma membrane Source: UniProtKB-SubCell
• membrane Source: UniProtKB-KW
• viral nucleocapsid Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGARASVLSG EELDRWEKIR LRPGGRKKYQ LKHIVWASRE LERFAVNPGL 
        60         70         80         90        100
LETSEGCRQI LGQLHPTLPT GSEELKSLYN TVAVLYCVHQ RLEVKDTKEA 
       110        120        130        140        150
LEKIEEEQNK CKKKAQQAAA GTGNSSQVSQ NYPIVQNIQG QMVHQAISAR 
       160        170        180        190        200
TLNAWVKVVE EKAFSPEVIP MFTALSEGAT PQDLNTMLNT VGGHQAAMQM 
       210        220        230        240        250
LKETINEEAA EWDRLHPVQA GPVAPGQMKE PRGSDIAGTT STLQEQIGWM 
       260        270        280        290        300
TNNPPIPVGD IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 
       310        320        330        340        350
YKTLRAEQAS QEVKNWMTET LLVQNANPDC RTILKALGPA ATLKEMMTAC 
       360        370        380        390        400
QGVGGPGHKA RVLAEAMSQA TSSAAVMMQR SNFRNQKKNV KCFNCGKEGH 
       410        420        430        440        450
IAKNCRAPRK RGCWKYGKEG HQMKDCTERQ AKFFRKNLAF PQGEARELSS 
       460        470        480        490        500
EQTRAISPTR RELQVWGENN HSPSEAGADR QGTVSFSFPQ ITLWQRPLVT 
       510        520        530        540        550
IKIGGQLKEA LLDTGADDTV LEKMNLPGRW KPKMIGGIGG FIKVRQYDQI 
       560        570        580        590        600
LVEICGHKAI GTVLVGPTPV NIIGKNLLTQ IGCTLNFPIS PIETVPVKLK 
       610        620        630        640        650
PEMDGPKVKQ WPLTEEKIKA LVEICTEMKK EGKISRIGPK NPYNTPVFAI 
       660        670        680        690        700
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPSGLKKK KSVTVLDVGD 
       710        720        730        740        750
AYFSVPLDES FRKYTAFTIP SINNETPGTR YQYNVLPQGW KGSPAIFQSS 
       760        770        780        790        800
MTKILEPFRK QNPDIVIYQY MDDLYVGSDL EIGQHRTKIE ELRQHLLRWG 
       810        820        830        840        850
FTTPDKKHQK EPPFLWMGYE LHPNKWTVQP IVLPEKDSWT VNDIQKLVGK 
       860        870        880        890        900
LYWASQIYAG IRVKQLCKLL RGAKALTEVV PLTEEAELEL AENREILRKP 
       910        920        930        940        950
VHEVYYDPSK DLIAEIQKQG QGQWTYQIYQ EPFKNLKTGK YAKTRGAHTN 
       960        970        980        990       1000
DVKQLTEAVQ KIATESIVIW KKTPKFKLPI QKETWEAWWT KYWQATWIPK 
      1010       1020       1030       1040       1050
WEFVNTPPLV KLWYQLEKEP IIGAETFYVN GAANRETKVK KAGYVTNKGR 
      1060       1070       1080       1090       1100
QKVVLLNDTT NQKTELQAIH LALQDSGLEV NIVTDSQYAL GIIQAQPDKS 
      1110       1120       1130       1140       1150
ESEIVNQIIE QLIKKEKVYL AWVPAHKGIG GNEQVDKLVS AGIRKVLFLD 
      1160       1170       1180       1190       1200
GIDKAQEEHE KYHSNWRAMA SDFNLPPVVA KEIVASCDKC QLKGEAMHGQ 
      1210       1220       1230       1240       1250
VDCSPGIWQL DCTHLEEKVI LVAVHVASGY IEAEVIPADT AQDTAYFLLR 
      1260       1270       1280       1290       1300
LAGRWPVKTI HTDNGSNFIS ATVKAACWWA GIKQEFGIPY NPQSQGVVES 
      1310       1320       1330       1340       1350
MNRELKKIIG QVRDQAEHLK TAVQMAVFIH NFKRKGGIGG YSAGERIVDI 
      1360       1370       1380       1390       1400
IATDIQTKEL QKQITKIQNF RVYYRDSRDP LWKGPAKLLW KGEGAVVIQD 
      1410       1420       1430 
NSDIKVVPRR KVKIIRDYGK QMAGDDCVAS RQDED            

Sequence databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ