UniProtKB - O92898 (O92898_9HIV1)
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Protein
Gag polyprotein
Gene
gag-pol
Organism
Human immunodeficiency virus 1
Status
Functioni
Catalytic activityi
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.SAAS annotation
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.SAAS annotation
Cofactori
Mg2+SAAS annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1370 – 1417 | Integrase-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA-directed DNA polymerase activity Source: UniProtKB-KW
- RNA-DNA hybrid ribonuclease activity Source: InterPro
- structural molecule activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- DNA integration Source: UniProtKB-KW
- DNA recombination Source: UniProtKB-KW
- establishment of integrated proviral latency Source: UniProtKB-KW
- suppression by virus of host gene expression Source: UniProtKB-KW
- viral entry into host cell Source: UniProtKB-KW
- viral genome integration into host DNA Source: UniProtKB-KW
- viral penetration into host nucleus Source: UniProtKB-KW
Keywordsi
Molecular function | Aspartyl proteaseSAAS annotation, DNA-bindingSAAS annotation, DNA-directed DNA polymeraseSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingUniRule annotationSAAS annotation, RNA-directed DNA polymeraseSAAS annotation, Transferase, Viral nucleoproteinUniRule annotation |
Biological process | DNA integration, DNA recombinationSAAS annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusSAAS annotation, Host gene expression shutoff by virus, Host-virus interaction, Viral genome integrationSAAS annotation, Viral penetration into host nucleusSAAS annotation, Viral release from host cell, Virion maturationSAAS annotation, Virus entry into host cell |
Ligand | MagnesiumSAAS annotation, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Gag polyproteinUniRule annotation |
Gene namesi | Name:gag-polImported |
Organismi | Human immunodeficiency virus 1Imported |
Taxonomic identifieri | 11676 [NCBI] |
Taxonomic lineagei | Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion UniRule annotation
- Host nucleus UniRule annotation
- Host cytoplasm UniRule annotation
- Host cell membrane SAAS annotation; Lipid-anchor SAAS annotation
- Host cytoplasm UniRule annotationSAAS annotation
- Host nucleus UniRule annotationSAAS annotation
- Virion UniRule annotation
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- host cell plasma membrane Source: UniProtKB-SubCell
- membrane Source: UniProtKB-KW
- viral nucleocapsid Source: UniProtKB-KW
Keywords - Cellular componenti
Capsid proteinUniRule annotationSAAS annotation, Host cell membraneSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host membrane, Host nucleusUniRule annotationSAAS annotation, Membrane, VirionPTM / Processingi
Post-translational modificationi
Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 391 – 406 | CCHC-typeInterPro annotationAdd BLAST | 16 | |
Domaini | 508 – 577 | Peptidase A2InterPro annotationAdd BLAST | 70 | |
Domaini | 631 – 821 | Reverse transcriptaseInterPro annotationAdd BLAST | 191 | |
Domaini | 1021 – 1144 | RNase HInterPro annotationAdd BLAST | 124 | |
Domaini | 1150 – 1191 | Integrase-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 1201 – 1351 | Integrase catalyticInterPro annotationAdd BLAST | 151 | |
Domaini | 1370 – 1417 | Integrase-typeInterPro annotationAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 87 – 121 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotationFamily and domain databases
CDDi | cd05482. HIV_retropepsin_like. 1 hit. |
Gene3Di | 1.10.10.200. 1 hit. 1.10.1200.30. 1 hit. 1.10.150.90. 1 hit. 1.10.375.10. 1 hit. 2.30.30.10. 1 hit. 2.40.70.10. 1 hit. 3.30.420.10. 2 hits. |
InterProi | View protein in InterPro IPR001969. Aspartic_peptidase_AS. IPR000721. Gag_p24. IPR017856. Integrase-like_N. IPR036862. Integrase_C_dom_sf_retrovir. IPR001037. Integrase_C_retrovir. IPR001584. Integrase_cat-core. IPR003308. Integrase_Zn-bd_dom_N. IPR000071. Lentvrl_matrix_N. IPR012344. Matrix_HIV/RSV_N. IPR001995. Peptidase_A2_cat. IPR021109. Peptidase_aspartic_dom_sf. IPR034170. Retropepsin-like_cat_dom. IPR018061. Retropepsins. IPR008916. Retrov_capsid_C. IPR008919. Retrov_capsid_N. IPR010999. Retrovr_matrix. IPR012337. RNaseH-like_sf. IPR002156. RNaseH_domain. IPR036397. RNaseH_sf. IPR000477. RT_dom. IPR010659. RVT_connect. IPR010661. RVT_thumb. IPR001878. Znf_CCHC. IPR036875. Znf_CCHC_sf. |
Pfami | View protein in Pfam PF00540. Gag_p17. 1 hit. PF00607. Gag_p24. 1 hit. PF00552. IN_DBD_C. 1 hit. PF02022. Integrase_Zn. 1 hit. PF00075. RNase_H. 1 hit. PF00665. rve. 1 hit. PF00077. RVP. 1 hit. PF00078. RVT_1. 1 hit. PF06815. RVT_connect. 1 hit. PF06817. RVT_thumb. 1 hit. PF00098. zf-CCHC. 1 hit. |
PRINTSi | PR00234. HIV1MATRIX. |
SMARTi | View protein in SMART SM00343. ZnF_C2HC. 2 hits. |
SUPFAMi | SSF46919. SSF46919. 1 hit. SSF47836. SSF47836. 1 hit. SSF47943. SSF47943. 1 hit. SSF50122. SSF50122. 1 hit. SSF50630. SSF50630. 1 hit. SSF53098. SSF53098. 2 hits. SSF57756. SSF57756. 1 hit. |
PROSITEi | View protein in PROSITE PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50994. INTEGRASE. 1 hit. PS51027. INTEGRASE_DBD. 1 hit. PS50879. RNASE_H. 1 hit. PS50878. RT_POL. 1 hit. PS50158. ZF_CCHC. 1 hit. PS50876. ZF_INTEGRASE. 1 hit. |
i Sequence
Sequence statusi: Complete.
O92898-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGARASVLSG EELDRWEKIR LRPGGRKKYQ LKHIVWASRE LERFAVNPGL
60 70 80 90 100
LETSEGCRQI LGQLHPTLPT GSEELKSLYN TVAVLYCVHQ RLEVKDTKEA
110 120 130 140 150
LEKIEEEQNK CKKKAQQAAA GTGNSSQVSQ NYPIVQNIQG QMVHQAISAR
160 170 180 190 200
TLNAWVKVVE EKAFSPEVIP MFTALSEGAT PQDLNTMLNT VGGHQAAMQM
210 220 230 240 250
LKETINEEAA EWDRLHPVQA GPVAPGQMKE PRGSDIAGTT STLQEQIGWM
260 270 280 290 300
TNNPPIPVGD IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF
310 320 330 340 350
YKTLRAEQAS QEVKNWMTET LLVQNANPDC RTILKALGPA ATLKEMMTAC
360 370 380 390 400
QGVGGPGHKA RVLAEAMSQA TSSAAVMMQR SNFRNQKKNV KCFNCGKEGH
410 420 430 440 450
IAKNCRAPRK RGCWKYGKEG HQMKDCTERQ AKFFRKNLAF PQGEARELSS
460 470 480 490 500
EQTRAISPTR RELQVWGENN HSPSEAGADR QGTVSFSFPQ ITLWQRPLVT
510 520 530 540 550
IKIGGQLKEA LLDTGADDTV LEKMNLPGRW KPKMIGGIGG FIKVRQYDQI
560 570 580 590 600
LVEICGHKAI GTVLVGPTPV NIIGKNLLTQ IGCTLNFPIS PIETVPVKLK
610 620 630 640 650
PEMDGPKVKQ WPLTEEKIKA LVEICTEMKK EGKISRIGPK NPYNTPVFAI
660 670 680 690 700
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPSGLKKK KSVTVLDVGD
710 720 730 740 750
AYFSVPLDES FRKYTAFTIP SINNETPGTR YQYNVLPQGW KGSPAIFQSS
760 770 780 790 800
MTKILEPFRK QNPDIVIYQY MDDLYVGSDL EIGQHRTKIE ELRQHLLRWG
810 820 830 840 850
FTTPDKKHQK EPPFLWMGYE LHPNKWTVQP IVLPEKDSWT VNDIQKLVGK
860 870 880 890 900
LYWASQIYAG IRVKQLCKLL RGAKALTEVV PLTEEAELEL AENREILRKP
910 920 930 940 950
VHEVYYDPSK DLIAEIQKQG QGQWTYQIYQ EPFKNLKTGK YAKTRGAHTN
960 970 980 990 1000
DVKQLTEAVQ KIATESIVIW KKTPKFKLPI QKETWEAWWT KYWQATWIPK
1010 1020 1030 1040 1050
WEFVNTPPLV KLWYQLEKEP IIGAETFYVN GAANRETKVK KAGYVTNKGR
1060 1070 1080 1090 1100
QKVVLLNDTT NQKTELQAIH LALQDSGLEV NIVTDSQYAL GIIQAQPDKS
1110 1120 1130 1140 1150
ESEIVNQIIE QLIKKEKVYL AWVPAHKGIG GNEQVDKLVS AGIRKVLFLD
1160 1170 1180 1190 1200
GIDKAQEEHE KYHSNWRAMA SDFNLPPVVA KEIVASCDKC QLKGEAMHGQ
1210 1220 1230 1240 1250
VDCSPGIWQL DCTHLEEKVI LVAVHVASGY IEAEVIPADT AQDTAYFLLR
1260 1270 1280 1290 1300
LAGRWPVKTI HTDNGSNFIS ATVKAACWWA GIKQEFGIPY NPQSQGVVES
1310 1320 1330 1340 1350
MNRELKKIIG QVRDQAEHLK TAVQMAVFIH NFKRKGGIGG YSAGERIVDI
1360 1370 1380 1390 1400
IATDIQTKEL QKQITKIQNF RVYYRDSRDP LWKGPAKLLW KGEGAVVIQD
1410 1420 1430
NSDIKVVPRR KVKIIRDYGK QMAGDDCVAS RQDED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF042105 Genomic DNA. Translation: AAD03233.1. |
PIRi | A47330. C47330. D47330. F47330. |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSAAS annotationSimilar proteinsi
Entry informationi
Entry namei | O92898_9HIV1 | |
Accessioni | O92898Primary (citable) accession number: O92898 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1998 |
Last sequence update: | November 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |