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UniProtKB - O92898 (O92898_9HIV1)

UniProt

O92898 - O92898_9HIV1

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Protein

Gag polyprotein

Gene

gag-pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

Catalytic activityi

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.SAAS annotation
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.SAAS annotation

Cofactori

Mg2+SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseSAAS annotation, DNA-directed DNA polymeraseSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

DNA integration, DNA recombinationSAAS annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusSAAS annotation, Host gene expression shutoff by virus, Host-virus interaction, Viral genome integrationSAAS annotation, Viral penetration into host nucleusSAAS annotation, Virion maturationSAAS annotation, Virus entry into host cell, Virus exit from host cell

Keywords - Ligandi

DNA-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-binding, RNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotation
Gene namesi
Name:gag-polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiViruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Lipid-anchor SAAS annotation
  • Host cytoplasm SAAS annotation
  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Virion UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cell membraneSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host membrane, Host nucleusUniRule annotationSAAS annotation, Membrane, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO92898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini391 – 40616CCHC-typeInterPro annotationAdd
BLAST
Domaini508 – 57770Peptidase A2InterPro annotationAdd
BLAST
Domaini631 – 821191Reverse transcriptaseInterPro annotationAdd
BLAST
Domaini1021 – 1144124RNase HInterPro annotationAdd
BLAST
Domaini1150 – 119142Integrase-typeInterPro annotationAdd
BLAST
Domaini1201 – 1351151Integrase catalyticInterPro annotationAdd
BLAST
Domaini1370 – 141748Integrase-type DNA-bindingInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 12135Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains CCHC-type zinc fingers.SAAS annotation
Contains RNase H domain.SAAS annotation
Contains integrase catalytic domain.SAAS annotation
Contains integrase-type DNA-binding domain.SAAS annotation
Contains integrase-type zinc finger.SAAS annotation
Contains peptidase A2 domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
2.30.30.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O92898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASVLSG EELDRWEKIR LRPGGRKKYQ LKHIVWASRE LERFAVNPGL 
        60         70         80         90        100
LETSEGCRQI LGQLHPTLPT GSEELKSLYN TVAVLYCVHQ RLEVKDTKEA 
       110        120        130        140        150
LEKIEEEQNK CKKKAQQAAA GTGNSSQVSQ NYPIVQNIQG QMVHQAISAR 
       160        170        180        190        200
TLNAWVKVVE EKAFSPEVIP MFTALSEGAT PQDLNTMLNT VGGHQAAMQM 
       210        220        230        240        250
LKETINEEAA EWDRLHPVQA GPVAPGQMKE PRGSDIAGTT STLQEQIGWM 
       260        270        280        290        300
TNNPPIPVGD IYKRWIILGL NKIVRMYSPT SILDIRQGPK EPFRDYVDRF 
       310        320        330        340        350
YKTLRAEQAS QEVKNWMTET LLVQNANPDC RTILKALGPA ATLKEMMTAC 
       360        370        380        390        400
QGVGGPGHKA RVLAEAMSQA TSSAAVMMQR SNFRNQKKNV KCFNCGKEGH 
       410        420        430        440        450
IAKNCRAPRK RGCWKYGKEG HQMKDCTERQ AKFFRKNLAF PQGEARELSS 
       460        470        480        490        500
EQTRAISPTR RELQVWGENN HSPSEAGADR QGTVSFSFPQ ITLWQRPLVT 
       510        520        530        540        550
IKIGGQLKEA LLDTGADDTV LEKMNLPGRW KPKMIGGIGG FIKVRQYDQI 
       560        570        580        590        600
LVEICGHKAI GTVLVGPTPV NIIGKNLLTQ IGCTLNFPIS PIETVPVKLK 
       610        620        630        640        650
PEMDGPKVKQ WPLTEEKIKA LVEICTEMKK EGKISRIGPK NPYNTPVFAI 
       660        670        680        690        700
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPSGLKKK KSVTVLDVGD 
       710        720        730        740        750
AYFSVPLDES FRKYTAFTIP SINNETPGTR YQYNVLPQGW KGSPAIFQSS 
       760        770        780        790        800
MTKILEPFRK QNPDIVIYQY MDDLYVGSDL EIGQHRTKIE ELRQHLLRWG 
       810        820        830        840        850
FTTPDKKHQK EPPFLWMGYE LHPNKWTVQP IVLPEKDSWT VNDIQKLVGK 
       860        870        880        890        900
LYWASQIYAG IRVKQLCKLL RGAKALTEVV PLTEEAELEL AENREILRKP 
       910        920        930        940        950
VHEVYYDPSK DLIAEIQKQG QGQWTYQIYQ EPFKNLKTGK YAKTRGAHTN 
       960        970        980        990       1000
DVKQLTEAVQ KIATESIVIW KKTPKFKLPI QKETWEAWWT KYWQATWIPK 
      1010       1020       1030       1040       1050
WEFVNTPPLV KLWYQLEKEP IIGAETFYVN GAANRETKVK KAGYVTNKGR 
      1060       1070       1080       1090       1100
QKVVLLNDTT NQKTELQAIH LALQDSGLEV NIVTDSQYAL GIIQAQPDKS 
      1110       1120       1130       1140       1150
ESEIVNQIIE QLIKKEKVYL AWVPAHKGIG GNEQVDKLVS AGIRKVLFLD 
      1160       1170       1180       1190       1200
GIDKAQEEHE KYHSNWRAMA SDFNLPPVVA KEIVASCDKC QLKGEAMHGQ 
      1210       1220       1230       1240       1250
VDCSPGIWQL DCTHLEEKVI LVAVHVASGY IEAEVIPADT AQDTAYFLLR 
      1260       1270       1280       1290       1300
LAGRWPVKTI HTDNGSNFIS ATVKAACWWA GIKQEFGIPY NPQSQGVVES 
      1310       1320       1330       1340       1350
MNRELKKIIG QVRDQAEHLK TAVQMAVFIH NFKRKGGIGG YSAGERIVDI 
      1360       1370       1380       1390       1400
IATDIQTKEL QKQITKIQNF RVYYRDSRDP LWKGPAKLLW KGEGAVVIQD 
      1410       1420       1430 
NSDIKVVPRR KVKIIRDYGK QMAGDDCVAS RQDED
Length:1,435
Mass (Da):162,263
Last modified:November 1, 1998 - v1
Checksum:i830F992E657635FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042105 Genomic DNA. Translation: AAD03233.1.
PIRiA47330.
C47330.
D47330.
F47330.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042105 Genomic DNA. Translation: AAD03233.1.
PIRiA47330.
C47330.
D47330.
F47330.

3D structure databases

ProteinModelPortaliO92898.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.10.200. 1 hit.
1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
2.30.30.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR017856. Integrase_Zn-bd_dom-like_N.
IPR003308. Integrase_Zn-bd_dom_N.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR010659. RVT_connect.
IPR010661. RVT_thumb.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF02022. Integrase_Zn. 1 hit.
PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF06815. RVT_connect. 1 hit.
PF06817. RVT_thumb. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF46919. SSF46919. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50122. SSF50122. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
PS50876. ZF_INTEGRASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO92898_9HIV1
AccessioniPrimary (citable) accession number: O92898
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.