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Protein

Gag polyprotein

Gene

gag-pol

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.SAAS annotation
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.SAAS annotation

Cofactori

Mg2+SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1371 – 1418Integrase-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl proteaseSAAS annotation, DNA-bindingSAAS annotation, DNA-directed DNA polymeraseSAAS annotation, EndonucleaseSAAS annotation, Hydrolase, Multifunctional enzymeSAAS annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingUniRule annotationSAAS annotation, RNA-directed DNA polymeraseSAAS annotation, Transferase, Viral nucleoproteinUniRule annotation
Biological processDNA integration, DNA recombinationSAAS annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusSAAS annotation, Host gene expression shutoff by virus, Host-virus interaction, Viral genome integrationSAAS annotation, Viral penetration into host nucleusSAAS annotation, Viral release from host cell, Virion maturationSAAS annotation, Virus entry into host cell
LigandMagnesiumSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotation
Gene namesi
Name:gag-polImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000121223 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host cell membrane SAAS annotation; Lipid-anchor SAAS annotation
  • Host cytoplasm UniRule annotationSAAS annotation
  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cell membraneSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host membrane, Host nucleusUniRule annotationSAAS annotation, Membrane, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO92894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini391 – 406CCHC-typeInterPro annotationAdd BLAST16
Domaini413 – 428CCHC-typeInterPro annotationAdd BLAST16
Domaini508 – 577Peptidase A2InterPro annotationAdd BLAST70
Domaini632 – 822Reverse transcriptaseInterPro annotationAdd BLAST191
Domaini1022 – 1145RNase HInterPro annotationAdd BLAST124
Domaini1151 – 1192Integrase-typeInterPro annotationAdd BLAST42
Domaini1202 – 1352Integrase catalyticInterPro annotationAdd BLAST151
Domaini1371 – 1418Integrase-typeInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 114Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

CDDicd05482 HIV_retropepsin_like, 1 hit
Gene3Di1.10.10.200, 1 hit
1.10.1200.30, 1 hit
1.10.150.90, 1 hit
1.10.375.10, 1 hit
2.30.30.10, 1 hit
2.40.70.10, 1 hit
3.30.420.10, 2 hits
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR000721 Gag_p24
IPR017856 Integrase-like_N
IPR036862 Integrase_C_dom_sf_retrovir
IPR001037 Integrase_C_retrovir
IPR001584 Integrase_cat-core
IPR003308 Integrase_Zn-bd_dom_N
IPR000071 Lentvrl_matrix_N
IPR012344 Matrix_HIV/RSV_N
IPR001995 Peptidase_A2_cat
IPR021109 Peptidase_aspartic_dom_sf
IPR034170 Retropepsin-like_cat_dom
IPR018061 Retropepsins
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
IPR000477 RT_dom
IPR010659 RVT_connect
IPR010661 RVT_thumb
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00540 Gag_p17, 1 hit
PF00607 Gag_p24, 1 hit
PF00552 IN_DBD_C, 1 hit
PF02022 Integrase_Zn, 1 hit
PF00075 RNase_H, 1 hit
PF00665 rve, 1 hit
PF00077 RVP, 1 hit
PF00078 RVT_1, 1 hit
PF06815 RVT_connect, 1 hit
PF06817 RVT_thumb, 1 hit
PF00098 zf-CCHC, 2 hits
PRINTSiPR00234 HIV1MATRIX
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF46919 SSF46919, 1 hit
SSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF50122 SSF50122, 1 hit
SSF50630 SSF50630, 1 hit
SSF53098 SSF53098, 2 hits
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50175 ASP_PROT_RETROV, 1 hit
PS00141 ASP_PROTEASE, 1 hit
PS50994 INTEGRASE, 1 hit
PS51027 INTEGRASE_DBD, 1 hit
PS50879 RNASE_H, 1 hit
PS50878 RT_POL, 1 hit
PS50158 ZF_CCHC, 2 hits
PS50876 ZF_INTEGRASE, 1 hit

Sequencei

Sequence statusi: Complete.

O92894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARASILSG GELDRWEKIR LRPGGKKKYQ LKHIVWASRE LERFAVNPGL
60 70 80 90 100
LETSEGCRQI LEQLQPALQT GSEDLRSVYN TVATLYCVHQ RIEVKDTKEA
110 120 130 140 150
VEKIEEEQNK SKKKAQQAAA GPGNSSQVSQ NYPIVQNIQG QMVHQAISPR
160 170 180 190 200
TLNAWVKVVE EKAFSPEVIP MFSALSEGAT PQDLNTMLNT VGGHQAAMQM
210 220 230 240 250
LKETINEEAA EWDRLHPVHA GPIAPGQMRE PRGSDIAGTT STLQEHIGWM
260 270 280 290 300
TNNPPIPVGD IYKRWIILGL NIIVRMYSPT SILDIRQGPK EPFRDYVDRF
310 320 330 340 350
YKTLRAEQAS QEVKNWMTET LLVQNANPDC KTILKALGPA ATLEEMMTAC
360 370 380 390 400
QGVGGPGHKA RVLAEAMSQA TQSATVMMQR SNFRNQKKNI KCFNCGKEGH
410 420 430 440 450
IAKYCRAPRI RGCWKCGKVG HQMIDCTERQ AKFFRENLAF PQGEAREFSS
460 470 480 490 500
EQTRANSPTR RELQVWGGDN NSLSEAGADR QGPVSFSFPH ITLWQRPLVT
510 520 530 540 550
IKIGGQLKVA LLDTGADDTV LEEMALPGRW KPNMIGGIGG FIRVTQYDQI
560 570 580 590 600
LIEICGHKAI GTVLVGPTPV NIIGRNLLTQ IGCTLNFPIS PIDTVPVKLK
610 620 630 640 650
PGMVHGPKVK QWPLTEEKIK ALVEICTEME KEGKISKIGP ENPYNTPVFA
660 670 680 690 700
IKKKDSTKWR KLVDFRELNK KTQDFWEVQL GIPHPAGLKK KKSVTVLDVG
710 720 730 740 750
DAYFSVPLDK DFRKYTAFTI PSINNETPGI RYQYNVLPQG WKGSPAIFQY
760 770 780 790 800
SMTKILEPFR KQNPDIVIYQ YMDDLYVGSD LEIGQHRTKI EELRRHLLRW
810 820 830 840 850
GFTTPDKKHQ KEPPFLWMGY ELHPDKWTVQ PIVLPEKDSW TVNDIQKLVG
860 870 880 890 900
KLNWASQIYP GIKVKQLCKL LRGTKALTEV IPLTEEAELE LADNREILKE
910 920 930 940 950
PVHGVYYDPS EDLIAEIQKQ GQGQWTYQIY QEPFKNLKTG KYARMRGAHT
960 970 980 990 1000
NDVRQLTEAV QKIATESIVI WGKTPKFKLP IQKETWEAWW TEYWQATWIP
1010 1020 1030 1040 1050
EWEFVNTPPL VKLWYQLERE PIIGAETFYV DGAANKETKL GKAGYVTDRG
1060 1070 1080 1090 1100
RQKVVSLTDT TNQKTELQAI HLALQDSGLE VNIVTDSQYA LGIIQAQPDK
1110 1120 1130 1140 1150
SESEVVSQII EQLIKKEKVY LAWVPAHKGI GGNEQVDKLV SAGIRKVLFL
1160 1170 1180 1190 1200
DGIDKAQEEH ETYHSNWRAM ASDFNLPPIV AKDIVASCDK CQLKGEAMHG
1210 1220 1230 1240 1250
QVDFSPGIWQ LDCTHLDGNI ILVAVHVASG YIDAEVIPAE TGQDTAYFLL
1260 1270 1280 1290 1300
TLAGRWPVNT LHTDNGSNFT STTVKAACWW AGITQEFGIP YNPQSQGVVA
1310 1320 1330 1340 1350
SMHRALKKII GQVRDQAEHL KTAVQMAVFI HNFIRKGGIG GYSAGERIVD
1360 1370 1380 1390 1400
IIATDIQTKE LQKQITKIQN FRVYYRDSRD PLWKGPAKLL WKGEGAVVIQ
1410 1420 1430
DNSDIKVVPR RKVKIIRDYG KQMAGDDCVA SRQDED
Length:1,436
Mass (Da):161,775
Last modified:November 1, 1998 - v1
Checksum:i5202E309E019E36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042104 Genomic DNA Translation: AAD03225.1
PIRiA47330
B47330
C47330
D47330
E47330
F47330

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Similar proteinsi

Entry informationi

Entry nameiO92894_9HIV1
AccessioniPrimary (citable) accession number: O92894
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health