Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

RT-IN

Gene

gag-pro-pol

Organism
Bovine leukemia virus (BLV)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseSAAS annotation, Hydrolase, Nuclease, Nucleotidyltransferase, ProteaseSAAS annotation, RNA-directed DNA polymeraseSAAS annotation, Transferase

Keywords - Biological processi

DNA integration, DNA recombinationSAAS annotation, Viral genome integrationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

DNA-bindingSAAS annotation, MagnesiumSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RT-INImported
Gene namesi
Name:gag-pro-polImported
OrganismiBovine leukemia virus (BLV)Imported
Taxonomic identifieri11901 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeDeltaretrovirus
Virus hostiBos taurus (Bovine) [TaxID: 9913]

Subcellular locationi

  • Virion SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Miscellaneous databases

PMAP-CutDBO92812.

Structurei

3D structure databases

ProteinModelPortaliO92812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini348 – 36215CCHC-typeInterPro annotationAdd
BLAST
Domaini448 – 52679Peptidase A2InterPro annotationAdd
BLAST
Domaini587 – 777191Reverse transcriptaseInterPro annotationAdd
BLAST
Domaini997 – 1127131RNase HInterPro annotationAdd
BLAST
Domaini1180 – 1344165Integrase catalyticInterPro annotationAdd
BLAST
Domaini1353 – 140149Integrase-type DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 reverse transcriptase domain.UniRule annotation
Contains CCHC-type zinc fingers.SAAS annotation
Contains RNase H domain.SAAS annotation
Contains integrase catalytic domain.SAAS annotation
Contains integrase-type DNA-binding domain.SAAS annotation
Contains peptidase A2 domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.185.10. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR003139. D_retro_matrix.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02228. Gag_p19. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O92812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSPSYNPP AGISPSDWLN LRQSAQRLNP RPSPSDFTDL KNYIHWFHKT
60 70 80 90 100
QKKPWTFTSG GPASCPPGKF GRVPLVLATL NEVLSNDEGA PGASAPEEQP
110 120 130 140 150
PPYDPPAILP IISEGNRNRH RAWALRELQD IKKEIENKAP GSQVWIQTLR
160 170 180 190 200
LAILQADPTP ADLEQLCQYI ASPVDQTAHM TSLTAAIAAA EAANTLQGFN
210 220 230 240 250
PQNGTLTQQS AQPNAGDLRS QYQNLWLQAW KNLPTRPSVQ PWSTIVQGPA
260 270 280 290 300
ESYVEFVNRL QISLADNLPD GVPKEPIIDS LSYANANKEC QQILQGRGLV
310 320 330 340 350
AAPVGQKLQA CAHWAPKVKQ PAILVHTPGP KMPGPRQPAP KRPPPGPCYR
360 370 380 390 400
CLKEGHWARD CPTKTTGPPP GPCPICKRSF PLETRLSNPQ IKKLIEGGLS
410 420 430 440 450
APQTVTPITD PLSEAELECL LSIPLARSRP SVAVYLSGPW LQPSQNQALM
460 470 480 490 500
LVDTGAENTV LPQNWLVRDY PRIPAAVLGA GGVSRNRYNW LQGPLTLALK
510 520 530 540 550
PEGPFITIPK ILVDTFDKWQ ILGRDVLSRL QASISIPEEV RPPMVGVLDA
560 570 580 590 600
PPSHIGLEHL PVPPEVPQFP LNLERLQALQ DLVHRSLEAG YISPWDGPGN
610 620 630 640 650
NPVFPVRKPN GTWRFVHDLR ATNALTKPIP ALSPGPPDLT AIPTHLPHII
660 670 680 690 700
CLDLKDAFFQ IPVEDRFRSY FAFTLPTPGG LQPHRRFAWR VLPQGFINSP
710 720 730 740 750
ALFERALQEP LRQVSAAFSQ SLLVSYMDDI LIASPTEEQR SQCYQALAAR
760 770 780 790 800
LRDLGFQVAS EKTRQTPSPV PFLGQMVHNQ IVTYQSLPTL QISSPISLHQ
810 820 830 840 850
LQAVLGDLQW VSRGTPTTRR PLQLLYSSLK GIDDPRAIIQ LSPEQLQGIA
860 870 880 890 900
ELRQALSHNA RSRYNEQEPL LAYVHLTRAG STLVLFQKGA QFPLAYFQTP
910 920 930 940 950
LTDNQASPWG LLLLLGCQYL QTQALSSYAK PILKYYHNLP KTSLDNWIQS
960 970 980 990 1000
SEDPRVQELL QLWPQISSQG IQPPGPWKTL ITRAEVFLTP QFSPEPIPAA
1010 1020 1030 1040 1050
LCLFSDGATG RGAYCLWKDH LLDFQAVPAP ESAQKGELAG LLAGLAAAPP
1060 1070 1080 1090 1100
EPLNIWVDSK YLYSLLRTLV LGAWLQPDPV PSYALLYKSL LRHPAIFVGH
1110 1120 1130 1140 1150
VRSHSSASHP IASLNNYVDQ LLPLETPEQW HKLTHCNSRA LSRWPNPRIS
1160 1170 1180 1190 1200
AWDPRSPATL CETCQRLNPT GGGKMRTIQR GWAPNHIWQA DITHYKYKQF
1210 1220 1230 1240 1250
TYALHVFVDT YSGATHASAK RGLTTQMTIE GLLEAIVHLG RPKKLNTDQG
1260 1270 1280 1290 1300
ANYTSKTFVR FCQQFGISLS HHVPYNPTSS GLVERTNGLL KLLLSKYHLD
1310 1320 1330 1340 1350
EPHLPMTQAL SRALWTHNQI NLLPILKTRW ELHHSPPLAV ISEGGETPKG
1360 1370 1380 1390 1400
SDKLFLYKLP GQNNRRWLGP LPALVEASGG ALLATNPPVW VPWRLLKAFK
1410
CPKNDGPEDA HNRSSDG
Length:1,417
Mass (Da):156,881
Last modified:December 1, 2001 - v2
Checksum:iCFA9CD8DB46EF611
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033818 Genomic RNA. Translation: AAC82587.1.
RefSeqiNP_056895.1. NC_001414.1.

Genome annotation databases

GeneIDi2760848.
KEGGivg:2760848.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF033818 Genomic RNA. Translation: AAC82587.1.
RefSeqiNP_056895.1. NC_001414.1.

3D structure databases

ProteinModelPortaliO92812.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2760848.
KEGGivg:2760848.

Miscellaneous databases

PMAP-CutDBO92812.

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.185.10. 1 hit.
1.10.375.10. 1 hit.
2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
4.10.60.10. 1 hit.
InterProiIPR003139. D_retro_matrix.
IPR000721. Gag_p24.
IPR001037. Integrase_C_retrovir.
IPR001584. Integrase_cat-core.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR018061. Retropepsins.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF02228. Gag_p19. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00552. IN_DBD_C. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
SMARTiSM00343. ZnF_C2HC. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS51027. INTEGRASE_DBD. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
PS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Appendix 2: Retroviral taxonomy, protein structure, sequences, and genetic maps."
    Petropoulos C.J.
    (In) Coffin, J.M. (eds.); RETROVIRUSES, pp.757-0, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, NY, USA (1997)
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Chappey C.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO92812_BLV
AccessioniPrimary (citable) accession number: O92812
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Multifunctional enzymeSAAS annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.