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O91466 (CATV_GVCPM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Viral cathepsin

Short name=V-cath
EC=3.4.22.50
Alternative name(s):
Cysteine proteinase
Short name=CP
Gene names
Name:VCATH
Synonyms:ORF8R
OrganismCydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) [Reference proteome]
Taxonomic identifier654905 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageBaculoviridaeBetabaculovirus
Virus hostCydia pomonella (Codling moth) [TaxID: 82600]

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.

Catalytic activity

Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

Post-translational modification

Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMDisulfide bond
Glycoprotein
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 124104Activation peptide Potential
PRO_0000322218
Chain125 – 333209Viral cathepsin
PRO_0000050588

Sites

Active site1481 By similarity
Active site2801 By similarity
Active site3001 By similarity

Amino acid modifications

Glycosylation1701N-linked (GlcNAc...); by host Potential
Disulfide bond145 ↔ 186 By similarity
Disulfide bond179 ↔ 219 By similarity
Disulfide bond272 ↔ 321 By similarity

Sequences

Sequence LengthMass (Da)Tools
O91466 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: F531CC9AC34FFF5A

FASTA33337,434
        10         20         30         40         50         60 
MTKLLNFVIL ASVLTVTAHA LTYDLNNSDE LFKNFAIKYN KTYVSDEERA IKLENFKNNL 

        70         80         90        100        110        120 
KMINEKNMAS KYAVFDINEY SDLNKNALLR RTTGFRLGLK KNPSAFTMTE CSVVVIKDEP 

       130        140        150        160        170        180 
QALLPETLDW RDKHGVTPVK NQMECGSCWA FSTIANIESL YNIKYDKALN LSEQHLVNCD 

       190        200        210        220        230        240 
NINNGCAGGL MHWALESILQ EGGVVSAENE PYYGFDGVCK KSPFELSISG SRRYVLQNEN 

       250        260        270        280        290        300 
KLRELLVVNG PISVAIDVSD LINYKAGIAD ICENNEGLNH AVLLVGYGVK NDVPYWILKN 

       310        320        330 
SWGAEWGEEG YFRVQRDKNS CGMMNEYASS AIL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of the Cydia pomonella granulovirus cathepsin and chitinase genes."
Kang W., Tristem M., Maeda S., Crook N.E., O'Reilly D.R.
J. Gen. Virol. 79:2283-2292(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Mexican 1.
[2]"The complete sequence of the Cydia pomonella granulovirus genome."
Luque T., Finch R., Crook N., O'Reilly D.R., Winstanley D.
J. Gen. Virol. 82:2531-2547(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Mexican 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53466 Genomic DNA. Translation: AAK70678.1.
RefSeqNP_148795.1. NC_002816.1.

3D structure databases

ProteinModelPortalO91466.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC01.047.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID921370.

Phylogenomic databases

ProtClustDBCLSP2509984.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATV_GVCPM
AccessionPrimary (citable) accession number: O91466
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries