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O91466

- CATV_GVCPM

UniProt

O91466 - CATV_GVCPM

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Protein

Viral cathepsin

Gene

VCATH

Organism
Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).By similarity

Catalytic activityi

Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei148 – 1481By similarity
Active sitei280 – 2801By similarity
Active sitei300 – 3001By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.047.

Names & Taxonomyi

Protein namesi
Recommended name:
Viral cathepsin (EC:3.4.22.50)
Short name:
V-cath
Alternative name(s):
Cysteine proteinase
Short name:
CP
Gene namesi
Name:VCATH
Synonyms:ORF8R
OrganismiCydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus)
Taxonomic identifieri654905 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeBetabaculovirus
Virus hostiCydia pomonella (Codling moth) [TaxID: 82600]
ProteomesiUP000009249: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 124104Activation peptideSequence AnalysisPRO_0000322218Add
BLAST
Chaini125 – 333209Viral cathepsinPRO_0000050588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi145 ↔ 186By similarity
Glycosylationi170 – 1701N-linked (GlcNAc...); by hostSequence Analysis
Disulfide bondi179 ↔ 219By similarity
Disulfide bondi272 ↔ 321By similarity

Post-translational modificationi

Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliO91466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O91466-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKLLNFVIL ASVLTVTAHA LTYDLNNSDE LFKNFAIKYN KTYVSDEERA
60 70 80 90 100
IKLENFKNNL KMINEKNMAS KYAVFDINEY SDLNKNALLR RTTGFRLGLK
110 120 130 140 150
KNPSAFTMTE CSVVVIKDEP QALLPETLDW RDKHGVTPVK NQMECGSCWA
160 170 180 190 200
FSTIANIESL YNIKYDKALN LSEQHLVNCD NINNGCAGGL MHWALESILQ
210 220 230 240 250
EGGVVSAENE PYYGFDGVCK KSPFELSISG SRRYVLQNEN KLRELLVVNG
260 270 280 290 300
PISVAIDVSD LINYKAGIAD ICENNEGLNH AVLLVGYGVK NDVPYWILKN
310 320 330
SWGAEWGEEG YFRVQRDKNS CGMMNEYASS AIL
Length:333
Mass (Da):37,434
Last modified:November 1, 1998 - v1
Checksum:iF531CC9AC34FFF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53466 Genomic DNA. Translation: AAK70678.1.
RefSeqiNP_148795.1. NC_002816.1.

Genome annotation databases

GeneIDi921370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53466 Genomic DNA. Translation: AAK70678.1 .
RefSeqi NP_148795.1. NC_002816.1.

3D structure databases

ProteinModelPortali O91466.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C01.047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 921370.

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the Cydia pomonella granulovirus cathepsin and chitinase genes."
    Kang W., Tristem M., Maeda S., Crook N.E., O'Reilly D.R.
    J. Gen. Virol. 79:2283-2292(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Mexican 1.
  2. "The complete sequence of the Cydia pomonella granulovirus genome."
    Luque T., Finch R., Crook N., O'Reilly D.R., Winstanley D.
    J. Gen. Virol. 82:2531-2547(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mexican 1.

Entry informationi

Entry nameiCATV_GVCPM
AccessioniPrimary (citable) accession number: O91466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3