O91466 (CATV_GVCPM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Viral cathepsin
Short name=V-cath
EC=3.4.22.50

Alternative name(s):
Cysteine proteinase
Short name=CP

Gene names

Name:	VCATH
Synonyms:	ORF8R

Organism

Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus) [Reference proteome]

Taxonomic identifier

654905 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Baculoviridae › Betabaculovirus › Cydia pomonella granulosis virus

Virus host

Cydia pomonella (Codling moth) [TaxID: 82600]

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system By similarity.
Catalytic activity	Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.
Post-translational modification	Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 124	104	Activation peptide Potential		PRO_0000322218
	Chain	125 – 333	209	Viral cathepsin		PRO_0000050588
Sites
	Active site	148	1	By similarity
	Active site	280	1	By similarity
	Active site	300	1	By similarity
Amino acid modifications
	Glycosylation	170	1	N-linked (GlcNAc...); by host Potential
	Disulfide bond	145 ↔ 186		By similarity
	Disulfide bond	179 ↔ 219		By similarity
	Disulfide bond	272 ↔ 321		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O91466 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: F531CC9AC34FFF5A	FASTA	333	37,434
	10 20 30 40 50 60 MTKLLNFVIL ASVLTVTAHA LTYDLNNSDE LFKNFAIKYN KTYVSDEERA IKLENFKNNL 70 80 90 100 110 120 KMINEKNMAS KYAVFDINEY SDLNKNALLR RTTGFRLGLK KNPSAFTMTE CSVVVIKDEP 130 140 150 160 170 180 QALLPETLDW RDKHGVTPVK NQMECGSCWA FSTIANIESL YNIKYDKALN LSEQHLVNCD 190 200 210 220 230 240 NINNGCAGGL MHWALESILQ EGGVVSAENE PYYGFDGVCK KSPFELSISG SRRYVLQNEN 250 260 270 280 290 300 KLRELLVVNG PISVAIDVSD LINYKAGIAD ICENNEGLNH AVLLVGYGVK NDVPYWILKN 310 320 330 SWGAEWGEEG YFRVQRDKNS CGMMNEYASS AIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the Cydia pomonella granulovirus cathepsin and chitinase genes." Kang W., Tristem M., Maeda S., Crook N.E., O'Reilly D.R. J. Gen. Virol. 79:2283-2292(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Mexican 1.
[2]	"The complete sequence of the Cydia pomonella granulovirus genome." Luque T., Finch R., Crook N., O'Reilly D.R., Winstanley D. J. Gen. Virol. 82:2531-2547(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mexican 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U53466 Genomic DNA. Translation: AAK70678.1.
RefSeq	NP_148795.1. NC_002816.1.
3D structure databases
ProteinModelPortal	O91466.
ModBase	Search...
Protein family/group databases
MEROPS	C01.047.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	921370.
Phylogenomic databases
ProtClustDB	CLSP2509984.
Family and domain databases
InterPro	IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. PTHR12411. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATV_GVCPM

Accession

Primary (citable) accession number: O91466

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program