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Protein

Viral cathepsin

Gene

VCATH

Organism
Cydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system (By similarity).By similarity

Catalytic activityi

Endopeptidase of broad specificity, hydrolyzing substrates of both cathepsin L and cathepsin B.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei148By similarity1
Active sitei280By similarity1
Active sitei300By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.047.

Names & Taxonomyi

Protein namesi
Recommended name:
Viral cathepsin (EC:3.4.22.50)
Short name:
V-cath
Alternative name(s):
Cysteine proteinase
Short name:
CP
Gene namesi
Name:VCATH
Synonyms:ORF8R
OrganismiCydia pomonella granulosis virus (isolate Mexico/1963) (CpGV) (Cydia pomonella granulovirus)
Taxonomic identifieri654905 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageBaculoviridaeBetabaculovirus
Virus hostiCydia pomonella (Codling moth) [TaxID: 82600]
Proteomesi
  • UP000009249 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000032221821 – 124Activation peptideSequence analysisAdd BLAST104
ChainiPRO_0000050588125 – 333Viral cathepsinAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi145 ↔ 186By similarity
Glycosylationi170N-linked (GlcNAc...); by hostSequence analysis1
Disulfide bondi179 ↔ 219By similarity
Disulfide bondi272 ↔ 321By similarity

Post-translational modificationi

Synthesized as an inactive proenzyme and activated by proteolytic removal of the inhibitory propeptide.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliO91466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01373.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O91466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKLLNFVIL ASVLTVTAHA LTYDLNNSDE LFKNFAIKYN KTYVSDEERA
60 70 80 90 100
IKLENFKNNL KMINEKNMAS KYAVFDINEY SDLNKNALLR RTTGFRLGLK
110 120 130 140 150
KNPSAFTMTE CSVVVIKDEP QALLPETLDW RDKHGVTPVK NQMECGSCWA
160 170 180 190 200
FSTIANIESL YNIKYDKALN LSEQHLVNCD NINNGCAGGL MHWALESILQ
210 220 230 240 250
EGGVVSAENE PYYGFDGVCK KSPFELSISG SRRYVLQNEN KLRELLVVNG
260 270 280 290 300
PISVAIDVSD LINYKAGIAD ICENNEGLNH AVLLVGYGVK NDVPYWILKN
310 320 330
SWGAEWGEEG YFRVQRDKNS CGMMNEYASS AIL
Length:333
Mass (Da):37,434
Last modified:November 1, 1998 - v1
Checksum:iF531CC9AC34FFF5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53466 Genomic DNA. Translation: AAK70678.1.
RefSeqiNP_148795.1. NC_002816.1.

Genome annotation databases

GeneIDi921370.
KEGGivg:921370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53466 Genomic DNA. Translation: AAK70678.1.
RefSeqiNP_148795.1. NC_002816.1.

3D structure databases

ProteinModelPortaliO91466.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC01.047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi921370.
KEGGivg:921370.

Phylogenomic databases

KOiK01373.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATV_GVCPM
AccessioniPrimary (citable) accession number: O91466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.