ID   O90754_9PICO            Unreviewed;       746 AA.
AC   O90754;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE   Flags: Fragment;
OS   Foot-and-mouth disease virus.
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Picornaviridae; Caphthovirinae; Aphthovirus.
OX   NCBI_TaxID=12110 {ECO:0000313|EMBL:CAB10893.1};
RN   [1] {ECO:0007829|PDB:1BBT}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-85.
RX   PubMed=8382928; DOI=10.1107/S0108767392005737;
RA   Fry E., Acharya R., Stuart D.;
RT   "Methods used in the structure determination of foot-and-mouth disease
RT   virus.";
RL   Acta Crystallogr. A 49 ( Pt 1):45-55(1993).
RN   [2] {ECO:0000313|EMBL:CAB10893.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BOT/1/68 {ECO:0000313|EMBL:CAB10893.1};
RA   Knowles N.J., Ansell D.M., Samuel A.R.;
RT   "Nucleotide sequence of the capsid-coding region of foot-and-mouth disease
RT   virus type SAT 1.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC       cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
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DR   EMBL; Z98203; CAB10893.1; -; Genomic_RNA.
DR   PDB; 1BBT; X-ray; 2.60 A; 4=1-85.
DR   PDBsum; 1BBT; -.
DR   SMR; O90754; -.
DR   EvolutionaryTrace; O90754; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019030; C:icosahedral viral capsid; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   CDD; cd00205; rhv_like; 3.
DR   Gene3D; 2.60.120.20; -; 3.
DR   Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR   InterPro; IPR015031; Capsid_VP4_Picornavir.
DR   InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR   InterPro; IPR004080; FMDV_VP1_coat.
DR   InterPro; IPR001676; Picornavirus_capsid.
DR   InterPro; IPR033703; Rhv-like.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF00073; Rhv; 3.
DR   Pfam; PF08935; VP4_2; 1.
DR   PRINTS; PR01542; FMDVP1COAT.
DR   SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:1BBT};
KW   Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW   Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW   Virion {ECO:0000256|ARBA:ARBA00022561};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT   DOMAIN          1..84
FT                   /note="Capsid protein VP4 Picornavirus"
FT                   /evidence="ECO:0000259|Pfam:PF08935"
FT   DOMAIN          110..272
FT                   /note="Picornavirus capsid"
FT                   /evidence="ECO:0000259|Pfam:PF00073"
FT   DOMAIN          365..489
FT                   /note="Picornavirus capsid"
FT                   /evidence="ECO:0000259|Pfam:PF00073"
FT   DOMAIN          522..667
FT                   /note="Picornavirus capsid"
FT                   /evidence="ECO:0000259|Pfam:PF00073"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          36..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          521..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAB10893.1"
FT   NON_TER         746
FT                   /evidence="ECO:0000313|EMBL:CAB10893.1"
SQ   SEQUENCE   746 AA;  81990 MW;  F4E5D8C13FC8EC86 CRC64;
     GAGQSSPATG SQNQSGNTGS IINNYYMQQY QNSMDTQLGD NAISGGSNEG STDTTSTHTN
     NTQNNDWFSK LAQSAFSGLV GALLADKKTE ETTLLEDRIV TTSHGTTTST TQSSVGVTYG
     YALTDKFLPG PNTNGLETRV EQAERFFKHK LFDWTLDQQF GTTYVLELPT DHKGIYGQLV
     DSHAYIRNGW DVQVSATATQ FNGGCLLVAM VPELCKLDDR EKYQLTLFPH QFLNPRTNTT
     AHIQVPYLGV DRHDQGTRHK AWTLVVMVLA PYTNDQTIGS TKAEVYVNIA PTNVYVAGEK
     PVKQGILPVA VSDGYGGFQN TDPKTSDPVY GHVYNPGRTL YPGRFTNLLD VAEACPTLLD
     FNGVPYVQTQ SNSGSKVLAC FDLAFGHKNM KNTYMSGLAQ YFAQYSGTLN LHFMYTGPTN
     NKAKYMVAYI PPGTHPLPET PEMASHCYHA EWDTGLNSTF TFTVPYFSAA DYAYTYADEP
     EQASVQGWVG VYQITDTHEK DGAVIVTVSA GPDFEFRMPI SPSRQTTSAG EGADPVTTDA
     SAHGGDTRTT RRAHTDVTFL LDRFTLVGKT NDNKLVLDLL STKEKSLVGA LLRAATYYFS
     DLEVACVGTN AWVGWTPNGS PVLTEVGDNQ VVFSRRGTTR FALPYTAPHR VLATVYNGDC
     KYKPTGTAPR ENIRGDLATL AARIASETHI PTTFNYGMIY TQAEVDVYLR MKRAELYCPR
     PVLTHYDHNG RDRYKTTLVK PAKQLS
//