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Protein

Glycoprotein G

Gene

G

Organism
Hendra virus (isolate Horse/Autralia/Hendra/1994)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of glycoprotein G to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein G
Gene namesi
Name:G
OrganismiHendra virus (isolate Horse/Autralia/Hendra/1994)
Taxonomic identifieri928303 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeHenipavirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Homo sapiens (Human) [TaxID: 9606]
Pteropus alecto (Black flying fox) [TaxID: 9402]
Pteropus poliocephalus (Grey-headed flying fox) [TaxID: 9403]
Pteropus scapulatus (Little red flying fox) [TaxID: 94117]
Proteomesi
  • UP000008771 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49IntravirionSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 604Virion surfaceSequence analysisAdd BLAST534

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360081 – 604Glycoprotein GAdd BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi159N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi306N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi378N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi417N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi481N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi529N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

DIPiDIP-46379N.

Structurei

Secondary structure

1604
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi205 – 208Combined sources4
Beta strandi214 – 225Combined sources12
Beta strandi228 – 238Combined sources11
Turni240 – 242Combined sources3
Beta strandi243 – 257Combined sources15
Beta strandi259 – 261Combined sources3
Beta strandi263 – 271Combined sources9
Helixi276 – 278Combined sources3
Beta strandi279 – 287Combined sources9
Beta strandi290 – 297Combined sources8
Beta strandi299 – 301Combined sources3
Turni303 – 305Combined sources3
Turni307 – 309Combined sources3
Beta strandi314 – 322Combined sources9
Beta strandi328 – 337Combined sources10
Beta strandi339 – 341Combined sources3
Beta strandi346 – 350Combined sources5
Beta strandi352 – 354Combined sources3
Beta strandi356 – 358Combined sources3
Beta strandi361 – 371Combined sources11
Helixi372 – 374Combined sources3
Helixi379 – 381Combined sources3
Helixi394 – 397Combined sources4
Beta strandi400 – 402Combined sources3
Beta strandi406 – 417Combined sources12
Beta strandi425 – 431Combined sources7
Beta strandi442 – 447Combined sources6
Beta strandi450 – 455Combined sources6
Beta strandi465 – 471Combined sources7
Turni472 – 474Combined sources3
Beta strandi475 – 479Combined sources5
Beta strandi491 – 493Combined sources3
Beta strandi511 – 515Combined sources5
Turni516 – 519Combined sources4
Beta strandi520 – 526Combined sources7
Beta strandi529 – 533Combined sources5
Beta strandi535 – 541Combined sources7
Beta strandi544 – 552Combined sources9
Beta strandi561 – 568Combined sources8
Beta strandi571 – 578Combined sources8
Beta strandi586 – 588Combined sources3
Beta strandi591 – 596Combined sources6
Beta strandi599 – 601Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VSKX-ray3.30A/C188-603[»]
2X9MX-ray2.90A/B/C/D185-604[»]
ProteinModelPortaliO89343.
SMRiO89343.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO89343.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19247.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

O89343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMADSKLVSL NNNLSGKIKD QGKVIKNYYG TMDIKKINDG LLDSKILGAF
60 70 80 90 100
NTVIALLGSI IIIVMNIMII QNYTRTTDNQ ALIKESLQSV QQQIKALTDK
110 120 130 140 150
IGTEIGPKVS LIDTSSTITI PANIGLLGSK ISQSTSSINE NVNDKCKFTL
160 170 180 190 200
PPLKIHECNI SCPNPLPFRE YRPISQGVSD LVGLPNQICL QKTTSTILKP
210 220 230 240 250
RLISYTLPIN TREGVCITDP LLAVDNGFFA YSHLEKIGSC TRGIAKQRII
260 270 280 290 300
GVGEVLDRGD KVPSMFMTNV WTPPNPSTIH HCSSTYHEDF YYTLCAVSHV
310 320 330 340 350
GDPILNSTSW TESLSLIRLA VRPKSDSGDY NQKYIAITKV ERGKYDKVMP
360 370 380 390 400
YGPSGIKQGD TLYFPAVGFL PRTEFQYNDS NCPIIHCKYS KAENCRLSMG
410 420 430 440 450
VNSKSHYILR SGLLKYNLSL GGDIILQFIE IADNRLTIGS PSKIYNSLGQ
460 470 480 490 500
PVFYQASYSW DTMIKLGDVD TVDPLRVQWR NNSVISRPGQ SQCPRFNVCP
510 520 530 540 550
EVCWEGTYND AFLIDRLNWV SAGVYLNSNQ TAENPVFAVF KDNEILYQVP
560 570 580 590 600
LAEDDTNAQK TITDCFLLEN VIWCISLVEI YDTGDSVIRP KLFAVKIPAQ

CSES
Length:604
Mass (Da):67,191
Last modified:June 1, 2003 - v2
Checksum:iE2FA826A8ED5BE4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017149 Genomic RNA. Translation: AAC83193.2.
PIRiT08211.
RefSeqiNP_047112.2. NC_001906.3.

Genome annotation databases

GeneIDi1446471.
KEGGivg:1446471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017149 Genomic RNA. Translation: AAC83193.2.
PIRiT08211.
RefSeqiNP_047112.2. NC_001906.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VSKX-ray3.30A/C188-603[»]
2X9MX-ray2.90A/B/C/D185-604[»]
ProteinModelPortaliO89343.
SMRiO89343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46379N.

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1446471.
KEGGivg:1446471.

Phylogenomic databases

KOiK19247.

Miscellaneous databases

EvolutionaryTraceiO89343.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR016285. Hemagglutn-neuramid.
IPR000665. Hemagglutn/HN.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLYCP_HENDH
AccessioniPrimary (citable) accession number: O89343
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

Henipavirus glycoproteins have no neuraminidase activity.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.