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Protein

Beta-defensin 1

Gene

Defb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-RNO-1461957. Beta defensins.
R-RNO-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 1
Short name:
BD-1
Short name:
rBD-1
Alternative name(s):
Defensin, beta 1
Gene namesi
Name:Defb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi619943. Defb1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 3211By similarityPRO_0000006959Add
BLAST
Peptidei33 – 6937Beta-defensin 1PRO_0000006960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 66By similarity
Disulfide bondi44 ↔ 59By similarity
Disulfide bondi49 ↔ 67By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO89117.

Expressioni

Tissue specificityi

Highly expressed in kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000013768.
GenevisibleiO89117. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018428.

Structurei

3D structure databases

ProteinModelPortaliO89117.
SMRiO89117. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
GeneTreeiENSGT00390000017014.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiO89117.
OMAiKIQGTCY.
OrthoDBiEOG091G18L0.
PhylomeDBiO89117.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHYFLLVM LFFLFSQMEL GAGILTSLGR RTDQYRCLQN GGFCLRSSCP
60
SHTKLQGTCK PDKPNCCRS
Length:69
Mass (Da):7,837
Last modified:November 1, 1998 - v1
Checksum:i66B1F0C29BB5C991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093536 mRNA. Translation: AAC61871.1.
AF068860 mRNA. Translation: AAC28071.1.
RefSeqiNP_113998.1. NM_031810.1.
UniGeneiRn.31800.

Genome annotation databases

EnsembliENSRNOT00000018427; ENSRNOP00000018428; ENSRNOG00000013768.
GeneIDi83687.
KEGGirno:83687.
UCSCiRGD:619943. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093536 mRNA. Translation: AAC61871.1.
AF068860 mRNA. Translation: AAC28071.1.
RefSeqiNP_113998.1. NM_031810.1.
UniGeneiRn.31800.

3D structure databases

ProteinModelPortaliO89117.
SMRiO89117. Positions 33-68.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018428.

Proteomic databases

PaxDbiO89117.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018427; ENSRNOP00000018428; ENSRNOG00000013768.
GeneIDi83687.
KEGGirno:83687.
UCSCiRGD:619943. rat.

Organism-specific databases

CTDi1672.
RGDi619943. Defb1.

Phylogenomic databases

eggNOGiENOG410J7H1. Eukaryota.
ENOG41119QC. LUCA.
GeneTreeiENSGT00390000017014.
HOGENOMiHOG000112188.
HOVERGENiHBG084156.
InParanoidiO89117.
OMAiKIQGTCY.
OrthoDBiEOG091G18L0.
PhylomeDBiO89117.

Enzyme and pathway databases

ReactomeiR-RNO-1461957. Beta defensins.
R-RNO-1461973. Defensins.

Miscellaneous databases

PROiO89117.

Gene expression databases

BgeeiENSRNOG00000013768.
GenevisibleiO89117. RN.

Family and domain databases

InterProiIPR001855. Defensin_beta-typ.
[Graphical view]
PfamiPF00711. Defensin_beta. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEFB1_RAT
AccessioniPrimary (citable) accession number: O89117
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.