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Protein

Vesicle transport through interaction with t-SNAREs homolog 1A

Gene

Vti1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with cellular senescence.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport through interaction with t-SNAREs homolog 1A
Alternative name(s):
Vesicle transport v-SNARE protein Vti1-like 2
Vti1-rp2
Gene namesi
Name:Vti1a
Synonyms:Vti1, Vti1l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1855699. Vti1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 192CytoplasmicSequence analysisAdd BLAST192
Transmembranei193 – 213Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini214 – 217VesicularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182261 – 217Vesicle transport through interaction with t-SNAREs homolog 1AAdd BLAST217

Proteomic databases

EPDiO89116.
MaxQBiO89116.
PaxDbiO89116.
PeptideAtlasiO89116.
PRIDEiO89116.

PTM databases

iPTMnetiO89116.
PhosphoSitePlusiO89116.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000024983.
GenevisibleiO89116. MM.

Interactioni

Subunit structurei

Interacts with distinct SNARE complexes that contain either STX5 or STX6. Interacts with NAPA and, to a lesser extent, with NAPG. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207331. 2 interactors.
IntActiO89116. 2 interactors.
MINTiMINT-4140161.
STRINGi10090.ENSMUSP00000093644.

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 25Combined sources17
Helixi26 – 28Combined sources3
Turni31 – 33Combined sources3
Helixi34 – 59Combined sources26
Turni64 – 66Combined sources3
Helixi67 – 87Combined sources21
Helixi89 – 92Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCSNMR-A6-94[»]
ProteinModelPortaliO89116.
SMRiO89116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO89116.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 92Sequence analysisAdd BLAST62
Coiled coili112 – 178Sequence analysisAdd BLAST67

Sequence similaritiesi

Belongs to the VTI1 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1666. Eukaryota.
ENOG4111J90. LUCA.
GeneTreeiENSGT00530000063466.
HOGENOMiHOG000116573.
HOVERGENiHBG104027.
InParanoidiO89116.
KOiK08493.
OMAiMMETEEI.
OrthoDBiEOG091G0L3Z.
PhylomeDBiO89116.
TreeFamiTF312874.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view]
PfamiPF05008. V-SNARE. 1 hit.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.

Sequencei

Sequence statusi: Complete.

O89116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDFEGYEQ DFAVLTAEIT SKIARVPRLP PDEKKQMVAN VEKQLEEARE
60 70 80 90 100
LLEQMDLEVR EIPPQSRGMY SNRMRSYKQE MGKLETDFKR SRIAYSDEVR
110 120 130 140 150
NELLGDAGNS SENQRAHLLD NTERLERSSR RLEAGYQIAV ETEQIGQEML
160 170 180 190 200
ENLSHDREKI QRARDRLRDA DANLGKSSRI LTGMLRRIIQ NRILLVILGI
210
IVVIAILTAI AFFVKGH
Length:217
Mass (Da):24,986
Last modified:November 1, 1998 - v1
Checksum:i3FD7B7A5A16E3522
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035823 mRNA. Translation: AAC32049.1.
AF035209 mRNA. Translation: AAC23482.1.
AK004751 mRNA. Translation: BAB23532.1.
AK028646 mRNA. Translation: BAC26046.1.
BC019386 mRNA. Translation: AAH19386.1.
CCDSiCCDS29910.1.
RefSeqiNP_001280615.1. NM_001293686.1.
NP_058558.1. NM_016862.4.
UniGeneiMm.258637.
Mm.451075.
Mm.451214.

Genome annotation databases

EnsembliENSMUST00000095950; ENSMUSP00000093644; ENSMUSG00000024983.
GeneIDi53611.
KEGGimmu:53611.
UCSCiuc008hxw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035823 mRNA. Translation: AAC32049.1.
AF035209 mRNA. Translation: AAC23482.1.
AK004751 mRNA. Translation: BAB23532.1.
AK028646 mRNA. Translation: BAC26046.1.
BC019386 mRNA. Translation: AAH19386.1.
CCDSiCCDS29910.1.
RefSeqiNP_001280615.1. NM_001293686.1.
NP_058558.1. NM_016862.4.
UniGeneiMm.258637.
Mm.451075.
Mm.451214.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCSNMR-A6-94[»]
ProteinModelPortaliO89116.
SMRiO89116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207331. 2 interactors.
IntActiO89116. 2 interactors.
MINTiMINT-4140161.
STRINGi10090.ENSMUSP00000093644.

PTM databases

iPTMnetiO89116.
PhosphoSitePlusiO89116.

Proteomic databases

EPDiO89116.
MaxQBiO89116.
PaxDbiO89116.
PeptideAtlasiO89116.
PRIDEiO89116.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095950; ENSMUSP00000093644; ENSMUSG00000024983.
GeneIDi53611.
KEGGimmu:53611.
UCSCiuc008hxw.2. mouse.

Organism-specific databases

CTDi143187.
MGIiMGI:1855699. Vti1a.

Phylogenomic databases

eggNOGiKOG1666. Eukaryota.
ENOG4111J90. LUCA.
GeneTreeiENSGT00530000063466.
HOGENOMiHOG000116573.
HOVERGENiHBG104027.
InParanoidiO89116.
KOiK08493.
OMAiMMETEEI.
OrthoDBiEOG091G0L3Z.
PhylomeDBiO89116.
TreeFamiTF312874.

Enzyme and pathway databases

ReactomeiR-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiVti1a. mouse.
EvolutionaryTraceiO89116.
PROiO89116.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024983.
GenevisibleiO89116. MM.

Family and domain databases

InterProiIPR027027. GOSR2/Membrin/Bos1.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
IPR007705. Vesicle_trsprt_v-SNARE_N.
[Graphical view]
PfamiPF05008. V-SNARE. 1 hit.
[Graphical view]
PIRSFiPIRSF028865. Membrin-2. 1 hit.
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVTI1A_MOUSE
AccessioniPrimary (citable) accession number: O89116
Secondary accession number(s): Q545P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.