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Protein

DnaJ homolog subfamily B member 5

Gene

Dnajb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • chaperone binding Source: MGI
  • unfolded protein binding Source: MGI

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein folding Source: InterPro
  • response to unfolded protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 5
Alternative name(s):
Heat shock protein Hsp40-3
Heat shock protein cognate 40
Short name:
Hsc40
Gene namesi
Name:Dnajb5
Synonyms:Hsc40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1930018. Dnajb5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348DnaJ homolog subfamily B member 5PRO_0000071024Add
BLAST

Proteomic databases

EPDiO89114.
PaxDbiO89114.
PRIDEiO89114.

PTM databases

iPTMnetiO89114.
PhosphoSiteiO89114.

Expressioni

Inductioni

Expressed under normal conditions, its expression can further be increased after various stress treatments.

Gene expression databases

BgeeiENSMUSG00000036052.
CleanExiMM_DNAJB5.
ExpressionAtlasiO89114. baseline and differential.
GenevisibleiO89114. MM.

Interactioni

GO - Molecular functioni

  • chaperone binding Source: MGI
  • unfolded protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081712.

Structurei

3D structure databases

ProteinModelPortaliO89114.
SMRiO89114. Positions 1-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 6865JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiO89114.
KOiK09511.
TreeFamiTF105141.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDYYKILG IPSGANEDEI KKAYRKMALK YHPDKNKEPN AEEKFKEIAE
60 70 80 90 100
AYDVLSDPKK RSLYDQYGEE GLKTGGGSSG GSGGSFHYTF HGDPHATFAS
110 120 130 140 150
FFGGSNPFDI FFASSRSTRP FSGFDPDDMD VDEDEDPFGA FGRFGFNGLS
160 170 180 190 200
RGPRRAPEPL YPRRKVQDPP VVHELRVSLE EIYHGSTKRM KITRRRLNPD
210 220 230 240 250
GRTVRTEDKI LHIVIKRGWK EGTKITFPKE GDATPDNIPA DIVFVLKDKP
260 270 280 290 300
HAHFRRDGTN VLYSALISLK EALCGCTVNI PTIDGRVIPL PCNDVIKPGT
310 320 330 340
VKRLRGEGLP FPKVPTQRGD LIVEFKVRFP DRLTPQTRQI LKQHLPCS
Length:348
Mass (Da):39,119
Last modified:November 1, 1998 - v1
Checksum:i833D2F3547321687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092536 Genomic DNA. Translation: AAC64141.1.
AF088983 mRNA. Translation: AAC35861.1.
AF321322 mRNA. Translation: AAG53972.1.
BC048902 mRNA. Translation: AAH48902.1.
BC057087 mRNA. Translation: AAH57087.1.
CCDSiCCDS18084.1.
RefSeqiNP_063927.1. NM_019874.3.
XP_006538174.1. XM_006538111.2.
XP_006538175.1. XM_006538112.2.
UniGeneiMm.20437.

Genome annotation databases

EnsembliENSMUST00000084662; ENSMUSP00000081712; ENSMUSG00000036052.
ENSMUST00000098112; ENSMUSP00000095716; ENSMUSG00000036052.
ENSMUST00000107973; ENSMUSP00000103607; ENSMUSG00000036052.
GeneIDi56323.
KEGGimmu:56323.
UCSCiuc008som.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092536 Genomic DNA. Translation: AAC64141.1.
AF088983 mRNA. Translation: AAC35861.1.
AF321322 mRNA. Translation: AAG53972.1.
BC048902 mRNA. Translation: AAH48902.1.
BC057087 mRNA. Translation: AAH57087.1.
CCDSiCCDS18084.1.
RefSeqiNP_063927.1. NM_019874.3.
XP_006538174.1. XM_006538111.2.
XP_006538175.1. XM_006538112.2.
UniGeneiMm.20437.

3D structure databases

ProteinModelPortaliO89114.
SMRiO89114. Positions 1-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081712.

PTM databases

iPTMnetiO89114.
PhosphoSiteiO89114.

Proteomic databases

EPDiO89114.
PaxDbiO89114.
PRIDEiO89114.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084662; ENSMUSP00000081712; ENSMUSG00000036052.
ENSMUST00000098112; ENSMUSP00000095716; ENSMUSG00000036052.
ENSMUST00000107973; ENSMUSP00000103607; ENSMUSG00000036052.
GeneIDi56323.
KEGGimmu:56323.
UCSCiuc008som.1. mouse.

Organism-specific databases

CTDi25822.
MGIiMGI:1930018. Dnajb5.

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiO89114.
KOiK09511.
TreeFamiTF105141.

Miscellaneous databases

PROiO89114.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036052.
CleanExiMM_DNAJB5.
ExpressionAtlasiO89114. baseline and differential.
GenevisibleiO89114. MM.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 2 hits.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNJB5_MOUSE
AccessioniPrimary (citable) accession number: O89114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.