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Protein

DnaJ homolog subfamily B member 5

Gene

Dnajb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • chaperone binding Source: MGI
  • unfolded protein binding Source: MGI

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • protein folding Source: InterPro
  • response to unfolded protein Source: Ensembl

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 5
Alternative name(s):
Heat shock protein Hsp40-3
Heat shock protein cognate 40
Short name:
Hsc40
Gene namesi
Name:Dnajb5
Synonyms:Hsc40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1930018 Dnajb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710241 – 348DnaJ homolog subfamily B member 5Add BLAST348

Proteomic databases

EPDiO89114
PaxDbiO89114
PRIDEiO89114

PTM databases

iPTMnetiO89114
PhosphoSitePlusiO89114

Expressioni

Inductioni

Expressed under normal conditions, its expression can further be increased after various stress treatments.

Gene expression databases

BgeeiENSMUSG00000036052
CleanExiMM_DNAJB5
ExpressionAtlasiO89114 baseline and differential
GenevisibleiO89114 MM

Interactioni

GO - Molecular functioni

  • chaperone binding Source: MGI
  • unfolded protein binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081712

Structurei

3D structure databases

ProteinModelPortaliO89114
SMRiO89114
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 68JPROSITE-ProRule annotationAdd BLAST65

Phylogenomic databases

eggNOGiKOG0714 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00760000118947
HOGENOMiHOG000226718
HOVERGENiHBG066727
InParanoidiO89114
TreeFamiTF105141

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR002939 DnaJ_C
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR008971 HSP40/DnaJ_pept-bd
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF01556 DnaJ_C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF49493 SSF49493, 2 hits
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequencei

Sequence statusi: Complete.

O89114-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDYYKILG IPSGANEDEI KKAYRKMALK YHPDKNKEPN AEEKFKEIAE
60 70 80 90 100
AYDVLSDPKK RSLYDQYGEE GLKTGGGSSG GSGGSFHYTF HGDPHATFAS
110 120 130 140 150
FFGGSNPFDI FFASSRSTRP FSGFDPDDMD VDEDEDPFGA FGRFGFNGLS
160 170 180 190 200
RGPRRAPEPL YPRRKVQDPP VVHELRVSLE EIYHGSTKRM KITRRRLNPD
210 220 230 240 250
GRTVRTEDKI LHIVIKRGWK EGTKITFPKE GDATPDNIPA DIVFVLKDKP
260 270 280 290 300
HAHFRRDGTN VLYSALISLK EALCGCTVNI PTIDGRVIPL PCNDVIKPGT
310 320 330 340
VKRLRGEGLP FPKVPTQRGD LIVEFKVRFP DRLTPQTRQI LKQHLPCS
Length:348
Mass (Da):39,119
Last modified:November 1, 1998 - v1
Checksum:i833D2F3547321687
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092536 Genomic DNA Translation: AAC64141.1
AF088983 mRNA Translation: AAC35861.1
AF321322 mRNA Translation: AAG53972.1
BC048902 mRNA Translation: AAH48902.1
BC057087 mRNA Translation: AAH57087.1
CCDSiCCDS18084.1
RefSeqiNP_063927.1, NM_019874.3
XP_006538174.1, XM_006538111.3
XP_006538175.1, XM_006538112.3
UniGeneiMm.20437
Mm.488495

Genome annotation databases

EnsembliENSMUST00000084662; ENSMUSP00000081712; ENSMUSG00000036052
ENSMUST00000098112; ENSMUSP00000095716; ENSMUSG00000036052
ENSMUST00000107973; ENSMUSP00000103607; ENSMUSG00000036052
GeneIDi56323
UCSCiuc008som.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDNJB5_MOUSE
AccessioniPrimary (citable) accession number: O89114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health