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Protein

Immediate early response gene 5 protein

Gene

Ier5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone gene during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 5 protein
Gene namesi
Name:Ier5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1337072 Ier5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904391 – 308Immediate early response gene 5 proteinAdd BLAST308

Proteomic databases

EPDiO89113
PaxDbiO89113
PRIDEiO89113

PTM databases

PhosphoSitePlusiO89113

Expressioni

Inductioni

By serum and growth factors.1 Publication

Gene expression databases

BgeeiENSMUSG00000056708
CleanExiMM_IER5
ExpressionAtlasiO89113 baseline and differential
GenevisibleiO89113 MM

Interactioni

Subunit structurei

Monomer. Homodimer. Associates with the catalytic subunit of protein phosphatase PP2A. Interacts (via N- and C-terminal regions) with PPP2R2B. Interacts with PPP2R2A, PPP2R2C and PPP2R2D. Interacts (via N-terminus) with RPS6KB1. Interacts (via central region) with HSF1; this interaction promotes PPP2CA-induced HSF1 dephosphorylation, leading to enhanced HSF1 transcriptional activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056948

Structurei

3D structure databases

ProteinModelPortaliO89113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410J10V Eukaryota
ENOG4111NZJ LUCA
GeneTreeiENSGT00900000141021
HOGENOMiHOG000112999
HOVERGENiHBG105469
InParanoidiO89113
OMAiMNPWSTA
OrthoDBiEOG091G0HLK
PhylomeDBiO89113
TreeFamiTF331376

Family and domain databases

InterProiView protein in InterPro
IPR008653 IER
PANTHERiPTHR15895 PTHR15895, 1 hit
PfamiView protein in Pfam
PF05760 IER, 2 hits

Sequencei

Sequence statusi: Complete.

O89113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD
60 70 80 90 100
PCPGLYLAGP AGTPAVPPPQ QPGEPVAGPP SGWGEPPPPV ARAAWPEPEP
110 120 130 140 150
QPQPQPQRPS VCHTPGAGSS EPVAAVAGSG EALRGGEEDS AAAAWGRVER
160 170 180 190 200
PRAASSGGGS DACPEGPRAV RRPCGCPPAV EERSSEDGSP APPAPCPRKR
210 220 230 240 250
GAAGVGGGRA SCSAPGSTPL KKPRRNSEEQ PVTGEDDTDE EMETGNVANL
260 270 280 290 300
ISIFGSSFSG LLRKSPAGGR EEEEAEEGGP EAAEPGQICC DKPVLRDMSP

WSTAIVAF
Length:308
Mass (Da):31,784
Last modified:November 1, 1998 - v1
Checksum:iF9484E63F69FC02B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079527 mRNA Translation: AAC31197.1
AF079528 Genomic DNA Translation: AAC28389.1
BC037147 mRNA Translation: AAH37147.1
BC051986 mRNA Translation: AAH51986.1
CCDSiCCDS15382.1
RefSeqiNP_034630.1, NM_010500.2
UniGeneiMm.12246

Genome annotation databases

EnsembliENSMUST00000055322; ENSMUSP00000056948; ENSMUSG00000056708
GeneIDi15939
KEGGimmu:15939
UCSCiuc007dax.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIER5_MOUSE
AccessioniPrimary (citable) accession number: O89113
Secondary accession number(s): Q8CGI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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