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Protein

LanC-like protein 1

Gene

Lancl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi276ZincBy similarity1
Binding sitei317GlutathioneBy similarity1
Metal bindingi322ZincBy similarity1
Metal bindingi323ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:Lancl1
Synonyms:Gpr69a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1336997. Lancl1.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912692 – 399LanC-like protein 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei142N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO89112.
MaxQBiO89112.
PaxDbiO89112.
PeptideAtlasiO89112.
PRIDEiO89112.

PTM databases

iPTMnetiO89112.
PhosphoSitePlusiO89112.

Expressioni

Tissue specificityi

Detected in spinal cord (at protein level). Ubiquitous. Strongly expressed in brain, testis, alveolar macrophages and epithelial cells of the lung, kidney and intestine.2 Publications

Gene expression databases

BgeeiENSMUSG00000026000.
ExpressionAtlasiO89112. baseline and differential.
GenevisibleiO89112. MM.

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200033. 1 interactor.
IntActiO89112. 4 interactors.
MINTiMINT-4100174.
STRINGi10090.ENSMUSP00000027149.

Structurei

3D structure databases

ProteinModelPortaliO89112.
SMRiO89112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 367Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiO89112.
OMAiFAEWCLS.
OrthoDBiEOG091G02TS.
PhylomeDBiO89112.
TreeFamiTF300068.

Family and domain databases

CDDicd04794. euk_LANCL. 1 hit.
Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPRDGT GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKQSLNCLS
110 120 130 140 150
RRSITFLCGD AGPLAVAAVL YHKMNSEKQA EECITRLIHL NKIDPHVPNE
160 170 180 190 200
MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ QICENILTSG ENLSRKRNLA
210 220 230 240 250
AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVNQGKL HSLVKPSVDF
260 270 280 290 300
VCRLKFPSGN YPPCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEERYLC
310 320 330 340 350
DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DLKYLYRACK
360 370 380 390
FAEWCLDYGE HGCRTADTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL
Length:399
Mass (Da):45,341
Last modified:November 1, 1998 - v1
Checksum:i542A628818C30B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11550 mRNA. Translation: CAA72314.1.
Y16518 mRNA. Translation: CAA76269.1.
AJ294535 mRNA. Translation: CAC69241.1.
AJ289603
, AJ289604, AJ289605, AJ289606, AJ289607, AJ289608 Genomic DNA. Translation: CAC40153.1.
BC058560 mRNA. Translation: AAH58560.1.
CCDSiCCDS15025.1.
RefSeqiNP_001177913.1. NM_001190984.1.
NP_001177914.1. NM_001190985.1.
NP_067270.1. NM_021295.3.
UniGeneiMm.20522.

Genome annotation databases

EnsembliENSMUST00000027149; ENSMUSP00000027149; ENSMUSG00000026000.
ENSMUST00000113979; ENSMUSP00000109612; ENSMUSG00000026000.
ENSMUST00000119559; ENSMUSP00000113080; ENSMUSG00000026000.
GeneIDi14768.
KEGGimmu:14768.
UCSCiuc007biv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11550 mRNA. Translation: CAA72314.1.
Y16518 mRNA. Translation: CAA76269.1.
AJ294535 mRNA. Translation: CAC69241.1.
AJ289603
, AJ289604, AJ289605, AJ289606, AJ289607, AJ289608 Genomic DNA. Translation: CAC40153.1.
BC058560 mRNA. Translation: AAH58560.1.
CCDSiCCDS15025.1.
RefSeqiNP_001177913.1. NM_001190984.1.
NP_001177914.1. NM_001190985.1.
NP_067270.1. NM_021295.3.
UniGeneiMm.20522.

3D structure databases

ProteinModelPortaliO89112.
SMRiO89112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200033. 1 interactor.
IntActiO89112. 4 interactors.
MINTiMINT-4100174.
STRINGi10090.ENSMUSP00000027149.

PTM databases

iPTMnetiO89112.
PhosphoSitePlusiO89112.

Proteomic databases

EPDiO89112.
MaxQBiO89112.
PaxDbiO89112.
PeptideAtlasiO89112.
PRIDEiO89112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027149; ENSMUSP00000027149; ENSMUSG00000026000.
ENSMUST00000113979; ENSMUSP00000109612; ENSMUSG00000026000.
ENSMUST00000119559; ENSMUSP00000113080; ENSMUSG00000026000.
GeneIDi14768.
KEGGimmu:14768.
UCSCiuc007biv.1. mouse.

Organism-specific databases

CTDi10314.
MGIiMGI:1336997. Lancl1.

Phylogenomic databases

eggNOGiKOG2787. Eukaryota.
ENOG410XQIA. LUCA.
GeneTreeiENSGT00530000063186.
HOGENOMiHOG000240926.
HOVERGENiHBG065387.
InParanoidiO89112.
OMAiFAEWCLS.
OrthoDBiEOG091G02TS.
PhylomeDBiO89112.
TreeFamiTF300068.

Miscellaneous databases

PROiO89112.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026000.
ExpressionAtlasiO89112. baseline and differential.
GenevisibleiO89112. MM.

Family and domain databases

CDDicd04794. euk_LANCL. 1 hit.
Gene3Di1.50.10.10. 1 hit.
InterProiIPR012341. 6hp_glycosidase.
IPR007822. LANC-like.
IPR020464. LanC-like_prot_euk.
[Graphical view]
PfamiPF05147. LANC_like. 1 hit.
[Graphical view]
PRINTSiPR01951. LANCEUKARYTE.
PR01950. LANCSUPER.
SMARTiSM01260. LANC_like. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLANC1_MOUSE
AccessioniPrimary (citable) accession number: O89112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Was originally thought to be a G-protein coupled receptor.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.