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Protein

LanC-like protein 1

Gene

Lancl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in EPS8 signaling. Binds glutathione (By similarity).By similarity

Miscellaneous

Was originally thought to be a G-protein coupled receptor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi276ZincBy similarity1
Binding sitei317GlutathioneBy similarity1
Metal bindingi322ZincBy similarity1
Metal bindingi323ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LanC-like protein 1
Alternative name(s):
40 kDa erythrocyte membrane protein
Short name:
p40
Gene namesi
Name:Lancl1
Synonyms:Gpr69a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1336997 Lancl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001912692 – 399LanC-like protein 1Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei142N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO89112
MaxQBiO89112
PaxDbiO89112
PeptideAtlasiO89112
PRIDEiO89112

PTM databases

iPTMnetiO89112
PhosphoSitePlusiO89112
SwissPalmiO89112

Expressioni

Tissue specificityi

Detected in spinal cord (at protein level). Ubiquitous. Strongly expressed in brain, testis, alveolar macrophages and epithelial cells of the lung, kidney and intestine.2 Publications

Gene expression databases

BgeeiENSMUSG00000026000
ExpressionAtlasiO89112 baseline and differential
GenevisibleiO89112 MM

Interactioni

Subunit structurei

Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200033, 1 interactor
IntActiO89112, 5 interactors
MINTiO89112
STRINGi10090.ENSMUSP00000027149

Structurei

3D structure databases

ProteinModelPortaliO89112
SMRiO89112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni364 – 367Glutathione bindingBy similarity4

Sequence similaritiesi

Belongs to the LanC-like protein family.Curated

Phylogenomic databases

eggNOGiKOG2787 Eukaryota
ENOG410XQIA LUCA
GeneTreeiENSGT00530000063186
HOGENOMiHOG000240926
HOVERGENiHBG065387
InParanoidiO89112
OMAiNYPPCVD
OrthoDBiEOG091G02TS
PhylomeDBiO89112
TreeFamiTF300068

Family and domain databases

CDDicd04794 euk_LANCL, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk
PfamiView protein in Pfam
PF05147 LANC_like, 1 hit
PRINTSiPR01951 LANCEUKARYTE
PR01950 LANCSUPER
SMARTiView protein in SMART
SM01260 LANC_like, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG
60 70 80 90 100
LKSADPRDGT GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKQSLNCLS
110 120 130 140 150
RRSITFLCGD AGPLAVAAVL YHKMNSEKQA EECITRLIHL NKIDPHVPNE
160 170 180 190 200
MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ QICENILTSG ENLSRKRNLA
210 220 230 240 250
AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVNQGKL HSLVKPSVDF
260 270 280 290 300
VCRLKFPSGN YPPCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEERYLC
310 320 330 340 350
DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DLKYLYRACK
360 370 380 390
FAEWCLDYGE HGCRTADTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL
Length:399
Mass (Da):45,341
Last modified:November 1, 1998 - v1
Checksum:i542A628818C30B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11550 mRNA Translation: CAA72314.1
Y16518 mRNA Translation: CAA76269.1
AJ294535 mRNA Translation: CAC69241.1
AJ289603
, AJ289604, AJ289605, AJ289606, AJ289607, AJ289608 Genomic DNA Translation: CAC40153.1
BC058560 mRNA Translation: AAH58560.1
CCDSiCCDS15025.1
RefSeqiNP_001177913.1, NM_001190984.1
NP_001177914.1, NM_001190985.1
NP_067270.1, NM_021295.3
UniGeneiMm.20522

Genome annotation databases

EnsembliENSMUST00000027149; ENSMUSP00000027149; ENSMUSG00000026000
ENSMUST00000113979; ENSMUSP00000109612; ENSMUSG00000026000
ENSMUST00000119559; ENSMUSP00000113080; ENSMUSG00000026000
GeneIDi14768
KEGGimmu:14768
UCSCiuc007biv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLANC1_MOUSE
AccessioniPrimary (citable) accession number: O89112
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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