O89112 (LANC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LanC-like protein 1

Alternative name(s):
40 kDa erythrocyte membrane protein
Short name=p40

Gene names

Name:	Lancl1
Synonyms:	Gpr69a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in EPS8 signaling. Binds glutathion By similarity.
Subunit structure	Interacts with the C-terminal of STOM. Interacts with the EPS8 SH3 domain. Interaction with EPS8 is inhibited by glutathione binding By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Nucleus By similarity.
Tissue specificity	Detected in spinal cord (at protein level). Ubiquitous. Strongly expressed in brain, testis, alveolar macrophages and epithelial cells of the lung, kidney and intestine. Ref.1 Ref.4
Miscellaneous	Was originally (Ref.1) thought to be a G-protein coupled receptor.
Sequence similarities	Belongs to the LanC-like protein family.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Nucleus
Ligand	Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro glutathione binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 399	398	LanC-like protein 1		PRO_0000191269
Regions
	Region	364 – 367	4	Glutathione binding By similarity
Sites
	Metal binding	276	1	Zinc By similarity
	Metal binding	322	1	Zinc By similarity
	Metal binding	323	1	Zinc By similarity
	Binding site	317	1	Glutathione By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	142	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O89112 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 542A628818C30B89	FASTA	399	45,341
	10 20 30 40 50 60 MAQRAFPNPY ADYNKSLAEN YFDSTGRLTP EFSHRLTNKI RELLQQMERG LKSADPRDGT 70 80 90 100 110 120 GYTGWAGIAV LYLHLHNVFG DPAYLQMAHS YVKQSLNCLS RRSITFLCGD AGPLAVAAVL 130 140 150 160 170 180 YHKMNSEKQA EECITRLIHL NKIDPHVPNE MLYGRIGYIF ALLFVNKNFG EEKIPQSHIQ 190 200 210 220 230 240 QICENILTSG ENLSRKRNLA AKSPLMYEWY QEYYVGAAHG LAGIYYYLMQ PSLQVNQGKL 250 260 270 280 290 300 HSLVKPSVDF VCRLKFPSGN YPPCLDDTRD LLVHWCHGAP GVIYMLIQAY KVFKEERYLC 310 320 330 340 350 360 DAQQCADVIW QYGLLKKGYG LCHGAAGNAY AFLALYNLTQ DLKYLYRACK FAEWCLDYGE 370 380 390 HGCRTADTPF SLFEGMAGTI YFLADLLVPT KAKFPAFEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization and tissue-specific expression of a murine putative G-protein-coupled receptor." Mayer H., Breuss J., Ziegler S., Prohaska R. Biochim. Biophys. Acta 1399:51-56(1998) [PubMed: 9714732] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c. Tissue: Brain, Diaphragm and Fetal brain.
[2]	"Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1)." Mayer H., Bauer H., Prohaska R. Cytogenet. Cell Genet. 93:100-104(2001) [PubMed: 11474189] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Brain and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Mammary gland and Olfactory epithelium.
[4]	"Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system." Chung C.H.Y., Kurien B.T., Mehta P., Mhatre M., Mou S., Pye Q.N., Stewart C., West M., Williamson K.S., Post J., Liu L., Wang R., Hensley K. Biochemistry 46:3262-3269(2007) [PubMed: 17305318] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11550 mRNA. Translation: CAA72314.1. Y16518 mRNA. Translation: CAA76269.1. AJ294535 mRNA. Translation: CAC69241.1. AJ289603 , AJ289604, AJ289605, AJ289606, AJ289607, AJ289608 Genomic DNA. Translation: CAC40153.1. BC058560 mRNA. Translation: AAH58560.1.
IPI	IPI00131535.
RefSeq	NP_001177913.1. NM_001190984.1. NP_001177914.1. NM_001190985.1. NP_067270.1. NM_021295.3.
UniGene	Mm.20522.
3D structure databases
ProteinModelPortal	O89112.
SMR	O89112. Positions 1-399.
ModBase	Search...
Protein-protein interaction databases
IntAct	O89112. 1 interaction.
STRING	O89112.
PTM databases
PhosphoSite	O89112.
Proteomic databases
PRIDE	O89112.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027149; ENSMUSP00000027149; ENSMUSG00000026000. ENSMUST00000113979; ENSMUSP00000109612; ENSMUSG00000026000. ENSMUST00000119559; ENSMUSP00000113080; ENSMUSG00000026000.
GeneID	14768.
KEGG	mmu:14768.
UCSC	uc007biv.1. mouse.
Organism-specific databases
CTD	10314.
MGI	MGI:1336997. Lancl1.
Phylogenomic databases
eggNOG	roNOG09084.
HOGENOM	HBG715012.
HOVERGEN	HBG065387.
InParanoid	O89112.
OMA	TGWAGIA.
OrthoDB	EOG4NZTT7.
PhylomeDB	O89112.
Gene expression databases
ArrayExpress	O89112.
Bgee	O89112.
Genevestigator	O89112.
GermOnline	ENSMUSG00000026000. Mus musculus.
Family and domain databases
InterPro	IPR008928. 6-hairpin_glycosidase-like. IPR012341. 6hp_glycosidase. IPR007822. LANC-like. IPR020464. LanC-like_prot_euk. [Graphical view]
Gene3D	G3DSA:1.50.10.10. CelA/Cel48F_cat. 1 hit.
Pfam	PF05147. LANC_like. 1 hit. [Graphical view]
PRINTS	PR01951. LANCEUKARYTE. PR01950. LANCSUPER.
SUPFAM	SSF48208. Glyco_trans_6hp. 1 hit.
ProtoNet	Search...
Other
NextBio	286863.
SOURCE	Search...

Entry information

Entry name

LANC1_MOUSE

Accession

Primary (citable) accession number: O89112

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	November 1, 1998
Last modified:	September 21, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program