ID   SYPL2_MOUSE             Reviewed;         264 AA.
AC   O89104;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 140.
DE   RecName: Full=Synaptophysin-like protein 2;
DE   AltName: Full=Mitsugumin-29;
DE            Short=Mg29;
GN   Name=Sypl2; Synonyms=Mg29;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=129, and C57BL/6J;
RX   PubMed=9708916; DOI=10.1016/s0014-5793(98)00770-4;
RA   Shimuta M., Komazaki S., Nishi M., Iino M., Nakagawara K., Takeshima H.;
RT   "Structure and expression of mitsugumin29 gene.";
RL   FEBS Lett. 431:263-267(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, and Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Involved in communication between the T-tubular and
CC       junctional sarcoplasmic reticulum (SR) membranes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note=Triad
CC       junction, the junctional complex between the transverse tubule and the
CC       sarcoplasmic reticulum.
CC   -!- TISSUE SPECIFICITY: Expressed abundantly in skeletal muscle and at
CC       lower levels in the kidney. {ECO:0000269|PubMed:9708916}.
CC   -!- SIMILARITY: Belongs to the synaptophysin/synaptobrevin family.
CC       {ECO:0000305}.
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DR   EMBL; AB010144; BAA32531.1; -; Genomic_DNA.
DR   EMBL; AB010140; BAA32530.1; -; mRNA.
DR   EMBL; BC030038; AAH30038.1; -; mRNA.
DR   CCDS; CCDS57253.1; -.
DR   RefSeq; NP_032622.1; NM_008596.1.
DR   AlphaFoldDB; O89104; -.
DR   STRING; 10090.ENSMUSP00000116756; -.
DR   GlyCosmos; O89104; 1 site, No reported glycans.
DR   GlyGen; O89104; 1 site.
DR   iPTMnet; O89104; -.
DR   PhosphoSitePlus; O89104; -.
DR   jPOST; O89104; -.
DR   MaxQB; O89104; -.
DR   PaxDb; 10090-ENSMUSP00000116756; -.
DR   ProteomicsDB; 254743; -.
DR   Antibodypedia; 33759; 42 antibodies from 20 providers.
DR   DNASU; 17306; -.
DR   Ensembl; ENSMUST00000141387.4; ENSMUSP00000116756.3; ENSMUSG00000027887.12.
DR   GeneID; 17306; -.
DR   KEGG; mmu:17306; -.
DR   UCSC; uc008qyn.1; mouse.
DR   AGR; MGI:1328311; -.
DR   CTD; 284612; -.
DR   MGI; MGI:1328311; Sypl2.
DR   VEuPathDB; HostDB:ENSMUSG00000027887; -.
DR   eggNOG; ENOG502RR69; Eukaryota.
DR   GeneTree; ENSGT01030000234637; -.
DR   HOGENOM; CLU_064642_1_1_1; -.
DR   InParanoid; O89104; -.
DR   OMA; VFYLRFH; -.
DR   OrthoDB; 2881347at2759; -.
DR   BioGRID-ORCS; 17306; 0 hits in 77 CRISPR screens.
DR   ChiTaRS; Sypl2; mouse.
DR   PRO; PR:O89104; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; O89104; Protein.
DR   Bgee; ENSMUSG00000027887; Expressed in vastus lateralis and 67 other cell types or tissues.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; IGI:MGI.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IMP:MGI.
DR   GO; GO:0033292; P:T-tubule organization; IGI:MGI.
DR   InterPro; IPR008253; Marvel.
DR   InterPro; IPR001285; Synaptophysin/porin.
DR   PANTHER; PTHR10306; SYNAPTOPHYSIN; 1.
DR   PANTHER; PTHR10306:SF8; SYNAPTOPHYSIN-LIKE PROTEIN 2; 1.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR00220; SYNAPTOPHYSN.
DR   PROSITE; PS51225; MARVEL; 1.
DR   Genevisible; O89104; MM.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..264
FT                   /note="Synaptophysin-like protein 2"
FT                   /id="PRO_0000179167"
FT   TOPO_DOM        1..33
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..116
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..150
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..213
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..238
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   REGION          242..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        213
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   264 AA;  29224 MW;  5CB8A169533B6704 CRC64;
     MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET
     GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS TSKTMNLMGD FSAPAEFFVT
     LGIFSFFYTM AALVIYLRFH KLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG
     ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH
     GQGQDQGQGP SQESAAEQGA VEKQ
//