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Protein

Synaptophysin-like protein 2

Gene

Sypl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. cellular calcium ion homeostasis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Alternative name(s):
Mitsugumin-29
Short name:
Mg29
Gene namesi
Name:Sypl2
Synonyms:Mg29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1328311. Sypl2.

Subcellular locationi

Membrane; Multi-pass membrane protein
Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Topological domaini55 – 11662VesicularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 21342VesicularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 26430CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of synaptic vesicle membrane Source: GO_Central
  2. synaptic vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Synaptophysin-like protein 2PRO_0000179167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO89104.
PRIDEiO89104.

Expressioni

Tissue specificityi

Expressed abundantly in skeletal muscle and at lower levels in the kidney.1 Publication

Gene expression databases

BgeeiO89104.
CleanExiMM_SYPL2.
ExpressionAtlasiO89104. baseline and differential.
GenevestigatoriO89104.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 238209MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82723.
GeneTreeiENSGT00390000010039.
HOVERGENiHBG006681.
InParanoidiO89104.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89104-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS
110 120 130 140 150
TSKTMNLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH KLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH GQGQDQGQGP
260
SQESAAEQGA VEKQ
Length:264
Mass (Da):29,224
Last modified:November 1, 1998 - v1
Checksum:i5CB8A169533B6704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010144 Genomic DNA. Translation: BAA32531.1.
AB010140 mRNA. Translation: BAA32530.1.
BC030038 mRNA. Translation: AAH30038.1.
CCDSiCCDS57253.1.
RefSeqiNP_032622.1. NM_008596.1.
UniGeneiMm.316885.

Genome annotation databases

EnsembliENSMUST00000029486; ENSMUSP00000029486; ENSMUSG00000027887.
GeneIDi17306.
KEGGimmu:17306.
UCSCiuc008qyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010144 Genomic DNA. Translation: BAA32531.1.
AB010140 mRNA. Translation: BAA32530.1.
BC030038 mRNA. Translation: AAH30038.1.
CCDSiCCDS57253.1.
RefSeqiNP_032622.1. NM_008596.1.
UniGeneiMm.316885.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029486.

Proteomic databases

PaxDbiO89104.
PRIDEiO89104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029486; ENSMUSP00000029486; ENSMUSG00000027887.
GeneIDi17306.
KEGGimmu:17306.
UCSCiuc008qyn.1. mouse.

Organism-specific databases

CTDi284612.
MGIiMGI:1328311. Sypl2.

Phylogenomic databases

eggNOGiNOG82723.
GeneTreeiENSGT00390000010039.
HOVERGENiHBG006681.
InParanoidiO89104.

Miscellaneous databases

NextBioi291852.
PROiO89104.
SOURCEiSearch...

Gene expression databases

BgeeiO89104.
CleanExiMM_SYPL2.
ExpressionAtlasiO89104. baseline and differential.
GenevestigatoriO89104.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: 129 and C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiSYPL2_MOUSE
AccessioniPrimary (citable) accession number: O89104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.