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O89104

- SYPL2_MOUSE

UniProt

O89104 - SYPL2_MOUSE

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Protein

Synaptophysin-like protein 2

Gene

Sypl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. cellular calcium ion homeostasis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptophysin-like protein 2
Alternative name(s):
Mitsugumin-29
Short name:
Mg29
Gene namesi
Name:Sypl2
Synonyms:Mg29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1328311. Sypl2.

Subcellular locationi

Membrane; Multi-pass membrane protein
Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Topological domaini55 – 11662VesicularSequence AnalysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence AnalysisAdd
BLAST
Topological domaini138 – 15013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 21342VesicularSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Topological domaini235 – 26430CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of synaptic vesicle membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Synaptophysin-like protein 2PRO_0000179167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO89104.
PRIDEiO89104.

Expressioni

Tissue specificityi

Expressed abundantly in skeletal muscle and at lower levels in the kidney.1 Publication

Gene expression databases

BgeeiO89104.
CleanExiMM_SYPL2.
ExpressionAtlasiO89104. baseline and differential.
GenevestigatoriO89104.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029486.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 238209MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82723.
GeneTreeiENSGT00390000010039.
HOVERGENiHBG006681.
InParanoidiO89104.

Family and domain databases

InterProiIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERiPTHR10306. PTHR10306. 1 hit.
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR00220. SYNAPTOPHYSN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89104-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF
60 70 80 90 100
GSCGSYSGET GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS
110 120 130 140 150
TSKTMNLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH KLYTENKRFP
160 170 180 190 200
LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV
210 220 230 240 250
CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH GQGQDQGQGP
260
SQESAAEQGA VEKQ
Length:264
Mass (Da):29,224
Last modified:November 1, 1998 - v1
Checksum:i5CB8A169533B6704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010144 Genomic DNA. Translation: BAA32531.1.
AB010140 mRNA. Translation: BAA32530.1.
BC030038 mRNA. Translation: AAH30038.1.
CCDSiCCDS57253.1.
RefSeqiNP_032622.1. NM_008596.1.
UniGeneiMm.316885.

Genome annotation databases

EnsembliENSMUST00000029486; ENSMUSP00000029486; ENSMUSG00000027887.
GeneIDi17306.
KEGGimmu:17306.
UCSCiuc008qyn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010144 Genomic DNA. Translation: BAA32531.1 .
AB010140 mRNA. Translation: BAA32530.1 .
BC030038 mRNA. Translation: AAH30038.1 .
CCDSi CCDS57253.1.
RefSeqi NP_032622.1. NM_008596.1.
UniGenei Mm.316885.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029486.

Proteomic databases

PaxDbi O89104.
PRIDEi O89104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029486 ; ENSMUSP00000029486 ; ENSMUSG00000027887 .
GeneIDi 17306.
KEGGi mmu:17306.
UCSCi uc008qyn.1. mouse.

Organism-specific databases

CTDi 284612.
MGIi MGI:1328311. Sypl2.

Phylogenomic databases

eggNOGi NOG82723.
GeneTreei ENSGT00390000010039.
HOVERGENi HBG006681.
InParanoidi O89104.

Miscellaneous databases

NextBioi 291852.
PROi O89104.
SOURCEi Search...

Gene expression databases

Bgeei O89104.
CleanExi MM_SYPL2.
ExpressionAtlasi O89104. baseline and differential.
Genevestigatori O89104.

Family and domain databases

InterProi IPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view ]
PANTHERi PTHR10306. PTHR10306. 1 hit.
Pfami PF01284. MARVEL. 1 hit.
[Graphical view ]
PRINTSi PR00220. SYNAPTOPHYSN.
PROSITEi PS51225. MARVEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: 129 and C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiSYPL2_MOUSE
AccessioniPrimary (citable) accession number: O89104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3