O89104 (SYPL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptophysin-like protein 2

Alternative name(s):
Mitsugumin-29
Short name=Mg29

Gene names

Name:	Sypl2
Synonyms:	Mg29

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein. Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.
Tissue specificity	Expressed abundantly in skeletal muscle and at lower levels in the kidney. Ref.1
Sequence similarities	Belongs to the synaptophysin/synaptobrevin family. Contains 1 MARVEL domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 14559251. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle Inferred from electronic annotation. Source: InterPro
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Synaptophysin-like protein 2		PRO_0000179167
Regions
	Topological domain	1 – 33	33	Cytoplasmic Potential
	Transmembrane	34 – 54	21	Helical; Potential
	Topological domain	55 – 116	62	Vesicular Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Topological domain	138 – 150	13	Cytoplasmic Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Topological domain	172 – 213	42	Vesicular Potential
	Transmembrane	214 – 234	21	Helical; Potential
	Topological domain	235 – 264	30	Cytoplasmic Potential
	Domain	30 – 238	209	MARVEL
Amino acid modifications
	Glycosylation	213	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O89104 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 5CB8A169533B6704	FASTA	264	29,224
	10 20 30 40 50 60 MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET 70 80 90 100 110 120 GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS TSKTMNLMGD FSAPAEFFVT 130 140 150 160 170 180 LGIFSFFYTM AALVIYLRFH KLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG 190 200 210 220 230 240 ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH 250 260 GQGQDQGQGP SQESAAEQGA VEKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and expression of mitsugumin29 gene." Shimuta M., Komazaki S., Nishi M., Iino M., Nakagawara K., Takeshima H. FEBS Lett. 431:263-267(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. Strain: 129 and C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB010144 Genomic DNA. Translation: BAA32531.1. AB010140 mRNA. Translation: BAA32530.1. BC030038 mRNA. Translation: AAH30038.1.
IPI	IPI00131500.
RefSeq	NP_032622.1. NM_008596.1.
UniGene	Mm.316885.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000029486.
Proteomic databases
PaxDb	O89104.
PRIDE	O89104.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029486; ENSMUSP00000029486; ENSMUSG00000027887.
GeneID	17306.
KEGG	mmu:17306.
Organism-specific databases
CTD	284612.
MGI	MGI:1328311. Sypl2.
Phylogenomic databases
eggNOG	NOG82723.
GeneTree	ENSGT00390000010039.
HOVERGEN	HBG006681.
InParanoid	O89104.
Gene expression databases
ArrayExpress	O89104.
Bgee	O89104.
CleanEx	MM_SYPL2.
Genevestigator	O89104.
GermOnline	ENSMUSG00000027887. Mus musculus.
Family and domain databases
InterPro	IPR008253. Marvel. IPR021128. MARVEL-like_dom. IPR001285. Synaptophysin/porin. [Graphical view]
PANTHER	PTHR10306. PTHR10306. 1 hit.
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PRINTS	PR00220. SYNAPTOPHYSN.
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291852.
SOURCE	Search...

Entry information

Entry name

SYPL2_MOUSE

Accession

Primary (citable) accession number: O89104

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program