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O89104

- SYPL2_MOUSE

UniProt

O89104 - SYPL2_MOUSE

Protein

Synaptophysin-like protein 2

Gene

Sypl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptophysin-like protein 2
    Alternative name(s):
    Mitsugumin-29
    Short name:
    Mg29
    Gene namesi
    Name:Sypl2
    Synonyms:Mg29
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1328311. Sypl2.

    Subcellular locationi

    Membrane; Multi-pass membrane protein
    Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.

    GO - Cellular componenti

    1. integral component of synaptic vesicle membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Synaptophysin-like protein 2PRO_0000179167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO89104.
    PRIDEiO89104.

    Expressioni

    Tissue specificityi

    Expressed abundantly in skeletal muscle and at lower levels in the kidney.1 Publication

    Gene expression databases

    BgeeiO89104.
    CleanExiMM_SYPL2.
    GenevestigatoriO89104.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029486.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 11662VesicularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini172 – 21342VesicularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 26430CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 238209MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptophysin/synaptobrevin family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82723.
    GeneTreeiENSGT00390000010039.
    HOVERGENiHBG006681.
    InParanoidiO89104.

    Family and domain databases

    InterProiIPR008253. Marvel.
    IPR001285. Synaptophysin/porin.
    [Graphical view]
    PANTHERiPTHR10306. PTHR10306. 1 hit.
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PRINTSiPR00220. SYNAPTOPHYSN.
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O89104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF    50
    GSCGSYSGET GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS 100
    TSKTMNLMGD FSAPAEFFVT LGIFSFFYTM AALVIYLRFH KLYTENKRFP 150
    LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG ATRPSSLTAA MSVCHGEEAV 200
    CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH GQGQDQGQGP 250
    SQESAAEQGA VEKQ 264
    Length:264
    Mass (Da):29,224
    Last modified:November 1, 1998 - v1
    Checksum:i5CB8A169533B6704
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010144 Genomic DNA. Translation: BAA32531.1.
    AB010140 mRNA. Translation: BAA32530.1.
    BC030038 mRNA. Translation: AAH30038.1.
    CCDSiCCDS57253.1.
    RefSeqiNP_032622.1. NM_008596.1.
    UniGeneiMm.316885.

    Genome annotation databases

    EnsembliENSMUST00000029486; ENSMUSP00000029486; ENSMUSG00000027887.
    GeneIDi17306.
    KEGGimmu:17306.
    UCSCiuc008qyn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010144 Genomic DNA. Translation: BAA32531.1 .
    AB010140 mRNA. Translation: BAA32530.1 .
    BC030038 mRNA. Translation: AAH30038.1 .
    CCDSi CCDS57253.1.
    RefSeqi NP_032622.1. NM_008596.1.
    UniGenei Mm.316885.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029486.

    Proteomic databases

    PaxDbi O89104.
    PRIDEi O89104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029486 ; ENSMUSP00000029486 ; ENSMUSG00000027887 .
    GeneIDi 17306.
    KEGGi mmu:17306.
    UCSCi uc008qyn.1. mouse.

    Organism-specific databases

    CTDi 284612.
    MGIi MGI:1328311. Sypl2.

    Phylogenomic databases

    eggNOGi NOG82723.
    GeneTreei ENSGT00390000010039.
    HOVERGENi HBG006681.
    InParanoidi O89104.

    Miscellaneous databases

    NextBioi 291852.
    PROi O89104.
    SOURCEi Search...

    Gene expression databases

    Bgeei O89104.
    CleanExi MM_SYPL2.
    Genevestigatori O89104.

    Family and domain databases

    InterProi IPR008253. Marvel.
    IPR001285. Synaptophysin/porin.
    [Graphical view ]
    PANTHERi PTHR10306. PTHR10306. 1 hit.
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PRINTSi PR00220. SYNAPTOPHYSN.
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Strain: 129 and C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiSYPL2_MOUSE
    AccessioniPrimary (citable) accession number: O89104
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3