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O89104 (SYPL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptophysin-like protein 2
Alternative name(s):
Mitsugumin-29
Short name=Mg29
Gene names
Name:Sypl2
Synonyms:Mg29
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes By similarity.

Subcellular location

Membrane; Multi-pass membrane protein. Note: Triad junction, the junctional complex between the transverse tubule and the sarcoplasmic reticulum.

Tissue specificity

Expressed abundantly in skeletal muscle and at lower levels in the kidney. Ref.1

Sequence similarities

Belongs to the synaptophysin/synaptobrevin family.

Contains 1 MARVEL domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Synaptophysin-like protein 2
PRO_0000179167

Regions

Topological domain1 – 3333Cytoplasmic Potential
Transmembrane34 – 5421Helical; Potential
Topological domain55 – 11662Vesicular Potential
Transmembrane117 – 13721Helical; Potential
Topological domain138 – 15013Cytoplasmic Potential
Transmembrane151 – 17121Helical; Potential
Topological domain172 – 21342Vesicular Potential
Transmembrane214 – 23421Helical; Potential
Topological domain235 – 26430Cytoplasmic Potential
Domain30 – 238209MARVEL

Amino acid modifications

Glycosylation2131N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O89104 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 5CB8A169533B6704

FASTA26429,224
        10         20         30         40         50         60 
MSSTESPGRT SDKSPRQQVD RLLLGLRWQR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET 

        70         80         90        100        110        120 
GALVLCNNEA KDVSSIIVLF GYPFRLYQVQ YEMPLCDQDS TSKTMNLMGD FSAPAEFFVT 

       130        140        150        160        170        180 
LGIFSFFYTM AALVIYLRFH KLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG 

       190        200        210        220        230        240 
ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANLSVLFGF INFFLWAGNC WFVFKETPWH 

       250        260 
GQGQDQGQGP SQESAAEQGA VEKQ 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of mitsugumin29 gene."
Shimuta M., Komazaki S., Nishi M., Iino M., Nakagawara K., Takeshima H.
FEBS Lett. 431:263-267(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Strain: 129 and C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010144 Genomic DNA. Translation: BAA32531.1.
AB010140 mRNA. Translation: BAA32530.1.
BC030038 mRNA. Translation: AAH30038.1.
CCDSCCDS57253.1.
RefSeqNP_032622.1. NM_008596.1.
UniGeneMm.316885.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029486.

Proteomic databases

PaxDbO89104.
PRIDEO89104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029486; ENSMUSP00000029486; ENSMUSG00000027887.
GeneID17306.
KEGGmmu:17306.
UCSCuc008qyn.1. mouse.

Organism-specific databases

CTD284612.
MGIMGI:1328311. Sypl2.

Phylogenomic databases

eggNOGNOG82723.
GeneTreeENSGT00390000010039.
HOVERGENHBG006681.
InParanoidO89104.

Gene expression databases

BgeeO89104.
CleanExMM_SYPL2.
GenevestigatorO89104.

Family and domain databases

InterProIPR008253. Marvel.
IPR001285. Synaptophysin/porin.
[Graphical view]
PANTHERPTHR10306. PTHR10306. 1 hit.
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR00220. SYNAPTOPHYSN.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291852.
PROO89104.
SOURCESearch...

Entry information

Entry nameSYPL2_MOUSE
AccessionPrimary (citable) accession number: O89104
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot