Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Complement component C1q receptor

Gene

Cd93

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C1q receptor
Alternative name(s):
C1q/MBL/SPA receptor
Short name:
C1qR(p)
Short name:
C1qRp
Cell surface antigen AA4
Complement component 1 q subcomponent receptor 1
Lymphocyte antigen 68
Short name:
Ly-68
CD_antigen: CD93
Gene namesi
Name:Cd93
Synonyms:Aa4, C1qr1, C1qrp, Ly68
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:106664. Cd93.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 572ExtracellularSequence analysisAdd BLAST550
Transmembranei573 – 593HelicalSequence analysisAdd BLAST21
Topological domaini594 – 644CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • extracellular matrix Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001736823 – 644Complement component C1q receptorAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi140 ↔ 164By similarity
Disulfide bondi261 ↔ 272By similarity
Disulfide bondi268 ↔ 282By similarity
Disulfide bondi284 ↔ 297By similarity
Disulfide bondi303 ↔ 314By similarity
Disulfide bondi308 ↔ 325By similarity
Glycosylationi322N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi327 ↔ 340By similarity
Disulfide bondi346 ↔ 355By similarity
Disulfide bondi351 ↔ 364By similarity
Disulfide bondi366 ↔ 380By similarity
Disulfide bondi386 ↔ 397By similarity
Disulfide bondi393 ↔ 406By similarity
Disulfide bondi408 ↔ 422By similarity
Disulfide bondi428 ↔ 440By similarity
Disulfide bondi436 ↔ 449By similarity
Disulfide bondi451 ↔ 464By similarity
Modified residuei619PhosphoserineBy similarity1
Modified residuei636PhosphotyrosineCombined sources1

Post-translational modificationi

N- and O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO89103.
MaxQBiO89103.
PaxDbiO89103.
PeptideAtlasiO89103.
PRIDEiO89103.

PTM databases

iPTMnetiO89103.
PhosphoSitePlusiO89103.

Expressioni

Tissue specificityi

Expressed in lung, heart and bone marrow. Expressed at lower level in ovary, whole embryo and fetal liver. Not detected in brain, adult liver or thymus. Highly expressed in peritoneal cavity and bone marrow macrophages. Not detected in epithelial cells.

Developmental stagei

First detectable in day 9 embryos, in the endocardium and vascular endothelium in the anterior part of the embryo. Expression in endothelial cells, initially restricted to aorta, omphalomesenteric and umbilical arteries, later extends to subcardinal veins, intersomitic arteries and perineural vessels. On day 10, detectable in the entire embryo.

Gene expression databases

BgeeiENSMUSG00000027435.
CleanExiMM_CD93.
GenevisibleiO89103. MM.

Interactioni

Subunit structurei

Interacts with C1QBP; the association may represent a cell surface C1q receptor.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO89103. 1 interactor.
MINTiMINT-4089466.
STRINGi10090.ENSMUSP00000096876.

Structurei

3D structure databases

ProteinModelPortaliO89103.
SMRiO89103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 173C-type lectinPROSITE-ProRule annotationAdd BLAST143
Domaini257 – 298EGF-like 1PROSITE-ProRule annotationAdd BLAST42
Domaini299 – 341EGF-like 2PROSITE-ProRule annotationAdd BLAST43
Domaini342 – 381EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini382 – 423EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini424 – 465EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST42

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 5 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJQN. Eukaryota.
ENOG410ZKXP. LUCA.
GeneTreeiENSGT00810000125382.
HOGENOMiHOG000232038.
HOVERGENiHBG050751.
InParanoidiO89103.
KOiK06702.
OMAiHYFLCKE.
OrthoDBiEOG091G04OD.
PhylomeDBiO89103.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR026823. cEGF.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 5 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89103-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISTGLFLL LGLLGQPWAG AAADSQAVVC EGTACYTAHW GKLSAAEAQH
60 70 80 90 100
RCNENGGNLA TVKSEEEARH VQQALTQLLK TKAPLEAKMG KFWIGLQREK
110 120 130 140 150
GNCTYHDLPM RGFSWVGGGE DTAYSNWYKA SKSSCIFKRC VSLILDLSLT
160 170 180 190 200
PHPSHLPKWH ESPCGTPEAP GNSIEGFLCK FNFKGMCRPL ALGGPGRVTY
210 220 230 240 250
TTPFQATTSS LEAVPFASVA NVACGDEAKS ETHYFLCNEK TPGIFHWGSS
260 270 280 290 300
GPLCVSPKFG CSFNNGGCQQ DCFEGGDGSF RCGCRPGFRL LDDLVTCASR
310 320 330 340 350
NPCSSNPCTG GGMCHSVPLS ENYTCRCPSG YQLDSSQVHC VDIDECQDSP
360 370 380 390 400
CAQDCVNTLG SFHCECWVGY QPSGPKEEAC EDVDECAAAN SPCAQGCINT
410 420 430 440 450
DGSFYCSCKE GYIVSGEDST QCEDIDECSD ARGNPCDSLC FNTDGSFRCG
460 470 480 490 500
CPPGWELAPN GVFCSRGTVF SELPARPPQK EDNDDRKEST MPPTEMPSSP
510 520 530 540 550
SGSKDVSNRA QTTGLFVQSD IPTASVPLEI EIPSEVSDVW FELGTYLPTT
560 570 580 590 600
SGHSKPTHED SVSAHSDTDG QNLLLFYILG TVVAISLLLV LALGILIYHK
610 620 630 640
RRAKKEEIKE KKPQNAADSY SWVPERAESQ APENQYSPTP GTDC
Length:644
Mass (Da):69,354
Last modified:November 1, 1998 - v1
Checksum:iEB4351648BF8635A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074856 Genomic DNA. Translation: AAC63274.1.
AF081789 mRNA. Translation: AAC62649.1.
AF099939, AF099938 Genomic DNA. Translation: AAD47906.1.
AK079060 mRNA. Translation: BAC37518.1.
AK155060 mRNA. Translation: BAE33020.1.
AL935149 Genomic DNA. Translation: CAM26726.1.
CCDSiCCDS16839.1.
RefSeqiNP_034870.1. NM_010740.3.
UniGeneiMm.681.

Genome annotation databases

EnsembliENSMUST00000099269; ENSMUSP00000096876; ENSMUSG00000027435.
GeneIDi17064.
KEGGimmu:17064.
UCSCiuc008mte.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074856 Genomic DNA. Translation: AAC63274.1.
AF081789 mRNA. Translation: AAC62649.1.
AF099939, AF099938 Genomic DNA. Translation: AAD47906.1.
AK079060 mRNA. Translation: BAC37518.1.
AK155060 mRNA. Translation: BAE33020.1.
AL935149 Genomic DNA. Translation: CAM26726.1.
CCDSiCCDS16839.1.
RefSeqiNP_034870.1. NM_010740.3.
UniGeneiMm.681.

3D structure databases

ProteinModelPortaliO89103.
SMRiO89103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO89103. 1 interactor.
MINTiMINT-4089466.
STRINGi10090.ENSMUSP00000096876.

PTM databases

iPTMnetiO89103.
PhosphoSitePlusiO89103.

Proteomic databases

EPDiO89103.
MaxQBiO89103.
PaxDbiO89103.
PeptideAtlasiO89103.
PRIDEiO89103.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099269; ENSMUSP00000096876; ENSMUSG00000027435.
GeneIDi17064.
KEGGimmu:17064.
UCSCiuc008mte.1. mouse.

Organism-specific databases

CTDi22918.
MGIiMGI:106664. Cd93.

Phylogenomic databases

eggNOGiENOG410IJQN. Eukaryota.
ENOG410ZKXP. LUCA.
GeneTreeiENSGT00810000125382.
HOGENOMiHOG000232038.
HOVERGENiHBG050751.
InParanoidiO89103.
KOiK06702.
OMAiHYFLCKE.
OrthoDBiEOG091G04OD.
PhylomeDBiO89103.
TreeFamiTF330714.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO89103.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027435.
CleanExiMM_CD93.
GenevisibleiO89103. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR026823. cEGF.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
SM00181. EGF. 5 hits.
SM00179. EGF_CA. 5 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 4 hits.
PS01187. EGF_CA. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QR1_MOUSE
AccessioniPrimary (citable) accession number: O89103
Secondary accession number(s): A2AVY5, Q3U2X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.