ID   FGF18_MOUSE             Reviewed;         207 AA.
AC   O89101;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   24-JAN-2024, entry version 154.
DE   RecName: Full=Fibroblast growth factor 18;
DE            Short=FGF-18;
DE   AltName: Full=zFGF5;
DE   Flags: Precursor;
GN   Name=Fgf18;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9742123; DOI=10.1128/mcb.18.10.6063;
RA   Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B.,
RA   Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.;
RT   "FGF-18, a novel member of the fibroblast growth factor family, stimulates
RT   hepatic and intestinal proliferation.";
RL   Mol. Cell. Biol. 18:6063-6074(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=9660775; DOI=10.1074/jbc.273.29.18161;
RA   Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.;
RT   "Structure and expression of the mRNA encoding a novel fibroblast growth
RT   factor, FGF-18.";
RL   J. Biol. Chem. 273:18161-18164(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B.,
RA   Sheppard P., O'Hara P.;
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation, cell differentiation and cell migration. Required for
CC       normal ossification and bone development. Stimulates hepatic and
CC       intestinal proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FGFR3 and FGFR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; AF075291; AAC62239.1; -; mRNA.
DR   EMBL; AB004639; BAA31980.1; -; mRNA.
DR   EMBL; AF211187; AAF22976.1; -; mRNA.
DR   CCDS; CCDS24531.1; -.
DR   RefSeq; NP_032031.1; NM_008005.2.
DR   AlphaFoldDB; O89101; -.
DR   SMR; O89101; -.
DR   STRING; 10090.ENSMUSP00000020507; -.
DR   GlyCosmos; O89101; 2 sites, No reported glycans.
DR   GlyGen; O89101; 2 sites.
DR   PhosphoSitePlus; O89101; -.
DR   PaxDb; 10090-ENSMUSP00000020507; -.
DR   ProteomicsDB; 271576; -.
DR   Antibodypedia; 16955; 274 antibodies from 30 providers.
DR   DNASU; 14172; -.
DR   Ensembl; ENSMUST00000020507.8; ENSMUSP00000020507.8; ENSMUSG00000057967.13.
DR   GeneID; 14172; -.
DR   KEGG; mmu:14172; -.
DR   UCSC; uc007ikc.2; mouse.
DR   AGR; MGI:1277980; -.
DR   CTD; 8817; -.
DR   MGI; MGI:1277980; Fgf18.
DR   VEuPathDB; HostDB:ENSMUSG00000057967; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000159553; -.
DR   HOGENOM; CLU_090682_1_0_1; -.
DR   InParanoid; O89101; -.
DR   OMA; PQKPFKY; -.
DR   OrthoDB; 4098345at2759; -.
DR   PhylomeDB; O89101; -.
DR   TreeFam; TF331233; -.
DR   Reactome; R-MMU-109704; PI3K Cascade.
DR   Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-MMU-190322; FGFR4 ligand binding and activation.
DR   Reactome; R-MMU-190371; FGFR3b ligand binding and activation.
DR   Reactome; R-MMU-190372; FGFR3c ligand binding and activation.
DR   Reactome; R-MMU-190375; FGFR2c ligand binding and activation.
DR   Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR   Reactome; R-MMU-5654227; Phospholipase C-mediated cascade, FGFR3.
DR   Reactome; R-MMU-5654228; Phospholipase C-mediated cascade, FGFR4.
DR   Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR   Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR   Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR   Reactome; R-MMU-5654704; SHC-mediated cascade:FGFR3.
DR   Reactome; R-MMU-5654706; FRS-mediated FGFR3 signaling.
DR   Reactome; R-MMU-5654710; PI-3K cascade:FGFR3.
DR   Reactome; R-MMU-5654712; FRS-mediated FGFR4 signaling.
DR   Reactome; R-MMU-5654719; SHC-mediated cascade:FGFR4.
DR   Reactome; R-MMU-5654720; PI-3K cascade:FGFR4.
DR   Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR   Reactome; R-MMU-5654732; Negative regulation of FGFR3 signaling.
DR   Reactome; R-MMU-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-MMU-5658623; FGFRL1 modulation of FGFR1 signaling.
DR   Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   BioGRID-ORCS; 14172; 1 hit in 79 CRISPR screens.
DR   PRO; PR:O89101; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; O89101; Protein.
DR   Bgee; ENSMUSG00000057967; Expressed in mesenchyme of tongue and 166 other cell types or tissues.
DR   ExpressionAtlas; O89101; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; TAS:MGI.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; ISO:MGI.
DR   GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:MGI.
DR   GO; GO:0001525; P:angiogenesis; IMP:MGI.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR   GO; GO:0002063; P:chondrocyte development; IMP:MGI.
DR   GO; GO:0002062; P:chondrocyte differentiation; IGI:MGI.
DR   GO; GO:0001958; P:endochondral ossification; IMP:MGI.
DR   GO; GO:0070371; P:ERK1 and ERK2 cascade; IDA:MGI.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:MGI.
DR   GO; GO:0001957; P:intramembranous ossification; IMP:MGI.
DR   GO; GO:0030324; P:lung development; IMP:MGI.
DR   GO; GO:0007399; P:nervous system development; ISO:MGI.
DR   GO; GO:0001503; P:ossification; IMP:MGI.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR   GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:MGI.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:MGI.
DR   GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IGI:MGI.
DR   GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:MGI.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:2000347; P:positive regulation of hepatocyte proliferation; ISO:MGI.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IMP:MGI.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; TAS:MGI.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:MGI.
DR   Gene3D; 2.80.10.50; -; 1.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR   PANTHER; PTHR11486:SF4; FIBROBLAST GROWTH FACTOR 18; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; Cytokine; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
DR   Genevisible; O89101; MM.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..207
FT                   /note="Fibroblast growth factor 18"
FT                   /id="PRO_0000008991"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..127
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   207 AA;  23921 MW;  CD5F987B271628B8 CRC64;
     MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR
     TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP
     DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK
     GQAELQKPFK YTTVTKRSRR IRPTHPG
//