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Protein

Fibroblast growth factor 18

Gene

Fgf18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity).By similarity

GO - Molecular functioni

  1. fibroblast growth factor receptor binding Source: MGI
  2. type 1 fibroblast growth factor receptor binding Source: MGI
  3. type 2 fibroblast growth factor receptor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. chondrocyte development Source: MGI
  3. endochondral ossification Source: MGI
  4. fibroblast growth factor receptor signaling pathway Source: MGI
  5. intramembranous ossification Source: MGI
  6. lung development Source: MGI
  7. nervous system development Source: Ensembl
  8. ossification Source: MGI
  9. positive regulation of cell proliferation Source: MGI
  10. positive regulation of chondrocyte differentiation Source: MGI
  11. positive regulation of ERK1 and ERK2 cascade Source: MGI
  12. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
  13. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_230708. Phospholipase C-mediated cascade.
REACT_234357. FRS2-mediated cascade.
REACT_240139. PI3K Cascade.
REACT_94437. SHC-mediated cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 18
Short name:
FGF-18
Alternative name(s):
zFGF5
Gene namesi
Name:Fgf18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1277980. Fgf18.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 207180Fibroblast growth factor 18PRO_0000008991Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 127By similarity
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO89101.

PTM databases

PhosphoSiteiO89101.

Expressioni

Gene expression databases

BgeeiO89101.
CleanExiMM_FGF18.
ExpressionAtlasiO89101. baseline and differential.
GenevestigatoriO89101.

Interactioni

Subunit structurei

Interacts with FGFR3 and FGFR4.By similarity

Structurei

3D structure databases

ProteinModelPortaliO89101.
SMRiO89101. Positions 51-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG269838.
GeneTreeiENSGT00730000110785.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiO89101.
KOiK04358.
OMAiEDGDKYE.
PhylomeDBiO89101.
TreeFamiTF331233.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89101-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK
60 70 80 90 100
QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK
110 120 130 140 150
GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY
160 170 180 190 200
VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQAELQKPFK YTTVTKRSRR

IRPTHPG
Length:207
Mass (Da):23,921
Last modified:November 1, 1998 - v1
Checksum:iCD5F987B271628B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075291 mRNA. Translation: AAC62239.1.
AB004639 mRNA. Translation: BAA31980.1.
AF211187 mRNA. Translation: AAF22976.1.
CCDSiCCDS24531.1.
RefSeqiNP_032031.1. NM_008005.2.
UniGeneiMm.339812.

Genome annotation databases

EnsembliENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967.
GeneIDi14172.
KEGGimmu:14172.
UCSCiuc007ikc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075291 mRNA. Translation: AAC62239.1.
AB004639 mRNA. Translation: BAA31980.1.
AF211187 mRNA. Translation: AAF22976.1.
CCDSiCCDS24531.1.
RefSeqiNP_032031.1. NM_008005.2.
UniGeneiMm.339812.

3D structure databases

ProteinModelPortaliO89101.
SMRiO89101. Positions 51-179.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO89101.

Proteomic databases

PRIDEiO89101.

Protocols and materials databases

DNASUi14172.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967.
GeneIDi14172.
KEGGimmu:14172.
UCSCiuc007ikc.1. mouse.

Organism-specific databases

CTDi8817.
MGIiMGI:1277980. Fgf18.

Phylogenomic databases

eggNOGiNOG269838.
GeneTreeiENSGT00730000110785.
HOGENOMiHOG000115986.
HOVERGENiHBG005659.
InParanoidiO89101.
KOiK04358.
OMAiEDGDKYE.
PhylomeDBiO89101.
TreeFamiTF331233.

Enzyme and pathway databases

ReactomeiREACT_196455. Signaling by FGFR mutants.
REACT_196505. Signaling by FGFR3 mutants.
REACT_196507. Signaling by activated point mutants of FGFR3.
REACT_196536. Activated point mutants of FGFR2.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198525. Negative regulation of FGFR signaling.
REACT_206694. FGFR4 ligand binding and activation.
REACT_206745. FGFR2c ligand binding and activation.
REACT_213224. FGFR3b ligand binding and activation.
REACT_220750. FGFR3c ligand binding and activation.
REACT_223993. PI-3K cascade.
REACT_226341. PIP3 activates AKT signaling.
REACT_230708. Phospholipase C-mediated cascade.
REACT_234357. FRS2-mediated cascade.
REACT_240139. PI3K Cascade.
REACT_94437. SHC-mediated cascade.

Miscellaneous databases

NextBioi285338.
PROiO89101.
SOURCEiSearch...

Gene expression databases

BgeeiO89101.
CleanExiMM_FGF18.
ExpressionAtlasiO89101. baseline and differential.
GenevestigatoriO89101.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PRINTSiPR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation."
    Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.
    Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
    Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
    J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  3. Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFGF18_MOUSE
AccessioniPrimary (citable) accession number: O89101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.