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O89101 (FGF18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 18

Short name=FGF-18
Alternative name(s):
zFGF5
Gene names
Name:Fgf18
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation By similarity.

Subunit structure

Interacts with FGFR3 and FGFR4 By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from mutant phenotype PubMed 17014841. Source: MGI

chondrocyte development

Inferred from mutant phenotype PubMed 17014841. Source: MGI

endochondral ossification

Inferred from mutant phenotype PubMed 17014841. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction PubMed 15781473. Source: MGI

intramembranous ossification

Inferred from mutant phenotype PubMed 17014841. Source: MGI

lung development

Inferred from mutant phenotype PubMed 15336546. Source: MGI

nervous system development

Inferred from electronic annotation. Source: Ensembl

ossification

Inferred from mutant phenotype PubMed 11937493PubMed 11937494. Source: MGI

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 11741978. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 17014841. Source: MGI

positive regulation of chondrocyte differentiation

Inferred from genetic interaction PubMed 15781473. Source: MGI

positive regulation of vascular endothelial growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 17014841. Source: MGI

signal transduction

Traceable author statement PubMed 11937493. Source: MGI

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionfibroblast growth factor receptor binding

Traceable author statement PubMed 11937493. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 207180Fibroblast growth factor 18
PRO_0000008991

Amino acid modifications

Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 127 By similarity

Sequences

Sequence LengthMass (Da)Tools
O89101 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: CD5F987B271628B8

FASTA20723,921
        10         20         30         40         50         60 
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 

        70         80         90        100        110        120 
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 

       130        140        150        160        170        180 
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 

       190        200 
GQAELQKPFK YTTVTKRSRR IRPTHPG 

« Hide

References

[1]"FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation."
Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.
Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[3]Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF075291 mRNA. Translation: AAC62239.1.
AB004639 mRNA. Translation: BAA31980.1.
AF211187 mRNA. Translation: AAF22976.1.
CCDSCCDS24531.1.
RefSeqNP_032031.1. NM_008005.2.
UniGeneMm.339812.

3D structure databases

ProteinModelPortalO89101.
SMRO89101. Positions 33-180.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO89101.

Proteomic databases

PRIDEO89101.

Protocols and materials databases

DNASU14172.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967.
GeneID14172.
KEGGmmu:14172.
UCSCuc007ikc.1. mouse.

Organism-specific databases

CTD8817.
MGIMGI:1277980. Fgf18.

Phylogenomic databases

eggNOGNOG269838.
GeneTreeENSGT00730000110785.
HOGENOMHOG000115986.
HOVERGENHBG005659.
InParanoidO89101.
KOK04358.
OMATRMEVEP.
PhylomeDBO89101.
TreeFamTF331233.

Gene expression databases

ArrayExpressO89101.
BgeeO89101.
CleanExMM_FGF18.
GenevestigatorO89101.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028289. FGF18.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF4. PTHR11486:SF4. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285338.
PROO89101.
SOURCESearch...

Entry information

Entry nameFGF18_MOUSE
AccessionPrimary (citable) accession number: O89101
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot