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O89101

- FGF18_MOUSE

UniProt

O89101 - FGF18_MOUSE

Protein

Fibroblast growth factor 18

Gene

Fgf18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation By similarity.By similarity

    GO - Molecular functioni

    1. fibroblast growth factor receptor binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. chondrocyte development Source: MGI
    3. endochondral ossification Source: MGI
    4. fibroblast growth factor receptor signaling pathway Source: MGI
    5. intramembranous ossification Source: MGI
    6. lung development Source: MGI
    7. nervous system development Source: Ensembl
    8. ossification Source: MGI
    9. positive regulation of cell proliferation Source: MGI
    10. positive regulation of chondrocyte differentiation Source: MGI
    11. positive regulation of ERK1 and ERK2 cascade Source: MGI
    12. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: MGI
    13. signal transduction Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_213224. FGFR3b ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 18
    Short name:
    FGF-18
    Alternative name(s):
    zFGF5
    Gene namesi
    Name:Fgf18
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1277980. Fgf18.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 207180Fibroblast growth factor 18PRO_0000008991Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 127By similarity
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO89101.

    PTM databases

    PhosphoSiteiO89101.

    Expressioni

    Gene expression databases

    ArrayExpressiO89101.
    BgeeiO89101.
    CleanExiMM_FGF18.
    GenevestigatoriO89101.

    Interactioni

    Subunit structurei

    Interacts with FGFR3 and FGFR4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO89101.
    SMRiO89101. Positions 33-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG269838.
    GeneTreeiENSGT00730000110785.
    HOGENOMiHOG000115986.
    HOVERGENiHBG005659.
    InParanoidiO89101.
    KOiK04358.
    OMAiTRMEVEP.
    PhylomeDBiO89101.
    TreeFamiTF331233.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028289. FGF18.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF4. PTHR11486:SF4. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O89101-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK    50
    QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK 100
    GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY 150
    VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQAELQKPFK YTTVTKRSRR 200
    IRPTHPG 207
    Length:207
    Mass (Da):23,921
    Last modified:November 1, 1998 - v1
    Checksum:iCD5F987B271628B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075291 mRNA. Translation: AAC62239.1.
    AB004639 mRNA. Translation: BAA31980.1.
    AF211187 mRNA. Translation: AAF22976.1.
    CCDSiCCDS24531.1.
    RefSeqiNP_032031.1. NM_008005.2.
    UniGeneiMm.339812.

    Genome annotation databases

    EnsembliENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967.
    GeneIDi14172.
    KEGGimmu:14172.
    UCSCiuc007ikc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075291 mRNA. Translation: AAC62239.1 .
    AB004639 mRNA. Translation: BAA31980.1 .
    AF211187 mRNA. Translation: AAF22976.1 .
    CCDSi CCDS24531.1.
    RefSeqi NP_032031.1. NM_008005.2.
    UniGenei Mm.339812.

    3D structure databases

    ProteinModelPortali O89101.
    SMRi O89101. Positions 33-180.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O89101.

    Proteomic databases

    PRIDEi O89101.

    Protocols and materials databases

    DNASUi 14172.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020507 ; ENSMUSP00000020507 ; ENSMUSG00000057967 .
    GeneIDi 14172.
    KEGGi mmu:14172.
    UCSCi uc007ikc.1. mouse.

    Organism-specific databases

    CTDi 8817.
    MGIi MGI:1277980. Fgf18.

    Phylogenomic databases

    eggNOGi NOG269838.
    GeneTreei ENSGT00730000110785.
    HOGENOMi HOG000115986.
    HOVERGENi HBG005659.
    InParanoidi O89101.
    KOi K04358.
    OMAi TRMEVEP.
    PhylomeDBi O89101.
    TreeFami TF331233.

    Enzyme and pathway databases

    Reactomei REACT_196455. Signaling by FGFR mutants.
    REACT_196505. Signaling by FGFR3 mutants.
    REACT_196507. Signaling by activated point mutants of FGFR3.
    REACT_196536. Activated point mutants of FGFR2.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198525. Negative regulation of FGFR signaling.
    REACT_206694. FGFR4 ligand binding and activation.
    REACT_206745. FGFR2c ligand binding and activation.
    REACT_213224. FGFR3b ligand binding and activation.
    REACT_220750. FGFR3c ligand binding and activation.
    REACT_223993. PI-3K cascade.
    REACT_226341. PIP3 activates AKT signaling.
    REACT_94437. SHC-mediated cascade.

    Miscellaneous databases

    NextBioi 285338.
    PROi O89101.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O89101.
    Bgeei O89101.
    CleanExi MM_FGF18.
    Genevestigatori O89101.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028289. FGF18.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF4. PTHR11486:SF4. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation."
      Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.
      Mol. Cell. Biol. 18:6063-6074(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18."
      Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.
      J. Biol. Chem. 273:18161-18164(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    3. Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFGF18_MOUSE
    AccessioniPrimary (citable) accession number: O89101
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3