Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O89093

- CCL20_MOUSE

UniProt

O89093 - CCL20_MOUSE

Protein

C-C motif chemokine 20

Gene

Ccl20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. chemokinesis Source: Ensembl
    3. immune response Source: InterPro
    4. inflammatory response Source: UniProtKB-KW
    5. positive regulation of T cell migration Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 20
    Alternative name(s):
    Beta-chemokine exodus-1
    CC chemokine LARC
    CC chemokine ST38
    Liver and activation-regulated chemokine
    Macrophage inflammatory protein 3 alpha
    Short name:
    MIP-3-alpha
    Small-inducible cytokine A20
    Gene namesi
    Name:Ccl20
    Synonyms:Larc, Scya20
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1329031. Ccl20.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 9770C-C motif chemokine 20PRO_0000005218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 591 Publication
    Disulfide bondi34 ↔ 751 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO89093.

    Expressioni

    Tissue specificityi

    Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues.

    Inductioni

    By lipopolysaccharide (LPS), TNF-alpha and interleukin-1. IFN-gamma alone showed no effect, but potentiated the effect of TNF.

    Gene expression databases

    BgeeiO89093.
    CleanExiMM_CCL20.
    GenevestigatoriO89093.

    Interactioni

    Subunit structurei

    Binds to and activate CCR6.

    Structurei

    Secondary structure

    1
    97
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 374
    Helixi44 – 463
    Beta strandi47 – 537
    Beta strandi55 – 584
    Beta strandi63 – 7614
    Helixi81 – 9313

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HA6NMR-A28-97[»]
    ProteinModelPortaliO89093.
    SMRiO89093. Positions 28-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO89093.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44269.
    HOGENOMiHOG000036685.
    HOVERGENiHBG017871.
    KOiK14625.
    PhylomeDBiO89093.
    TreeFamiTF334888.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: O89093-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MACGGKRLLF LALAWVLLAH LCSQAEAASN YDCCLSYIQT PLPSRAIVGF   50
    TRQMADEACD INAIIFHTKK RKSVCADPKQ NWVKRAVNLL SLRVKKM 97
    Length:97
    Mass (Da):10,826
    Last modified:November 1, 1998 - v1
    Checksum:i6E0C73C8AC80AB0A
    GO
    Isoform Short (identifier: O89093-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         28-28: Missing.

    Show »
    Length:96
    Mass (Da):10,755
    Checksum:iA5236C18BC0E09DB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei28 – 281Missing in isoform Short. CuratedVSP_001062

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053313 mRNA. Translation: AAC78295.1.
    AJ007862 Genomic DNA. Translation: CAA07714.1.
    AF099052 mRNA. Translation: AAC78680.1.
    AJ222694 mRNA. Translation: CAA10948.1.
    AB015136 mRNA. Translation: BAA76955.1.
    CCDSiCCDS35632.1. [O89093-1]
    RefSeqiNP_001153210.1. NM_001159738.1. [O89093-2]
    NP_058656.1. NM_016960.2. [O89093-1]
    UniGeneiMm.116739.

    Genome annotation databases

    EnsembliENSMUST00000113437; ENSMUSP00000109064; ENSMUSG00000026166. [O89093-1]
    GeneIDi20297.
    KEGGimmu:20297.
    UCSCiuc007bsk.2. mouse. [O89093-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053313 mRNA. Translation: AAC78295.1 .
    AJ007862 Genomic DNA. Translation: CAA07714.1 .
    AF099052 mRNA. Translation: AAC78680.1 .
    AJ222694 mRNA. Translation: CAA10948.1 .
    AB015136 mRNA. Translation: BAA76955.1 .
    CCDSi CCDS35632.1. [O89093-1 ]
    RefSeqi NP_001153210.1. NM_001159738.1. [O89093-2 ]
    NP_058656.1. NM_016960.2. [O89093-1 ]
    UniGenei Mm.116739.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HA6 NMR - A 28-97 [» ]
    ProteinModelPortali O89093.
    SMRi O89093. Positions 28-97.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O89093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113437 ; ENSMUSP00000109064 ; ENSMUSG00000026166 . [O89093-1 ]
    GeneIDi 20297.
    KEGGi mmu:20297.
    UCSCi uc007bsk.2. mouse. [O89093-1 ]

    Organism-specific databases

    CTDi 6364.
    MGIi MGI:1329031. Ccl20.

    Phylogenomic databases

    eggNOGi NOG44269.
    HOGENOMi HOG000036685.
    HOVERGENi HBG017871.
    KOi K14625.
    PhylomeDBi O89093.
    TreeFami TF334888.

    Miscellaneous databases

    EvolutionaryTracei O89093.
    NextBioi 298025.
    PROi O89093.
    SOURCEi Search...

    Gene expression databases

    Bgeei O89093.
    CleanExi MM_CCL20.
    Genevestigatori O89093.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel rat CC chemokine, identified by targeted differential display, is upregulated in brain inflammation."
      Utans-Schneitz U., Lorez H., Klinkert W.E.F., da Silva J., Lesslauer W.
      J. Neuroimmunol. 92:179-190(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    2. Villares R.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM LONG).
    3. "Cloning and characterization of a murine homolog of macrophage inflammatory protein 3 alpha."
      McColl S.R., Carney T., Neote K.S.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
      Strain: BALB/c.
    4. "Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha."
      Varona R., Zaballos A., Gutierrez J., Martin P., Roncal F., Albar J.P., Ardavin C., Marquez G.
      FEBS Lett. 440:188-194(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), CHARACTERIZATION.
      Tissue: Thymus.
    5. "Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans."
      Tanaka Y., Imai T., Baba M., Ishikawa I., Uehira M., Nomiyama H., Yoshie O.
      Eur. J. Immunol. 29:633-642(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, PROTEIN SEQUENCE OF N-TERMINUS.
      Tissue: Liver.
    6. "NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6."
      Perez-Canadillas J.M., Zaballos A., Gutierrez J., Varona R., Roncal F., Albar J.P., Marquez G., Bruix M.
      J. Biol. Chem. 276:28372-28379(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 28-97, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCCL20_MOUSE
    AccessioniPrimary (citable) accession number: O89093
    Secondary accession number(s): Q9Z1X3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3