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O89091

- KLF10_MOUSE

UniProt

O89091 - KLF10_MOUSE

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Protein

Krueppel-like factor 10

Gene

Klf10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation By similarity. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri368 – 39225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. DNA binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. bone mineralization Source: MGI
  2. cellular response to peptide Source: Ensembl
  3. cellular response to starvation Source: UniProtKB
  4. circadian rhythm Source: UniProtKB
  5. negative regulation of transcription, DNA-templated Source: UniProtKB
  6. positive regulation of osteoclast differentiation Source: MGI
  7. regulation of circadian rhythm Source: UniProtKB
  8. regulation of transcription, DNA-templated Source: MGI
  9. somatic stem cell maintenance Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
GDNF-inducible factor
Transcription factor GIF
Short name:
mGIF
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Gene namesi
Name:Klf10
Synonyms:Gdnfif, Tieg, Tieg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1101353. Klf10.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice display postprandial and fasting hyperglycemia while female mice are normoglycemic but display higher plasma triglycerides.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Krueppel-like factor 10PRO_0000047178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiO89091.

PTM databases

PhosphoSiteiO89091.

Expressioni

Inductioni

By TGF-beta and GDNF. Expressed in a circadian manner in the liver with a high at ZT14-18 and a low at ZT2 (at protein level). Expressed in a circadian manner in the bone, kidney and skeletal muscle. Up-regulated in response to glucose.3 Publications

Gene expression databases

BgeeiO89091.
CleanExiMM_KLF10.
GenevestigatoriO89091.

Interactioni

Protein-protein interaction databases

BioGridi204195. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliO89091.
SMRiO89091. Positions 352-451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri368 – 39225C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri398 – 42225C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri428 – 45023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000059558.
HOVERGENiHBG052264.
InParanoidiO89091.
KOiK09209.
OMAiVQNPKPP.
OrthoDBiEOG7FJH0Q.
PhylomeDBiO89091.
TreeFamiTF315506.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89091-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD
60 70 80 90 100
WKSHFKKYLE NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF
110 120 130 140 150
EPSQGSNLTA SAPSTGHFKS FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ
160 170 180 190 200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHG NVEATRKNIP
210 220 230 240 250
CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC RSQPAPSSPV
260 270 280 290 300
QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV
310 320 330 340 350
CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS
360 370 380 390 400
PSAARVTPQI DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC
410 420 430 440 450
SWKGCERRFA RSDELSRHRR THTGEKKFAC PMCDRRFMRS DHLTKHARRH
460 470
LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ
Length:479
Mass (Da):51,756
Last modified:November 1, 1998 - v1
Checksum:i99A5969665962963
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064088 mRNA. Translation: AAC16734.1.
AF049880 Genomic DNA. Translation: AAC77797.1.
AF049879 mRNA. Translation: AAC77796.1.
BC003316 mRNA. Translation: AAH03316.1.
CCDSiCCDS27438.1.
RefSeqiNP_038720.1. NM_013692.3.
UniGeneiMm.4292.

Genome annotation databases

EnsembliENSMUST00000074043; ENSMUSP00000073690; ENSMUSG00000037465.
GeneIDi21847.
KEGGimmu:21847.
UCSCiuc007vnr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064088 mRNA. Translation: AAC16734.1 .
AF049880 Genomic DNA. Translation: AAC77797.1 .
AF049879 mRNA. Translation: AAC77796.1 .
BC003316 mRNA. Translation: AAH03316.1 .
CCDSi CCDS27438.1.
RefSeqi NP_038720.1. NM_013692.3.
UniGenei Mm.4292.

3D structure databases

ProteinModelPortali O89091.
SMRi O89091. Positions 352-451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204195. 4 interactions.

PTM databases

PhosphoSitei O89091.

Proteomic databases

PRIDEi O89091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074043 ; ENSMUSP00000073690 ; ENSMUSG00000037465 .
GeneIDi 21847.
KEGGi mmu:21847.
UCSCi uc007vnr.1. mouse.

Organism-specific databases

CTDi 7071.
MGIi MGI:1101353. Klf10.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118984.
HOGENOMi HOG000059558.
HOVERGENi HBG052264.
InParanoidi O89091.
KOi K09209.
OMAi VQNPKPP.
OrthoDBi EOG7FJH0Q.
PhylomeDBi O89091.
TreeFami TF315506.

Miscellaneous databases

NextBioi 301322.
PROi O89091.
SOURCEi Search...

Gene expression databases

Bgeei O89091.
CleanExi MM_KLF10.
Genevestigatori O89091.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF)."
    Yajima S., Lammers C.H., Lee S.H., Hara Y., Mizuno K., Mouradian M.M.
    J. Neurosci. 17:8657-8666(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
  2. "Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts."
    Fautsch M.P., Vrabel A., Rickard D., Subramaniam M., Spelsberg T.C., Wieben E.D.
    Mamm. Genome 9:838-842(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary gland.
  4. "Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork."
    Hirota T., Kon N., Itagaki T., Hoshina N., Okano T., Fukada Y.
    Genes Cells 15:111-121(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION, PHOSPHORYLATION.
  5. Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiKLF10_MOUSE
AccessioniPrimary (citable) accession number: O89091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3