Reviewed, UniProtKB/Swiss-Prot O89091 (KLF10_MOUSE)

Names and origin

Protein names

Recommended name:
    Krueppel-like factor 10
Alternative name(s):
    Transforming growth factor-beta-inducible early growth response protein 1
      Short name=TGFB-inducible early growth response protein 1
      Short name=TIEG-1
    GDNF-inducible factor
    Transcription factor GIF
      Short name=mGIF

Gene names

Name:	Klf10
Synonyms:	Gdnfif, Tieg, Tieg1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth.
Subcellular location	Nucleus By similarity.
Induction	By TGF-beta and GDNF.
Post-translational modification	Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation By similarity.
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	bone mineralization Inferred from mutant phenotype. Source: MGI positive regulation of osteoclast differentiation Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to protein stimulus Inferred from direct assay. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Krueppel-like factor 10		PRO_0000047178
Regions
	Zinc finger	368 – 392	25	C2H2-type 1
	Zinc finger	398 – 422	25	C2H2-type 2
	Zinc finger	428 – 450	23	C2H2-type 3
Amino acid modifications
	Modified residue	248	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O89091-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 99A5969665962963	FASTA	479	51,756
	10 20 30 40 50 60 MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD WKSHFKKYLE 70 80 90 100 110 120 NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF EPSQGSNLTA SAPSTGHFKS 130 140 150 160 170 180 FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ ATSVIRHTAD AQLCNHQSCP VKAASILNYQ 190 200 210 220 230 240 DNSFRRRTHG NVEATRKNIP CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC 250 260 270 280 290 300 RSQPAPSSPV QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV 310 320 330 340 350 360 CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS PSAARVTPQI 370 380 390 400 410 420 DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC SWKGCERRFA RSDELSRHRR 430 440 450 460 470 THTGEKKFAC PMCDRRFMRS DHLTKHARRH LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF)." Yajima S., Lammers C.H., Lee S.H., Hara Y., Mizuno K., Mouradian M.M. J. Neurosci. 17:8657-8666(1997) [PubMed: 9348334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts." Fautsch M.P., Vrabel A., Rickard D., Subramaniam M., Spelsberg T.C., Wieben E.D. Mamm. Genome 9:838-842(1998) [PubMed: 9745041] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF064088 mRNA. Translation: AAC16734.1. AF049880 Genomic DNA. Translation: AAC77797.1. AF049879 mRNA. Translation: AAC77796.1. BC003316 mRNA. Translation: AAH03316.1.
IPI	IPI00130916.
RefSeq	NP_038720.1.
UniGene	Mm.4292
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBase	Search...
PTM databases
PhosphoSite	O89091.
Proteomic databases
PRIDE	O89091.
Genome annotation databases
Ensembl	ENSMUSG00000037465. Mus musculus. [Contig view]
GeneID	21847.
KEGG	mmu:21847.
Organism-specific databases
MGI	MGI:1101353. Klf10.
Phylogenomic databases
HOGENOM	O89091.
HOVERGEN	O89091.
OMA	O89091. LNDIALP.
Gene expression databases
ArrayExpress	O89091.
Bgee	O89091.
CleanEx	MM_KLF10.
GermOnline	ENSMUSG00000037465. Mus musculus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 3 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	301322.
SOURCE	Search...

Entry information

Entry name

KLF10_MOUSE

Accession

Primary (citable) accession number: O89091

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)