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Protein

Krueppel-like factor 10

Gene

Klf10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri368 – 392C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri398 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri428 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • bone mineralization Source: MGI
  • cellular response to peptide Source: Ensembl
  • cellular response to starvation Source: UniProtKB
  • circadian rhythm Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of osteoclast differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of circadian rhythm Source: UniProtKB
  • regulation of transcription, DNA-templated Source: MGI
  • somatic stem cell population maintenance Source: MGI

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 10
Alternative name(s):
GDNF-inducible factor
Transcription factor GIF
Short name:
mGIF
Transforming growth factor-beta-inducible early growth response protein 1
Short name:
TGFB-inducible early growth response protein 1
Short name:
TIEG-1
Gene namesi
Name:Klf10
Synonyms:Gdnfif, Tieg, Tieg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1101353 Klf10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Male mice display postprandial and fasting hyperglycemia while female mice are normoglycemic but display higher plasma triglycerides.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471781 – 479Krueppel-like factor 10Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183PhosphoserineBy similarity1
Modified residuei248PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO89091
PeptideAtlasiO89091
PRIDEiO89091

PTM databases

iPTMnetiO89091
PhosphoSitePlusiO89091

Expressioni

Inductioni

By TGF-beta and GDNF. Expressed in a circadian manner in the liver with a high at ZT14-18 and a low at ZT2 (at protein level). Expressed in a circadian manner in the bone, kidney and skeletal muscle. Up-regulated in response to glucose.3 Publications

Gene expression databases

BgeeiENSMUSG00000037465
CleanExiMM_KLF10
ExpressionAtlasiO89091 baseline and differential
GenevisibleiO89091 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ItchQ8C8634EBI-10949150,EBI-851782

Protein-protein interaction databases

BioGridi204195, 3 interactors
IntActiO89091, 1 interactor
STRINGi10090.ENSMUSP00000073690

Structurei

3D structure databases

ProteinModelPortaliO89091
SMRiO89091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri368 – 392C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri398 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri428 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiO89091
KOiK09209
OMAiKPHIAAP
OrthoDBiEOG091G1BN0
PhylomeDBiO89091
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

O89091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD
60 70 80 90 100
WKSHFKKYLE NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF
110 120 130 140 150
EPSQGSNLTA SAPSTGHFKS FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ
160 170 180 190 200
ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHG NVEATRKNIP
210 220 230 240 250
CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC RSQPAPSSPV
260 270 280 290 300
QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV
310 320 330 340 350
CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS
360 370 380 390 400
PSAARVTPQI DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC
410 420 430 440 450
SWKGCERRFA RSDELSRHRR THTGEKKFAC PMCDRRFMRS DHLTKHARRH
460 470
LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ
Length:479
Mass (Da):51,756
Last modified:November 1, 1998 - v1
Checksum:i99A5969665962963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064088 mRNA Translation: AAC16734.1
AF049880 Genomic DNA Translation: AAC77797.1
AF049879 mRNA Translation: AAC77796.1
BC003316 mRNA Translation: AAH03316.1
CCDSiCCDS27438.1
RefSeqiNP_038720.1, NM_013692.3
UniGeneiMm.4292

Genome annotation databases

EnsembliENSMUST00000074043; ENSMUSP00000073690; ENSMUSG00000037465
GeneIDi21847
KEGGimmu:21847
UCSCiuc007vnr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiKLF10_MOUSE
AccessioniPrimary (citable) accession number: O89091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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