Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O89091 (KLF10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 10
Alternative name(s):
GDNF-inducible factor
Transcription factor GIF
Short name=mGIF
Transforming growth factor-beta-inducible early growth response protein 1
Short name=TGFB-inducible early growth response protein 1
Short name=TIEG-1
Gene names
Name:Klf10
Synonyms:Gdnfif, Tieg, Tieg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth.

Subcellular location

Nucleus By similarity.

Induction

By TGF-beta and GDNF.

Post-translational modification

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation By similarity.

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Krueppel-like factor 10
PRO_0000047178

Regions

Zinc finger368 – 39225C2H2-type 1
Zinc finger398 – 42225C2H2-type 2
Zinc finger428 – 45023C2H2-type 3

Amino acid modifications

Modified residue2481Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O89091 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 99A5969665962963

FASTA47951,756
        10         20         30         40         50         60 
MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD WKSHFKKYLE 

        70         80         90        100        110        120 
NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF EPSQGSNLTA SAPSTGHFKS 

       130        140        150        160        170        180 
FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ ATSVIRHTAD AQLCNHQSCP VKAASILNYQ 

       190        200        210        220        230        240 
DNSFRRRTHG NVEATRKNIP CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC 

       250        260        270        280        290        300 
RSQPAPSSPV QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV 

       310        320        330        340        350        360 
CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS PSAARVTPQI 

       370        380        390        400        410        420 
DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC SWKGCERRFA RSDELSRHRR 

       430        440        450        460        470 
THTGEKKFAC PMCDRRFMRS DHLTKHARRH LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF)."
Yajima S., Lammers C.H., Lee S.H., Hara Y., Mizuno K., Mouradian M.M.
J. Neurosci. 17:8657-8666(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts."
Fautsch M.P., Vrabel A., Rickard D., Subramaniam M., Spelsberg T.C., Wieben E.D.
Mamm. Genome 9:838-842(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064088 mRNA. Translation: AAC16734.1.
AF049880 Genomic DNA. Translation: AAC77797.1.
AF049879 mRNA. Translation: AAC77796.1.
BC003316 mRNA. Translation: AAH03316.1.
CCDSCCDS27438.1.
RefSeqNP_038720.1. NM_013692.3.
UniGeneMm.4292.

3D structure databases

ProteinModelPortalO89091.
SMRO89091. Positions 352-451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204195. 4 interactions.

PTM databases

PhosphoSiteO89091.

Proteomic databases

PRIDEO89091.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000074043; ENSMUSP00000073690; ENSMUSG00000037465.
GeneID21847.
KEGGmmu:21847.
UCSCuc007vnr.1. mouse.

Organism-specific databases

CTD7071.
MGIMGI:1101353. Klf10.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117414.
HOGENOMHOG000059558.
HOVERGENHBG052264.
InParanoidO89091.
KOK09209.
OMAVQNPKPP.
OrthoDBEOG7FJH0Q.
PhylomeDBO89091.
TreeFamTF315506.

Gene expression databases

BgeeO89091.
CleanExMM_KLF10.
GenevestigatorO89091.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio301322.
PROO89091.
SOURCESearch...

Entry information

Entry nameKLF10_MOUSE
AccessionPrimary (citable) accession number: O89091
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot