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O89091

- KLF10_MOUSE

UniProt

O89091 - KLF10_MOUSE

Protein

Krueppel-like factor 10

Gene

Klf10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri368 – 39225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. bone mineralization Source: MGI
    2. cellular response to peptide Source: Ensembl
    3. positive regulation of osteoclast differentiation Source: MGI
    4. regulation of transcription, DNA-templated Source: MGI
    5. somatic stem cell maintenance Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 10
    Alternative name(s):
    GDNF-inducible factor
    Transcription factor GIF
    Short name:
    mGIF
    Transforming growth factor-beta-inducible early growth response protein 1
    Short name:
    TGFB-inducible early growth response protein 1
    Short name:
    TIEG-1
    Gene namesi
    Name:Klf10
    Synonyms:Gdnfif, Tieg, Tieg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1101353. Klf10.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Krueppel-like factor 10PRO_0000047178Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiO89091.

    PTM databases

    PhosphoSiteiO89091.

    Expressioni

    Inductioni

    By TGF-beta and GDNF.

    Gene expression databases

    BgeeiO89091.
    CleanExiMM_KLF10.
    GenevestigatoriO89091.

    Interactioni

    Protein-protein interaction databases

    BioGridi204195. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO89091.
    SMRiO89091. Positions 352-451.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri368 – 39225C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri398 – 42225C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117414.
    HOGENOMiHOG000059558.
    HOVERGENiHBG052264.
    InParanoidiO89091.
    KOiK09209.
    OMAiVQNPKPP.
    OrthoDBiEOG7FJH0Q.
    PhylomeDBiO89091.
    TreeFamiTF315506.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O89091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNFGASLQQ ASEGKMELIS EKPREGMHPW DKAEQSDFEA VEALMSMSCD    50
    WKSHFKKYLE NRPVTPVSDT SEDDSLLPGT PDLQTVPAFC LTPPYSPSDF 100
    EPSQGSNLTA SAPSTGHFKS FSDAAKPPGA TPFKEEEKNP LAAPPLPKAQ 150
    ATSVIRHTAD AQLCNHQSCP VKAASILNYQ DNSFRRRTHG NVEATRKNIP 200
    CAAVSPNRSK PEPSTVSDGD EKAGAALYDF AVPSSETVIC RSQPAPSSPV 250
    QKSVLVSSPT VSTGGVPPLP VICQMVPLPA NNSLVSTVVP STPPSQPPAV 300
    CSPVLFMGTQ VPEGTVVFVV PQPVVQSPRP PVVSPSGTRL SPIAPAPGFS 350
    PSAARVTPQI DSSRVRSHIC SHPGCGKTYF KSSHLKAHVR THTGEKPFSC 400
    SWKGCERRFA RSDELSRHRR THTGEKKFAC PMCDRRFMRS DHLTKHARRH 450
    LSAKKLPNWQ MEVSKLNDIA LPPTPASAQ 479
    Length:479
    Mass (Da):51,756
    Last modified:November 1, 1998 - v1
    Checksum:i99A5969665962963
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064088 mRNA. Translation: AAC16734.1.
    AF049880 Genomic DNA. Translation: AAC77797.1.
    AF049879 mRNA. Translation: AAC77796.1.
    BC003316 mRNA. Translation: AAH03316.1.
    CCDSiCCDS27438.1.
    RefSeqiNP_038720.1. NM_013692.3.
    UniGeneiMm.4292.

    Genome annotation databases

    EnsembliENSMUST00000074043; ENSMUSP00000073690; ENSMUSG00000037465.
    GeneIDi21847.
    KEGGimmu:21847.
    UCSCiuc007vnr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064088 mRNA. Translation: AAC16734.1 .
    AF049880 Genomic DNA. Translation: AAC77797.1 .
    AF049879 mRNA. Translation: AAC77796.1 .
    BC003316 mRNA. Translation: AAH03316.1 .
    CCDSi CCDS27438.1.
    RefSeqi NP_038720.1. NM_013692.3.
    UniGenei Mm.4292.

    3D structure databases

    ProteinModelPortali O89091.
    SMRi O89091. Positions 352-451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204195. 4 interactions.

    PTM databases

    PhosphoSitei O89091.

    Proteomic databases

    PRIDEi O89091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074043 ; ENSMUSP00000073690 ; ENSMUSG00000037465 .
    GeneIDi 21847.
    KEGGi mmu:21847.
    UCSCi uc007vnr.1. mouse.

    Organism-specific databases

    CTDi 7071.
    MGIi MGI:1101353. Klf10.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117414.
    HOGENOMi HOG000059558.
    HOVERGENi HBG052264.
    InParanoidi O89091.
    KOi K09209.
    OMAi VQNPKPP.
    OrthoDBi EOG7FJH0Q.
    PhylomeDBi O89091.
    TreeFami TF315506.

    Miscellaneous databases

    NextBioi 301322.
    PROi O89091.
    SOURCEi Search...

    Gene expression databases

    Bgeei O89091.
    CleanExi MM_KLF10.
    Genevestigatori O89091.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of murine glial cell-derived neurotrophic factor inducible transcription factor (MGIF)."
      Yajima S., Lammers C.H., Lee S.H., Hara Y., Mizuno K., Mouradian M.M.
      J. Neurosci. 17:8657-8666(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts."
      Fautsch M.P., Vrabel A., Rickard D., Subramaniam M., Spelsberg T.C., Wieben E.D.
      Mamm. Genome 9:838-842(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiKLF10_MOUSE
    AccessioniPrimary (citable) accession number: O89091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3