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Protein

Voltage-dependent N-type calcium channel subunit alpha

Gene

Cacna1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent N-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1bImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi628852. Cacna1b.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei97 – 114HelicalSequence analysisAdd BLAST18
Transmembranei135 – 156HelicalSequence analysisAdd BLAST22
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei223 – 245HelicalSequence analysisAdd BLAST23
Transmembranei300 – 321HelicalSequence analysisAdd BLAST22
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Transmembranei510 – 527HelicalSequence analysisAdd BLAST18
Transmembranei548 – 566HelicalSequence analysisAdd BLAST19
Transmembranei609 – 631HelicalSequence analysisAdd BLAST23
Transmembranei687 – 709HelicalSequence analysisAdd BLAST23
Transmembranei1148 – 1166HelicalSequence analysisAdd BLAST19
Transmembranei1186 – 1206HelicalSequence analysisAdd BLAST21
Transmembranei1218 – 1236HelicalSequence analysisAdd BLAST19
Transmembranei1279 – 1301HelicalSequence analysisAdd BLAST23
Transmembranei1391 – 1416HelicalSequence analysisAdd BLAST26
Transmembranei1472 – 1490HelicalSequence analysisAdd BLAST19
Transmembranei1502 – 1528HelicalSequence analysisAdd BLAST27
Transmembranei1595 – 1613HelicalSequence analysisAdd BLAST19
Transmembranei1682 – 1705HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO89089.

Expressioni

Gene expression databases

GenevisibleiO89089. RN.

Interactioni

Protein-protein interaction databases

IntActiO89089. 1 interactor.
STRINGi10116.ENSRNOP00000006162.

Structurei

3D structure databases

ProteinModelPortaliO89089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1721 – 1756EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili712 – 738Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRFGDELGG RYGGTGGGER ARGGGAGGAG GPGQGGLPPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
160 170 180 190 200
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDA EPVGDFPCGK EAPARLCDSD TECREYWPGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDKNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFVD LCAAGSPFAR
460 470 480 490 500
ASLKSGKTES SSYFRRKEKM FRFLIRRMVK AQSFYWVVLC VVALNTLCVA
510 520 530 540 550
MVHYNQPQRL TTALYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD
560 570 580 590 600
FGVIVGSIFE VVWAAIKPGT SFGISVLRAL RLLRIFKVTK YWNSLRNLVV
610 620 630 640 650
SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP
660 670 680 690 700
AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL
710 720 730 740 750
LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA
760 770 780 790 800
NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRYA
810 820 830 840 850
STRHVRPDMK THMDRPLVVE PGRDGLRGPA GNKSKPEGTE ATEGADPPRR
860 870 880 890 900
HHRHRDRDKT SASTPAGGEQ DRTDCPKAES TETGAREERA RPRRSHSKEA
910 920 930 940 950
PGADTQVRCE RSRRHHRRGS PEEATEREPR RHRAHRHAQD SSKEGKEGTA
960 970 980 990 1000
PVLVPKGERR ARHRGPRTGP RETENSEEPT RRHRAKHKVP PTLEPPEREV
1010 1020 1030 1040 1050
AEKESNVVEG DKETRNHQPK EPRCDLEAIA VTGVGSLHML PSTCLQKVDE
1060 1070 1080 1090 1100
QPEDADNQRN VTRMGSQPSD PSTTVHVPVT LTGPPGEATV VPSANTDLEG
1110 1120 1130 1140 1150
QAEGKKEAEA DDVLRRGPRP IVPYSSMFCL SPTNLLRRFC HYIVTMRYFE
1160 1170 1180 1190 1200
MVILVVIALS SIALAAEDPV RTDSFRNNAL KYMDYIFTGV FTFEMVIKMI
1210 1220 1230 1240 1250
DLGLLLHPGA YFRDLWNILD FIVVSGALVA FAFSGSKGKD INTIKSLRVL
1260 1270 1280 1290 1300
RVLRPLKTIK RLPKLKAVFD CVVNSLKNVL NILIVYMLFM FIFAVIAVQL
1310 1320 1330 1340 1350
FKGKFFYCTD ESKELERDCR GQYLDYEKEE VEAQPRQWKK YDFHYDNVLW
1360 1370 1380 1390 1400
ALLTLFTVST GEGWPMVLKH SVDATYEEQG PSPGFRMELS IFYVVYFVVF
1410 1420 1430 1440 1450
PFFFVNIFVA LIIITFQEQG DKVMSECSLE KNERACIDFA ISAKPLTRYM
1460 1470 1480 1490 1500
PQNKQSFQYK TWTFVVSPPF EYFIMAMIAL NTVVLMMKFY DAPYEYELML
1510 1520 1530 1540 1550
KCLNIVFTSM FSLECILKII AFGVLNYFRD AWNVFDFVTV LGSITDILVT
1560 1570 1580 1590 1600
EIAETNNFIN LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC
1610 1620 1630 1640 1650
LLIAMLFFIY AIIGMQVFGN IALDDGTSIN RHNNFRTFLQ ALMLLFRSAT
1660 1670 1680 1690 1700
GEAWHEIMLS CLGNRACDPH ANASECGSDF AYFYFVSFIF LCSFLMLNLF
1710 1720 1730 1740 1750
VAVIMDNFEY LTRDSSILGP HHLDEFIRVW AEYDPAACGR ISYNDMFEML
1760 1770 1780 1790 1800
KHMSPPLGLG KKCPARVAYK RLVRMNMPIS NEDMTVHFTS TLMALIRTAL
1810 1820 1830 1840 1850
EIKLAPAGTK QHQCDAELRK EISSVWANLP QKTLDLLVPP HKPDEMTVGK
1860 1870 1880 1890 1900
VYAALMIFDF YKQNKTTRDQ THQAPGGLSQ MGPVSLFHPL KATLEQTQPA
1910 1920 1930 1940 1950
VLRGARVFLR QKSATSLSNG GAIQTQESGI KESLSWGTQR TQDVLYEARA
1960 1970 1980 1990 2000
PLERGHSAEI PVGQPGALAV DVQMQNMTLR GPDGEPQPGL ESQGRAASMP
2010 2020 2030 2040 2050
RLAAETQPAP NASPMKRSIS TLAPRPHGTQ LCNTVLDRPP PSQVSHHHHH
2060 2070 2080 2090 2100
RCHRRRDKKQ RSLEKGPSLS VDTEGAPSTA AGSGLPHGEG STGCRRERKQ
2110 2120 2130 2140 2150
ERGRSQERRQ PSSSSSEKQR FYSCDRFGSR EPPQPKPSLS SHPISPTAAL
2160 2170 2180 2190 2200
EPGPHPQGSG SVNGSPLMST SGASTPGRGG RRQLPQTPLT PRPSITYKTA
2210 2220 2230 2240 2250
NSSPVHFAEG QSGLPAFSPG RLSRGLSEHN ALLQKEPLSQ PLASGSRIGS
2260 2270 2280 2290 2300
DPYLGQRLDS EASAHNLPED TLTFEEAVAT NSGRSSRTSY VSSLTSQSHP
2310 2320 2330
LRRVPNGYHC TLGLSTGVRA RHSYHHPDQD HWC
Length:2,333
Mass (Da):261,931
Last modified:November 1, 1998 - v1
Checksum:i14FC8E180CB2AAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055477 mRNA. Translation: AAC29043.1.
PIRiA45386.
RefSeqiNP_671482.1. NM_147141.1.
UniGeneiRn.85880.

Genome annotation databases

GeneIDi257648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055477 mRNA. Translation: AAC29043.1.
PIRiA45386.
RefSeqiNP_671482.1. NM_147141.1.
UniGeneiRn.85880.

3D structure databases

ProteinModelPortaliO89089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO89089. 1 interactor.
STRINGi10116.ENSRNOP00000006162.

Proteomic databases

PaxDbiO89089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi257648.

Organism-specific databases

CTDi774.
RGDi628852. Cacna1b.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Gene expression databases

GenevisibleiO89089. RN.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO89089_RAT
AccessioniPrimary (citable) accession number: O89089
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.