ID   PDE4A_CAVPO             Reviewed;         117 AA.
AC   O89085;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   16-JUN-2009, entry version 40.
DE   RecName: Full=cAMP-specific 3',5'-cyclic phosphodiesterase 4A;
DE            EC=3.1.4.17;
DE   Flags: Fragment;
GN   Name=PDE4A;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricognathi; Caviidae; Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=98343959; PubMed=9677330;
RA   Sullivan M., Rena G., Begg F., Gordon L., Olsen A.S., Houslay M.D.;
RT   "Identification and characterization of the human homologue of the
RT   short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by
RT   analysis of the human HSPDE4A gene locus located at chromosome
RT   19p13.2.";
RL   Biochem. J. 333:693-703(1998).
CC   -!- CATALYTIC ACTIVITY: Adenosine 3',5'-cyclic phosphate + H(2)O =
CC       adenosine 5'-phosphate.
CC   -!- PATHWAY: Purine metabolism; cAMP degradation; AMP from cAMP: step
CC       1/1.
CC   -!- PTM: Phosphorylated on serine residues (By similarity).
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family.
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DR   EMBL; U97588; AAC25683.1; -; mRNA.
DR   Ensembl; ENSCPOG00000024714; Cavia porcellus.
DR   HOVERGEN; O89085; -.
DR   BRENDA; 3.1.4.17; 44.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase a...; IEA:EC.
DR   InterPro; IPR000886; ER_targeting_sequence.
DR   InterPro; IPR002073; PDEase.
DR   PROSITE; PS00014; ER_TARGET; 1.
DR   PROSITE; PS00126; PDEASE_I; PARTIAL.
PE   3: Inferred from homology;
KW   cAMP; Hydrolase; Phosphoprotein.
FT   CHAIN        <1   >117       cAMP-specific 3',5'-cyclic
FT                                phosphodiesterase 4A.
FT                                /FTId=PRO_0000198805.
FT   REGION       78   >117       Catalytic (By similarity).
FT   NON_TER       1      1
FT   NON_TER     117    117
SQ   SEQUENCE   117 AA;  13503 MW;  87288E127BA6D008 CRC64;
     PWLVGWWDQF KRMLNRELTH LSEMSRSGNQ VSEYISTTFL DKQNEVEIPS PTMKDREPQE
     APRQRPCQQL PPPVPHLQPM SQITGVKRLS HNSGLNNASI PRFGVKTDQE ELLAQEL
//