O89085 (PDE4A_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
EC=3.1.4.17

Gene names

Name:

PDE4A

Organism

Cavia porcellus (Guinea pig) [Reference proteome]

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	117 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity.
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Subunit structure	Interacts with LYN and ARRB2 By similarity.
Subcellular location	Cytoplasm › perinuclear region By similarity.
Post-translational modification	Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation By similarity. Sumoylated by PIAS4 By similarity.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	cAMP
Molecular function	Hydrolase
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cAMP catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›117	›117	cAMP-specific 3',5'-cyclic phosphodiesterase 4A		PRO_0000198805
Regions
	Region	78 – ›117	›40	Catalytic By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	117	1

Sequences

	Sequence		Length	Mass (Da)
	O89085 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 87288E127BA6D008	FASTA	117	13,503
	10 20 30 40 50 60 PWLVGWWDQF KRMLNRELTH LSEMSRSGNQ VSEYISTTFL DKQNEVEIPS PTMKDREPQE 70 80 90 100 110 APRQRPCQQL PPPVPHLQPM SQITGVKRLS HNSGLNNASI PRFGVKTDQE ELLAQEL

References

[1]

"Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2." Sullivan M., Rena G., Begg F., Gordon L., Olsen A.S., Houslay M.D. Biochem. J. 333:693-703(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U97588 mRNA. Translation: AAC25683.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10141.ENSCPOP00000014250.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG122287.
Enzyme and pathway databases
UniPathway	UPA00762; UER00747.
Family and domain databases
PROSITE	PS00014. ER_TARGET. 1 hit. PS00126. PDEASE_I. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDE4A_CAVPO

Accession

Primary (citable) accession number: O89085

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program