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Reviewed, UniProtKB/Swiss-Prot O89085 (PDE4A_CAVPO)

Last modified October 13, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4A
    EC=3.1.4.17
Gene names
Name: PDE4A
OrganismCavia porcellus (Guinea pig)
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length117 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Subunit structure

Interacts with LYN and ARRB2 By similarity.

Subcellular location

Cytoplasmperinuclear region By similarity.

Post-translational modification

Phosphorylated on serine residues By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandcAMP
   Molecular functionHydrolase
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: InterPro

   Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›117›117cAMP-specific 3',5'-cyclic phosphodiesterase 4A
PRO_0000198805

Regions

Region78 – ›117›40Catalytic By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1171

Sequences

Sequence LengthMass (Da)Tools
O89085-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 87288E127BA6D008

FASTA11713,503
        10         20         30         40         50         60 
PWLVGWWDQF KRMLNRELTH LSEMSRSGNQ VSEYISTTFL DKQNEVEIPS PTMKDREPQE 

        70         80         90        100        110 
APRQRPCQQL PPPVPHLQPM SQITGVKRLS HNSGLNNASI PRFGVKTDQE ELLAQEL 

« Hide

References

[1]"Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2."
Sullivan M., Rena G., Begg F., Gordon L., Olsen A.S., Houslay M.D.
Biochem. J. 333:693-703(1998) [PubMed: 9677330] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

U97588 mRNA. Translation: AAC25683.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSCPOT00000027878; ENSCPOP00000014250; ENSCPOG00000024714; Cavia porcellus. [Genome view]
ENSCPOT00000028334; ENSCPOP00000016396; ENSCPOG00000024714; Cavia porcellus. [Genome view]

Phylogenomic databases

HOVERGENO89085.

Enzyme and pathway databases

BRENDA3.1.4.17. 44.

Family and domain databases

InterProIPR000886. ER_target_seq_motif.
IPR002073. PDEase.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS00126. PDEASE_I. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDE4A_CAVPO
AccessionPrimary (citable) accession number: O89085
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 1, 1998
Last modified: October 13, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents