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O89085 (PDE4A_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A

EC=3.1.4.53
Gene names
Name:PDE4A
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length117 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity.

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

Pathway

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Subunit structure

Interacts with LYN and ARRB2 By similarity.

Subcellular location

Cytoplasmperinuclear region By similarity.

Post-translational modification

Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation By similarity.

Sumoylated by PIAS4 By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandcAMP
   Molecular functionHydrolase
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcAMP catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentperinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›117›117cAMP-specific 3',5'-cyclic phosphodiesterase 4A
PRO_0000198805

Regions

Region78 – ›117›40Catalytic By similarity

Experimental info

Non-terminal residue11
Non-terminal residue1171

Sequences

Sequence LengthMass (Da)Tools
O89085 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 87288E127BA6D008

FASTA11713,503
        10         20         30         40         50         60 
PWLVGWWDQF KRMLNRELTH LSEMSRSGNQ VSEYISTTFL DKQNEVEIPS PTMKDREPQE 

        70         80         90        100        110 
APRQRPCQQL PPPVPHLQPM SQITGVKRLS HNSGLNNASI PRFGVKTDQE ELLAQEL 

« Hide

References

[1]"Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2."
Sullivan M., Rena G., Begg F., Gordon L., Olsen A.S., Houslay M.D.
Biochem. J. 333:693-703(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U97588 mRNA. Translation: AAC25683.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000014250.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG122287.

Enzyme and pathway databases

UniPathwayUPA00762; UER00747.

Family and domain databases

PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDE4A_CAVPO
AccessionPrimary (citable) accession number: O89085
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 1, 1998
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways