Reviewed, UniProtKB/Swiss-Prot O89085 (PDE4A_CAVPO)

Names and origin

Protein names

Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4A
    EC=3.1.4.17

Gene names

Name:

PDE4A

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	117 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Subunit structure	Interacts with LYN and ARRB2 By similarity.
Subcellular location	Cytoplasm › perinuclear region By similarity.
Post-translational modification	Phosphorylated on serine residues By similarity.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	cAMP
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: InterPro
Molecular function	3',5'-cyclic-nucleotide phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›117	›117	cAMP-specific 3',5'-cyclic phosphodiesterase 4A		PRO_0000198805
Regions
	Region	78 – ›117	›40	Catalytic By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	117	1

Sequences

	Sequence		Length	Mass (Da)
	O89085-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 87288E127BA6D008	FASTA	117	13,503
	10 20 30 40 50 60 PWLVGWWDQF KRMLNRELTH LSEMSRSGNQ VSEYISTTFL DKQNEVEIPS PTMKDREPQE 70 80 90 100 110 APRQRPCQQL PPPVPHLQPM SQITGVKRLS HNSGLNNASI PRFGVKTDQE ELLAQEL

References

[1]

"Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2." Sullivan M., Rena G., Begg F., Gordon L., Olsen A.S., Houslay M.D. Biochem. J. 333:693-703(1998) [PubMed: 9677330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U97588 mRNA. Translation: AAC25683.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000027878; ENSCPOP00000014250; ENSCPOG00000024714; Cavia porcellus. [Genome view] ENSCPOT00000028334; ENSCPOP00000016396; ENSCPOG00000024714; Cavia porcellus. [Genome view]
Phylogenomic databases
HOVERGEN	O89085.
Enzyme and pathway databases
BRENDA	3.1.4.17. 44.
Family and domain databases
InterPro	IPR000886. ER_target_seq_motif. IPR002073. PDEase. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. PS00126. PDEASE_I. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDE4A_CAVPO

Accession

Primary (citable) accession number: O89085

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	November 1, 1998
Last modified:	October 13, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)