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O89079

- COPE_MOUSE

UniProt

O89079 - COPE_MOUSE

Protein

Coatomer subunit epsilon

Gene

Cope

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. retrograde vesicle-mediated transport, Golgi to ER Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_227904. COPI Mediated Transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coatomer subunit epsilon
    Alternative name(s):
    Epsilon-coat protein
    Short name:
    Epsilon-COP
    Gene namesi
    Name:Cope
    Synonyms:Cope1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1891702. Cope.

    Subcellular locationi

    Cytoplasm By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.By similarity

    GO - Cellular componenti

    1. COPI-coated vesicle Source: MGI
    2. COPI-coated vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 308307Coatomer subunit epsilonPRO_0000193852Add
    BLAST

    Post-translational modificationi

    Phosphorylated by PKA.By similarity
    Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO89079.
    PaxDbiO89079.
    PRIDEiO89079.

    2D gel databases

    REPRODUCTION-2DPAGEO89079.

    PTM databases

    PhosphoSiteiO89079.

    Expressioni

    Gene expression databases

    ArrayExpressiO89079.
    BgeeiO89079.
    CleanExiMM_COPE.
    GenevestigatoriO89079.

    Interactioni

    Subunit structurei

    Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

    Protein-protein interaction databases

    MINTiMINT-1865171.
    STRINGi10090.ENSMUSP00000071078.

    Structurei

    3D structure databases

    ProteinModelPortaliO89079.
    SMRiO89079. Positions 17-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COPE family.Curated

    Phylogenomic databases

    eggNOGiNOG289253.
    GeneTreeiENSGT00390000003478.
    HOGENOMiHOG000205825.
    HOVERGENiHBG002201.
    InParanoidiO89079.
    KOiK17268.
    OMAiMAQGKWD.
    OrthoDBiEOG7QK0CC.
    PhylomeDBiO89079.
    TreeFamiTF313390.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006822. Coatomer_esu.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR10805. PTHR10805. 1 hit.
    PfamiPF04733. Coatomer_E. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016478. Coatomer_esu. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O89079-1 [UniParc]FASTAAdd to Basket

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    MAPPVPGAVS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPEREV    50
    ERDVFLYRAY LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASENQRDSI 100
    VLELDREMSR SVDVTNTTFL LMAASIYFHD QNPDAALRTL HQGDGLECMA 150
    MTIQILLKLD RLDLARKELK KMQDQDEDAT LTQLATAWVN LAVGGEKLQE 200
    AYYIFQELAD KCSPTLLLLN GQAACHSAQG RWETAEGVLQ EALDKDSGHP 250
    ETLINLIVLS QHLGKPPEVT NRYLSQLKDA HRAHPFIKEY QAKENDFDRL 300
    AMQYAPSA 308
    Length:308
    Mass (Da):34,567
    Last modified:January 23, 2007 - v3
    Checksum:i81331BDDB1F99270
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti291 – 2911Q → R in AAC36533. (PubMed:9798653)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039837 mRNA. Translation: BAA92384.1.
    BC009170 mRNA. Translation: AAH09170.1.
    BC083336 mRNA. Translation: AAH83336.1.
    U89427 mRNA. Translation: AAC36533.1.
    CCDSiCCDS22365.1.
    RefSeqiNP_067513.1. NM_021538.1.
    UniGeneiMm.28668.

    Genome annotation databases

    EnsembliENSMUST00000066469; ENSMUSP00000071078; ENSMUSG00000055681.
    GeneIDi59042.
    KEGGimmu:59042.
    UCSCiuc009lzx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB039837 mRNA. Translation: BAA92384.1 .
    BC009170 mRNA. Translation: AAH09170.1 .
    BC083336 mRNA. Translation: AAH83336.1 .
    U89427 mRNA. Translation: AAC36533.1 .
    CCDSi CCDS22365.1.
    RefSeqi NP_067513.1. NM_021538.1.
    UniGenei Mm.28668.

    3D structure databases

    ProteinModelPortali O89079.
    SMRi O89079. Positions 17-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1865171.
    STRINGi 10090.ENSMUSP00000071078.

    PTM databases

    PhosphoSitei O89079.

    2D gel databases

    REPRODUCTION-2DPAGE O89079.

    Proteomic databases

    MaxQBi O89079.
    PaxDbi O89079.
    PRIDEi O89079.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066469 ; ENSMUSP00000071078 ; ENSMUSG00000055681 .
    GeneIDi 59042.
    KEGGi mmu:59042.
    UCSCi uc009lzx.1. mouse.

    Organism-specific databases

    CTDi 11316.
    MGIi MGI:1891702. Cope.

    Phylogenomic databases

    eggNOGi NOG289253.
    GeneTreei ENSGT00390000003478.
    HOGENOMi HOG000205825.
    HOVERGENi HBG002201.
    InParanoidi O89079.
    KOi K17268.
    OMAi MAQGKWD.
    OrthoDBi EOG7QK0CC.
    PhylomeDBi O89079.
    TreeFami TF313390.

    Enzyme and pathway databases

    Reactomei REACT_227904. COPI Mediated Transport.

    Miscellaneous databases

    NextBioi 314654.
    PROi O89079.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O89079.
    Bgeei O89079.
    CleanExi MM_COPE.
    Genevestigatori O89079.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006822. Coatomer_esu.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR10805. PTHR10805. 1 hit.
    Pfami PF04733. Coatomer_E. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016478. Coatomer_esu. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Cope1 gene for nonclathrin coat protein epsilon-COP."
      Hahn Y., Chung J.H.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Mammary tumor.
    3. "Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
      Chu C.C., Paul W.E.
      Mol. Immunol. 35:487-502(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-298.
      Strain: BALB/c.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCOPE_MOUSE
    AccessioniPrimary (citable) accession number: O89079
    Secondary accession number(s): Q9JM65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3