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O89079 (COPE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name=Epsilon-COP
Gene names
Name:Cope
Synonyms:Cope1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.

Subunit structure

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Subcellular location

Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity.

Post-translational modification

Phosphorylated by PKA By similarity.

Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation By similarity.

Sequence similarities

Belongs to the COPE family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 308307Coatomer subunit epsilon
PRO_0000193852

Experimental info

Sequence conflict2911Q → R in AAC36533. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O89079 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 81331BDDB1F99270

FASTA30834,567
        10         20         30         40         50         60 
MAPPVPGAVS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPEREV ERDVFLYRAY 

        70         80         90        100        110        120 
LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASENQRDSI VLELDREMSR SVDVTNTTFL 

       130        140        150        160        170        180 
LMAASIYFHD QNPDAALRTL HQGDGLECMA MTIQILLKLD RLDLARKELK KMQDQDEDAT 

       190        200        210        220        230        240 
LTQLATAWVN LAVGGEKLQE AYYIFQELAD KCSPTLLLLN GQAACHSAQG RWETAEGVLQ 

       250        260        270        280        290        300 
EALDKDSGHP ETLINLIVLS QHLGKPPEVT NRYLSQLKDA HRAHPFIKEY QAKENDFDRL 


AMQYAPSA 

« Hide

References

« Hide 'large scale' references
[1]"Mouse Cope1 gene for nonclathrin coat protein epsilon-COP."
Hahn Y., Chung J.H.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Mammary tumor.
[3]"Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
Chu C.C., Paul W.E.
Mol. Immunol. 35:487-502(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-298.
Strain: BALB/c.
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB039837 mRNA. Translation: BAA92384.1.
BC009170 mRNA. Translation: AAH09170.1.
BC083336 mRNA. Translation: AAH83336.1.
U89427 mRNA. Translation: AAC36533.1.
RefSeqNP_067513.1. NM_021538.1.
UniGeneMm.28668.

3D structure databases

ProteinModelPortalO89079.
SMRO89079. Positions 17-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1865171.
STRING10090.ENSMUSP00000071078.

PTM databases

PhosphoSiteO89079.

2D gel databases

REPRODUCTION-2DPAGEO89079.

Proteomic databases

PaxDbO89079.
PRIDEO89079.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066469; ENSMUSP00000071078; ENSMUSG00000055681.
GeneID59042.
KEGGmmu:59042.
UCSCuc009lzx.1. mouse.

Organism-specific databases

CTD11316.
MGIMGI:1891702. Cope.

Phylogenomic databases

eggNOGNOG289253.
GeneTreeENSGT00390000003478.
HOGENOMHOG000205825.
HOVERGENHBG002201.
InParanoidO89079.
KOK17268.
OMASIYYHEM.
OrthoDBEOG7QK0CC.
PhylomeDBO89079.
TreeFamTF313390.

Gene expression databases

ArrayExpressO89079.
BgeeO89079.
CleanExMM_COPE.
GenevestigatorO89079.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR006822. Coatomer_esu.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERPTHR10805. PTHR10805. 1 hit.
PfamPF04733. Coatomer_E. 1 hit.
[Graphical view]
PIRSFPIRSF016478. Coatomer_esu. 1 hit.
ProtoNetSearch...

Other

NextBio314654.
PROO89079.
SOURCESearch...

Entry information

Entry nameCOPE_MOUSE
AccessionPrimary (citable) accession number: O89079
Secondary accession number(s): Q9JM65
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot