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O89079

- COPE_MOUSE

UniProt

O89079 - COPE_MOUSE

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Protein

Coatomer subunit epsilon

Gene
Cope, Cope1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors By similarity.

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. retrograde vesicle-mediated transport, Golgi to ER Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_227904. COPI Mediated Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name:
Epsilon-COP
Gene namesi
Name:Cope
Synonyms:Cope1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1891702. Cope.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it By similarity.

GO - Cellular componenti

  1. COPI-coated vesicle Source: MGI
  2. COPI-coated vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 308307Coatomer subunit epsilonPRO_0000193852Add
BLAST

Post-translational modificationi

Phosphorylated by PKA By similarity.
Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO89079.
PaxDbiO89079.
PRIDEiO89079.

2D gel databases

REPRODUCTION-2DPAGEO89079.

PTM databases

PhosphoSiteiO89079.

Expressioni

Gene expression databases

ArrayExpressiO89079.
BgeeiO89079.
CleanExiMM_COPE.
GenevestigatoriO89079.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Protein-protein interaction databases

MINTiMINT-1865171.
STRINGi10090.ENSMUSP00000071078.

Structurei

3D structure databases

ProteinModelPortaliO89079.
SMRiO89079. Positions 17-307.

Family & Domainsi

Sequence similaritiesi

Belongs to the COPE family.

Phylogenomic databases

eggNOGiNOG289253.
GeneTreeiENSGT00390000003478.
HOGENOMiHOG000205825.
HOVERGENiHBG002201.
InParanoidiO89079.
KOiK17268.
OMAiMAQGKWD.
OrthoDBiEOG7QK0CC.
PhylomeDBiO89079.
TreeFamiTF313390.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006822. Coatomer_esu.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR10805. PTHR10805. 1 hit.
PfamiPF04733. Coatomer_E. 1 hit.
[Graphical view]
PIRSFiPIRSF016478. Coatomer_esu. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O89079-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPVPGAVS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPEREV    50
ERDVFLYRAY LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASENQRDSI 100
VLELDREMSR SVDVTNTTFL LMAASIYFHD QNPDAALRTL HQGDGLECMA 150
MTIQILLKLD RLDLARKELK KMQDQDEDAT LTQLATAWVN LAVGGEKLQE 200
AYYIFQELAD KCSPTLLLLN GQAACHSAQG RWETAEGVLQ EALDKDSGHP 250
ETLINLIVLS QHLGKPPEVT NRYLSQLKDA HRAHPFIKEY QAKENDFDRL 300
AMQYAPSA 308
Length:308
Mass (Da):34,567
Last modified:January 23, 2007 - v3
Checksum:i81331BDDB1F99270
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti291 – 2911Q → R in AAC36533. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039837 mRNA. Translation: BAA92384.1.
BC009170 mRNA. Translation: AAH09170.1.
BC083336 mRNA. Translation: AAH83336.1.
U89427 mRNA. Translation: AAC36533.1.
CCDSiCCDS22365.1.
RefSeqiNP_067513.1. NM_021538.1.
UniGeneiMm.28668.

Genome annotation databases

EnsembliENSMUST00000066469; ENSMUSP00000071078; ENSMUSG00000055681.
GeneIDi59042.
KEGGimmu:59042.
UCSCiuc009lzx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB039837 mRNA. Translation: BAA92384.1 .
BC009170 mRNA. Translation: AAH09170.1 .
BC083336 mRNA. Translation: AAH83336.1 .
U89427 mRNA. Translation: AAC36533.1 .
CCDSi CCDS22365.1.
RefSeqi NP_067513.1. NM_021538.1.
UniGenei Mm.28668.

3D structure databases

ProteinModelPortali O89079.
SMRi O89079. Positions 17-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1865171.
STRINGi 10090.ENSMUSP00000071078.

PTM databases

PhosphoSitei O89079.

2D gel databases

REPRODUCTION-2DPAGE O89079.

Proteomic databases

MaxQBi O89079.
PaxDbi O89079.
PRIDEi O89079.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066469 ; ENSMUSP00000071078 ; ENSMUSG00000055681 .
GeneIDi 59042.
KEGGi mmu:59042.
UCSCi uc009lzx.1. mouse.

Organism-specific databases

CTDi 11316.
MGIi MGI:1891702. Cope.

Phylogenomic databases

eggNOGi NOG289253.
GeneTreei ENSGT00390000003478.
HOGENOMi HOG000205825.
HOVERGENi HBG002201.
InParanoidi O89079.
KOi K17268.
OMAi MAQGKWD.
OrthoDBi EOG7QK0CC.
PhylomeDBi O89079.
TreeFami TF313390.

Enzyme and pathway databases

Reactomei REACT_227904. COPI Mediated Transport.

Miscellaneous databases

NextBioi 314654.
PROi O89079.
SOURCEi Search...

Gene expression databases

ArrayExpressi O89079.
Bgeei O89079.
CleanExi MM_COPE.
Genevestigatori O89079.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006822. Coatomer_esu.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR10805. PTHR10805. 1 hit.
Pfami PF04733. Coatomer_E. 1 hit.
[Graphical view ]
PIRSFi PIRSF016478. Coatomer_esu. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse Cope1 gene for nonclathrin coat protein epsilon-COP."
    Hahn Y., Chung J.H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.
  3. "Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
    Chu C.C., Paul W.E.
    Mol. Immunol. 35:487-502(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 155-298.
    Strain: BALB/c.
    Tissue: Spleen.

Entry informationi

Entry nameiCOPE_MOUSE
AccessioniPrimary (citable) accession number: O89079
Secondary accession number(s): Q9JM65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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