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O89047

- KCNH3_RAT

UniProt

O89047 - KCNH3_RAT

Protein

Potassium voltage-gated channel subfamily H member 3

Gene

Kcnh3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi585 – 700116cNMPAdd
    BLAST

    GO - Molecular functioni

    1. phosphorelay sensor kinase activity Source: InterPro
    2. voltage-gated potassium channel activity Source: RefGenome

    GO - Biological processi

    1. potassium ion transmembrane transport Source: RefGenome
    2. regulation of membrane potential Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily H member 3
    Alternative name(s):
    Brain-specific eag-like channel 1
    Short name:
    BEC1
    Ether-a-go-go-like potassium channel 2
    Short name:
    ELK channel 2
    Short name:
    rElk2
    Voltage-gated potassium channel subunit Kv12.2
    Gene namesi
    Name:Kcnh3
    Synonyms:Elk2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi71070. Kcnh3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10871087Potassium voltage-gated channel subfamily H member 3PRO_0000054007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi421 – 4211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO89047.

    Expressioni

    Tissue specificityi

    Highly expressed in adult and embryonic brain, in particular in cerebellum, brain stem, hippocampus, cortex and striatum. Detected at slightly lower levels in heart, spinal cord, olfactory bulb, pituitary and medulla. In the hippocampus expression is strongest in the pyramidal cell body layers of the dentate gyrus. Also found in pituitary.1 Publication

    Gene expression databases

    GenevestigatoriO89047.

    Interactioni

    Subunit structurei

    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000047211.

    Structurei

    3D structure databases

    ProteinModelPortaliO89047.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 228228CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini250 – 25910ExtracellularSequence Analysis
    Topological domaini281 – 30222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 3318ExtracellularSequence Analysis
    Topological domaini353 – 3619CytoplasmicSequence Analysis
    Topological domaini383 – 45674ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini478 – 4825ExtracellularSequence Analysis
    Topological domaini504 – 1087584CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei457 – 47721Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei229 – 24921Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei483 – 50321Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 9073PASPROSITE-ProRule annotationAdd
    BLAST
    Domaini93 – 14553PACPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi468 – 4736Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi954 – 1061108Pro-richAdd
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 PAC (PAS-associated C-terminal) domain.PROSITE-ProRule annotation
    Contains 1 PAS (PER-ARNT-SIM) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2202.
    GeneTreeiENSGT00680000099929.
    HOGENOMiHOG000230794.
    HOVERGENiHBG052232.
    InParanoidiO89047.
    KOiK04906.
    OMAiPLMAPWP.
    OrthoDBiEOG7QG43V.
    PhylomeDBiO89047.
    TreeFamiTF313130.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view]
    PRINTSiPR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTiSM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O89047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC     50
    DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 100
    RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG 150
    GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 200
    NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 250
    AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 300
    HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD 350
    RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIENSE SELPEIGWLQ 400
    ELARRLETPY YLVSRSPDGG NSSGQSENCS SSGGGSEANG TGLELLGGPS 450
    LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF 500
    GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA 550
    VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 600
    LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC 650
    ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR 700
    GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTISPAPAD 750
    EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP 800
    SAHPRTLDGL QLPPMPWNVP PDLSPRVVDG IEDGCGSDQH KFSFRVGQSG 850
    PECSSSPSPG TESGLLTVPL VPSEARNTDT LDKLRQAVTE LSEQVLQMRE 900
    GLQSLRQAVQ LILVPQGEGQ CPRVSGEGPC PATASGLLQP LRVDTGASSY 950
    CLQPPAGSVL SGTWPHPRPG HPPPLMAPWP WGPPASQSSP WPRATALWTS 1000
    TSDSEPPGSG DLCSEPSTPA SPPPPEEGAR TGTPAPVSQA EATSTGEPPP 1050
    GSGGRALPWD PHSLEMVLIG CHGPGSVQWT QEEGTGV 1087
    Length:1,087
    Mass (Da):117,580
    Last modified:November 1, 1998 - v1
    Checksum:i16B5AFFC3B0A405B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007627 mRNA. Translation: CAA07586.1.
    AB022697 mRNA. Translation: BAA83591.1.
    AF073892 mRNA. Translation: AAC61522.1.
    PIRiT31100.
    RefSeqiNP_058804.1. NM_017108.1.
    UniGeneiRn.144567.

    Genome annotation databases

    EnsembliENSRNOT00000045515; ENSRNOP00000047211; ENSRNOG00000032075.
    GeneIDi27150.
    KEGGirno:27150.
    UCSCiRGD:71070. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007627 mRNA. Translation: CAA07586.1 .
    AB022697 mRNA. Translation: BAA83591.1 .
    AF073892 mRNA. Translation: AAC61522.1 .
    PIRi T31100.
    RefSeqi NP_058804.1. NM_017108.1.
    UniGenei Rn.144567.

    3D structure databases

    ProteinModelPortali O89047.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000047211.

    Proteomic databases

    PaxDbi O89047.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000045515 ; ENSRNOP00000047211 ; ENSRNOG00000032075 .
    GeneIDi 27150.
    KEGGi rno:27150.
    UCSCi RGD:71070. rat.

    Organism-specific databases

    CTDi 23416.
    RGDi 71070. Kcnh3.

    Phylogenomic databases

    eggNOGi COG2202.
    GeneTreei ENSGT00680000099929.
    HOGENOMi HOG000230794.
    HOVERGENi HBG052232.
    InParanoidi O89047.
    KOi K04906.
    OMAi PLMAPWP.
    OrthoDBi EOG7QG43V.
    PhylomeDBi O89047.
    TreeFami TF313130.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 608061.
    PROi O89047.

    Gene expression databases

    Genevestigatori O89047.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR005821. Ion_trans_dom.
    IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
    IPR003950. K_chnl_volt-dep_ELK.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR000700. PAS-assoc_C.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF13426. PAS_9. 1 hit.
    [Graphical view ]
    PRINTSi PR01463. EAGCHANLFMLY.
    PR01465. ELKCHANNEL.
    SMARTi SM00100. cNMP. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    SSF55785. SSF55785. 1 hit.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS50113. PAC. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional expression of rat ether-a-go-go-like K+ channel genes."
      Engeland B., Neu A., Ludwig J., Roeper J., Pongs O.
      J. Physiol. (Lond.) 513:647-654(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain cortex.
    2. "New ether-a-go-go K+ channel family members localized in human telencephalon."
      Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
      J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia."
      Shi W., Wang H.-S., Pan Z., Wymore R.S., Cohen I.S., McKinnon D., Dixon J.E.
      J. Physiol. (Lond.) 511:675-682(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-273.
      Tissue: Brain.
    4. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
      Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
      J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKCNH3_RAT
    AccessioniPrimary (citable) accession number: O89047
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3