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O89047

- KCNH3_RAT

UniProt

O89047 - KCNH3_RAT

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Protein

Potassium voltage-gated channel subfamily H member 3

Gene
Kcnh3, Elk2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi585 – 700116cNMPAdd
BLAST

GO - Molecular functioni

  1. phosphorelay sensor kinase activity Source: InterPro
  2. voltage-gated potassium channel activity Source: RefGenome

GO - Biological processi

  1. potassium ion transmembrane transport Source: RefGenome
  2. regulation of membrane potential Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 3
Alternative name(s):
Brain-specific eag-like channel 1
Short name:
BEC1
Ether-a-go-go-like potassium channel 2
Short name:
ELK channel 2
Short name:
rElk2
Voltage-gated potassium channel subunit Kv12.2
Gene namesi
Name:Kcnh3
Synonyms:Elk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi71070. Kcnh3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 228228Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei229 – 24921Helical; Name=Segment S1; Reviewed predictionAdd
BLAST
Topological domaini250 – 25910Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=Segment S2; Reviewed predictionAdd
BLAST
Topological domaini281 – 30222Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei303 – 32321Helical; Name=Segment S3; Reviewed predictionAdd
BLAST
Topological domaini324 – 3318Extracellular Reviewed prediction
Transmembranei332 – 35221Helical; Voltage-sensor; Name=Segment S4; Reviewed predictionAdd
BLAST
Topological domaini353 – 3619Cytoplasmic Reviewed prediction
Transmembranei362 – 38221Helical; Name=Segment S5; Reviewed predictionAdd
BLAST
Topological domaini383 – 45674Extracellular Reviewed predictionAdd
BLAST
Intramembranei457 – 47721Pore-forming; Name=Segment H5; Reviewed predictionAdd
BLAST
Topological domaini478 – 4825Extracellular Reviewed prediction
Transmembranei483 – 50321Helical; Name=Segment S6; Reviewed predictionAdd
BLAST
Topological domaini504 – 1087584Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10871087Potassium voltage-gated channel subfamily H member 3PRO_0000054007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi421 – 4211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO89047.

Expressioni

Tissue specificityi

Highly expressed in adult and embryonic brain, in particular in cerebellum, brain stem, hippocampus, cortex and striatum. Detected at slightly lower levels in heart, spinal cord, olfactory bulb, pituitary and medulla. In the hippocampus expression is strongest in the pyramidal cell body layers of the dentate gyrus. Also found in pituitary.1 Publication

Gene expression databases

GenevestigatoriO89047.

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047211.

Structurei

3D structure databases

ProteinModelPortaliO89047.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 9073PASAdd
BLAST
Domaini93 – 14553PACAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi468 – 4736Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi954 – 1061108Pro-richAdd
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2202.
GeneTreeiENSGT00680000099929.
HOGENOMiHOG000230794.
HOVERGENiHBG052232.
InParanoidiO89047.
KOiK04906.
OMAiPLMAPWP.
OrthoDBiEOG7QG43V.
PhylomeDBiO89047.
TreeFamiTF313130.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view]
PRINTSiPR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTiSM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89047-1 [UniParc]FASTAAdd to Basket

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MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC     50
DLTGFSRAEV MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY 100
RKSGLPFWCL LDVIPIKNEK GEVALFLVSH KDISETKNRG GPDNWKERGG 150
GRRRYGRAGS KGFNANRRRS RAVLYHLSGH LQKQPKGKHK LNKGVFGEKP 200
NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV TVPYSVCVST 250
AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 300
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD 350
RYSQYSAVVL TLLMAVFALL AHWVACVWFY IGQQEIENSE SELPEIGWLQ 400
ELARRLETPY YLVSRSPDGG NSSGQSENCS SSGGGSEANG TGLELLGGPS 450
LRSAYITSLY FALSSLTSVG FGNVSANTDT EKIFSICTML IGALMHAVVF 500
GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR MLEYFQATWA 550
VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 600
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC 650
ELPQREQVVK ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR 700
GELSYNLGAG GVSAEVDTSS LSGDNTLMST LEEKETDGEQ GHTISPAPAD 750
EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP RLGGRGRPSR AGVLKPEAGP 800
SAHPRTLDGL QLPPMPWNVP PDLSPRVVDG IEDGCGSDQH KFSFRVGQSG 850
PECSSSPSPG TESGLLTVPL VPSEARNTDT LDKLRQAVTE LSEQVLQMRE 900
GLQSLRQAVQ LILVPQGEGQ CPRVSGEGPC PATASGLLQP LRVDTGASSY 950
CLQPPAGSVL SGTWPHPRPG HPPPLMAPWP WGPPASQSSP WPRATALWTS 1000
TSDSEPPGSG DLCSEPSTPA SPPPPEEGAR TGTPAPVSQA EATSTGEPPP 1050
GSGGRALPWD PHSLEMVLIG CHGPGSVQWT QEEGTGV 1087
Length:1,087
Mass (Da):117,580
Last modified:November 1, 1998 - v1
Checksum:i16B5AFFC3B0A405B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007627 mRNA. Translation: CAA07586.1.
AB022697 mRNA. Translation: BAA83591.1.
AF073892 mRNA. Translation: AAC61522.1.
PIRiT31100.
RefSeqiNP_058804.1. NM_017108.1.
UniGeneiRn.144567.

Genome annotation databases

EnsembliENSRNOT00000045515; ENSRNOP00000047211; ENSRNOG00000032075.
GeneIDi27150.
KEGGirno:27150.
UCSCiRGD:71070. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007627 mRNA. Translation: CAA07586.1 .
AB022697 mRNA. Translation: BAA83591.1 .
AF073892 mRNA. Translation: AAC61522.1 .
PIRi T31100.
RefSeqi NP_058804.1. NM_017108.1.
UniGenei Rn.144567.

3D structure databases

ProteinModelPortali O89047.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000047211.

Proteomic databases

PaxDbi O89047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000045515 ; ENSRNOP00000047211 ; ENSRNOG00000032075 .
GeneIDi 27150.
KEGGi rno:27150.
UCSCi RGD:71070. rat.

Organism-specific databases

CTDi 23416.
RGDi 71070. Kcnh3.

Phylogenomic databases

eggNOGi COG2202.
GeneTreei ENSGT00680000099929.
HOGENOMi HOG000230794.
HOVERGENi HBG052232.
InParanoidi O89047.
KOi K04906.
OMAi PLMAPWP.
OrthoDBi EOG7QG43V.
PhylomeDBi O89047.
TreeFami TF313130.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 608061.
PROi O89047.

Gene expression databases

Genevestigatori O89047.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR005821. Ion_trans_dom.
IPR003938. K_chnl_volt-dep_EAG/ELK/ERG.
IPR003950. K_chnl_volt-dep_ELK.
IPR001610. PAC.
IPR000014. PAS.
IPR000700. PAS-assoc_C.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00520. Ion_trans. 1 hit.
PF13426. PAS_9. 1 hit.
[Graphical view ]
PRINTSi PR01463. EAGCHANLFMLY.
PR01465. ELKCHANNEL.
SMARTi SM00100. cNMP. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
SSF55785. SSF55785. 1 hit.
TIGRFAMsi TIGR00229. sensory_box. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS50113. PAC. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and functional expression of rat ether-a-go-go-like K+ channel genes."
    Engeland B., Neu A., Ludwig J., Roeper J., Pongs O.
    J. Physiol. (Lond.) 513:647-654(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain cortex.
  2. "New ether-a-go-go K+ channel family members localized in human telencephalon."
    Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K.
    J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia."
    Shi W., Wang H.-S., Pan Z., Wymore R.S., Cohen I.S., McKinnon D., Dixon J.E.
    J. Physiol. (Lond.) 511:675-682(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-273.
    Tissue: Brain.
  4. "Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary."
    Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R.
    J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiKCNH3_RAT
AccessioniPrimary (citable) accession number: O89047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi