Potassium voltage-gated channel subfamily H member 3

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O89047 (KCNH3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily H member 3

Alternative name(s):
Brain-specific eag-like channel 1
Short name=BEC1
Ether-a-go-go-like potassium channel 2
Short name=ELK channel 2
Short name=rElk2
Voltage-gated potassium channel subunit Kv12.2

Gene names

Name:	Kcnh3
Synonyms:	Elk2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1087 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.
Subunit structure	The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in adult and embryonic brain, in particular in cerebellum, brain stem, hippocampus, cortex and striatum. Detected at slightly lower levels in heart, spinal cord, olfactory bulb, pituitary and medulla. In the hippocampus expression is strongest in the pyramidal cell body layers of the dentate gyrus. Also found in pituitary. Ref.4
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily. [View classification] Contains 1 cyclic nucleotide-binding domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	phosphorelay sensor kinase activity Inferred from electronic annotation. Source: InterPro voltage-gated potassium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1087

1087

Potassium voltage-gated channel subfamily H member 3

PRO_0000054007

Regions

Topological domain

1 – 228

228

Cytoplasmic Potential

Transmembrane

229 – 249

Helical; Name=Segment S1; Potential

Topological domain

250 – 259

Extracellular Potential

Transmembrane

260 – 280

Helical; Name=Segment S2; Potential

Topological domain

281 – 302

Cytoplasmic Potential

Transmembrane

303 – 323

Helical; Name=Segment S3; Potential

Topological domain

324 – 331

Extracellular Potential

Transmembrane

332 – 352

Helical; Voltage-sensor; Name=Segment S4; Potential

Topological domain

353 – 361

Cytoplasmic Potential

Transmembrane

362 – 382

Helical; Name=Segment S5; Potential

Topological domain

383 – 456

Extracellular Potential

Intramembrane

457 – 477

Pore-forming; Name=Segment H5; Potential

Topological domain

478 – 482

Extracellular Potential

Transmembrane

483 – 503

Helical; Name=Segment S6; Potential

Topological domain

504 – 1087

584

Cytoplasmic Potential

Domain

18 – 90

PAS

Domain

93 – 145

PAC

Nucleotide binding

585 – 700

116

cNMP

Motif

468 – 473

Selectivity filter By similarity

Compositional bias

954 – 1061

108

Pro-rich

Amino acid modifications

Glycosylation

421

N-linked (GlcNAc...) Potential

Glycosylation

428

N-linked (GlcNAc...) Potential

Glycosylation

439

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O89047 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 16B5AFFC3B0A405B
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FASTA

1,087

117,580

        10         20         30         40         50         60 
MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC DLTGFSRAEV 

        70         80         90        100        110        120 
MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY RKSGLPFWCL LDVIPIKNEK 

       130        140        150        160        170        180 
GEVALFLVSH KDISETKNRG GPDNWKERGG GRRRYGRAGS KGFNANRRRS RAVLYHLSGH 

       190        200        210        220        230        240 
LQKQPKGKHK LNKGVFGEKP NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV 

       250        260        270        280        290        300 
TVPYSVCVST AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL 

       310        320        330        340        350        360 
HYVTTWFLLD VIAALPFDLL HAFKVNVYVG AHLLKTVRLL RLLRLLPRLD RYSQYSAVVL 

       370        380        390        400        410        420 
TLLMAVFALL AHWVACVWFY IGQQEIENSE SELPEIGWLQ ELARRLETPY YLVSRSPDGG 

       430        440        450        460        470        480 
NSSGQSENCS SSGGGSEANG TGLELLGGPS LRSAYITSLY FALSSLTSVG FGNVSANTDT 

       490        500        510        520        530        540 
EKIFSICTML IGALMHAVVF GNVTAIIQRM YARRFLYHSR TRDLRDYIRI HRIPKPLKQR 

       550        560        570        580        590        600 
MLEYFQATWA VNNGIDTTEL LQSLPDELRA DIAMHLHKEV LQLPLFEAAS RGCLRALSLA 

       610        620        630        640        650        660 
LRPAFCTPGE YLIHQGDALQ ALYFVCSGSM EVLKGGTVLA ILGKGDLIGC ELPQREQVVK 

       670        680        690        700        710        720 
ANADVKGLTY CVLQCLQLAG LHESLALYPE FAPRFSRGLR GELSYNLGAG GVSAEVDTSS 

       730        740        750        760        770        780 
LSGDNTLMST LEEKETDGEQ GHTISPAPAD EPSSPLLSPG CTSSSSAAKL LSPRRTAPRP 

       790        800        810        820        830        840 
RLGGRGRPSR AGVLKPEAGP SAHPRTLDGL QLPPMPWNVP PDLSPRVVDG IEDGCGSDQH 

       850        860        870        880        890        900 
KFSFRVGQSG PECSSSPSPG TESGLLTVPL VPSEARNTDT LDKLRQAVTE LSEQVLQMRE 

       910        920        930        940        950        960 
GLQSLRQAVQ LILVPQGEGQ CPRVSGEGPC PATASGLLQP LRVDTGASSY CLQPPAGSVL 

       970        980        990       1000       1010       1020 
SGTWPHPRPG HPPPLMAPWP WGPPASQSSP WPRATALWTS TSDSEPPGSG DLCSEPSTPA 

      1030       1040       1050       1060       1070       1080 
SPPPPEEGAR TGTPAPVSQA EATSTGEPPP GSGGRALPWD PHSLEMVLIG CHGPGSVQWT 


QEEGTGV

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References

[1]	"Cloning and functional expression of rat ether-a-go-go-like K+ channel genes." Engeland B., Neu A., Ludwig J., Roeper J., Pongs O. J. Physiol. (Lond.) 513:647-654(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain cortex.
[2]	"New ether-a-go-go K+ channel family members localized in human telencephalon." Miyake A., Mochizuki S., Yokoi H., Kohda M., Furuichi K. J. Biol. Chem. 274:25018-25025(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia." Shi W., Wang H.-S., Pan Z., Wymore R.S., Cohen I.S., McKinnon D., Dixon J.E. J. Physiol. (Lond.) 511:675-682(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 120-273. Tissue: Brain.
[4]	"Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary." Wulfsen I., Hauber H.-P., Schiemann D., Bauer C.K., Schwarz J.R. J. Neuroendocrinol. 12:263-272(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007627 mRNA. Translation: CAA07586.1. AB022697 mRNA. Translation: BAA83591.1. AF073892 mRNA. Translation: AAC61522.1.
IPI	IPI00209398.
PIR	T31100.
RefSeq	NP_058804.1. NM_017108.1.
UniGene	Rn.144567.
3D structure databases
ProteinModelPortal	O89047.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000047211.
Proteomic databases
PaxDb	O89047.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000045515; ENSRNOP00000047211; ENSRNOG00000032075.
GeneID	27150.
KEGG	rno:27150.
UCSC	RGD:71070. rat.
Organism-specific databases
CTD	23416.
RGD	71070. Kcnh3.
Phylogenomic databases
eggNOG	COG2202.
GeneTree	ENSGT00680000099929.
HOGENOM	HOG000230794.
HOVERGEN	HBG052232.
InParanoid	O89047.
KO	K04906.
OMA	PLMAPWP.
OrthoDB	EOG4255S1.
Gene expression databases
Genevestigator	O89047.
GermOnline	ENSRNOG00000032075. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.120.10. 1 hit.
InterPro	IPR018490. cNMP-bd-like. IPR000595. cNMP-bd_dom. IPR005821. Ion_trans_dom. IPR003938. K_chnl_volt-dep_EAG/ELK/ERG. IPR003950. K_chnl_volt-dep_ELK. IPR001610. PAC. IPR000014. PAS. IPR000700. PAS-assoc_C. IPR014710. RmlC-like_jellyroll. [Graphical view]
Pfam	PF00027. cNMP_binding. 1 hit. PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR01463. EAGCHANLFMLY. PR01465. ELKCHANNEL.
SMART	SM00100. cNMP. 1 hit. SM00086. PAC. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
SUPFAM	SSF51206. cNMP_binding. 1 hit.
TIGRFAMs	TIGR00229. sensory_box. 1 hit.
PROSITE	PS00888. CNMP_BINDING_1. False negative. PS00889. CNMP_BINDING_2. False negative. PS50042. CNMP_BINDING_3. 1 hit. PS50113. PAC. 1 hit. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	608061.

Entry information

Entry name

KCNH3_RAT

Accession

Primary (citable) accession number: O89047

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2002
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents