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Protein

Coronin-1B

Gene

Coro1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • Arp2/3 complex binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central
  • cellular response to platelet-derived growth factor stimulus Source: RGD
  • negative regulation of lamellipodium morphogenesis Source: UniProtKB
  • negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
  • protein kinase C signaling Source: RGD
  • regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1B
Alternative name(s):
Coronin-2
Gene namesi
Name:Coro1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2382 Coro1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509251 – 484Coronin-1BAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO89046
PRIDEiO89046

PTM databases

iPTMnetiO89046
PhosphoSitePlusiO89046
SwissPalmiO89046

Interactioni

Subunit structurei

Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiO89046, 3 interactors
MINTiO89046
STRINGi10116.ENSRNOP00000035020

Structurei

3D structure databases

ProteinModelPortaliO89046
SMRiO89046
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 120WD 1Add BLAST41
Repeati130 – 170WD 2Add BLAST41
Repeati174 – 213WD 3Add BLAST40
Repeati217 – 260WD 4Add BLAST44
Repeati265 – 305WD 5Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili447 – 481Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiO89046
KOiK13886
PhylomeDBiO89046

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027340 Coro1b
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF24 PTHR10856:SF24, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O89046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV
60 70 80 90 100
IVEASGGGAF MVLPLNKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS
110 120 130 140 150
GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIITW HPTARNVLLS
160 170 180 190 200
AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCTACKDKSV
210 220 230 240 250
RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTAGFS RMSERQLALW
260 270 280 290 300
DPENFEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITDE
310 320 330 340 350
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM
360 370 380 390 400
TVPRKSDLFQ DDLYPDTAGP DAALEAEDWV SGQDADPILI SLREAYVPSK
410 420 430 440 450
QRDLKVSRRN VLSDSKPAGY SRSGVSTATA ITDIPSGNLA GSGEAGKLEE
460 470 480
VMHGLRALRV LVKEQGERIS RLEEHLGRME NGDT
Length:484
Mass (Da):53,845
Last modified:November 1, 1998 - v1
Checksum:i746EDF119680EBBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006064 mRNA Translation: CAA06836.1
RefSeqiNP_062095.1, NM_019222.1
UniGeneiRn.2819

Genome annotation databases

GeneIDi29474
KEGGirno:29474
UCSCiRGD:2382 rat

Similar proteinsi

Entry informationi

Entry nameiCOR1B_RAT
AccessioniPrimary (citable) accession number: O89046
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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