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Protein

Coronin-1B

Gene

Coro1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).By similarity

GO - Molecular functioni

  • Arp2/3 complex binding Source: UniProtKB

GO - Biological processi

  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • negative regulation of lamellipodium morphogenesis Source: UniProtKB
  • negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
  • regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1B
Alternative name(s):
Coronin-2
Gene namesi
Name:Coro1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2382. Coro1b.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.By similarity

GO - Cellular componenti

  • cell periphery Source: UniProtKB
  • cytosol Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • stress fiber Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Coronin-1BPRO_0000050925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO89046.
PRIDEiO89046.

PTM databases

iPTMnetiO89046.
PhosphoSiteiO89046.
SwissPalmiO89046.

Interactioni

Subunit structurei

Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).By similarity

GO - Molecular functioni

  • Arp2/3 complex binding Source: UniProtKB

Protein-protein interaction databases

IntActiO89046. 3 interactions.
MINTiMINT-2982709.
STRINGi10116.ENSRNOP00000035020.

Structurei

3D structure databases

ProteinModelPortaliO89046.
SMRiO89046. Positions 10-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati80 – 12041WD 1Add
BLAST
Repeati130 – 17041WD 2Add
BLAST
Repeati174 – 21340WD 3Add
BLAST
Repeati217 – 26044WD 4Add
BLAST
Repeati265 – 30541WD 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili447 – 48135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiO89046.
KOiK13886.
PhylomeDBiO89046.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV
60 70 80 90 100
IVEASGGGAF MVLPLNKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS
110 120 130 140 150
GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIITW HPTARNVLLS
160 170 180 190 200
AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCTACKDKSV
210 220 230 240 250
RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTAGFS RMSERQLALW
260 270 280 290 300
DPENFEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITDE
310 320 330 340 350
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM
360 370 380 390 400
TVPRKSDLFQ DDLYPDTAGP DAALEAEDWV SGQDADPILI SLREAYVPSK
410 420 430 440 450
QRDLKVSRRN VLSDSKPAGY SRSGVSTATA ITDIPSGNLA GSGEAGKLEE
460 470 480
VMHGLRALRV LVKEQGERIS RLEEHLGRME NGDT
Length:484
Mass (Da):53,845
Last modified:November 1, 1998 - v1
Checksum:i746EDF119680EBBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006064 mRNA. Translation: CAA06836.1.
RefSeqiNP_062095.1. NM_019222.1.
UniGeneiRn.2819.

Genome annotation databases

GeneIDi29474.
KEGGirno:29474.
UCSCiRGD:2382. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006064 mRNA. Translation: CAA06836.1.
RefSeqiNP_062095.1. NM_019222.1.
UniGeneiRn.2819.

3D structure databases

ProteinModelPortaliO89046.
SMRiO89046. Positions 10-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO89046. 3 interactions.
MINTiMINT-2982709.
STRINGi10116.ENSRNOP00000035020.

PTM databases

iPTMnetiO89046.
PhosphoSiteiO89046.
SwissPalmiO89046.

Proteomic databases

PaxDbiO89046.
PRIDEiO89046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29474.
KEGGirno:29474.
UCSCiRGD:2382. rat.

Organism-specific databases

CTDi57175.
RGDi2382. Coro1b.

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiO89046.
KOiK13886.
PhylomeDBiO89046.

Miscellaneous databases

PROiO89046.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A cell surface form of rat coronin."
    Male D.K., Politopoulou G.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility."
    Cai L., Holoweckyj N., Schaller M.D., Bear J.E.
    J. Biol. Chem. 280:31913-31923(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ACTR2; ARPC1B AND ARPC2.

Entry informationi

Entry nameiCOR1B_RAT
AccessioniPrimary (citable) accession number: O89046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.