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Protein
Submitted name:

Mitochondrial dicarboxylate carrier

Gene

Slc25a10

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antiporter activity Source: RGD
  • malate transmembrane transporter activity Source: RGD
  • phosphate ion transmembrane transporter activity Source: RGD
  • succinate transmembrane transporter activity Source: RGD
  • sulfate transmembrane transporter activity Source: RGD
  • thiosulfate transmembrane transporter activity Source: RGD

GO - Biological processi

  • malate transport Source: RGD
  • mitochondrial transport Source: InterPro
  • phosphate ion transport Source: RGD
  • succinate transport Source: RGD
  • sulfate transport Source: RGD
  • thiosulfate transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-1614517. Sulfide oxidation to sulfate.
R-RNO-428643. Organic anion transporters.
R-RNO-70263. Gluconeogenesis.

Protein family/group databases

TCDBi2.A.29.2.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitochondrial dicarboxylate carrierImported
Submitted name:
Protein Slc25a10Imported
Submitted name:
Solute carrier family 25 (Mitochondrial carrier dicarboxylate transporter), member 10Imported
Submitted name:
Solute carrier family 25 (Mitochondrial carrier; dicarboxylate transporter), member 10, isoform CRA_bImported
Gene namesi
Name:Slc25a10Imported
ORF Names:rCG_34251Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621430. Slc25a10.

Subcellular locationi

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Ensembl
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000036693.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051846.

Family & Domainsi

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
KOiK13577.
OMAiMAVHVVK.
OrthoDBiEOG091G0BQ7.
TreeFamiTF312920.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARTSRWY FGGLASCGAA CCTHPLDLLK VHLQTQQEVK LRMTGMALQV
60 70 80 90 100
VRTDGFLALY NGLSASLCRQ MTYSLTRFAI YETMRDYMTK DSQGPLPFYS
110 120 130 140 150
KVLLGGISGL TGGFVGTPAD LVNVRMQNDM KLPLSQRRNY SHALDGLYRV
160 170 180 190 200
AREEGLKKLF SGATMASSRG ALVTVGQLSC YDQAKQLVLS TGYLSDNIFT
210 220 230 240 250
HFLSSFIAGG CATFLCQPLD VLKTRLMNSK GEYQGVFHCA VETAKLGPQA
260 270 280
FFKGLVPAGV RLVPHTVLTF MFLEQLRKHF GIKVAT
Length:286
Mass (Da):31,455
Last modified:November 1, 1998 - v1
Checksum:i5013459FAD08DBDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131537 Genomic DNA. No translation available.
BC081734 mRNA. Translation: AAH81734.1.
AJ223355 mRNA. Translation: CAA11278.1.
CH473948 Genomic DNA. Translation: EDM06845.1.
RefSeqiNP_596909.1. NM_133418.1.
UniGeneiRn.3631.

Genome annotation databases

EnsembliENSRNOT00000054963; ENSRNOP00000051846; ENSRNOG00000036693.
GeneIDi170943.
KEGGirno:170943.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131537 Genomic DNA. No translation available.
BC081734 mRNA. Translation: AAH81734.1.
AJ223355 mRNA. Translation: CAA11278.1.
CH473948 Genomic DNA. Translation: EDM06845.1.
RefSeqiNP_596909.1. NM_133418.1.
UniGeneiRn.3631.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051846.

Protein family/group databases

TCDBi2.A.29.2.2. the mitochondrial carrier (mc) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054963; ENSRNOP00000051846; ENSRNOG00000036693.
GeneIDi170943.
KEGGirno:170943.

Organism-specific databases

CTDi1468.
RGDi621430. Slc25a10.

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
KOiK13577.
OMAiMAVHVVK.
OrthoDBiEOG091G0BQ7.
TreeFamiTF312920.

Enzyme and pathway databases

ReactomeiR-RNO-1614517. Sulfide oxidation to sulfate.
R-RNO-428643. Organic anion transporters.
R-RNO-70263. Gluconeogenesis.

Gene expression databases

BgeeiENSRNOG00000036693.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002030. Mit_uncoupling.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00784. MTUNCOUPLING.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO89035_RAT
AccessioniPrimary (citable) accession number: O89035
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.