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O89033 (CDC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 6 homolog
Alternative name(s):
CDC6-related protein
p62(cdc6)
Gene names
Name:Cdc6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Subunit structure

Interacts with PCNA, ORC1, cyclin-CDK and HUWE1 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: The protein is nuclear in G1 and cytoplasmic in S-phase cells By similarity.

Sequence similarities

Belongs to the CDC6/cdc18 family.

Sequence caution

The sequence CAA08752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAA11110.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Cell division control protein 6 homolog
PRO_0000150980

Regions

Nucleotide binding204 – 2118ATP Potential

Amino acid modifications

Modified residue551Phosphoserine By similarity
Modified residue1291Phosphoserine By similarity

Experimental info

Sequence conflict1551E → K in BAB28090. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O89033 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: CB39D0178FAE4ED7

FASTA56262,614
        10         20         30         40         50         60 
MPQTRSQTQA TIGFPKKKLS NTLKKPNSRD CEVKLRNVQP VPTTPCVDVK LLPLSPRKRL 

        70         80         90        100        110        120 
GDDNLCNTPR LSPCSPPKLG KKENGPPRSH TWKGCRLVFD DEPTFKASPP KEQDRVRQHQ 

       130        140        150        160        170        180 
IRSSSAQRSP ESKADPEQKC PPEKESVCIR LFKQEGTCYQ QAKLVLNTAV PDRLPAREQE 

       190        200        210        220        230        240 
MGVIRNFLKE HICGKKAGSL YLSGAPGTGK TACLSRILQD FKKEVKGFKS ILLNCMSLRS 

       250        260        270        280        290        300 
AQAVFPAIAQ EIGREELCRP AGKDLMRKLE KHLTAEKGPM IVLVLDEMDQ LDSKGQDVLY 

       310        320        330        340        350        360 
TLFEWPWLSN SRLVLIGIAN TLDLTDRILP RLEARENCKP QLLNFPPYTR NQIAAILQDR 

       370        380        390        400        410        420 
LSQVSKDQVL DSAAIQFCAR KVSAVSGDIR KALDVCRRAI EIVESDVRSQ TVLKPLSECK 

       430        440        450        460        470        480 
SPSESPVPKR VGLAHISQVI SEVDGNRVTL SQENTQDSLP LQQKILVCSL LLLTRRLKIK 

       490        500        510        520        530        540 
EVTLGKLYEA YSSICRKQQV TAVDQSECLS LSGLLESRGL VGLKKNKESR LTKVSLKIEE 

       550        560 
KEIEHVLNGK AFTGNILAAG LP 

« Hide

References

« Hide 'large scale' references
[1]"Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F."
Hateboer G., Wobst A., Petersen B.O., Le Cam L., Vigo E., Sardet C., Helin K.
Mol. Cell. Biol. 18:6679-6697(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A mouse related protein to human Cdc6."
Strub A., Staib C., Grummt F.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ009559 mRNA. Translation: CAA08752.1. Different initiation.
AJ223087 mRNA. Translation: CAA11110.1. Different initiation.
AK012192 mRNA. Translation: BAB28090.1.
AK085020 mRNA. Translation: BAC39341.1.
AK166003 mRNA. Translation: BAE38512.1.
BC052434 mRNA. Translation: AAH52434.1.
CCDSCCDS25368.1.
RefSeqNP_001020950.1. NM_001025779.1.
NP_035929.1. NM_011799.2.
UniGeneMm.20912.

3D structure databases

ProteinModelPortalO89033.
SMRO89033. Positions 170-533.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204750. 6 interactions.
IntActO89033. 4 interactions.

PTM databases

PhosphoSiteO89033.

Proteomic databases

PRIDEO89033.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000092706; ENSMUSP00000090382; ENSMUSG00000017499.
ENSMUST00000093937; ENSMUSP00000091469; ENSMUSG00000017499.
GeneID23834.
KEGGmmu:23834.
UCSCuc007lhu.1. mouse.

Organism-specific databases

CTD990.
MGIMGI:1345150. Cdc6.

Phylogenomic databases

eggNOGCOG1474.
GeneTreeENSGT00530000063498.
HOGENOMHOG000045316.
HOVERGENHBG050860.
InParanoidO89033.
KOK02213.
OrthoDBEOG7QG44J.
PhylomeDBO89033.
TreeFamTF101051.

Gene expression databases

ArrayExpressO89033.
BgeeO89033.
CleanExMM_CDC6.
GenevestigatorO89033.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR016314. Cell_div_Cdc6/18.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF09079. Cdc6_C. 1 hit.
[Graphical view]
PIRSFPIRSF001767. Cdc6. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio303509.
PROO89033.
SOURCESearch...

Entry information

Entry nameCDC6_MOUSE
AccessionPrimary (citable) accession number: O89033
Secondary accession number(s): Q3TMD0, Q8C3S5, Q9CZT0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot