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O89033

- CDC6_MOUSE

UniProt

O89033 - CDC6_MOUSE

Protein

Cell division control protein 6 homolog

Gene

Cdc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi204 – 2118ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. chromatin binding Source: MGI
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. mitotic nuclear division Source: UniProtKB-KW
    3. positive regulation of chromosome segregation Source: Ensembl
    4. positive regulation of cytokinesis Source: Ensembl
    5. regulation of mitotic metaphase/anaphase transition Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Cell division, DNA replication, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198608. G1/S-Specific Transcription.
    REACT_199110. G0 and Early G1.
    REACT_206830. E2F mediated regulation of DNA replication.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 6 homolog
    Alternative name(s):
    CDC6-related protein
    p62(cdc6)
    Gene namesi
    Name:Cdc6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1345150. Cdc6.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: The protein is nuclear in G1 and cytoplasmic in S-phase cells.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: UniProtKB-SubCell
    3. spindle Source: MGI
    4. spindle midzone Source: Ensembl
    5. spindle pole Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Cell division control protein 6 homologPRO_0000150980Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei55 – 551PhosphoserineBy similarity
    Modified residuei129 – 1291PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO89033.

    PTM databases

    PhosphoSiteiO89033.

    Expressioni

    Gene expression databases

    ArrayExpressiO89033.
    BgeeiO89033.
    CleanExiMM_CDC6.
    GenevestigatoriO89033.

    Interactioni

    Subunit structurei

    Interacts with PCNA, ORC1, cyclin-CDK and HUWE1.By similarity

    Protein-protein interaction databases

    BioGridi204750. 6 interactions.
    IntActiO89033. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO89033.
    SMRiO89033. Positions 170-533.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDC6/cdc18 family.Curated

    Phylogenomic databases

    eggNOGiCOG1474.
    GeneTreeiENSGT00530000063498.
    HOGENOMiHOG000045316.
    HOVERGENiHBG050860.
    InParanoidiO89033.
    KOiK02213.
    OrthoDBiEOG7QG44J.
    PhylomeDBiO89033.
    TreeFamiTF101051.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR015163. Cdc6_C_dom.
    IPR016314. Cell_div_Cdc6/18.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF09079. Cdc6_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001767. Cdc6. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    SM01074. Cdc6_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O89033-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQTRSQTQA TIGFPKKKLS NTLKKPNSRD CEVKLRNVQP VPTTPCVDVK    50
    LLPLSPRKRL GDDNLCNTPR LSPCSPPKLG KKENGPPRSH TWKGCRLVFD 100
    DEPTFKASPP KEQDRVRQHQ IRSSSAQRSP ESKADPEQKC PPEKESVCIR 150
    LFKQEGTCYQ QAKLVLNTAV PDRLPAREQE MGVIRNFLKE HICGKKAGSL 200
    YLSGAPGTGK TACLSRILQD FKKEVKGFKS ILLNCMSLRS AQAVFPAIAQ 250
    EIGREELCRP AGKDLMRKLE KHLTAEKGPM IVLVLDEMDQ LDSKGQDVLY 300
    TLFEWPWLSN SRLVLIGIAN TLDLTDRILP RLEARENCKP QLLNFPPYTR 350
    NQIAAILQDR LSQVSKDQVL DSAAIQFCAR KVSAVSGDIR KALDVCRRAI 400
    EIVESDVRSQ TVLKPLSECK SPSESPVPKR VGLAHISQVI SEVDGNRVTL 450
    SQENTQDSLP LQQKILVCSL LLLTRRLKIK EVTLGKLYEA YSSICRKQQV 500
    TAVDQSECLS LSGLLESRGL VGLKKNKESR LTKVSLKIEE KEIEHVLNGK 550
    AFTGNILAAG LP 562
    Length:562
    Mass (Da):62,614
    Last modified:July 19, 2004 - v2
    Checksum:iCB39D0178FAE4ED7
    GO

    Sequence cautioni

    The sequence CAA08752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAA11110.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1551E → K in BAB28090. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ009559 mRNA. Translation: CAA08752.1. Different initiation.
    AJ223087 mRNA. Translation: CAA11110.1. Different initiation.
    AK012192 mRNA. Translation: BAB28090.1.
    AK085020 mRNA. Translation: BAC39341.1.
    AK166003 mRNA. Translation: BAE38512.1.
    BC052434 mRNA. Translation: AAH52434.1.
    CCDSiCCDS25368.1.
    RefSeqiNP_001020950.1. NM_001025779.1.
    NP_035929.1. NM_011799.2.
    UniGeneiMm.20912.

    Genome annotation databases

    EnsembliENSMUST00000092706; ENSMUSP00000090382; ENSMUSG00000017499.
    ENSMUST00000093937; ENSMUSP00000091469; ENSMUSG00000017499.
    GeneIDi23834.
    KEGGimmu:23834.
    UCSCiuc007lhu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ009559 mRNA. Translation: CAA08752.1 . Different initiation.
    AJ223087 mRNA. Translation: CAA11110.1 . Different initiation.
    AK012192 mRNA. Translation: BAB28090.1 .
    AK085020 mRNA. Translation: BAC39341.1 .
    AK166003 mRNA. Translation: BAE38512.1 .
    BC052434 mRNA. Translation: AAH52434.1 .
    CCDSi CCDS25368.1.
    RefSeqi NP_001020950.1. NM_001025779.1.
    NP_035929.1. NM_011799.2.
    UniGenei Mm.20912.

    3D structure databases

    ProteinModelPortali O89033.
    SMRi O89033. Positions 170-533.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204750. 6 interactions.
    IntActi O89033. 4 interactions.

    PTM databases

    PhosphoSitei O89033.

    Proteomic databases

    PRIDEi O89033.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092706 ; ENSMUSP00000090382 ; ENSMUSG00000017499 .
    ENSMUST00000093937 ; ENSMUSP00000091469 ; ENSMUSG00000017499 .
    GeneIDi 23834.
    KEGGi mmu:23834.
    UCSCi uc007lhu.1. mouse.

    Organism-specific databases

    CTDi 990.
    MGIi MGI:1345150. Cdc6.

    Phylogenomic databases

    eggNOGi COG1474.
    GeneTreei ENSGT00530000063498.
    HOGENOMi HOG000045316.
    HOVERGENi HBG050860.
    InParanoidi O89033.
    KOi K02213.
    OrthoDBi EOG7QG44J.
    PhylomeDBi O89033.
    TreeFami TF101051.

    Enzyme and pathway databases

    Reactomei REACT_198608. G1/S-Specific Transcription.
    REACT_199110. G0 and Early G1.
    REACT_206830. E2F mediated regulation of DNA replication.

    Miscellaneous databases

    NextBioi 303509.
    PROi O89033.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O89033.
    Bgeei O89033.
    CleanExi MM_CDC6.
    Genevestigatori O89033.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR015163. Cdc6_C_dom.
    IPR016314. Cell_div_Cdc6/18.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF09079. Cdc6_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001767. Cdc6. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    SM01074. Cdc6_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F."
      Hateboer G., Wobst A., Petersen B.O., Le Cam L., Vigo E., Sardet C., Helin K.
      Mol. Cell. Biol. 18:6679-6697(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A mouse related protein to human Cdc6."
      Strub A., Staib C., Grummt F.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCDC6_MOUSE
    AccessioniPrimary (citable) accession number: O89033
    Secondary accession number(s): Q3TMD0, Q8C3S5, Q9CZT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3