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Protein

Cell division control protein 6 homolog

Gene

Cdc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi204 – 2118ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. chromatin binding Source: MGI
  3. kinase binding Source: MGI

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. DNA replication Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
  4. positive regulation of chromosome segregation Source: MGI
  5. positive regulation of cytokinesis Source: MGI
  6. regulation of mitotic metaphase/anaphase transition Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA replication, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_274086. G0 and Early G1.
REACT_274616. Activation of ATR in response to replication stress.
REACT_293164. Removal of licensing factors from origins.
REACT_297337. CDC6 association with the ORC:origin complex.
REACT_314754. E2F mediated regulation of DNA replication.
REACT_315933. Orc1 removal from chromatin.
REACT_336463. CDK-mediated phosphorylation and removal of Cdc6.
REACT_336670. Assembly of the pre-replicative complex.
REACT_339329. G1/S-Specific Transcription.
REACT_343561. CDT1 association with the CDC6:ORC:origin complex.
REACT_349855. Association of licensing factors with the pre-replicative complex.
REACT_351504. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 6 homolog
Alternative name(s):
CDC6-related protein
p62(cdc6)
Gene namesi
Name:Cdc6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1345150. Cdc6.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: The protein is nuclear in G1 and cytoplasmic in S-phase cells.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. Golgi apparatus Source: MGI
  3. nucleoplasm Source: MGI
  4. nucleus Source: MGI
  5. spindle Source: MGI
  6. spindle midzone Source: MGI
  7. spindle pole Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Cell division control protein 6 homologPRO_0000150980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551PhosphoserineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO89033.
PRIDEiO89033.

PTM databases

PhosphoSiteiO89033.

Expressioni

Gene expression databases

BgeeiO89033.
CleanExiMM_CDC6.
ExpressionAtlasiO89033. baseline and differential.
GenevestigatoriO89033.

Interactioni

Subunit structurei

Interacts with PCNA, ORC1, cyclin-CDK and HUWE1. Interacts with ANKRD17.By similarity

Protein-protein interaction databases

BioGridi204750. 6 interactions.
IntActiO89033. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliO89033.
SMRiO89033. Positions 170-533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDC6/cdc18 family.Curated

Phylogenomic databases

eggNOGiCOG1474.
GeneTreeiENSGT00530000063498.
HOGENOMiHOG000045316.
HOVERGENiHBG050860.
InParanoidiO89033.
KOiK02213.
OrthoDBiEOG7QG44J.
PhylomeDBiO89033.
TreeFamiTF101051.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR016314. Cell_div_Cdc6/18.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001767. Cdc6. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O89033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQTRSQTQA TIGFPKKKLS NTLKKPNSRD CEVKLRNVQP VPTTPCVDVK
60 70 80 90 100
LLPLSPRKRL GDDNLCNTPR LSPCSPPKLG KKENGPPRSH TWKGCRLVFD
110 120 130 140 150
DEPTFKASPP KEQDRVRQHQ IRSSSAQRSP ESKADPEQKC PPEKESVCIR
160 170 180 190 200
LFKQEGTCYQ QAKLVLNTAV PDRLPAREQE MGVIRNFLKE HICGKKAGSL
210 220 230 240 250
YLSGAPGTGK TACLSRILQD FKKEVKGFKS ILLNCMSLRS AQAVFPAIAQ
260 270 280 290 300
EIGREELCRP AGKDLMRKLE KHLTAEKGPM IVLVLDEMDQ LDSKGQDVLY
310 320 330 340 350
TLFEWPWLSN SRLVLIGIAN TLDLTDRILP RLEARENCKP QLLNFPPYTR
360 370 380 390 400
NQIAAILQDR LSQVSKDQVL DSAAIQFCAR KVSAVSGDIR KALDVCRRAI
410 420 430 440 450
EIVESDVRSQ TVLKPLSECK SPSESPVPKR VGLAHISQVI SEVDGNRVTL
460 470 480 490 500
SQENTQDSLP LQQKILVCSL LLLTRRLKIK EVTLGKLYEA YSSICRKQQV
510 520 530 540 550
TAVDQSECLS LSGLLESRGL VGLKKNKESR LTKVSLKIEE KEIEHVLNGK
560
AFTGNILAAG LP
Length:562
Mass (Da):62,614
Last modified:July 19, 2004 - v2
Checksum:iCB39D0178FAE4ED7
GO

Sequence cautioni

The sequence CAA08752.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA11110.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551E → K in BAB28090 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009559 mRNA. Translation: CAA08752.1. Different initiation.
AJ223087 mRNA. Translation: CAA11110.1. Different initiation.
AK012192 mRNA. Translation: BAB28090.1.
AK085020 mRNA. Translation: BAC39341.1.
AK166003 mRNA. Translation: BAE38512.1.
BC052434 mRNA. Translation: AAH52434.1.
CCDSiCCDS25368.1.
RefSeqiNP_001020950.1. NM_001025779.1.
NP_035929.1. NM_011799.2.
UniGeneiMm.20912.

Genome annotation databases

EnsembliENSMUST00000092706; ENSMUSP00000090382; ENSMUSG00000017499.
GeneIDi23834.
KEGGimmu:23834.
UCSCiuc007lhu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ009559 mRNA. Translation: CAA08752.1. Different initiation.
AJ223087 mRNA. Translation: CAA11110.1. Different initiation.
AK012192 mRNA. Translation: BAB28090.1.
AK085020 mRNA. Translation: BAC39341.1.
AK166003 mRNA. Translation: BAE38512.1.
BC052434 mRNA. Translation: AAH52434.1.
CCDSiCCDS25368.1.
RefSeqiNP_001020950.1. NM_001025779.1.
NP_035929.1. NM_011799.2.
UniGeneiMm.20912.

3D structure databases

ProteinModelPortaliO89033.
SMRiO89033. Positions 170-533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204750. 6 interactions.
IntActiO89033. 4 interactions.

PTM databases

PhosphoSiteiO89033.

Proteomic databases

MaxQBiO89033.
PRIDEiO89033.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092706; ENSMUSP00000090382; ENSMUSG00000017499.
GeneIDi23834.
KEGGimmu:23834.
UCSCiuc007lhu.1. mouse.

Organism-specific databases

CTDi990.
MGIiMGI:1345150. Cdc6.

Phylogenomic databases

eggNOGiCOG1474.
GeneTreeiENSGT00530000063498.
HOGENOMiHOG000045316.
HOVERGENiHBG050860.
InParanoidiO89033.
KOiK02213.
OrthoDBiEOG7QG44J.
PhylomeDBiO89033.
TreeFamiTF101051.

Enzyme and pathway databases

ReactomeiREACT_274086. G0 and Early G1.
REACT_274616. Activation of ATR in response to replication stress.
REACT_293164. Removal of licensing factors from origins.
REACT_297337. CDC6 association with the ORC:origin complex.
REACT_314754. E2F mediated regulation of DNA replication.
REACT_315933. Orc1 removal from chromatin.
REACT_336463. CDK-mediated phosphorylation and removal of Cdc6.
REACT_336670. Assembly of the pre-replicative complex.
REACT_339329. G1/S-Specific Transcription.
REACT_343561. CDT1 association with the CDC6:ORC:origin complex.
REACT_349855. Association of licensing factors with the pre-replicative complex.
REACT_351504. Activation of the pre-replicative complex.

Miscellaneous databases

NextBioi303509.
PROiO89033.
SOURCEiSearch...

Gene expression databases

BgeeiO89033.
CleanExiMM_CDC6.
ExpressionAtlasiO89033. baseline and differential.
GenevestigatoriO89033.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR015163. Cdc6_C_dom.
IPR016314. Cell_div_Cdc6/18.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09079. Cdc6_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001767. Cdc6. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM01074. Cdc6_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F."
    Hateboer G., Wobst A., Petersen B.O., Le Cam L., Vigo E., Sardet C., Helin K.
    Mol. Cell. Biol. 18:6679-6697(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A mouse related protein to human Cdc6."
    Strub A., Staib C., Grummt F.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCDC6_MOUSE
AccessioniPrimary (citable) accession number: O89033
Secondary accession number(s): Q3TMD0, Q8C3S5, Q9CZT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: April 1, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.