Reviewed,
UniProtKB/Swiss-Prot O89023 (TPP1_MOUSE)
Last modified
November 3, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Tripeptidyl-peptidase 1 Short name=TPP-1 EC=3.4.14.9 Alternative name(s): Tripeptidyl-peptidase I Short name=TPP-I Tripeptidyl aminopeptidase Lysosomal pepstatin-insensitive protease Short name=LPIC | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 562 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus By similarity. |
| Catalytic activity | Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity. |
| Subcellular location | Lysosome. Melanosome By similarity. |
| Post-translational modification | Activated by autocatalytic proteolytical processing upon acidification By similarity. |
| Sequence similarities | Belongs to the peptidase S53 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | By similarity | ||||||
| Propeptide | 20 – 194 | 175 | Removed in mature form By similarity | PRO_0000027378 | |||||
| Chain | 195 – 562 | 368 | Tripeptidyl-peptidase 1 | PRO_0000027379 | |||||
Sites | |||||||||
| Active site | 271 | 1 | Charge relay system By similarity | ||||||
| Active site | 275 | 1 | Charge relay system By similarity | ||||||
| Active site | 474 | 1 | Charge relay system By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 209 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 221 | 1 | N-linked (GlcNAc...) (high mannose) Ref.6 | ||||||
| Glycosylation | 285 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 312 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 442 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 1 | 1 | M → V Ref.1 | ||||||
| Sequence conflict | 562 | 1 | P → LDPFVP Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I." Vines D.J., Warburton M.J. FEBS Lett. 443:131-135(1999) [PubMed: 9989590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Characterization and chromosomal mapping of a mouse ortholog of the late-infantile ceroid-lipofuscinosis gene CLN2." Katz M.L., Liu P.-C., Grob-Nunn S.E., Shibuya H., Johnson G.S. Mamm. Genome 10:1050-1053(1999) [PubMed: 10556422] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Murine homologue of the lysosomal pepstatin insensitive protease which is deficient in human classical late infantile neuronal ceroid lipofuscinosis." Sleat D.E., Lobel P. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. |
| [4] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Head and Kidney. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Retina. |
| [6] | "High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis." Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K., Nishimura S. Mol. Cell. Proteomics 4:1977-1989(2005) [PubMed: 16170054] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221, MASS SPECTROMETRY. Tissue: Epidermis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ011912 mRNA. Translation: CAA09863.1. Different initiation. AF124599 Genomic DNA. Translation: AAD32573.1. AF111172 mRNA. Translation: AAD03083.1. AK002418 mRNA. Translation: BAB22085.1. AK048279 mRNA. Translation: BAC33293.1. AK170781 mRNA. Translation: BAE42026.1. BC024820 mRNA. Translation: AAH24820.1. | |
| IPI | IPI00130661. |
| RefSeq | NP_034036.1. |
| UniGene | Mm.20837 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O89023. |
PTM databases | |
| PhosphoSite | O89023. |
Proteomic databases | |
| PRIDE | O89023. |
Genome annotation databases | |
| Ensembl | ENSMUST00000033184; ENSMUSP00000033184; ENSMUSG00000030894; Mus musculus. [Genome view] |
| GeneID | 12751. |
| KEGG | mmu:12751. |
| UCSC | uc009izg.1. mouse. |
Organism-specific databases | |
| CTD | 12751. |
| MGI | MGI:1336194. Tpp1. |
Phylogenomic databases | |
| HOGENOM | O89023. |
| HOVERGEN | O89023. |
| OMA | SVIRKRY. |
Enzyme and pathway databases | |
| BRENDA | 3.4.14.9. 244. |
Gene expression databases | |
| ArrayExpress | O89023. |
| Bgee | O89023. |
| CleanEx | MM_TPP1. |
| Genevestigator | O89023. |
| GermOnline | ENSMUSG00000030894. Mus musculus. |
Family and domain databases | |
| InterPro | IPR015366. Peptidase_S53_propep. IPR000209. Peptidase_S8/S53. [Graphical view] |
| Gene3D | G3DSA:3.40.50.200. Pept_S8_S53. 1 hit. |
| Pfam | PF00082. Peptidase_S8. 1 hit. PF09286. Pro-kuma_activ. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 282084. |
| SOURCE | Search... |
Entry information
| Entry name | TPP1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O89023 Secondary accession number(s): Q543Q8, Q9QUS7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


