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Protein

ATP-binding cassette sub-family D member 4

Gene

Abcd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi421 – 4288ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_294704. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 4
Alternative name(s):
PMP70-related protein
Short name:
P70R
Peroxisomal membrane protein 1-like
Short name:
PXMP1-L
Peroxisomal membrane protein 69
Short name:
PMP69
Gene namesi
Name:Abcd4
Synonyms:Pxmp1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1349217. Abcd4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei76 – 9621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei190 – 21021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei279 – 29921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei314 – 33421HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 606606ATP-binding cassette sub-family D member 4PRO_0000093313Add
BLAST

Proteomic databases

MaxQBiO89016.
PaxDbiO89016.
PRIDEiO89016.

PTM databases

PhosphoSiteiO89016.

Expressioni

Gene expression databases

BgeeiO89016.
GenevisibleiO89016. MM.

Interactioni

Subunit structurei

Homodimer or heterodimer.Curated

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021666.

Structurei

3D structure databases

ProteinModelPortaliO89016.
SMRiO89016. Positions 271-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 332294ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 603215ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4178.
GeneTreeiENSGT00390000003950.
HOGENOMiHOG000007546.
HOVERGENiHBG106060.
InParanoidiO89016.
KOiK05678.
OMAiVQMLADF.
OrthoDBiEOG72RMXS.
TreeFamiTF105205.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O89016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPGPTARA GARPRLDLQL VQRFVRIQKV FFPSWSSQNV LMFMTLLCVT
60 70 80 90 100
LLEQLVIYQV GLIPSQYYGV LGNKDLDGFK ALTLLAVTLI VLNSTLKSFD
110 120 130 140 150
QFTCNLLYVS WRKDLTEHLH HLYFRARVYY TLNVLRDDID NPDQRISQDV
160 170 180 190 200
ERFCRQLSSV TSKLIISPFT LTYYTYQCFQ STGWLGPVSI FGYFIVGTMV
210 220 230 240 250
NKTLMGPIVT KLVQQEKLEG DFRFKHMQIR VNAEPAAFYR AGLVEHMRTD
260 270 280 290 300
RRLQRLLQTQ RELMSRELWL YIGINTFDYL GSILSYVVIA IPIFSGVYGD
310 320 330 340 350
LSPTELSTLV SKNAFVCIYL ISCFTQLIDL STTLSDVAGY THRIGELQEA
360 370 380 390 400
LLDMSRKSQD CEALGESEWD LDKTPGCPTT EPSDTAFLLD RVSILAPSSD
410 420 430 440 450
KPLIKDLSLK ICEGQSLLIT GNTGTGKTSL LRVLGGLWEG MKGSVQMLAD
460 470 480 490 500
FGPHGVLFLP QKPFFTDGTL REQVIYPLKE IYPDSGSADD ERIVRFLELA
510 520 530 540 550
GLSSLVARTG GLDQQVDWNW YDVLSPGEMQ RLSFARLFYL QPKYAVLDEA
560 570 580 590 600
TSALTEEAES ELYRIGQQLG MTFISVGHRP SLEKFHSWVL RLHGGGSWEL

TRIKLE
Length:606
Mass (Da):68,583
Last modified:June 28, 2011 - v2
Checksum:iF93CF046ADA776A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431F → L in CAA04570 (PubMed:9738957).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001166 mRNA. Translation: CAA04570.1.
AC110564 Genomic DNA. No translation available.
CCDSiCCDS26047.1.
RefSeqiNP_033018.2. NM_008992.2.
UniGeneiMm.229109.

Genome annotation databases

EnsembliENSMUST00000021666; ENSMUSP00000021666; ENSMUSG00000021240.
GeneIDi19300.
KEGGimmu:19300.
UCSCiuc007ofo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001166 mRNA. Translation: CAA04570.1.
AC110564 Genomic DNA. No translation available.
CCDSiCCDS26047.1.
RefSeqiNP_033018.2. NM_008992.2.
UniGeneiMm.229109.

3D structure databases

ProteinModelPortaliO89016.
SMRiO89016. Positions 271-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021666.

PTM databases

PhosphoSiteiO89016.

Proteomic databases

MaxQBiO89016.
PaxDbiO89016.
PRIDEiO89016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021666; ENSMUSP00000021666; ENSMUSG00000021240.
GeneIDi19300.
KEGGimmu:19300.
UCSCiuc007ofo.2. mouse.

Organism-specific databases

CTDi5826.
MGIiMGI:1349217. Abcd4.

Phylogenomic databases

eggNOGiCOG4178.
GeneTreeiENSGT00390000003950.
HOGENOMiHOG000007546.
HOVERGENiHBG106060.
InParanoidiO89016.
KOiK05678.
OMAiVQMLADF.
OrthoDBiEOG72RMXS.
TreeFamiTF105205.

Enzyme and pathway databases

ReactomeiREACT_294704. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

NextBioi296249.
PROiO89016.
SOURCEiSearch...

Gene expression databases

BgeeiO89016.
GenevisibleiO89016. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies."
    Holzinger A., Muntau A., Mayerhofer P., Kammerer S., Albet S., Bugaut M., Roscher A.A.
    FEBS Lett. 433:179-183(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiABCD4_MOUSE
AccessioniPrimary (citable) accession number: O89016
Secondary accession number(s): E9QKU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 28, 2011
Last modified: June 24, 2015
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.