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O89016

- ABCD4_MOUSE

UniProt

O89016 - ABCD4_MOUSE

Protein

ATP-binding cassette sub-family D member 4

Gene

Abcd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (28 Jun 2011)
      Previous versions | rss
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    • Comment

    Functioni

    May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi421 – 4288ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cobalamin metabolic process Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family D member 4
    Alternative name(s):
    PMP70-related protein
    Short name:
    P70R
    Peroxisomal membrane protein 1-like
    Short name:
    PXMP1-L
    Peroxisomal membrane protein 69
    Short name:
    PMP69
    Gene namesi
    Name:Abcd4
    Synonyms:Pxmp1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1349217. Abcd4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 606606ATP-binding cassette sub-family D member 4PRO_0000093313Add
    BLAST

    Proteomic databases

    MaxQBiO89016.
    PaxDbiO89016.
    PRIDEiO89016.

    PTM databases

    PhosphoSiteiO89016.

    Expressioni

    Gene expression databases

    BgeeiO89016.
    GenevestigatoriO89016.

    Interactioni

    Subunit structurei

    Homodimer or heterodimer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliO89016.
    SMRiO89016. Positions 271-595.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei76 – 9621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei190 – 21021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei279 – 29921HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei314 – 33421HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 332294ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini389 – 603215ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4178.
    GeneTreeiENSGT00390000003950.
    HOGENOMiHOG000007546.
    HOVERGENiHBG106060.
    InParanoidiO89016.
    KOiK05678.
    OMAiIAGIWPY.
    OrthoDBiEOG72RMXS.
    TreeFamiTF105205.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O89016-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVPGPTARA GARPRLDLQL VQRFVRIQKV FFPSWSSQNV LMFMTLLCVT    50
    LLEQLVIYQV GLIPSQYYGV LGNKDLDGFK ALTLLAVTLI VLNSTLKSFD 100
    QFTCNLLYVS WRKDLTEHLH HLYFRARVYY TLNVLRDDID NPDQRISQDV 150
    ERFCRQLSSV TSKLIISPFT LTYYTYQCFQ STGWLGPVSI FGYFIVGTMV 200
    NKTLMGPIVT KLVQQEKLEG DFRFKHMQIR VNAEPAAFYR AGLVEHMRTD 250
    RRLQRLLQTQ RELMSRELWL YIGINTFDYL GSILSYVVIA IPIFSGVYGD 300
    LSPTELSTLV SKNAFVCIYL ISCFTQLIDL STTLSDVAGY THRIGELQEA 350
    LLDMSRKSQD CEALGESEWD LDKTPGCPTT EPSDTAFLLD RVSILAPSSD 400
    KPLIKDLSLK ICEGQSLLIT GNTGTGKTSL LRVLGGLWEG MKGSVQMLAD 450
    FGPHGVLFLP QKPFFTDGTL REQVIYPLKE IYPDSGSADD ERIVRFLELA 500
    GLSSLVARTG GLDQQVDWNW YDVLSPGEMQ RLSFARLFYL QPKYAVLDEA 550
    TSALTEEAES ELYRIGQQLG MTFISVGHRP SLEKFHSWVL RLHGGGSWEL 600
    TRIKLE 606
    Length:606
    Mass (Da):68,583
    Last modified:June 28, 2011 - v2
    Checksum:iF93CF046ADA776A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431F → L in CAA04570. (PubMed:9738957)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001166 mRNA. Translation: CAA04570.1.
    AC110564 Genomic DNA. No translation available.
    CCDSiCCDS26047.1.
    RefSeqiNP_033018.2. NM_008992.2.
    UniGeneiMm.229109.

    Genome annotation databases

    EnsembliENSMUST00000021666; ENSMUSP00000021666; ENSMUSG00000021240.
    GeneIDi19300.
    KEGGimmu:19300.
    UCSCiuc007ofo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001166 mRNA. Translation: CAA04570.1 .
    AC110564 Genomic DNA. No translation available.
    CCDSi CCDS26047.1.
    RefSeqi NP_033018.2. NM_008992.2.
    UniGenei Mm.229109.

    3D structure databases

    ProteinModelPortali O89016.
    SMRi O89016. Positions 271-595.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O89016.

    Proteomic databases

    MaxQBi O89016.
    PaxDbi O89016.
    PRIDEi O89016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021666 ; ENSMUSP00000021666 ; ENSMUSG00000021240 .
    GeneIDi 19300.
    KEGGi mmu:19300.
    UCSCi uc007ofo.2. mouse.

    Organism-specific databases

    CTDi 5826.
    MGIi MGI:1349217. Abcd4.

    Phylogenomic databases

    eggNOGi COG4178.
    GeneTreei ENSGT00390000003950.
    HOGENOMi HOG000007546.
    HOVERGENi HBG106060.
    InParanoidi O89016.
    KOi K05678.
    OMAi IAGIWPY.
    OrthoDBi EOG72RMXS.
    TreeFami TF105205.

    Miscellaneous databases

    NextBioi 296249.
    PROi O89016.
    SOURCEi Search...

    Gene expression databases

    Bgeei O89016.
    Genevestigatori O89016.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies."
      Holzinger A., Muntau A., Mayerhofer P., Kammerer S., Albet S., Bugaut M., Roscher A.A.
      FEBS Lett. 433:179-183(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiABCD4_MOUSE
    AccessioniPrimary (citable) accession number: O89016
    Secondary accession number(s): E9QKU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3