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O89016 (ABCD4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family D member 4
Alternative name(s):
PMP70-related protein
Short name=P70R
Peroxisomal membrane protein 1-like
Short name=PXMP1-L
Peroxisomal membrane protein 69
Short name=PMP69
Gene names
Name:Abcd4
Synonyms:Pxmp1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length606 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm By similarity.

Subunit structure

Homodimer or heterodimer Potential.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 606606ATP-binding cassette sub-family D member 4
PRO_0000093313

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane314 – 33421Helical; Potential
Domain39 – 332294ABC transmembrane type-1
Domain389 – 603215ABC transporter
Nucleotide binding421 – 4288ATP Potential

Experimental info

Sequence conflict431F → L in CAA04570. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O89016 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: F93CF046ADA776A0

FASTA60668,583
        10         20         30         40         50         60 
MAVPGPTARA GARPRLDLQL VQRFVRIQKV FFPSWSSQNV LMFMTLLCVT LLEQLVIYQV 

        70         80         90        100        110        120 
GLIPSQYYGV LGNKDLDGFK ALTLLAVTLI VLNSTLKSFD QFTCNLLYVS WRKDLTEHLH 

       130        140        150        160        170        180 
HLYFRARVYY TLNVLRDDID NPDQRISQDV ERFCRQLSSV TSKLIISPFT LTYYTYQCFQ 

       190        200        210        220        230        240 
STGWLGPVSI FGYFIVGTMV NKTLMGPIVT KLVQQEKLEG DFRFKHMQIR VNAEPAAFYR 

       250        260        270        280        290        300 
AGLVEHMRTD RRLQRLLQTQ RELMSRELWL YIGINTFDYL GSILSYVVIA IPIFSGVYGD 

       310        320        330        340        350        360 
LSPTELSTLV SKNAFVCIYL ISCFTQLIDL STTLSDVAGY THRIGELQEA LLDMSRKSQD 

       370        380        390        400        410        420 
CEALGESEWD LDKTPGCPTT EPSDTAFLLD RVSILAPSSD KPLIKDLSLK ICEGQSLLIT 

       430        440        450        460        470        480 
GNTGTGKTSL LRVLGGLWEG MKGSVQMLAD FGPHGVLFLP QKPFFTDGTL REQVIYPLKE 

       490        500        510        520        530        540 
IYPDSGSADD ERIVRFLELA GLSSLVARTG GLDQQVDWNW YDVLSPGEMQ RLSFARLFYL 

       550        560        570        580        590        600 
QPKYAVLDEA TSALTEEAES ELYRIGQQLG MTFISVGHRP SLEKFHSWVL RLHGGGSWEL 


TRIKLE 

« Hide

References

« Hide 'large scale' references
[1]"The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies."
Holzinger A., Muntau A., Mayerhofer P., Kammerer S., Albet S., Bugaut M., Roscher A.A.
FEBS Lett. 433:179-183(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001166 mRNA. Translation: CAA04570.1.
AC110564 Genomic DNA. No translation available.
RefSeqNP_033018.2. NM_008992.2.
UniGeneMm.229109.

3D structure databases

ProteinModelPortalO89016.
SMRO89016. Positions 271-595.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO89016.

Proteomic databases

PaxDbO89016.
PRIDEO89016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021666; ENSMUSP00000021666; ENSMUSG00000021240.
GeneID19300.
KEGGmmu:19300.
UCSCuc007ofo.2. mouse.

Organism-specific databases

CTD5826.
MGIMGI:1349217. Abcd4.

Phylogenomic databases

eggNOGCOG4178.
GeneTreeENSGT00390000003950.
HOGENOMHOG000007546.
HOVERGENHBG106060.
InParanoidO89016.
KOK05678.
OMAISCFTQL.
OrthoDBEOG72RMXS.
TreeFamTF105205.

Gene expression databases

BgeeO89016.
GenevestigatorO89016.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio296249.
PROO89016.
SOURCESearch...

Entry information

Entry nameABCD4_MOUSE
AccessionPrimary (citable) accession number: O89016
Secondary accession number(s): E9QKU3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot