Reviewed,
UniProtKB/Swiss-Prot O89000 (DPYD_RAT)
Last modified
November 25, 2008.
Version 54.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Dihydropyrimidine dehydrogenase [NADP+] Short name=DHPDHase Short name=DPD EC=1.3.1.2 Alternative name(s): Dihydrouracil dehydrogenase Dihydrothymine dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 1025 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine By similarity. |
| Catalytic activity | 5,6-dihydrouracil + NADP(+) = uracil + NADPH. |
| Cofactor | Binds 2 4Fe-4S clusters By similarity. FAD By similarity. FMN By similarity. |
| Enzyme regulation | Inactivated by 5-iodouracil By similarity. |
| Pathway | |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | CytoplasmBy similarity. |
| Sequence similarities | Belongs to the dihydropyrimidine dehydrogenase family. Contains 3 4Fe-4S ferredoxin-type domains. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1025 | 1025 | Dihydropyrimidine dehydrogenase [NADP+] | PRO_0000327502 | |||||
Regions | |||||||||
| Domain | 69 – 100 | 32 | 4Fe-4S ferredoxin-type 1 | ||||||
| Domain | 944 – 976 | 33 | 4Fe-4S ferredoxin-type 2 | ||||||
| Domain | 978 – 1007 | 30 | 4Fe-4S ferredoxin-type 3 | ||||||
Sites | |||||||||
| Metal binding | 953 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 956 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 959 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 963 | 1 | Iron-sulfur 1 (4Fe-4S) Potential | ||||||
| Metal binding | 986 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 989 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 992 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
| Metal binding | 996 | 1 | Iron-sulfur 2 (4Fe-4S) Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 577 | 1 | Phosphoserine By similarity | ||||||
Sequences
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References
| [1] | "Cloning of rat dihydropyrimidine dehydrogenase and correlation of its mRNA increase in the rat liver with age." Kimura M., Fujimoto Sakata S., Matoba Y., Matsuda K., Kontani Y., Kaneko M., Tamaki N. J. Nutr. Sci. Vitaminol. 44:537-546(1998) [PubMed: 9819714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Liver. |
Cross-references
Sequence databases | |
|---|---|
| D85035 mRNA. Translation: BAA33218.1. | |
| RefSeq | NP_112289.1. |
| UniGene | Rn.158382 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1H7X based on UniProtKB Q28943. |
| SMR | O89000. Positions 2-1017. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000017105. Rattus norvegicus. [Contig view] |
| GeneID | 81656. |
| KEGG | rno:81656. |
Organism-specific databases | |
| RGD | 621218. Dpyd. |
Phylogenomic databases | |
| HOVERGEN | O89000. |
Gene expression databases | |
| ArrayExpress | O89000. |
Family and domain databases | |
| InterPro | IPR001450. 4Fe4S_Fe_S_bd. IPR000759. Adrndx_reductase. IPR013785. Aldolase_TIM. IPR005720. DHO_DHase_1_core. IPR001295. Dihydroorotate_DHase_core. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR012285. Fum_reductase_C. IPR016040. NAD(P)-bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF01180. DHO_dh. 1 hit. PF00037. Fer4. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view] |
| PRINTS | PR00353. 4FE4SFRDOXIN. PR00419. ADXRDTASE. PR00368. FADPNR. PR00469. PNDRDTASEII. |
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01037. pyrD_sub1_fam. 1 hit. |
| PROSITE | PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 615210. |
Entry information
| Entry name | DPYD_RAT | ||||||||
| Accession | Primary (citable) accession number: O89000 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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