O88998 (NOE1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Noelin

Alternative name(s):
Neuronal olfactomedin-related ER localized protein
Olfactomedin-1
Pancortin

Gene names

Name:	Olfm1
Synonyms:	Noe1, Noel, Noel1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in regulating the production of neural crest cells by the neural tube By similarity.
Subunit structure	Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM1. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Ref.5
Subcellular location	Secreted Potential. Cell junction › synapse Probable Ref.5.
Tissue specificity	Expressed in the brain (at protein level). Ref.5
Sequence similarities	Contains 1 olfactomedin-like domain.

Ontologies

Keywords
Cellular component	Cell junction Secreted Synapse
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW protein oligomerization Inferred from direct assay PubMed 15927402. Source: MGI
Cellular_component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Inferred from direct assay Ref.5. Source: MGI cell junction Inferred from electronic annotation. Source: UniProtKB-KW extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from direct assay PubMed 15927402. Source: MGI synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O88998-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O88998-2)

The sequence of this isoform differs from the canonical sequence as follows:
     153-153: A → G
     154-485: Missing.

Isoform 3 (identifier: O88998-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTRLSAASGGTLDRSTG → MQPARKLLSLLVLLVMGTELTQ

Isoform 4 (identifier: O88998-4)

Also known as: AMY;

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTRLSAASGGTLDRSTG → MQPARKLLSLLVLLVMGTELTQ
     153-153: A → G
     154-485: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 485	469	Noelin		PRO_0000020075
Regions
	Domain	226 – 478	253	Olfactomedin-like
	Coiled coil	87 – 225	139	Potential
Amino acid modifications
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Glycosylation	288	1	N-linked (GlcNAc...) Potential
	Glycosylation	307	1	N-linked (GlcNAc...) Potential
	Glycosylation	394	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
	Glycosylation	473	1	N-linked (GlcNAc...) Potential
	Disulfide bond	227 ↔ 409		By similarity
Natural variations
	Alternative sequence	1 – 50	50	MSVPL…DRSTG → MQPARKLLSLLVLLVMGTEL TQ in isoform 3 and isoform 4.		VSP_003762
	Alternative sequence	153	1	A → G in isoform 2 and isoform 4.		VSP_003763
	Alternative sequence	154 – 485	332	Missing in isoform 2 and isoform 4.		VSP_003764
Experimental info
	Sequence conflict	69	1	S → M in AAB84058. Ref.2
	Sequence conflict	329	1	A → M in AAB84058. Ref.2
	Sequence conflict	429	1	Q → R in AAB84058. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 6429574ECD814944	FASTA	485	55,398
	10 20 30 40 50 60 MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTRLSAA SGGTLDRSTG VLPTNPEESW 70 80 90 100 110 120 QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK VQNMSQSIEV LDRRTQRDLQ 130 140 150 160 170 180 YVEKMENQMK GLETKFKQVE ESHKQHLARQ FKAIKAKMDE LRPLIPVLEE YKADAKLVLQ 190 200 210 220 230 240 FKEEVQNLTS VLNELQEEIG AYDYDELQSR VSNLEERLRA CMQKLACGKL TGISDPVTVK 250 260 270 280 290 300 TSGSRFGSWM TDPLAPEGDN RVWYMDGYHN NRFVREYKSM VDFMNTDNFT SHRLPHPWSG 310 320 330 340 350 360 TGQVVYNGSI YFNKFQSHII IRFDLKTEAI LKTRSLDYAG YNNMYHYAWG GHSDIDLMVD 370 380 390 400 410 420 ENGLWAVYAT NQNAGNIVIS KLDPVSLQIL QTWNTSYPKR SAGEAFIICG TLYVTNGYSG 430 440 450 460 470 480 GTKVHYAYQT NASTYEYIDI PFQNKYSHIS MLDYNPKDRA LYAWNNGHQT LYNVTLFHVI RSDEL
	Isoform 2 [UniParc]. Checksum: C47571A8DCAE09E9	FASTA	153	17,232
	10 20 30 40 50 60 MSVPLLKIGV VLSTMAMITN WMSQTLPSLV GLNTTRLSAA SGGTLDRSTG VLPTNPEESW 70 80 90 100 110 120 QVYSSAQDSE GRCICTVVAP QQTMCSRDAR TKQLRQLLEK VQNMSQSIEV LDRRTQRDLQ 130 140 150 YVEKMENQMK GLETKFKQVE ESHKQHLARQ FKG
	Isoform 3 [UniParc]. Checksum: CA2AD328E37A0F16	FASTA	457	52,674
	10 20 30 40 50 60 MQPARKLLSL LVLLVMGTEL TQVLPTNPEE SWQVYSSAQD SEGRCICTVV APQQTMCSRD 70 80 90 100 110 120 ARTKQLRQLL EKVQNMSQSI EVLDRRTQRD LQYVEKMENQ MKGLETKFKQ VEESHKQHLA 130 140 150 160 170 180 RQFKAIKAKM DELRPLIPVL EEYKADAKLV LQFKEEVQNL TSVLNELQEE IGAYDYDELQ 190 200 210 220 230 240 SRVSNLEERL RACMQKLACG KLTGISDPVT VKTSGSRFGS WMTDPLAPEG DNRVWYMDGY 250 260 270 280 290 300 HNNRFVREYK SMVDFMNTDN FTSHRLPHPW SGTGQVVYNG SIYFNKFQSH IIIRFDLKTE 310 320 330 340 350 360 AILKTRSLDY AGYNNMYHYA WGGHSDIDLM VDENGLWAVY ATNQNAGNIV ISKLDPVSLQ 370 380 390 400 410 420 ILQTWNTSYP KRSAGEAFII CGTLYVTNGY SGGTKVHYAY QTNASTYEYI DIPFQNKYSH 430 440 450 ISMLDYNPKD RALYAWNNGH QTLYNVTLFH VIRSDEL
	Isoform 4 (AMY) [UniParc]. Checksum: 6EE703826C61DF78	FASTA	125	14,508
	10 20 30 40 50 60 MQPARKLLSL LVLLVMGTEL TQVLPTNPEE SWQVYSSAQD SEGRCICTVV APQQTMCSRD 70 80 90 100 110 120 ARTKQLRQLL EKVQNMSQSI EVLDRRTQRD LQYVEKMENQ MKGLETKFKQ VEESHKQHLA RQFKG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differentially expressed olfactomedin-related glycoproteins (Pancortins) in the brain." Nagano T., Nakamura A., Mori Y., Maeda M., Takami T., Shiosaka S., Takagi H., Sato M. Brain Res. Mol. Brain Res. 53:13-23(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING. Strain: ICR. Tissue: Brain.
[2]	Anholt R., Kulkarni N., Karavanich C. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Strain: C57BL/6J. Tissue: Brain.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes." Schwenk J., Harmel N., Brechet A., Zolles G., Berkefeld H., Muller C.S., Bildl W., Baehrens D., Huber B., Kulik A., Klocker N., Schulte U., Fakler B. Neuron 74:621-633(2012) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN AMPAR COMPLEX, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D78262 mRNA. Translation: BAA28765.1. D78263 mRNA. Translation: BAA28766.1. D78264 mRNA. Translation: BAA28767.1. D78265 mRNA. Translation: BAA28764.1. AF028740 mRNA. Translation: AAB84058.1. AK003031 mRNA. Translation: BAB22520.1. AL731778 Genomic DNA. Translation: CAM46249.1.
IPI	IPI00129227. IPI00136712. IPI00225046. IPI00267253.
RefSeq	NP_001033701.1. NM_001038612.1. NP_001033703.1. NM_001038614.1.
UniGene	Mm.43278.
3D structure databases
ProteinModelPortal	O88998.
ModBase	Search...
Protein-protein interaction databases
IntAct	O88998. 1 interaction.
PTM databases
PhosphoSite	O88998.
Proteomic databases
PaxDb	O88998.
PRIDE	O88998.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000102879; ENSMUSP00000099943; ENSMUSG00000026833.
GeneID	56177.
KEGG	mmu:56177.
UCSC	uc008iya.1. mouse. uc008iyc.1. mouse.
Organism-specific databases
CTD	10439.
MGI	MGI:1860437. Olfm1.
Phylogenomic databases
eggNOG	NOG283888.
GeneTree	ENSGT00660000095208.
HOVERGEN	HBG006513.
InParanoid	O88998.
OrthoDB	EOG46MBJC.
Gene expression databases
ArrayExpress	O88998.
Bgee	O88998.
CleanEx	MM_OLFM1.
Genevestigator	O88998.
GermOnline	ENSMUSG00000026833. Mus musculus.
Family and domain databases
InterPro	IPR022082. Noelin-1. IPR003112. Olfac-like. [Graphical view]
Pfam	PF12308. Noelin-1. 1 hit. PF02191. OLF. 1 hit. [Graphical view]
SMART	SM00284. OLF. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. PS51132. OLF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OLFM1. mouse.
NextBio	311952.
SOURCE	Search...

Entry information

Entry name

NOE1_MOUSE

Accession

Primary (citable) accession number: O88998
Secondary accession number(s): A3KGE5 , O35429, O88999, Q91XK8, Q9QWQ9, Q9QWR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program