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Protein
Submitted name:

BCL-W

Gene

Bcl2l2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • BH domain binding Source: RGD
  • disordered domain specific binding Source: Ensembl
  • protein heterodimerization activity Source: RGD

GO - Biological processi

Keywordsi

Biological processApoptosisPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
BCL-WImported
Submitted name:
Bcl-wImported
Submitted name:
Bcl2-like 2Imported
Submitted name:
RCG23437, isoform CRA_bImported
Gene namesi
Name:Bcl2l2Imported
Synonyms:bcl-wImported
ORF Names:rCG_23437Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi620717. Bcl2l2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei170 – 191HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • Bcl-2 family protein complex Source: Ensembl
  • cytoplasm Source: RGD
  • cytosol Source: Ensembl
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: Ensembl
  • mitochondrion Source: RGD

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000015732.

Interactioni

GO - Molecular functioni

  • BH domain binding Source: RGD
  • disordered domain specific binding Source: Ensembl
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiO88996. 1 interactor.
STRINGi10116.ENSRNOP00000020409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 27BH4_2InterPro annotationAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 27BH4PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
GeneTreeiENSGT00530000062935.
HOVERGENiHBG004472.
KOiK02163.
OMAiVQDWMVT.
OrthoDBiEOG091G0PAK.
TreeFamiTF315834.

Family and domain databases

InterProiView protein in InterPro
IPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF56. PTHR11256:SF56. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
SUPFAMiSSF56854. SSF56854. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O88996-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPASTPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG
60 70 80 90 100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF
110 120 130 140 150
VFGAALCAES VNKEMEPLVG QVQDWMVTYL ETRLADWIHS SGGWAEFTAL
160 170 180 190
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
Length:193
Mass (Da):20,820
Last modified:November 1, 1998 - v1
Checksum:i36D6742F4529AFB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115371 Genomic DNA. No translation available.
AF096291 mRNA. Translation: AAC64200.1.
BC074021 mRNA. Translation: AAH74021.1.
AY185098 mRNA. Translation: AAO64468.1.
CH474049 Genomic DNA. Translation: EDM14197.1.
CH474049 Genomic DNA. Translation: EDM14198.1.
RefSeqiNP_068622.1. NM_021850.2.
XP_006252078.1. XM_006252016.3.
XP_017455283.1. XM_017599794.1.
UniGeneiRn.44267.

Genome annotation databases

EnsembliENSRNOT00000020409; ENSRNOP00000020409; ENSRNOG00000015732.
GeneIDi60434.
KEGGirno:60434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115371 Genomic DNA. No translation available.
AF096291 mRNA. Translation: AAC64200.1.
BC074021 mRNA. Translation: AAH74021.1.
AY185098 mRNA. Translation: AAO64468.1.
CH474049 Genomic DNA. Translation: EDM14197.1.
CH474049 Genomic DNA. Translation: EDM14198.1.
RefSeqiNP_068622.1. NM_021850.2.
XP_006252078.1. XM_006252016.3.
XP_017455283.1. XM_017599794.1.
UniGeneiRn.44267.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88996. 1 interactor.
STRINGi10116.ENSRNOP00000020409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020409; ENSRNOP00000020409; ENSRNOG00000015732.
GeneIDi60434.
KEGGirno:60434.

Organism-specific databases

CTDi599.
RGDi620717. Bcl2l2.

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
GeneTreeiENSGT00530000062935.
HOVERGENiHBG004472.
KOiK02163.
OMAiVQDWMVT.
OrthoDBiEOG091G0PAK.
TreeFamiTF315834.

Miscellaneous databases

PROiPR:O88996.

Gene expression databases

BgeeiENSRNOG00000015732.

Family and domain databases

InterProiView protein in InterPro
IPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF56. PTHR11256:SF56. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
SUPFAMiSSF56854. SSF56854. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO88996_RAT
AccessioniPrimary (citable) accession number: O88996
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.