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O88992 (C1QRF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name=C1q/TNF-related protein 14
Short name=CTRP14
Complement component 1 Q subcomponent-like 1
Gene names
Name:C1ql1
Synonyms:C1qrf, Crf, Ctrp14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Ref.4

Subunit structure

Interacts with BAI3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion. Ref.4 Ref.5

Subcellular location

Secreted.

Tissue specificity

Expressed in brainstem. More abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus.

Sequence similarities

Contains 1 C1q domain.

Contains 1 collagen-like domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainCollagen
Signal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcollagen trimer

Inferred from electronic annotation. Source: UniProtKB-KW

cytoplasm

Inferred from direct assay Ref.1. Source: MGI

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 258242C1q-related factor
PRO_0000003528

Regions

Domain67 – 11549Collagen-like
Domain125 – 258134C1q

Experimental info

Mutagenesis281C → A: Does not affect heterooligomerization with C1QL4; when associated with A-32. Ref.5
Mutagenesis321C → A: Does not affect heterooligomerization with C1QL4; when associated with A-28. Ref.5
Sequence conflict521L → V in AAC64187. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O88992 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 3C769203069B2137

FASTA25826,500
        10         20         30         40         50         60 
MLLVLVVLIP VLVSSGGPDG HYEMLGTCRM VCDPYPARGP GAGARSDGGD ALSEQSGAPP 

        70         80         90        100        110        120 
PSTLVQGPQG KPGRTGKPGP PGPPGDRGPP GPVGPPGEKG EPGKPGPPGL PGSGGSGAIS 

       130        140        150        160        170        180 
TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV 

       190        200        210        220        230        240 
LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH 

       250 
GGNSNKYSTF SGFIIYSD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins."
Bolliger M.F., Martinelli D.C., Sudhof T.C.
Proc. Natl. Acad. Sci. U.S.A. 108:2534-2539(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH BAI3.
[5]"C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis."
Wei Z., Seldin M.M., Natarajan N., Djemal D.C., Peterson J.M., Wong G.W.
J. Biol. Chem. 288:10214-10229(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH C1QL4, MUTAGENESIS OF CYS-28 AND CYS-32.
Strain: C57BL/6.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF095155 mRNA. Translation: AAC64187.1.
AL731670 Genomic DNA. Translation: CAM25117.1.
CH466558 Genomic DNA. Translation: EDL34162.1.
CCDSCCDS25509.1.
RefSeqNP_035925.2. NM_011795.2.
UniGeneMm.57154.

3D structure databases

ProteinModelPortalO88992.
SMRO88992. Positions 129-258.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO88992.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532.
GeneID23829.
KEGGmmu:23829.
UCSCuc007lsz.2. mouse.

Organism-specific databases

CTD10882.
MGIMGI:1344400. C1ql1.

Phylogenomic databases

eggNOGNOG134911.
GeneTreeENSGT00730000110222.
HOGENOMHOG000085653.
HOVERGENHBG108220.
InParanoidO88992.
OMALSDHSNV.
OrthoDBEOG757CZJ.
TreeFamTF329591.

Gene expression databases

CleanExMM_C1QL1.
GenevestigatorO88992.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303489.
PROO88992.
SOURCESearch...

Entry information

Entry nameC1QRF_MOUSE
AccessionPrimary (citable) accession number: O88992
Secondary accession number(s): A2AH89
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot