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O88992

- C1QRF_MOUSE

UniProt

O88992 - C1QRF_MOUSE

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Protein

C1q-related factor

Gene

C1ql1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name:
C1q/TNF-related protein 14
Short name:
CTRP14
Complement component 1 Q subcomponent-like 1
Gene namesi
Name:C1ql1
Synonyms:C1qrf, Crf, Ctrp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1344400. C1ql1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. cytoplasm Source: MGI
  3. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi28 – 281C → A: Does not affect heterooligomerization with C1QL4; when associated with A-32. 1 Publication
Mutagenesisi32 – 321C → A: Does not affect heterooligomerization with C1QL4; when associated with A-28. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 258242C1q-related factorPRO_0000003528Add
BLAST

Proteomic databases

PRIDEiO88992.

Expressioni

Tissue specificityi

Expressed in brainstem. More abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus.

Gene expression databases

CleanExiMM_C1QL1.
ExpressionAtlasiO88992. baseline.
GenevestigatoriO88992.

Interactioni

Subunit structurei

Interacts with BAI3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.2 Publications

Structurei

3D structure databases

ProteinModelPortaliO88992.
SMRiO88992. Positions 129-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 11549Collagen-likeAdd
BLAST
Domaini125 – 258134C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiNOG134911.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiO88992.
OMAiLSDHSNV.
OrthoDBiEOG757CZJ.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88992-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLVLVVLIP VLVSSGGPDG HYEMLGTCRM VCDPYPARGP GAGARSDGGD
60 70 80 90 100
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDRGPP GPVGPPGEKG
110 120 130 140 150
EPGKPGPPGL PGSGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD
160 170 180 190 200
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV
210 220 230 240 250
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF

SGFIIYSD
Length:258
Mass (Da):26,500
Last modified:October 3, 2012 - v2
Checksum:i3C769203069B2137
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521L → V in AAC64187. (PubMed:9878755)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095155 mRNA. Translation: AAC64187.1.
AL731670 Genomic DNA. Translation: CAM25117.1.
CH466558 Genomic DNA. Translation: EDL34162.1.
CCDSiCCDS25509.1.
RefSeqiNP_035925.2. NM_011795.2.
UniGeneiMm.57154.

Genome annotation databases

EnsembliENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532.
GeneIDi23829.
KEGGimmu:23829.
UCSCiuc007lsz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095155 mRNA. Translation: AAC64187.1 .
AL731670 Genomic DNA. Translation: CAM25117.1 .
CH466558 Genomic DNA. Translation: EDL34162.1 .
CCDSi CCDS25509.1.
RefSeqi NP_035925.2. NM_011795.2.
UniGenei Mm.57154.

3D structure databases

ProteinModelPortali O88992.
SMRi O88992. Positions 129-258.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O88992.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057849 ; ENSMUSP00000050469 ; ENSMUSG00000045532 .
GeneIDi 23829.
KEGGi mmu:23829.
UCSCi uc007lsz.2. mouse.

Organism-specific databases

CTDi 10882.
MGIi MGI:1344400. C1ql1.

Phylogenomic databases

eggNOGi NOG134911.
GeneTreei ENSGT00760000119052.
HOGENOMi HOG000085653.
HOVERGENi HBG108220.
InParanoidi O88992.
OMAi LSDHSNV.
OrthoDBi EOG757CZJ.
TreeFami TF329591.

Miscellaneous databases

NextBioi 303489.
PROi O88992.
SOURCEi Search...

Gene expression databases

CleanExi MM_C1QL1.
ExpressionAtlasi O88992. baseline.
Genevestigatori O88992.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
    Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
    Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins."
    Bolliger M.F., Martinelli D.C., Sudhof T.C.
    Proc. Natl. Acad. Sci. U.S.A. 108:2534-2539(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BAI3.
  5. "C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis."
    Wei Z., Seldin M.M., Natarajan N., Djemal D.C., Peterson J.M., Wong G.W.
    J. Biol. Chem. 288:10214-10229(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH C1QL4, MUTAGENESIS OF CYS-28 AND CYS-32.
    Strain: C57BL/6.
    Tissue: Testis.

Entry informationi

Entry nameiC1QRF_MOUSE
AccessioniPrimary (citable) accession number: O88992
Secondary accession number(s): A2AH89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3