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Protein

C1q-related factor

Gene

C1ql1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.1 Publication

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

  • maintenance of synapse structure Source: MGI
  • motor learning Source: MGI
  • neuron remodeling Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
C1q-related factor
Alternative name(s):
C1q and tumor necrosis factor-related protein 14
Short name:
C1q/TNF-related protein 14
Short name:
CTRP14
Complement component 1 Q subcomponent-like 1
Gene namesi
Name:C1ql1
Synonyms:C1qrf, Crf, Ctrp14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1344400. C1ql1.

Subcellular locationi

GO - Cellular componenti

  • climbing fiber Source: MGI
  • collagen trimer Source: UniProtKB-KW
  • cytoplasm Source: MGI
  • presynapse Source: MGI
  • synaptic cleft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi28C → A: Does not affect heterooligomerization with C1QL4; when associated with A-32. 1 Publication1
Mutagenesisi32C → A: Does not affect heterooligomerization with C1QL4; when associated with A-28. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000352817 – 258C1q-related factorAdd BLAST242

Proteomic databases

PaxDbiO88992.
PeptideAtlasiO88992.
PRIDEiO88992.

PTM databases

PhosphoSitePlusiO88992.

Expressioni

Tissue specificityi

Expressed in brainstem. More abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus.

Gene expression databases

BgeeiENSMUSG00000045532.
CleanExiMM_C1QL1.
GenevisibleiO88992. MM.

Interactioni

Subunit structurei

Interacts with ADGRB3 (PubMed:21262840). Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion (PubMed:23449976).2 Publications

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

DIPiDIP-61402N.
STRINGi10090.ENSMUSP00000050469.

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi131 – 135Combined sources5
Beta strandi140 – 145Combined sources6
Beta strandi150 – 155Combined sources6
Turni161 – 163Combined sources3
Beta strandi172 – 182Combined sources11
Beta strandi184 – 186Combined sources3
Beta strandi188 – 196Combined sources9
Beta strandi199 – 207Combined sources9
Beta strandi214 – 224Combined sources11
Beta strandi229 – 239Combined sources11
Beta strandi243 – 245Combined sources3
Beta strandi248 – 257Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D7YX-ray1.44A125-258[»]
4QQ2X-ray1.80A/B/C122-258[»]
ProteinModelPortaliO88992.
SMRiO88992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 115Collagen-likeAdd BLAST49
Domaini125 – 258C1qPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Contains 1 C1q domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Signal

Phylogenomic databases

eggNOGiENOG410IFA6. Eukaryota.
ENOG4111FAZ. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiO88992.
OMAiLSDHSNV.
OrthoDBiEOG091G0UOF.
TreeFamiTF329591.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVLVVLIP VLVSSGGPDG HYEMLGTCRM VCDPYPARGP GAGARSDGGD
60 70 80 90 100
ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDRGPP GPVGPPGEKG
110 120 130 140 150
EPGKPGPPGL PGSGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD
160 170 180 190 200
VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV
210 220 230 240 250
RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF

SGFIIYSD
Length:258
Mass (Da):26,500
Last modified:October 3, 2012 - v2
Checksum:i3C769203069B2137
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52L → V in AAC64187 (PubMed:9878755).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095155 mRNA. Translation: AAC64187.1.
AL731670 Genomic DNA. Translation: CAM25117.1.
CH466558 Genomic DNA. Translation: EDL34162.1.
CCDSiCCDS25509.1.
RefSeqiNP_035925.2. NM_011795.2.
UniGeneiMm.57154.

Genome annotation databases

EnsembliENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532.
GeneIDi23829.
KEGGimmu:23829.
UCSCiuc007lsz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095155 mRNA. Translation: AAC64187.1.
AL731670 Genomic DNA. Translation: CAM25117.1.
CH466558 Genomic DNA. Translation: EDL34162.1.
CCDSiCCDS25509.1.
RefSeqiNP_035925.2. NM_011795.2.
UniGeneiMm.57154.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D7YX-ray1.44A125-258[»]
4QQ2X-ray1.80A/B/C122-258[»]
ProteinModelPortaliO88992.
SMRiO88992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61402N.
STRINGi10090.ENSMUSP00000050469.

PTM databases

PhosphoSitePlusiO88992.

Proteomic databases

PaxDbiO88992.
PeptideAtlasiO88992.
PRIDEiO88992.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532.
GeneIDi23829.
KEGGimmu:23829.
UCSCiuc007lsz.2. mouse.

Organism-specific databases

CTDi10882.
MGIiMGI:1344400. C1ql1.

Phylogenomic databases

eggNOGiENOG410IFA6. Eukaryota.
ENOG4111FAZ. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000085653.
HOVERGENiHBG108220.
InParanoidiO88992.
OMAiLSDHSNV.
OrthoDBiEOG091G0UOF.
TreeFamiTF329591.

Miscellaneous databases

PROiO88992.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045532.
CleanExiMM_C1QL1.
GenevisibleiO88992. MM.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q_dom.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1QRF_MOUSE
AccessioniPrimary (citable) accession number: O88992
Secondary accession number(s): A2AH89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.