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O88992

- C1QRF_MOUSE

UniProt

O88992 - C1QRF_MOUSE

Protein

C1q-related factor

Gene

C1ql1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C1q-related factor
    Alternative name(s):
    C1q and tumor necrosis factor-related protein 14
    Short name:
    C1q/TNF-related protein 14
    Short name:
    CTRP14
    Complement component 1 Q subcomponent-like 1
    Gene namesi
    Name:C1ql1
    Synonyms:C1qrf, Crf, Ctrp14
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1344400. C1ql1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. cytoplasm Source: MGI
    3. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi28 – 281C → A: Does not affect heterooligomerization with C1QL4; when associated with A-32. 1 Publication
    Mutagenesisi32 – 321C → A: Does not affect heterooligomerization with C1QL4; when associated with A-28. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 258242C1q-related factorPRO_0000003528Add
    BLAST

    Proteomic databases

    PRIDEiO88992.

    Expressioni

    Tissue specificityi

    Expressed in brainstem. More abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus.

    Gene expression databases

    CleanExiMM_C1QL1.
    GenevestigatoriO88992.

    Interactioni

    Subunit structurei

    Interacts with BAI3. Forms heterooligomers with C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.2 Publications

    Structurei

    3D structure databases

    ProteinModelPortaliO88992.
    SMRiO88992. Positions 129-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 11549Collagen-likeAdd
    BLAST
    Domaini125 – 258134C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C1q domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Signal

    Phylogenomic databases

    eggNOGiNOG134911.
    GeneTreeiENSGT00730000110222.
    HOGENOMiHOG000085653.
    HOVERGENiHBG108220.
    InParanoidiO88992.
    OMAiLSDHSNV.
    OrthoDBiEOG757CZJ.
    TreeFamiTF329591.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88992-1 [UniParc]FASTAAdd to Basket

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    MLLVLVVLIP VLVSSGGPDG HYEMLGTCRM VCDPYPARGP GAGARSDGGD    50
    ALSEQSGAPP PSTLVQGPQG KPGRTGKPGP PGPPGDRGPP GPVGPPGEKG 100
    EPGKPGPPGL PGSGGSGAIS TATYTTVPRV AFYAGLKNPH EGYEVLKFDD 150
    VVTNLGNNYD AASGKFTCNI PGTYFFTYHV LMRGGDGTSM WADLCKNGQV 200
    RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH GGNSNKYSTF 250
    SGFIIYSD 258
    Length:258
    Mass (Da):26,500
    Last modified:October 3, 2012 - v2
    Checksum:i3C769203069B2137
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521L → V in AAC64187. (PubMed:9878755)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095155 mRNA. Translation: AAC64187.1.
    AL731670 Genomic DNA. Translation: CAM25117.1.
    CH466558 Genomic DNA. Translation: EDL34162.1.
    CCDSiCCDS25509.1.
    RefSeqiNP_035925.2. NM_011795.2.
    UniGeneiMm.57154.

    Genome annotation databases

    EnsembliENSMUST00000057849; ENSMUSP00000050469; ENSMUSG00000045532.
    GeneIDi23829.
    KEGGimmu:23829.
    UCSCiuc007lsz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095155 mRNA. Translation: AAC64187.1 .
    AL731670 Genomic DNA. Translation: CAM25117.1 .
    CH466558 Genomic DNA. Translation: EDL34162.1 .
    CCDSi CCDS25509.1.
    RefSeqi NP_035925.2. NM_011795.2.
    UniGenei Mm.57154.

    3D structure databases

    ProteinModelPortali O88992.
    SMRi O88992. Positions 129-258.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O88992.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057849 ; ENSMUSP00000050469 ; ENSMUSG00000045532 .
    GeneIDi 23829.
    KEGGi mmu:23829.
    UCSCi uc007lsz.2. mouse.

    Organism-specific databases

    CTDi 10882.
    MGIi MGI:1344400. C1ql1.

    Phylogenomic databases

    eggNOGi NOG134911.
    GeneTreei ENSGT00730000110222.
    HOGENOMi HOG000085653.
    HOVERGENi HBG108220.
    InParanoidi O88992.
    OMAi LSDHSNV.
    OrthoDBi EOG757CZJ.
    TreeFami TF329591.

    Miscellaneous databases

    NextBioi 303489.
    PROi O88992.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_C1QL1.
    Genevestigatori O88992.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR008160. Collagen.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00386. C1q. 1 hit.
    PF01391. Collagen. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function."
      Berube N.G., Swanson X.H., Bertram M.J., Kittle J.D., Didenko V., Baskin D.S., Smith J.R., Pereira-Smith O.M.
      Brain Res. Mol. Brain Res. 63:233-240(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins."
      Bolliger M.F., Martinelli D.C., Sudhof T.C.
      Proc. Natl. Acad. Sci. U.S.A. 108:2534-2539(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BAI3.
    5. "C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis."
      Wei Z., Seldin M.M., Natarajan N., Djemal D.C., Peterson J.M., Wong G.W.
      J. Biol. Chem. 288:10214-10229(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH C1QL4, MUTAGENESIS OF CYS-28 AND CYS-32.
      Strain: C57BL/6.
      Tissue: Testis.

    Entry informationi

    Entry nameiC1QRF_MOUSE
    AccessioniPrimary (citable) accession number: O88992
    Secondary accession number(s): A2AH89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3