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O88983

- STX8_MOUSE

UniProt

O88983 - STX8_MOUSE

Protein

Syntaxin-8

Gene

Stx8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.By similarity

    GO - Molecular functioni

    1. SNAP receptor activity Source: RefGenome
    2. SNARE binding Source: MGI
    3. ubiquitin protein ligase binding Source: UniProtKB

    GO - Biological processi

    1. endosome to lysosome transport Source: Ensembl
    2. intracellular protein transport Source: RefGenome
    3. vesicle fusion Source: RefGenome

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Syntaxin-8
    Alternative name(s):
    Syntaxin-like protein 3I35
    Gene namesi
    Name:Stx8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1890156. Stx8.

    Subcellular locationi

    Membrane By similarity; Single-pass type IV membrane protein By similarity
    Note: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: RefGenome
    2. late endosome membrane Source: Ensembl
    3. lysosomal membrane Source: Ensembl
    4. SNARE complex Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236Syntaxin-8PRO_0000210218Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei160 – 1601Phosphoserine1 Publication

    Post-translational modificationi

    Ubiquitinated by HECTD3.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO88983.
    PaxDbiO88983.
    PRIDEiO88983.

    PTM databases

    PhosphoSiteiO88983.

    Expressioni

    Gene expression databases

    ArrayExpressiO88983.
    BgeeiO88983.
    CleanExiMM_STX8.
    GenevestigatoriO88983.

    Interactioni

    Subunit structurei

    Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 By similarity. Interacts with HECTD3.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi207739. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO88983.
    SMRiO88983. Positions 152-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 215215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini233 – 2364VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei216 – 23217Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 20763t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili42 – 6524By similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the syntaxin family.Curated
    Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG259218.
    GeneTreeiENSGT00390000007779.
    HOGENOMiHOG000031515.
    HOVERGENiHBG007572.
    InParanoidiO88983.
    KOiK08501.
    OMAiNQYERNG.
    OrthoDBiEOG7PS1GG.
    PhylomeDBiO88983.
    TreeFamiTF323262.

    Family and domain databases

    InterProiIPR000727. T_SNARE_dom.
    [Graphical view]
    PfamiPF05739. SNARE. 1 hit.
    [Graphical view]
    SMARTiSM00397. t_SNARE. 1 hit.
    [Graphical view]
    PROSITEiPS50192. T_SNARE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88983-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN    50
    LKVKIDLLKD LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE 100
    GAEPDLIRSS LMSEEAKRGT PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE 150
    QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRTE 200
    ARRVTLVDRK STSCGMIMVI LLLLVAIVVV AVWPTN 236
    Length:236
    Mass (Da):26,925
    Last modified:November 1, 1998 - v1
    Checksum:iEAE1D9D150C2EF2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093064 mRNA. Translation: AAC64149.1.
    AF036716 mRNA. Translation: AAC95286.1.
    AB040054 mRNA. Translation: BAB20500.1.
    AK003297 mRNA. Translation: BAB22698.1.
    AL669842, AL663076 Genomic DNA. Translation: CAI24774.1.
    BC048167 mRNA. Translation: AAH48167.1.
    BC048479 mRNA. Translation: AAH48479.1.
    CCDSiCCDS24863.1.
    RefSeqiNP_061238.1. NM_018768.2.
    UniGeneiMm.3973.

    Genome annotation databases

    EnsembliENSMUST00000021285; ENSMUSP00000021285; ENSMUSG00000020903.
    GeneIDi55943.
    KEGGimmu:55943.
    UCSCiuc007jnj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF093064 mRNA. Translation: AAC64149.1 .
    AF036716 mRNA. Translation: AAC95286.1 .
    AB040054 mRNA. Translation: BAB20500.1 .
    AK003297 mRNA. Translation: BAB22698.1 .
    AL669842 , AL663076 Genomic DNA. Translation: CAI24774.1 .
    BC048167 mRNA. Translation: AAH48167.1 .
    BC048479 mRNA. Translation: AAH48479.1 .
    CCDSi CCDS24863.1.
    RefSeqi NP_061238.1. NM_018768.2.
    UniGenei Mm.3973.

    3D structure databases

    ProteinModelPortali O88983.
    SMRi O88983. Positions 152-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207739. 5 interactions.

    PTM databases

    PhosphoSitei O88983.

    Proteomic databases

    MaxQBi O88983.
    PaxDbi O88983.
    PRIDEi O88983.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021285 ; ENSMUSP00000021285 ; ENSMUSG00000020903 .
    GeneIDi 55943.
    KEGGi mmu:55943.
    UCSCi uc007jnj.1. mouse.

    Organism-specific databases

    CTDi 9482.
    MGIi MGI:1890156. Stx8.

    Phylogenomic databases

    eggNOGi NOG259218.
    GeneTreei ENSGT00390000007779.
    HOGENOMi HOG000031515.
    HOVERGENi HBG007572.
    InParanoidi O88983.
    KOi K08501.
    OMAi NQYERNG.
    OrthoDBi EOG7PS1GG.
    PhylomeDBi O88983.
    TreeFami TF323262.

    Miscellaneous databases

    NextBioi 311626.
    PROi O88983.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88983.
    Bgeei O88983.
    CleanExi MM_STX8.
    Genevestigatori O88983.

    Family and domain databases

    InterProi IPR000727. T_SNARE_dom.
    [Graphical view ]
    Pfami PF05739. SNARE. 1 hit.
    [Graphical view ]
    SMARTi SM00397. t_SNARE. 1 hit.
    [Graphical view ]
    PROSITEi PS50192. T_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Thoreau V., Bilan F., Kitzis A., Chomel J.-C.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Subramaniam V.N., Loh E., Hong W.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Mouse syntaxin8."
      Nakamura N., Wada Y., Futai M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Testis.
    7. "Interaction between syntaxin 8 and HECTd3, a HECT domain ligase."
      Zhang L., Kang L., Bond W., Zhang N.
      Cell. Mol. Neurobiol. 29:115-121(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HECTD3, UBIQUITINATION.
    8. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTX8_MOUSE
    AccessioniPrimary (citable) accession number: O88983
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3