SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O88983

- STX8_MOUSE

UniProt

O88983 - STX8_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Syntaxin-8
Gene
Stx8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER By similarity.

GO - Molecular functioni

  1. SNAP receptor activity Source: RefGenome
  2. SNARE binding Source: MGI
  3. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. endosome to lysosome transport Source: Ensembl
  2. intracellular protein transport Source: RefGenome
  3. vesicle fusion Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-8
Alternative name(s):
Syntaxin-like protein 3I35
Gene namesi
Name:Stx8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1890156. Stx8.

Subcellular locationi

Membrane; Single-pass type IV membrane protein By similarity
Note: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 215215Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei216 – 23217Helical; Anchor for type IV membrane protein; Reviewed prediction
Add
BLAST
Topological domaini233 – 2364Vesicular Reviewed prediction

GO - Cellular componenti

  1. SNARE complex Source: RefGenome
  2. integral component of membrane Source: RefGenome
  3. late endosome membrane Source: Ensembl
  4. lysosomal membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Syntaxin-8
PRO_0000210218Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei160 – 1601Phosphoserine1 Publication

Post-translational modificationi

Ubiquitinated by HECTD3.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO88983.
PaxDbiO88983.
PRIDEiO88983.

PTM databases

PhosphoSiteiO88983.

Expressioni

Gene expression databases

ArrayExpressiO88983.
BgeeiO88983.
CleanExiMM_STX8.
GenevestigatoriO88983.

Interactioni

Subunit structurei

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 By similarity. Interacts with HECTD3.1 Publication

Protein-protein interaction databases

BioGridi207739. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliO88983.
SMRiO88983. Positions 152-205.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 20763t-SNARE coiled-coil homology
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili42 – 6524 By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG259218.
GeneTreeiENSGT00390000007779.
HOGENOMiHOG000031515.
HOVERGENiHBG007572.
InParanoidiO88983.
KOiK08501.
OMAiNQYERNG.
OrthoDBiEOG7PS1GG.
PhylomeDBiO88983.
TreeFamiTF323262.

Family and domain databases

InterProiIPR000727. T_SNARE_dom.
[Graphical view]
PfamiPF05739. SNARE. 1 hit.
[Graphical view]
SMARTiSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEiPS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88983-1 [UniParc]FASTAAdd to Basket

« Hide

MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN    50
LKVKIDLLKD LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE 100
GAEPDLIRSS LMSEEAKRGT PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE 150
QDAGLDALSS IISRQKQMGQ EIGNELDEQN EIIDDLANLV ENTDEKLRTE 200
ARRVTLVDRK STSCGMIMVI LLLLVAIVVV AVWPTN 236
Length:236
Mass (Da):26,925
Last modified:November 1, 1998 - v1
Checksum:iEAE1D9D150C2EF2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093064 mRNA. Translation: AAC64149.1.
AF036716 mRNA. Translation: AAC95286.1.
AB040054 mRNA. Translation: BAB20500.1.
AK003297 mRNA. Translation: BAB22698.1.
AL669842, AL663076 Genomic DNA. Translation: CAI24774.1.
BC048167 mRNA. Translation: AAH48167.1.
BC048479 mRNA. Translation: AAH48479.1.
CCDSiCCDS24863.1.
RefSeqiNP_061238.1. NM_018768.2.
UniGeneiMm.3973.

Genome annotation databases

EnsembliENSMUST00000021285; ENSMUSP00000021285; ENSMUSG00000020903.
GeneIDi55943.
KEGGimmu:55943.
UCSCiuc007jnj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF093064 mRNA. Translation: AAC64149.1 .
AF036716 mRNA. Translation: AAC95286.1 .
AB040054 mRNA. Translation: BAB20500.1 .
AK003297 mRNA. Translation: BAB22698.1 .
AL669842 , AL663076 Genomic DNA. Translation: CAI24774.1 .
BC048167 mRNA. Translation: AAH48167.1 .
BC048479 mRNA. Translation: AAH48479.1 .
CCDSi CCDS24863.1.
RefSeqi NP_061238.1. NM_018768.2.
UniGenei Mm.3973.

3D structure databases

ProteinModelPortali O88983.
SMRi O88983. Positions 152-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207739. 5 interactions.

PTM databases

PhosphoSitei O88983.

Proteomic databases

MaxQBi O88983.
PaxDbi O88983.
PRIDEi O88983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021285 ; ENSMUSP00000021285 ; ENSMUSG00000020903 .
GeneIDi 55943.
KEGGi mmu:55943.
UCSCi uc007jnj.1. mouse.

Organism-specific databases

CTDi 9482.
MGIi MGI:1890156. Stx8.

Phylogenomic databases

eggNOGi NOG259218.
GeneTreei ENSGT00390000007779.
HOGENOMi HOG000031515.
HOVERGENi HBG007572.
InParanoidi O88983.
KOi K08501.
OMAi NQYERNG.
OrthoDBi EOG7PS1GG.
PhylomeDBi O88983.
TreeFami TF323262.

Miscellaneous databases

NextBioi 311626.
PROi O88983.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88983.
Bgeei O88983.
CleanExi MM_STX8.
Genevestigatori O88983.

Family and domain databases

InterProi IPR000727. T_SNARE_dom.
[Graphical view ]
Pfami PF05739. SNARE. 1 hit.
[Graphical view ]
SMARTi SM00397. t_SNARE. 1 hit.
[Graphical view ]
PROSITEi PS50192. T_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Thoreau V., Bilan F., Kitzis A., Chomel J.-C.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Subramaniam V.N., Loh E., Hong W.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Mouse syntaxin8."
    Nakamura N., Wada Y., Futai M.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Testis.
  7. "Interaction between syntaxin 8 and HECTd3, a HECT domain ligase."
    Zhang L., Kang L., Bond W., Zhang N.
    Cell. Mol. Neurobiol. 29:115-121(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HECTD3, UBIQUITINATION.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTX8_MOUSE
AccessioniPrimary (citable) accession number: O88983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi