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O88983 (STX8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Syntaxin-8
Alternative name(s):
Syntaxin-like protein 3I35
Gene names
Name:Stx8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER By similarity.

Subunit structure

Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 By similarity. Interacts with HECTD3. Ref.7

Subcellular location

Membrane; Single-pass type IV membrane protein By similarity. Note: Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits By similarity.

Post-translational modification

Ubiquitinated by HECTD3. Ref.7

Sequence similarities

Belongs to the syntaxin family.

Contains 1 t-SNARE coiled-coil homology domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236Syntaxin-8
PRO_0000210218

Regions

Topological domain1 – 215215Cytoplasmic Potential
Transmembrane216 – 23217Helical; Anchor for type IV membrane protein; Potential
Topological domain233 – 2364Vesicular Potential
Domain145 – 20763t-SNARE coiled-coil homology
Coiled coil42 – 6524 By similarity

Amino acid modifications

Modified residue1601Phosphoserine Ref.8

Sequences

Sequence LengthMass (Da)Tools
O88983 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: EAE1D9D150C2EF2D

FASTA23626,925
        10         20         30         40         50         60 
MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN LKVKIDLLKD 

        70         80         90        100        110        120 
LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGT 

       130        140        150        160        170        180 
PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN 

       190        200        210        220        230 
EIIDDLANLV ENTDEKLRTE ARRVTLVDRK STSCGMIMVI LLLLVAIVVV AVWPTN 

« Hide

References

« Hide 'large scale' references
[1]Thoreau V., Bilan F., Kitzis A., Chomel J.-C.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Subramaniam V.N., Loh E., Hong W.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Mouse syntaxin8."
Nakamura N., Wada Y., Futai M.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[5]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Testis.
[7]"Interaction between syntaxin 8 and HECTd3, a HECT domain ligase."
Zhang L., Kang L., Bond W., Zhang N.
Cell. Mol. Neurobiol. 29:115-121(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HECTD3, UBIQUITINATION.
[8]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF093064 mRNA. Translation: AAC64149.1.
AF036716 mRNA. Translation: AAC95286.1.
AB040054 mRNA. Translation: BAB20500.1.
AK003297 mRNA. Translation: BAB22698.1.
AL669842, AL663076 Genomic DNA. Translation: CAI24774.1.
BC048167 mRNA. Translation: AAH48167.1.
BC048479 mRNA. Translation: AAH48479.1.
RefSeqNP_061238.1. NM_018768.2.
UniGeneMm.3973.

3D structure databases

ProteinModelPortalO88983.
SMRO88983. Positions 152-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207739. 5 interactions.

PTM databases

PhosphoSiteO88983.

Proteomic databases

PaxDbO88983.
PRIDEO88983.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021285; ENSMUSP00000021285; ENSMUSG00000020903.
GeneID55943.
KEGGmmu:55943.
UCSCuc007jnj.1. mouse.

Organism-specific databases

CTD9482.
MGIMGI:1890156. Stx8.

Phylogenomic databases

eggNOGNOG259218.
GeneTreeENSGT00390000007779.
HOGENOMHOG000031515.
HOVERGENHBG007572.
InParanoidO88983.
KOK08501.
OMANQYERNG.
OrthoDBEOG7PS1GG.
PhylomeDBO88983.
TreeFamTF323262.

Gene expression databases

ArrayExpressO88983.
BgeeO88983.
CleanExMM_STX8.
GenevestigatorO88983.

Family and domain databases

InterProIPR015640. Syntax_8.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERPTHR12380:SF6. PTHR12380:SF6. 1 hit.
PfamPF05739. SNARE. 1 hit.
[Graphical view]
SMARTSM00397. t_SNARE. 1 hit.
[Graphical view]
PROSITEPS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311626.
PROO88983.
SOURCESearch...

Entry information

Entry nameSTX8_MOUSE
AccessionPrimary (citable) accession number: O88983
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot