Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein tilB homolog

Gene

Lrrc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tilB homolog
Alternative name(s):
Leucine-rich repeat-containing protein 6
Leucine-rich testis-specific protein
Testis-specific leucine-rich repeat protein
Gene namesi
Name:Lrrc6
Synonyms:Lrtp, Mc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859553 Lrrc6

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844981 – 473Protein tilB homologAdd BLAST473

Proteomic databases

PaxDbiO88978
PRIDEiO88978

PTM databases

PhosphoSitePlusiO88978

Expressioni

Tissue specificityi

Testis-specific (at protein level). Expressed in testis. Abundant expression in late prophase of meiosis I with a dramatic decrease after the first meiotic division.1 Publication

Gene expression databases

BgeeiENSMUSG00000022375
CleanExiMM_LRRC6
GenevisibleiO88978 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023006

Structurei

3D structure databases

ProteinModelPortaliO88978
SMRiO88978
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 43LRR 1Add BLAST22
Repeati45 – 66LRR 2Add BLAST22
Repeati67 – 88LRR 3Add BLAST22
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39
Domaini305 – 402CSAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 205Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 290Poly-Lys6

Sequence similaritiesi

Belongs to the tilB family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00860000133819
HOGENOMiHOG000258801
HOVERGENiHBG053229
InParanoidiO88978
KOiK19753
OMAiDFDGYRQ
OrthoDBiEOG091G0J6C
PhylomeDBiO88978
TreeFamiTF324815

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequencei

Sequence statusi: Complete.

O88978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRITEDLIR RNAEHNDCVI FSLEELSLHQ QEIERLEHID KWCRDLKILY
60 70 80 90 100
LQNNLIGKIE NVSKLKKLEY LNLALNNIER IENLEGCEWL TKLDLTVNFI
110 120 130 140 150
GELSSVKTLT HNIHLKELFL MGNPCADFDG YRQFVVVTLQ QLKWLDGKEI
160 170 180 190 200
ERSERIQALQ NYTSVEQQIR EQEKAYCLRR AKEKEEAQRK LEEENESEDK
210 220 230 240 250
KKSSTGFDGH WYTDIHTACP SATENQDYPQ VPETQEEQHN TKESDDIEDD
260 270 280 290 300
LAFWNKPSLF TPESRLETLR HMEKQRKAQD KLSEKKKKAK PPRTLITEDG
310 320 330 340 350
KVLNVNEAKL DFSLKDDEKH NQIILDLAVY RYMDTSLIEV DVQPTYVRVM
360 370 380 390 400
VKGKPFQLAL STEVQPDRSS AKRSQTTGHL LICMPKVGEM ITGGQRTPTS
410 420 430 440 450
VKTTSTSSRE QTNPRKKQIE RLEVDPSKHS CPDVSTIVQE KRHRPKRMES
460 470
QPRDEPSEED PDFEDNPEVP PLI
Length:473
Mass (Da):55,049
Last modified:November 1, 1998 - v1
Checksum:iA7181C5B4560E135
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225N → I in BAB30161 (PubMed:16141072).Curated1
Sequence conflicti239H → N in BAB30161 (PubMed:16141072).Curated1
Sequence conflicti259 – 262LFTP → FFFL in BAB30161 (PubMed:16141072).Curated4
Sequence conflicti271 – 272HM → FL in BAB30161 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092208 mRNA Translation: AAC61765.1
AK016236 mRNA Translation: BAB30161.1
AK077124 mRNA Translation: BAC36627.1
BC046277 mRNA Translation: AAH46277.1
CCDSiCCDS49620.1
RefSeqiNP_062330.1, NM_019457.2
UniGeneiMm.244890

Genome annotation databases

EnsembliENSMUST00000023006; ENSMUSP00000023006; ENSMUSG00000022375
GeneIDi54562
KEGGimmu:54562
UCSCiuc011ztm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTILB_MOUSE
AccessioniPrimary (citable) accession number: O88978
Secondary accession number(s): Q9CUG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health