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Protein

Protein tilB homolog

Gene

Lrrc6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tilB homolog
Alternative name(s):
Leucine-rich repeat-containing protein 6
Leucine-rich testis-specific protein
Testis-specific leucine-rich repeat protein
Gene namesi
Name:Lrrc6
Synonyms:Lrtp, Mc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859553. Lrrc6.

Subcellular locationi

GO - Cellular componenti

  • cilium Source: MGI
  • cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844981 – 473Protein tilB homologAdd BLAST473

Proteomic databases

PaxDbiO88978.
PRIDEiO88978.

PTM databases

PhosphoSitePlusiO88978.

Expressioni

Tissue specificityi

Testis-specific (at protein level). Expressed in testis. Abundant expression in late prophase of meiosis I with a dramatic decrease after the first meiotic division.1 Publication

Gene expression databases

BgeeiENSMUSG00000022375.
CleanExiMM_LRRC6.
GenevisibleiO88978. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023006.

Structurei

3D structure databases

ProteinModelPortaliO88978.
SMRiO88978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 43LRR 1Add BLAST22
Repeati45 – 66LRR 2Add BLAST22
Repeati67 – 88LRR 3Add BLAST22
Repeati89 – 110LRR 4Add BLAST22
Domaini123 – 161LRRCTAdd BLAST39
Domaini305 – 402CSAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 205Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi285 – 290Poly-Lys6

Sequence similaritiesi

Belongs to the tilB family.Curated
Contains 1 CS domain.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133819.
HOGENOMiHOG000258801.
HOVERGENiHBG053229.
InParanoidiO88978.
KOiK19753.
OMAiNLEGCEG.
OrthoDBiEOG091G0J6C.
PhylomeDBiO88978.
TreeFamiTF324815.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRITEDLIR RNAEHNDCVI FSLEELSLHQ QEIERLEHID KWCRDLKILY
60 70 80 90 100
LQNNLIGKIE NVSKLKKLEY LNLALNNIER IENLEGCEWL TKLDLTVNFI
110 120 130 140 150
GELSSVKTLT HNIHLKELFL MGNPCADFDG YRQFVVVTLQ QLKWLDGKEI
160 170 180 190 200
ERSERIQALQ NYTSVEQQIR EQEKAYCLRR AKEKEEAQRK LEEENESEDK
210 220 230 240 250
KKSSTGFDGH WYTDIHTACP SATENQDYPQ VPETQEEQHN TKESDDIEDD
260 270 280 290 300
LAFWNKPSLF TPESRLETLR HMEKQRKAQD KLSEKKKKAK PPRTLITEDG
310 320 330 340 350
KVLNVNEAKL DFSLKDDEKH NQIILDLAVY RYMDTSLIEV DVQPTYVRVM
360 370 380 390 400
VKGKPFQLAL STEVQPDRSS AKRSQTTGHL LICMPKVGEM ITGGQRTPTS
410 420 430 440 450
VKTTSTSSRE QTNPRKKQIE RLEVDPSKHS CPDVSTIVQE KRHRPKRMES
460 470
QPRDEPSEED PDFEDNPEVP PLI
Length:473
Mass (Da):55,049
Last modified:November 1, 1998 - v1
Checksum:iA7181C5B4560E135
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225N → I in BAB30161 (PubMed:16141072).Curated1
Sequence conflicti239H → N in BAB30161 (PubMed:16141072).Curated1
Sequence conflicti259 – 262LFTP → FFFL in BAB30161 (PubMed:16141072).Curated4
Sequence conflicti271 – 272HM → FL in BAB30161 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092208 mRNA. Translation: AAC61765.1.
AK016236 mRNA. Translation: BAB30161.1.
AK077124 mRNA. Translation: BAC36627.1.
BC046277 mRNA. Translation: AAH46277.1.
CCDSiCCDS49620.1.
RefSeqiNP_062330.1. NM_019457.2.
UniGeneiMm.244890.

Genome annotation databases

EnsembliENSMUST00000023006; ENSMUSP00000023006; ENSMUSG00000022375.
GeneIDi54562.
KEGGimmu:54562.
UCSCiuc011ztm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092208 mRNA. Translation: AAC61765.1.
AK016236 mRNA. Translation: BAB30161.1.
AK077124 mRNA. Translation: BAC36627.1.
BC046277 mRNA. Translation: AAH46277.1.
CCDSiCCDS49620.1.
RefSeqiNP_062330.1. NM_019457.2.
UniGeneiMm.244890.

3D structure databases

ProteinModelPortaliO88978.
SMRiO88978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023006.

PTM databases

PhosphoSitePlusiO88978.

Proteomic databases

PaxDbiO88978.
PRIDEiO88978.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023006; ENSMUSP00000023006; ENSMUSG00000022375.
GeneIDi54562.
KEGGimmu:54562.
UCSCiuc011ztm.1. mouse.

Organism-specific databases

CTDi23639.
MGIiMGI:1859553. Lrrc6.

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00860000133819.
HOGENOMiHOG000258801.
HOVERGENiHBG053229.
InParanoidiO88978.
KOiK19753.
OMAiNLEGCEG.
OrthoDBiEOG091G0J6C.
PhylomeDBiO88978.
TreeFamiTF324815.

Miscellaneous databases

PROiO88978.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022375.
CleanExiMM_LRRC6.
GenevisibleiO88978. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTILB_MOUSE
AccessioniPrimary (citable) accession number: O88978
Secondary accession number(s): Q9CUG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.