##gff-version 3 O88974 UniProtKB Chain 1 1307 . . . ID=PRO_0000186065;Note=Histone-lysine N-methyltransferase SETDB1 O88974 UniProtKB Domain 257 320 . . . Note=Tudor 1 O88974 UniProtKB Domain 347 403 . . . Note=Tudor 2 O88974 UniProtKB Domain 611 682 . . . Note=MBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00338 O88974 UniProtKB Domain 744 817 . . . Note=Pre-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00157 O88974 UniProtKB Domain 820 1282 . . . Note=SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 O88974 UniProtKB Domain 1291 1307 . . . Note=Post-SET;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00155 O88974 UniProtKB Region 127 148 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Region 404 424 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Region 444 512 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Region 531 570 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Region 885 1174 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Coiled coil 30 65 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O88974 UniProtKB Compositional bias 451 467 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 471 512 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 538 566 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 910 927 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 946 962 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 982 1024 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 1051 1067 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Compositional bias 1095 1156 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O88974 UniProtKB Binding site 746 746 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 746 746 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 748 748 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 752 752 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 752 752 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 758 758 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 760 760 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 798 798 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 798 798 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 802 802 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 804 804 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 809 809 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 830 832 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 868 868 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 O88974 UniProtKB Binding site 870 870 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 O88974 UniProtKB Binding site 1236 1236 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00190 O88974 UniProtKB Binding site 1239 1240 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 1242 1242 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 1295 1295 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 1297 1297 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Binding site 1302 1302 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 O88974 UniProtKB Modified residue 112 112 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 O88974 UniProtKB Modified residue 117 117 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 O88974 UniProtKB Modified residue 120 120 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 O88974 UniProtKB Modified residue 1042 1042 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Modified residue 1186 1186 . . . Note=N6%2CN6%2CN6-trimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Modified residue 1186 1186 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Modified residue 1194 1194 . . . Note=N6%2CN6%2CN6-trimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Modified residue 1194 1194 . . . Note=N6%2CN6-dimethyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 182 182 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 182 182 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 1049 1049 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 1049 1049 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 1055 1055 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 1085 1085 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Cross-link 1165 1165 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q15047 O88974 UniProtKB Alternative sequence 1 807 . . . ID=VSP_002221;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O88974 UniProtKB Alternative sequence 474 474 . . . ID=VSP_024031;Note=In isoform 4 and isoform 6. D->ES;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:12693553,ECO:0000303|PubMed:16141072;Dbxref=PMID:12693553,PMID:16141072 O88974 UniProtKB Alternative sequence 482 486 . . . ID=VSP_002219;Note=In isoform 2. SRKQV->AQSQK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11791185;Dbxref=PMID:11791185 O88974 UniProtKB Alternative sequence 489 1307 . . . ID=VSP_002220;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:11791185;Dbxref=PMID:11791185 O88974 UniProtKB Alternative sequence 527 1307 . . . ID=VSP_024032;Note=In isoform 5 and isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14522075;Dbxref=PMID:14522075 O88974 UniProtKB Alternative sequence 756 1307 . . . ID=VSP_024033;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 O88974 UniProtKB Mutagenesis 798 798 . . . Note=Abolishes methyltransferase activity. C->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11791185;Dbxref=PMID:11791185 O88974 UniProtKB Mutagenesis 1242 1242 . . . Note=Decreases endogenous retroviruses silencing and cell growth. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20164836;Dbxref=PMID:20164836 O88974 UniProtKB Mutagenesis 1242 1242 . . . Note=Abolishes methyltransferase activity. C->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11791185;Dbxref=PMID:11791185 O88974 UniProtKB Sequence conflict 463 463 . . . Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 O88974 UniProtKB Sequence conflict 1092 1092 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305