O88974 (SETB1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase SETDB1
EC=2.1.1.43

Alternative name(s):
ERG-associated protein with SET domain
Short name=ESET
SET domain bifurcated 1

Gene names

Name:	Setdb1
Synonyms:	Eset, Kiaa0067

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1307 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. Ref.1
Subunit structure	Interacts with MBD1; interaction is abolished when MBD1 is sumoylated. Interacts with ATF7IP and ATF7IP2; the interaction with ATF7IP is required to stimulate histone methyltransferase activity and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9'. During DNA replication, it is recruited by SETDB1 to form a S phase-specific complex that facilitates methylation of H3 'Lys-9' during replication-coupled chromatin assembly and is at least composed of the CAF-1 subunit CHAF1A, MBD1 and SETDB1. Interacts with TRIM28/TIF1B, CBX1, CBX5, CHD7, DNMT3A, DNMT3B, NLK, PPARG and SUMO2. Interacts with MPHOSPH8 By similarity. Interacts with ERG, HDAC1, HDAC2, SIN3A, SIN3B. Ref.1 Ref.6
Subcellular location	Nucleus By similarity. Chromosome By similarity. Note: Associated with non-pericentromeric regions of chromatin By similarity.
Tissue specificity	Ubiquitously expressed. Strong expression in liver and testis. Ref.2
Domain	The pre-SET, SET and post-SET domains are all required for methyltransferase activity. The 347-amino-acid insertion in the SET domain has no effect on the catalytic activity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. Contains 1 MBD (methyl-CpG-binding) domain. Contains 1 post-SET domain. Contains 1 pre-SET domain. Contains 1 SET domain. Contains 2 Tudor domains.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Repressor Transferase
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone development Inferred from mutant phenotype PubMed 22876197. Source: MGI inner cell mass cell proliferation Inferred from mutant phenotype PubMed 14993285. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay PubMed 14993285. Source: MGI
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Erg	P81270	3	EBI-79658,EBI-79647

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: O88974-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O88974-2)

The sequence of this isoform differs from the canonical sequence as follows:
     482-486: SRKQV → AQSQK
     489-1307: Missing.

Isoform 3 (identifier: O88974-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-807: Missing.

Isoform 4 (identifier: O88974-4)

The sequence of this isoform differs from the canonical sequence as follows:
     474-474: D → ES

Isoform 5 (identifier: O88974-5)

The sequence of this isoform differs from the canonical sequence as follows:
     527-1307: Missing.

Isoform 6 (identifier: O88974-6)

The sequence of this isoform differs from the canonical sequence as follows:
     474-474: D → ES
     527-1307: Missing.

Isoform 7 (identifier: O88974-7)

The sequence of this isoform differs from the canonical sequence as follows:
     756-1307: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1307	1307	Histone-lysine N-methyltransferase SETDB1		PRO_0000186065
Regions
	Domain	257 – 320	64	Tudor 1
	Domain	347 – 403	57	Tudor 2
	Domain	611 – 682	72	MBD
	Domain	744 – 817	74	Pre-SET
	Domain	819 – 1286	468	SET
	Domain	1291 – 1307	17	Post-SET
	Coiled coil	30 – 65	36	Potential
Amino acid modifications
	Modified residue	993	1	Phosphothreonine; by NLK By similarity
	Cross-link	182		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Natural variations
	Alternative sequence	1 – 807	807	Missing in isoform 3.		VSP_002221
	Alternative sequence	474	1	D → ES in isoform 4 and isoform 6.		VSP_024031
	Alternative sequence	482 – 486	5	SRKQV → AQSQK in isoform 2.		VSP_002219
	Alternative sequence	489 – 1307	819	Missing in isoform 2.		VSP_002220
	Alternative sequence	527 – 1307	781	Missing in isoform 5 and isoform 6.		VSP_024032
	Alternative sequence	756 – 1307	552	Missing in isoform 7.		VSP_024033
Experimental info
	Mutagenesis	798	1	C → T: Abolishes methyltransferase activity. Ref.1
	Mutagenesis	1242	1	C → T: Abolishes methyltransferase activity. Ref.1
	Sequence conflict	463	1	I → M in BAC40439. Ref.5
	Sequence conflict	1092	1	P → S in BAC65480. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 326AED6371D156C2	FASTA	1,307	144,549
	10 20 30 40 50 60 MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 70 80 90 100 110 120 LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTDLESQLA 490 500 510 520 530 540 QSRKQVAKKS TSFRPGSVGS GHSSPTSSTL SENVSAGKLG INQTYRSPLA SVTSTPASAA 550 560 570 580 590 600 PPVPPVPPGP PTPPGPPAPP GPLAPPAFHG MLERAPAEPS YRAPMEKLFY LPHVCSYTCL 610 620 630 640 650 660 SRIRPMRNEQ YRGKNPLLVP LLYDFRRMTA RRRVNRKMGF HVIYKTPCGL CLRTMQEIER 670 680 690 700 710 720 YLFETGCDFL FLEMFCLDPY VLVDRKFQPF KPFYYILDIT YGKEDVPLSC VNEIDTTPPP 730 740 750 760 770 780 QVAYSKERIP GKGVFINTGP EFLVGCDCKD GCRDKSKCAC HQLTIQATAC TPGGQVNPNS 790 800 810 820 830 840 GYQYKRLEEC LPTGVYECNK RCNCDPNMCT NRLVQHGLQV RLQLFKTQNK GWGIRCLDDI 850 860 870 880 890 900 AKGSFVCIYA GKILTDDFAD KEGLEMGDEY FANLDHIESV ENFKEGYESD VPTSSDSSGV 910 920 930 940 950 960 DMKDQEDGNS GSEDPEESND DSSDDNFCKD EDFSTSSVWR SYATRRQTRG QKENELSEMT 970 980 990 1000 1010 1020 SKDSRPPDLG PPHVPIPSSV SVGGCNPPSS EETPKNKVAS WLSCNSVSEG GFADSDSRSS 1030 1040 1050 1060 1070 1080 FKTSEGGDGR AGGGRGEAER ASTSGLSFKD EGDNKQPKKE DPENRNKMPV VTEGSQNHGH 1090 1100 1110 1120 1130 1140 NPPMKSEGLR RPASKMSVLQ SQRVVTSTQS NPDDILTLSS STESEGESGT SRKPTAGHTS 1150 1160 1170 1180 1190 1200 ATAVDSDDIQ TISSGSDGDD FEDKKNLSGP TKRQVAVKST RGFALKSTHG IAIKSTNMAS 1210 1220 1230 1240 1250 1260 VDKGESAPVR KNTRQFYDGE ESCYIIDAKL EGNLGRYLNH SCSPNLFVQN VFVDTHDLRF 1270 1280 1290 1300 PWVAFFASKR IRAGTELTWD YNYEVGSVEG KELLCCCGAI ECRGRLL
	Isoform 2 [UniParc]. Checksum: 8874BF6A963B5415	FASTA	488	54,696
	10 20 30 40 50 60 MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 70 80 90 100 110 120 LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTDLESQLA QAQSQKAK
	Isoform 3 [UniParc]. Checksum: 164B400024020B2F	FASTA	500	54,477
	10 20 30 40 50 60 MCTNRLVQHG LQVRLQLFKT QNKGWGIRCL DDIAKGSFVC IYAGKILTDD FADKEGLEMG 70 80 90 100 110 120 DEYFANLDHI ESVENFKEGY ESDVPTSSDS SGVDMKDQED GNSGSEDPEE SNDDSSDDNF 130 140 150 160 170 180 CKDEDFSTSS VWRSYATRRQ TRGQKENELS EMTSKDSRPP DLGPPHVPIP SSVSVGGCNP 190 200 210 220 230 240 PSSEETPKNK VASWLSCNSV SEGGFADSDS RSSFKTSEGG DGRAGGGRGE AERASTSGLS 250 260 270 280 290 300 FKDEGDNKQP KKEDPENRNK MPVVTEGSQN HGHNPPMKSE GLRRPASKMS VLQSQRVVTS 310 320 330 340 350 360 TQSNPDDILT LSSSTESEGE SGTSRKPTAG HTSATAVDSD DIQTISSGSD GDDFEDKKNL 370 380 390 400 410 420 SGPTKRQVAV KSTRGFALKS THGIAIKSTN MASVDKGESA PVRKNTRQFY DGEESCYIID 430 440 450 460 470 480 AKLEGNLGRY LNHSCSPNLF VQNVFVDTHD LRFPWVAFFA SKRIRAGTEL TWDYNYEVGS 490 500 VEGKELLCCC GAIECRGRLL
	Isoform 4 [UniParc]. Checksum: E224818F50D56E25	FASTA	1,308	144,650
	10 20 30 40 50 60 MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 70 80 90 100 110 120 LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTESLESQL 490 500 510 520 530 540 AQSRKQVAKK STSFRPGSVG SGHSSPTSST LSENVSAGKL GINQTYRSPL ASVTSTPASA 550 560 570 580 590 600 APPVPPVPPG PPTPPGPPAP PGPLAPPAFH GMLERAPAEP SYRAPMEKLF YLPHVCSYTC 610 620 630 640 650 660 LSRIRPMRNE QYRGKNPLLV PLLYDFRRMT ARRRVNRKMG FHVIYKTPCG LCLRTMQEIE 670 680 690 700 710 720 RYLFETGCDF LFLEMFCLDP YVLVDRKFQP FKPFYYILDI TYGKEDVPLS CVNEIDTTPP 730 740 750 760 770 780 PQVAYSKERI PGKGVFINTG PEFLVGCDCK DGCRDKSKCA CHQLTIQATA CTPGGQVNPN 790 800 810 820 830 840 SGYQYKRLEE CLPTGVYECN KRCNCDPNMC TNRLVQHGLQ VRLQLFKTQN KGWGIRCLDD 850 860 870 880 890 900 IAKGSFVCIY AGKILTDDFA DKEGLEMGDE YFANLDHIES VENFKEGYES DVPTSSDSSG 910 920 930 940 950 960 VDMKDQEDGN SGSEDPEESN DDSSDDNFCK DEDFSTSSVW RSYATRRQTR GQKENELSEM 970 980 990 1000 1010 1020 TSKDSRPPDL GPPHVPIPSS VSVGGCNPPS SEETPKNKVA SWLSCNSVSE GGFADSDSRS 1030 1040 1050 1060 1070 1080 SFKTSEGGDG RAGGGRGEAE RASTSGLSFK DEGDNKQPKK EDPENRNKMP VVTEGSQNHG 1090 1100 1110 1120 1130 1140 HNPPMKSEGL RRPASKMSVL QSQRVVTSTQ SNPDDILTLS SSTESEGESG TSRKPTAGHT 1150 1160 1170 1180 1190 1200 SATAVDSDDI QTISSGSDGD DFEDKKNLSG PTKRQVAVKS TRGFALKSTH GIAIKSTNMA 1210 1220 1230 1240 1250 1260 SVDKGESAPV RKNTRQFYDG EESCYIIDAK LEGNLGRYLN HSCSPNLFVQ NVFVDTHDLR 1270 1280 1290 1300 FPWVAFFASK RIRAGTELTW DYNYEVGSVE GKELLCCCGA IECRGRLL
	Isoform 5 [UniParc]. Checksum: F5B6903C06D91D11	FASTA	526	58,617
	10 20 30 40 50 60 MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 70 80 90 100 110 120 LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTDLESQLA 490 500 510 520 QSRKQVAKKS TSFRPGSVGS GHSSPTSSTL SENVSAGKLG INQTYR
	Isoform 6 [UniParc]. Checksum: F2B3561EAA10EC06	FASTA	527	58,719
	10 20 30 40 50 60 MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 70 80 90 100 110 120 LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTESLESQL 490 500 510 520 AQSRKQVAKK STSFRPGSVG SGHSSPTSST LSENVSAGKL GINQTYR
	Isoform 7 [UniParc]. Checksum: 3AE0FFE5C3542A60	FASTA	755	84,400
	10 20 30 40 50 60 MSSLPGCMSL AAAPAAADSA EIAELQQAVV EELGISMEEL RQYIDEELEK MDCIQQRKKQ 70 80 90 100 110 120 LAELETWVLQ KESEVAYVDR LFDDASREVT NCESLVKDFY SKLGLQYHDS SSEDEASRPT 130 140 150 160 170 180 EIIEIPDEDD DVLSIDSGDA GSRTPKDQKL REAMAALRKS AQDVQKFMDA VNKKSSSQDL 190 200 210 220 230 240 HKGTLGQVSG ELSKDGDLIV SMRILGKKRT KTWHKGTLIA IQTVGLGKKY KVKFDNKGKS 250 260 270 280 290 300 LLSGNHIAYD YHPPADKLFV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG 310 320 330 340 350 360 YASYVTQSEL YPICRPLKKT WEDIEDSSCR DFIEEYITAY PNRPMVLLKS GQLIKTEWEG 370 380 390 400 410 420 TWWKSRVEEV DGSLVRILFL DDKRCEWIYR GSTRLEPMFS MKTSSASAME KKQGGQLRTR 430 440 450 460 470 480 PNMGAVRSKG PVVQYTQDLT GTGIQFKPME PLQPIAPPAP LPIPPLSPQA ADTDLESQLA 490 500 510 520 530 540 QSRKQVAKKS TSFRPGSVGS GHSSPTSSTL SENVSAGKLG INQTYRSPLA SVTSTPASAA 550 560 570 580 590 600 PPVPPVPPGP PTPPGPPAPP GPLAPPAFHG MLERAPAEPS YRAPMEKLFY LPHVCSYTCL 610 620 630 640 650 660 SRIRPMRNEQ YRGKNPLLVP LLYDFRRMTA RRRVNRKMGF HVIYKTPCGL CLRTMQEIER 670 680 690 700 710 720 YLFETGCDFL FLEMFCLDPY VLVDRKFQPF KPFYYILDIT YGKEDVPLSC VNEIDTTPPP 730 740 750 QVAYSKERIP GKGVFINTGP EFLVGCDCKD GCRDK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor." Yang L., Xia L., Wu D.Y., Wang H., Chansky H.A., Schubach W.H., Hickstein D.D., Zhang Y. Oncogene 21:148-152(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ENZYME ACTIVITY, INTERACTION WITH ERG, MUTAGENESIS OF CYS-798 AND CYS-1242. Strain: BDF1. Tissue: Blood.
[2]	"Genomic structure and expression of the mouse ESET gene encoding an ERG-associated histone methyltransferase with a SET domain." Blackburn M.L., Chansky H.A., Zielinska-Kwiatkowska A., Matsui Y., Yang L. Biochim. Biophys. Acta 1629:8-14(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 6), TISSUE SPECIFICITY. Strain: BDF1 and C57BL/6J X DBA/2.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 7). Strain: C57BL/6. Tissue: Brain.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H. DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-1307 (ISOFORM 4). Tissue: Brain.
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1307 (ISOFORM 4). Strain: NOD. Tissue: Thymus.
[6]	"An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B." Yang L., Mei Q., Zielinska-Kwiatkowska A., Matsui Y., Blackburn M.L., Benedetti D., Krumm A.A., Taborsky G.J. Jr., Chansky H.A. Biochem. J. 369:651-657(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HDAC1; HDAC2; SIN3A AND SIN3B.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF091628 mRNA. Translation: AAC43039.1. AY091600 mRNA. Translation: AAM13922.1. AF546078 mRNA. Translation: AAN52358.1. AY226577 Genomic DNA. Translation: AAO73535.2. AY226577 Genomic DNA. Translation: AAO73536.2. BC007176 mRNA. Translation: AAH07176.1. BC079537 mRNA. Translation: AAH79537.1. AK122198 Transcribed RNA. Translation: BAC65480.3. AK088590 mRNA. Translation: BAC40439.1.
IPI	IPI00221958. IPI00221959. IPI00421201. IPI00844635. IPI00844648. IPI00844681. IPI00844695.
PIR	T17453.
UniGene	Mm.490259.
3D structure databases
ProteinModelPortal	O88974.
SMR	O88974. Positions 196-397, 698-903, 1181-1306.
ModBase	Search...
Protein-protein interaction databases
IntAct	O88974. 9 interactions.
MINT	MINT-1753431.
STRING	10090.ENSMUSP00000102788.
PTM databases
PhosphoSite	O88974.
Proteomic databases
PaxDb	O88974.
PRIDE	O88974.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008qjo.2. mouse.
Organism-specific databases
MGI	MGI:1934229. Setdb1.
Rouge	Search...
Phylogenomic databases
eggNOG	COG2940.
HOVERGEN	HBG061013.
OrthoDB	EOG46Q6RR.
Gene expression databases
CleanEx	MM_SETDB1.
Genevestigator	O88974.
GermOnline	ENSMUSG00000015697. Mus musculus.
Family and domain databases
InterPro	IPR016177. DNA-bd_integrase-typ. IPR025796. Hist-Lys_N-MeTrfase_SETDB1. IPR001739. Methyl_CpG_DNA-bd. IPR003616. Post-SET_dom. IPR007728. Pre-SET_dom. IPR003606. Pre-SET_Zn-bd_sub. IPR001214. SET_dom. IPR002999. Tudor. [Graphical view]
Pfam	PF01429. MBD. 1 hit. PF05033. Pre-SET. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00391. MBD. 1 hit. SM00508. PostSET. 1 hit. SM00468. PreSET. 1 hit. SM00317. SET. 1 hit. SM00333. TUDOR. 2 hits. [Graphical view]
SUPFAM	SSF54171. DNA-binding_integrase-type. 1 hit.
PROSITE	PS50982. MBD. 1 hit. PS50868. POST_SET. 1 hit. PS50867. PRE_SET. 1 hit. PS50280. SET. 1 hit. PS50304. TUDOR. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SETDB1. mouse.
SOURCE	Search...

Entry information

Entry name

SETB1_MOUSE

Accession

Primary (citable) accession number: O88974
Secondary accession number(s): Q6AXH8 , Q78N64, Q78N65, Q80U84, Q8BTV6, Q8CIX7, Q922K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 120 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program