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O88968

- TCO2_MOUSE

UniProt

O88968 - TCO2_MOUSE

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Protein

Transcobalamin-2

Gene

Tcn2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi193 – 1931Cobalt (cobalamin axial ligand)By similarity
Binding sitei245 – 2451CobalaminBy similarity
Binding sitei248 – 2481CobalaminBy similarity
Binding sitei294 – 2941CobalaminBy similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cobalamin metabolic process Source: RefGenome
  2. cobalamin transport Source: InterPro
  3. cobalt ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cobalt transport, Ion transport, Transport

Keywords - Ligandi

Cobalt, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_189098. Defective CD320 causes methylmalonic aciduria.
REACT_189114. Defective TCN2 causes hereditary megaloblastic anemia.
REACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcobalamin-2
Short name:
TC-2
Alternative name(s):
Transcobalamin II
Short name:
TC II
Short name:
TCII
Gene namesi
Name:Tcn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98534. Tcn2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 430412Transcobalamin-2PRO_0000005565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 270By similarity
Disulfide bondi116 ↔ 312By similarity
Disulfide bondi165 ↔ 208By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiO88968.
PaxDbiO88968.
PRIDEiO88968.

PTM databases

PhosphoSiteiO88968.

Expressioni

Gene expression databases

BgeeiO88968.
CleanExiMM_TCN2.
GenevestigatoriO88968.

Structurei

3D structure databases

ProteinModelPortaliO88968.
SMRiO88968. Positions 19-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1565Cobalamin bindingBy similarity
Regioni193 – 1975Cobalamin bindingBy similarity
Regioni398 – 4003Cobalamin bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47054.
GeneTreeiENSGT00530000063370.
HOGENOMiHOG000074060.
HOVERGENiHBG001328.
InParanoidiO88968.
KOiK14619.
OMAiGHKGDRL.
OrthoDBiEOG79GT6F.
PhylomeDBiO88968.
TreeFamiTF333092.

Family and domain databases

InterProiIPR002157. Cbl-bd_transpt_euk.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PANTHERiPTHR10559. PTHR10559. 1 hit.
PfamiPF01122. Cobalamin_bind. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
PROSITEiPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88968-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLKALLLL SGVFGALAEF CVIPRIDSQL VEKLGQRLLP WMDRLSSEQL
60 70 80 90 100
NPSVFVGLRL SSMQAGTKED LYLHSLKIHY QQCLLRSTSS DDNSSCQPKL
110 120 130 140 150
SGGSLALYLL ALRANCEFFG SRKGDRLISQ LKWFLEDEKK AIGHNHEGHP
160 170 180 190 200
NTNYYQYGLS ILALCVHQKR LHDSVVGKLL YAVEHDYFTY QGHVSVDTEA
210 220 230 240 250
MAGLALTCLE RFNFNSDLRP RITMAIETVR EKILKSQAPE GYFGNIYSTP
260 270 280 290 300
LALQMLMTSP ASGVGLGTAC IKAGTSLLLS LQDGAFQNPL MISQLLPILN
310 320 330 340 350
HKTYLDLIFP DCQASRVMLV PAVEDPVHIS EVISVTLKVA SALSPYEQTF
360 370 380 390 400
FVFAGSSLED VLKLAQDGGG FTYGTQASLS GPYLTSVLGK DAGDREYWQL
410 420 430
LRAPDTPLLQ GIADYKPQDG ETIELRLVRW
Length:430
Mass (Da):47,586
Last modified:November 1, 1998 - v1
Checksum:i2EFF1427E48480A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191E → G in BAE25528. (PubMed:16141072)Curated
Sequence conflicti291 – 2911M → V in BAE41770. (PubMed:16141072)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021G → E in strain: NZB. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090686 mRNA. Translation: AAC61868.1.
AK133707 mRNA. Translation: BAE21792.1.
AK143761 mRNA. Translation: BAE25528.1.
AK147176 mRNA. Translation: BAE27739.1.
AK161618 mRNA. Translation: BAE36496.1.
AK170401 mRNA. Translation: BAE41770.1.
AL807395, AL807241 Genomic DNA. Translation: CAI26040.1.
AL807241, AL807395 Genomic DNA. Translation: CAI51997.1.
CH466574 Genomic DNA. Translation: EDL40449.1.
BC003720 mRNA. Translation: AAH03720.1.
CCDSiCCDS24371.1.
RefSeqiNP_001123930.1. NM_001130458.1.
NP_001123931.1. NM_001130459.1.
NP_056564.1. NM_015749.3.
XP_006514673.1. XM_006514610.1.
XP_006514674.1. XM_006514611.1.
XP_006514675.1. XM_006514612.1.
XP_006514676.1. XM_006514613.1.
UniGeneiMm.20948.

Genome annotation databases

EnsembliENSMUST00000020710; ENSMUSP00000020710; ENSMUSG00000020432.
ENSMUST00000109988; ENSMUSP00000105615; ENSMUSG00000020432.
ENSMUST00000109989; ENSMUSP00000105616; ENSMUSG00000020432.
ENSMUST00000109990; ENSMUSP00000105617; ENSMUSG00000020432.
ENSMUST00000109991; ENSMUSP00000105618; ENSMUSG00000020432.
ENSMUST00000109992; ENSMUSP00000105619; ENSMUSG00000020432.
ENSMUST00000109993; ENSMUSP00000105620; ENSMUSG00000020432.
GeneIDi21452.
KEGGimmu:21452.
UCSCiuc007htx.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090686 mRNA. Translation: AAC61868.1 .
AK133707 mRNA. Translation: BAE21792.1 .
AK143761 mRNA. Translation: BAE25528.1 .
AK147176 mRNA. Translation: BAE27739.1 .
AK161618 mRNA. Translation: BAE36496.1 .
AK170401 mRNA. Translation: BAE41770.1 .
AL807395 , AL807241 Genomic DNA. Translation: CAI26040.1 .
AL807241 , AL807395 Genomic DNA. Translation: CAI51997.1 .
CH466574 Genomic DNA. Translation: EDL40449.1 .
BC003720 mRNA. Translation: AAH03720.1 .
CCDSi CCDS24371.1.
RefSeqi NP_001123930.1. NM_001130458.1.
NP_001123931.1. NM_001130459.1.
NP_056564.1. NM_015749.3.
XP_006514673.1. XM_006514610.1.
XP_006514674.1. XM_006514611.1.
XP_006514675.1. XM_006514612.1.
XP_006514676.1. XM_006514613.1.
UniGenei Mm.20948.

3D structure databases

ProteinModelPortali O88968.
SMRi O88968. Positions 19-430.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O88968.

Proteomic databases

MaxQBi O88968.
PaxDbi O88968.
PRIDEi O88968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020710 ; ENSMUSP00000020710 ; ENSMUSG00000020432 .
ENSMUST00000109988 ; ENSMUSP00000105615 ; ENSMUSG00000020432 .
ENSMUST00000109989 ; ENSMUSP00000105616 ; ENSMUSG00000020432 .
ENSMUST00000109990 ; ENSMUSP00000105617 ; ENSMUSG00000020432 .
ENSMUST00000109991 ; ENSMUSP00000105618 ; ENSMUSG00000020432 .
ENSMUST00000109992 ; ENSMUSP00000105619 ; ENSMUSG00000020432 .
ENSMUST00000109993 ; ENSMUSP00000105620 ; ENSMUSG00000020432 .
GeneIDi 21452.
KEGGi mmu:21452.
UCSCi uc007htx.2. mouse.

Organism-specific databases

CTDi 6948.
MGIi MGI:98534. Tcn2.

Phylogenomic databases

eggNOGi NOG47054.
GeneTreei ENSGT00530000063370.
HOGENOMi HOG000074060.
HOVERGENi HBG001328.
InParanoidi O88968.
KOi K14619.
OMAi GHKGDRL.
OrthoDBi EOG79GT6F.
PhylomeDBi O88968.
TreeFami TF333092.

Enzyme and pathway databases

Reactomei REACT_189098. Defective CD320 causes methylmalonic aciduria.
REACT_189114. Defective TCN2 causes hereditary megaloblastic anemia.
REACT_189118. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

NextBioi 300812.
PROi O88968.
SOURCEi Search...

Gene expression databases

Bgeei O88968.
CleanExi MM_TCN2.
Genevestigatori O88968.

Family and domain databases

InterProi IPR002157. Cbl-bd_transpt_euk.
IPR019554. Soluble_ligand-bd.
[Graphical view ]
PANTHERi PTHR10559. PTHR10559. 1 hit.
Pfami PF01122. Cobalamin_bind. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view ]
PROSITEi PS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse transcobalamin II: polymorphism in NZB."
    Hasegawa M., Foote S.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-102.
    Strain: BALB/c and NZB.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head, Kidney and Spleen.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTCO2_MOUSE
AccessioniPrimary (citable) accession number: O88968
Secondary accession number(s): Q3TD34, Q3UP69, Q5SQ21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3