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Protein

Inhibin beta E chain

Gene

Inhbe

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta E chain
Alternative name(s):
Activin beta-E chain
Gene namesi
Name:Inhbe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621196. Inhbe.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000003374022 – 236Sequence analysisAdd BLAST215
ChainiPRO_0000033741237 – 350Inhibin beta E chainAdd BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 315By similarity
Disulfide bondi276 ↔ 347By similarity
Disulfide bondi280 ↔ 349By similarity
Disulfide bondi314InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88959.
PRIDEiO88959.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007601.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010106.

Structurei

3D structure databases

ProteinModelPortaliO88959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiO88959.
KOiK04667.
PhylomeDBiO88959.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSNVQLWT ILLWALAWVQ STRSACPSCG APTLTPQGER ALVLELAKQQ
60 70 80 90 100
ILEGLHLTSR PRITRPLPQA ALTRALRRLQ PRSMVPGNRE KVISFATSID
110 120 130 140 150
KSTSTYRSVL TFQLSPLWSH HLYHARLWLH VPPSFPATLY LRIFGCGTTR
160 170 180 190 200
CRGSRTFLAE HQTTSSGWHA LTLPSSGLRS EESGVTKLQL EFRPLDLNST
210 220 230 240 250
TARLPRLLLD TAGQQRPFLE LKIRANEPGA GRARRRTPTC ESETPLCCRR
260 270 280 290 300
DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
310 320 330 340 350
LLKANNPWPA GSSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
Length:350
Mass (Da):38,899
Last modified:November 1, 1998 - v1
Checksum:i0CEBF6E108E926E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160 – 161EH → DY in AAD30133 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089825 mRNA. Translation: AAC36741.1.
AF140032 mRNA. Translation: AAD30133.1.
RefSeqiNP_114003.2. NM_031815.2.
UniGeneiRn.30020.

Genome annotation databases

GeneIDi83711.
KEGGirno:83711.
UCSCiRGD:621196. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089825 mRNA. Translation: AAC36741.1.
AF140032 mRNA. Translation: AAD30133.1.
RefSeqiNP_114003.2. NM_031815.2.
UniGeneiRn.30020.

3D structure databases

ProteinModelPortaliO88959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010106.

Proteomic databases

PaxDbiO88959.
PRIDEiO88959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83711.
KEGGirno:83711.
UCSCiRGD:621196. rat.

Organism-specific databases

CTDi83729.
RGDi621196. Inhbe.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiO88959.
KOiK04667.
PhylomeDBiO88959.
TreeFamiTF318514.

Miscellaneous databases

PROiO88959.

Gene expression databases

BgeeiENSRNOG00000007601.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINHBE_RAT
AccessioniPrimary (citable) accession number: O88959
Secondary accession number(s): Q9R285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.