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O88944 (KCNQ3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily KQT member 3
Alternative name(s):
KQT-like 3
Potassium channel subunit alpha KvLQT3
Voltage-gated potassium channel subunit Kv7.3
Gene names
Name:Kcnq3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length873 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.

Subunit structure

Heteromultimer with KCNQ2.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus and at much lower levels in cerebellum. In sympathetic ganglia, expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily. [View classification]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O88944-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O88944-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MGLKARRAAG...GREEGQRRTP → MALEFPGLQP...GGEADGAQGS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 873873Potassium voltage-gated channel subfamily KQT member 3
PRO_0000054036

Regions

Transmembrane123 – 14321Helical; Name=Segment S1; Potential
Transmembrane154 – 17421Helical; Name=Segment S2; Potential
Transmembrane198 – 21821Helical; Name=Segment S3; Potential
Transmembrane227 – 24822Helical; Voltage-sensor; Name=Segment S4; Potential
Transmembrane263 – 28321Helical; Name=Segment S5; Potential
Intramembrane305 – 32521Pore-forming; Name=Segment H5; Potential
Transmembrane332 – 35221Helical; Name=Segment S6; Potential
Motif317 – 3226Selectivity filter By similarity
Compositional bias13 – 2513Poly-Gly

Natural variations

Alternative sequence1 – 8383MGLKA…QRRTP → MALEFPGLQPPPPPRPRTPS APSSRSSSGEGEAPSGGEAD GAQGS in isoform 2.
VSP_001012

Experimental info

Sequence conflict6541H → R in AAC79846. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 19, 2001. Version 2.
Checksum: D77AF88088051E15

FASTA87396,898
        10         20         30         40         50         60 
MGLKARRAAG AAGGGGGEGG GGGGGAANPA GGDSAVAGDE ERKVGLAPGD VEQVTLALGT 

        70         80         90        100        110        120 
GADKDGTLLL EGGGREEGQR RTPQGIGLLA KTPLSRPVKR NNAKYRRIQT LIYDALERPR 

       130        140        150        160        170        180 
GWALLYHALV FLIVLGCLIL AVLTTFKEYE TVSGDWLLLL ETFAIFIFGA EFALRIWAAG 

       190        200        210        220        230        240 
CCCRYKGWRG RLKFARKPLC MLDIFVLIAS VPVVAVGNQG NVLATSLRSL RFLQILRMLR 

       250        260        270        280        290        300 
MDRRGGTWKL LGSAICAHSK ELITAWYIGF LTLILSSFLV YLVEKDVPEM DAQGEEMKEE 

       310        320        330        340        350        360 
FETYADALWW GLITLATIGY GDKTPKTWEG RLIAATFSLI GVSFFALPAG ILGSGLALKV 

       370        380        390        400        410        420 
QEQHRQKHFE KRRKPAAELI QAAWRYYATN PNRLDLVATW RFYESVVSFP FFRKEQLEAA 

       430        440        450        460        470        480 
ASQKLGLLDR VRLSNPRGSN TKGKLFTPLN VDAIEESPSK EPKPVGLNNK ERFRTAFRMK 

       490        500        510        520        530        540 
AYAFWQSSED AGTGDPMTED RGYGNDFLIE DMIPTLKAAI RAVRILQFRL YKKKFKETLR 

       550        560        570        580        590        600 
PYDVKDVIEQ YSAGHLDMLS RIKYLQTRID MIFTPGPPST PKHKKSQKGS AFTYPSQQSP 

       610        620        630        640        650        660 
RNEPYVARAA TSETEDQSMM GKFVKVERQV HDMGKKLDFL VDMHMQHMER LQVHVTEYYP 

       670        680        690        700        710        720 
TKGASSPAEG EKKEDNRYSD LKTIICNYSE SGPPDPPYSF HQVPIDRVGP YGFFAHDPVK 

       730        740        750        760        770        780 
LTRGGPSSTK AQANLPSSGS TYAERPTVLP ILTLLDSCVS YHSQTELQGP YSDHISPRQR 

       790        800        810        820        830        840 
RSITRDSDTP LSLMSVNHEE LERSPSGFSI SQDRDDYVFG PSGGSSWMRE KRYLAEGETD 

       850        860        870 
TDTDPFTPSG SMPMSSTGDG ISDSIWTPSN KPT 

« Hide

Isoform 2 [UniParc].

Checksum: 3B532712B4C4E773
Show »

FASTA83593,601

References

[1]Derst C., Preisig-Mueller R., Hennighausen A., Daut J.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel."
Wang H.-S., Pan Z., Shi W., Brown B.S., Wymore R.S., Cohen I.S., Dixon J.E., McKinnon D.
Science 282:1890-1893(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087454 mRNA. Translation: AAC36723.2.
AF091247 mRNA. Translation: AAC79846.1.
UniGeneRn.205060.

3D structure databases

ProteinModelPortalO88944.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248303. 2 interactions.
STRING10116.ENSRNOP00000006930.

Chemistry

ChEMBLCHEMBL5531.

PTM databases

PhosphoSiteO88944.

Proteomic databases

PaxDbO88944.
PRIDEO88944.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000074573; ENSRNOP00000065354; ENSRNOG00000005206. [O88944-1]
UCSCRGD:69222. rat. [O88944-1]

Organism-specific databases

RGD69222. Kcnq3.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00550000074513.
HOGENOMHOG000220839.
HOVERGENHBG059014.
InParanoidO88944.
OMAFFAHDPV.
PhylomeDBO88944.

Gene expression databases

GenevestigatorO88944.

Family and domain databases

InterProIPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003948. K_chnl_volt-dep_KCNQ3.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF5. PTHR11537:SF5. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01462. KCNQ3CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetSearch...

Other

NextBio610039.
PROO88944.

Entry information

Entry nameKCNQ3_RAT
AccessionPrimary (citable) accession number: O88944
Secondary accession number(s): Q9Z240
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: December 19, 2001
Last modified: May 14, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families