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O88944

- KCNQ3_RAT

UniProt

O88944 - KCNQ3_RAT

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Protein
Potassium voltage-gated channel subfamily KQT member 3
Gene
Kcnq3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. membrane hyperpolarization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 3
Alternative name(s):
KQT-like 3
Potassium channel subunit alpha KvLQT3
Voltage-gated potassium channel subunit Kv7.3
Gene namesi
Name:Kcnq3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi69222. Kcnq3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 14321Helical; Name=Segment S1; Reviewed prediction
Add
BLAST
Transmembranei154 – 17421Helical; Name=Segment S2; Reviewed prediction
Add
BLAST
Transmembranei198 – 21821Helical; Name=Segment S3; Reviewed prediction
Add
BLAST
Transmembranei227 – 24822Helical; Voltage-sensor; Name=Segment S4; Reviewed prediction
Add
BLAST
Transmembranei263 – 28321Helical; Name=Segment S5; Reviewed prediction
Add
BLAST
Intramembranei305 – 32521Pore-forming; Name=Segment H5; Reviewed prediction
Add
BLAST
Transmembranei332 – 35221Helical; Name=Segment S6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon initial segment Source: Ensembl
  2. node of Ranvier Source: Ensembl
  3. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Potassium voltage-gated channel subfamily KQT member 3
PRO_0000054036Add
BLAST

Proteomic databases

PaxDbiO88944.
PRIDEiO88944.

PTM databases

PhosphoSiteiO88944.

Expressioni

Tissue specificityi

Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus and at much lower levels in cerebellum. In sympathetic ganglia, expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.

Gene expression databases

GenevestigatoriO88944.

Interactioni

Subunit structurei

Heteromultimer with KCNQ2.

Protein-protein interaction databases

BioGridi248303. 2 interactions.
STRINGi10116.ENSRNOP00000006930.

Structurei

3D structure databases

ProteinModelPortaliO88944.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi317 – 3226Selectivity filter By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 2513Poly-Gly
Add
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiO88944.
OMAiFFAHDPV.
PhylomeDBiO88944.

Family and domain databases

InterProiIPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003948. K_chnl_volt-dep_KCNQ3.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF5. PTHR11537:SF5. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01462. KCNQ3CHANNEL.
PR01459. KCNQCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88944-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLKARRAAG AAGGGGGEGG GGGGGAANPA GGDSAVAGDE ERKVGLAPGD    50
VEQVTLALGT GADKDGTLLL EGGGREEGQR RTPQGIGLLA KTPLSRPVKR 100
NNAKYRRIQT LIYDALERPR GWALLYHALV FLIVLGCLIL AVLTTFKEYE 150
TVSGDWLLLL ETFAIFIFGA EFALRIWAAG CCCRYKGWRG RLKFARKPLC 200
MLDIFVLIAS VPVVAVGNQG NVLATSLRSL RFLQILRMLR MDRRGGTWKL 250
LGSAICAHSK ELITAWYIGF LTLILSSFLV YLVEKDVPEM DAQGEEMKEE 300
FETYADALWW GLITLATIGY GDKTPKTWEG RLIAATFSLI GVSFFALPAG 350
ILGSGLALKV QEQHRQKHFE KRRKPAAELI QAAWRYYATN PNRLDLVATW 400
RFYESVVSFP FFRKEQLEAA ASQKLGLLDR VRLSNPRGSN TKGKLFTPLN 450
VDAIEESPSK EPKPVGLNNK ERFRTAFRMK AYAFWQSSED AGTGDPMTED 500
RGYGNDFLIE DMIPTLKAAI RAVRILQFRL YKKKFKETLR PYDVKDVIEQ 550
YSAGHLDMLS RIKYLQTRID MIFTPGPPST PKHKKSQKGS AFTYPSQQSP 600
RNEPYVARAA TSETEDQSMM GKFVKVERQV HDMGKKLDFL VDMHMQHMER 650
LQVHVTEYYP TKGASSPAEG EKKEDNRYSD LKTIICNYSE SGPPDPPYSF 700
HQVPIDRVGP YGFFAHDPVK LTRGGPSSTK AQANLPSSGS TYAERPTVLP 750
ILTLLDSCVS YHSQTELQGP YSDHISPRQR RSITRDSDTP LSLMSVNHEE 800
LERSPSGFSI SQDRDDYVFG PSGGSSWMRE KRYLAEGETD TDTDPFTPSG 850
SMPMSSTGDG ISDSIWTPSN KPT 873
Length:873
Mass (Da):96,898
Last modified:December 19, 2001 - v2
Checksum:iD77AF88088051E15
GO
Isoform 2 (identifier: O88944-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MGLKARRAAG...GREEGQRRTP → MALEFPGLQP...GGEADGAQGS

Note: No experimental confirmation available.

Show »
Length:835
Mass (Da):93,601
Checksum:i3B532712B4C4E773
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383MGLKA…QRRTP → MALEFPGLQPPPPPRPRTPS APSSRSSSGEGEAPSGGEAD GAQGS in isoform 2.
VSP_001012Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti654 – 6541H → R in AAC79846. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087454 mRNA. Translation: AAC36723.2.
AF091247 mRNA. Translation: AAC79846.1.
UniGeneiRn.205060.

Genome annotation databases

EnsembliENSRNOT00000074573; ENSRNOP00000065354; ENSRNOG00000005206. [O88944-1]
UCSCiRGD:69222. rat. [O88944-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087454 mRNA. Translation: AAC36723.2 .
AF091247 mRNA. Translation: AAC79846.1 .
UniGenei Rn.205060.

3D structure databases

ProteinModelPortali O88944.
ModBasei Search...

Protein-protein interaction databases

BioGridi 248303. 2 interactions.
STRINGi 10116.ENSRNOP00000006930.

Chemistry

ChEMBLi CHEMBL5531.

PTM databases

PhosphoSitei O88944.

Proteomic databases

PaxDbi O88944.
PRIDEi O88944.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000074573 ; ENSRNOP00000065354 ; ENSRNOG00000005206 . [O88944-1 ]
UCSCi RGD:69222. rat. [O88944-1 ]

Organism-specific databases

RGDi 69222. Kcnq3.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00550000074513.
HOGENOMi HOG000220839.
HOVERGENi HBG059014.
InParanoidi O88944.
OMAi FFAHDPV.
PhylomeDBi O88944.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 610039.
PROi O88944.

Gene expression databases

Genevestigatori O88944.

Family and domain databases

InterProi IPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003948. K_chnl_volt-dep_KCNQ3.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
PTHR11537:SF5. PTHR11537:SF5. 1 hit.
Pfami PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01462. KCNQ3CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNeti Search...

Publicationsi

  1. Derst C., Preisig-Mueller R., Hennighausen A., Daut J.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel."
    Wang H.-S., Pan Z., Shi W., Brown B.S., Wymore R.S., Cohen I.S., Dixon J.E., McKinnon D.
    Science 282:1890-1893(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiKCNQ3_RAT
AccessioniPrimary (citable) accession number: O88944
Secondary accession number(s): Q9Z240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: December 19, 2001
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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