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Protein

Potassium voltage-gated channel subfamily KQT member 3

Gene

Kcnq3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central

GO - Biological processi

  1. membrane hyperpolarization Source: Ensembl
  2. potassium ion transmembrane transport Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_352543. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 3
Alternative name(s):
KQT-like 3
Potassium channel subunit alpha KvLQT3
Voltage-gated potassium channel subunit Kv7.3
Gene namesi
Name:Kcnq3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi69222. Kcnq3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei123 – 14321Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei227 – 24822Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei305 – 32521Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei332 – 35221Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon initial segment Source: Ensembl
  2. integral component of membrane Source: GO_Central
  3. node of Ranvier Source: Ensembl
  4. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873Potassium voltage-gated channel subfamily KQT member 3PRO_0000054036Add
BLAST

Proteomic databases

PaxDbiO88944.
PRIDEiO88944.

PTM databases

PhosphoSiteiO88944.

Expressioni

Tissue specificityi

Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus and at much lower levels in cerebellum. In sympathetic ganglia, expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.

Gene expression databases

ExpressionAtlasiO88944. baseline.
GenevestigatoriO88944.

Interactioni

Subunit structurei

Heteromultimer with KCNQ2.

Protein-protein interaction databases

BioGridi248303. 2 interactions.
STRINGi10116.ENSRNOP00000006930.

Structurei

3D structure databases

ProteinModelPortaliO88944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi317 – 3226Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 2513Poly-GlyAdd
BLAST

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiO88944.
OMAiFFAHDPV.
PhylomeDBiO88944.

Family and domain databases

InterProiIPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003948. K_chnl_volt-dep_KCNQ3.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF5. PTHR11537:SF5. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01462. KCNQ3CHANNEL.
PR01459. KCNQCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88944-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLKARRAAG AAGGGGGEGG GGGGGAANPA GGDSAVAGDE ERKVGLAPGD
60 70 80 90 100
VEQVTLALGT GADKDGTLLL EGGGREEGQR RTPQGIGLLA KTPLSRPVKR
110 120 130 140 150
NNAKYRRIQT LIYDALERPR GWALLYHALV FLIVLGCLIL AVLTTFKEYE
160 170 180 190 200
TVSGDWLLLL ETFAIFIFGA EFALRIWAAG CCCRYKGWRG RLKFARKPLC
210 220 230 240 250
MLDIFVLIAS VPVVAVGNQG NVLATSLRSL RFLQILRMLR MDRRGGTWKL
260 270 280 290 300
LGSAICAHSK ELITAWYIGF LTLILSSFLV YLVEKDVPEM DAQGEEMKEE
310 320 330 340 350
FETYADALWW GLITLATIGY GDKTPKTWEG RLIAATFSLI GVSFFALPAG
360 370 380 390 400
ILGSGLALKV QEQHRQKHFE KRRKPAAELI QAAWRYYATN PNRLDLVATW
410 420 430 440 450
RFYESVVSFP FFRKEQLEAA ASQKLGLLDR VRLSNPRGSN TKGKLFTPLN
460 470 480 490 500
VDAIEESPSK EPKPVGLNNK ERFRTAFRMK AYAFWQSSED AGTGDPMTED
510 520 530 540 550
RGYGNDFLIE DMIPTLKAAI RAVRILQFRL YKKKFKETLR PYDVKDVIEQ
560 570 580 590 600
YSAGHLDMLS RIKYLQTRID MIFTPGPPST PKHKKSQKGS AFTYPSQQSP
610 620 630 640 650
RNEPYVARAA TSETEDQSMM GKFVKVERQV HDMGKKLDFL VDMHMQHMER
660 670 680 690 700
LQVHVTEYYP TKGASSPAEG EKKEDNRYSD LKTIICNYSE SGPPDPPYSF
710 720 730 740 750
HQVPIDRVGP YGFFAHDPVK LTRGGPSSTK AQANLPSSGS TYAERPTVLP
760 770 780 790 800
ILTLLDSCVS YHSQTELQGP YSDHISPRQR RSITRDSDTP LSLMSVNHEE
810 820 830 840 850
LERSPSGFSI SQDRDDYVFG PSGGSSWMRE KRYLAEGETD TDTDPFTPSG
860 870
SMPMSSTGDG ISDSIWTPSN KPT
Length:873
Mass (Da):96,898
Last modified:December 18, 2001 - v2
Checksum:iD77AF88088051E15
GO
Isoform 2 (identifier: O88944-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MGLKARRAAG...GREEGQRRTP → MALEFPGLQP...GGEADGAQGS

Note: No experimental confirmation available.

Show »
Length:835
Mass (Da):93,601
Checksum:i3B532712B4C4E773
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti654 – 6541H → R in AAC79846 (PubMed:9836639).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8383MGLKA…QRRTP → MALEFPGLQPPPPPRPRTPS APSSRSSSGEGEAPSGGEAD GAQGS in isoform 2. 1 PublicationVSP_001012Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087454 mRNA. Translation: AAC36723.2.
AF091247 mRNA. Translation: AAC79846.1.
UniGeneiRn.205060.

Genome annotation databases

EnsembliENSRNOT00000074573; ENSRNOP00000065354; ENSRNOG00000005206. [O88944-1]
UCSCiRGD:69222. rat. [O88944-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087454 mRNA. Translation: AAC36723.2.
AF091247 mRNA. Translation: AAC79846.1.
UniGeneiRn.205060.

3D structure databases

ProteinModelPortaliO88944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248303. 2 interactions.
STRINGi10116.ENSRNOP00000006930.

Chemistry

ChEMBLiCHEMBL5531.
GuidetoPHARMACOLOGYi562.

PTM databases

PhosphoSiteiO88944.

Proteomic databases

PaxDbiO88944.
PRIDEiO88944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074573; ENSRNOP00000065354; ENSRNOG00000005206. [O88944-1]
UCSCiRGD:69222. rat. [O88944-1]

Organism-specific databases

RGDi69222. Kcnq3.

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00550000074513.
HOGENOMiHOG000220839.
HOVERGENiHBG059014.
InParanoidiO88944.
OMAiFFAHDPV.
PhylomeDBiO88944.

Enzyme and pathway databases

ReactomeiREACT_352543. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi610039.
PROiO88944.

Gene expression databases

ExpressionAtlasiO88944. baseline.
GenevestigatoriO88944.

Family and domain databases

InterProiIPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003948. K_chnl_volt-dep_KCNQ3.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PTHR11537:SF5. PTHR11537:SF5. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01462. KCNQ3CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. Derst C., Preisig-Mueller R., Hennighausen A., Daut J.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel."
    Wang H.-S., Pan Z., Shi W., Brown B.S., Wymore R.S., Cohen I.S., Dixon J.E., McKinnon D.
    Science 282:1890-1893(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiKCNQ3_RAT
AccessioniPrimary (citable) accession number: O88944
Secondary accession number(s): Q9Z240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2001
Last sequence update: December 18, 2001
Last modified: March 31, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.