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O88944

- KCNQ3_RAT

UniProt

O88944 - KCNQ3_RAT

Protein

Potassium voltage-gated channel subfamily KQT member 3

Gene

Kcnq3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (19 Dec 2001)
      Previous versions | rss
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    Functioni

    Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. membrane hyperpolarization Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily KQT member 3
    Alternative name(s):
    KQT-like 3
    Potassium channel subunit alpha KvLQT3
    Voltage-gated potassium channel subunit Kv7.3
    Gene namesi
    Name:Kcnq3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi69222. Kcnq3.

    Subcellular locationi

    GO - Cellular componenti

    1. axon initial segment Source: Ensembl
    2. node of Ranvier Source: Ensembl
    3. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873Potassium voltage-gated channel subfamily KQT member 3PRO_0000054036Add
    BLAST

    Proteomic databases

    PaxDbiO88944.
    PRIDEiO88944.

    PTM databases

    PhosphoSiteiO88944.

    Expressioni

    Tissue specificityi

    Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus and at much lower levels in cerebellum. In sympathetic ganglia, expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.

    Gene expression databases

    GenevestigatoriO88944.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNQ2.

    Protein-protein interaction databases

    BioGridi248303. 2 interactions.
    STRINGi10116.ENSRNOP00000006930.

    Structurei

    3D structure databases

    ProteinModelPortaliO88944.
    ModBaseiSearch...
    MobiDBiSearch...

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei305 – 32521Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei123 – 14321Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24822Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi317 – 3226Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi13 – 2513Poly-GlyAdd
    BLAST

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00550000074513.
    HOGENOMiHOG000220839.
    HOVERGENiHBG059014.
    InParanoidiO88944.
    OMAiFFAHDPV.
    PhylomeDBiO88944.

    Family and domain databases

    InterProiIPR020969. Ankyrin-G_BS.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003937. K_chnl_volt-dep_KCNQ.
    IPR003948. K_chnl_volt-dep_KCNQ3.
    IPR013821. K_chnl_volt-dep_KCNQ_C.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF5. PTHR11537:SF5. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    PF03520. KCNQ_channel. 1 hit.
    PF11956. KCNQC3-Ank-G_bd. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01462. KCNQ3CHANNEL.
    PR01459. KCNQCHANNEL.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88944-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLKARRAAG AAGGGGGEGG GGGGGAANPA GGDSAVAGDE ERKVGLAPGD    50
    VEQVTLALGT GADKDGTLLL EGGGREEGQR RTPQGIGLLA KTPLSRPVKR 100
    NNAKYRRIQT LIYDALERPR GWALLYHALV FLIVLGCLIL AVLTTFKEYE 150
    TVSGDWLLLL ETFAIFIFGA EFALRIWAAG CCCRYKGWRG RLKFARKPLC 200
    MLDIFVLIAS VPVVAVGNQG NVLATSLRSL RFLQILRMLR MDRRGGTWKL 250
    LGSAICAHSK ELITAWYIGF LTLILSSFLV YLVEKDVPEM DAQGEEMKEE 300
    FETYADALWW GLITLATIGY GDKTPKTWEG RLIAATFSLI GVSFFALPAG 350
    ILGSGLALKV QEQHRQKHFE KRRKPAAELI QAAWRYYATN PNRLDLVATW 400
    RFYESVVSFP FFRKEQLEAA ASQKLGLLDR VRLSNPRGSN TKGKLFTPLN 450
    VDAIEESPSK EPKPVGLNNK ERFRTAFRMK AYAFWQSSED AGTGDPMTED 500
    RGYGNDFLIE DMIPTLKAAI RAVRILQFRL YKKKFKETLR PYDVKDVIEQ 550
    YSAGHLDMLS RIKYLQTRID MIFTPGPPST PKHKKSQKGS AFTYPSQQSP 600
    RNEPYVARAA TSETEDQSMM GKFVKVERQV HDMGKKLDFL VDMHMQHMER 650
    LQVHVTEYYP TKGASSPAEG EKKEDNRYSD LKTIICNYSE SGPPDPPYSF 700
    HQVPIDRVGP YGFFAHDPVK LTRGGPSSTK AQANLPSSGS TYAERPTVLP 750
    ILTLLDSCVS YHSQTELQGP YSDHISPRQR RSITRDSDTP LSLMSVNHEE 800
    LERSPSGFSI SQDRDDYVFG PSGGSSWMRE KRYLAEGETD TDTDPFTPSG 850
    SMPMSSTGDG ISDSIWTPSN KPT 873
    Length:873
    Mass (Da):96,898
    Last modified:December 19, 2001 - v2
    Checksum:iD77AF88088051E15
    GO
    Isoform 2 (identifier: O88944-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-83: MGLKARRAAG...GREEGQRRTP → MALEFPGLQP...GGEADGAQGS

    Note: No experimental confirmation available.

    Show »
    Length:835
    Mass (Da):93,601
    Checksum:i3B532712B4C4E773
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti654 – 6541H → R in AAC79846. (PubMed:9836639)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8383MGLKA…QRRTP → MALEFPGLQPPPPPRPRTPS APSSRSSSGEGEAPSGGEAD GAQGS in isoform 2. 1 PublicationVSP_001012Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087454 mRNA. Translation: AAC36723.2.
    AF091247 mRNA. Translation: AAC79846.1.
    UniGeneiRn.205060.

    Genome annotation databases

    EnsembliENSRNOT00000074573; ENSRNOP00000065354; ENSRNOG00000005206. [O88944-1]
    UCSCiRGD:69222. rat. [O88944-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087454 mRNA. Translation: AAC36723.2 .
    AF091247 mRNA. Translation: AAC79846.1 .
    UniGenei Rn.205060.

    3D structure databases

    ProteinModelPortali O88944.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248303. 2 interactions.
    STRINGi 10116.ENSRNOP00000006930.

    Chemistry

    ChEMBLi CHEMBL5531.

    PTM databases

    PhosphoSitei O88944.

    Proteomic databases

    PaxDbi O88944.
    PRIDEi O88944.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074573 ; ENSRNOP00000065354 ; ENSRNOG00000005206 . [O88944-1 ]
    UCSCi RGD:69222. rat. [O88944-1 ]

    Organism-specific databases

    RGDi 69222. Kcnq3.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00550000074513.
    HOGENOMi HOG000220839.
    HOVERGENi HBG059014.
    InParanoidi O88944.
    OMAi FFAHDPV.
    PhylomeDBi O88944.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 610039.
    PROi O88944.

    Gene expression databases

    Genevestigatori O88944.

    Family and domain databases

    InterProi IPR020969. Ankyrin-G_BS.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003937. K_chnl_volt-dep_KCNQ.
    IPR003948. K_chnl_volt-dep_KCNQ3.
    IPR013821. K_chnl_volt-dep_KCNQ_C.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    PTHR11537:SF5. PTHR11537:SF5. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    PF03520. KCNQ_channel. 1 hit.
    PF11956. KCNQC3-Ank-G_bd. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01462. KCNQ3CHANNEL.
    PR01459. KCNQCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. Derst C., Preisig-Mueller R., Hennighausen A., Daut J.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel."
      Wang H.-S., Pan Z., Shi W., Brown B.S., Wymore R.S., Cohen I.S., Dixon J.E., McKinnon D.
      Science 282:1890-1893(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNQ3_RAT
    AccessioniPrimary (citable) accession number: O88944
    Secondary accession number(s): Q9Z240
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: December 19, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3